AiPD: Autoinhibited Protein Database

P41597

Gene name	CCR2 (CMKBR2)
Protein name	C-C chemokine receptor type 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:729230
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

296-374 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

296-374 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for P41597

Entry ID	Method	Resolution	Chain	Position	Source
2MLO	NMR	-	A	310-318	PDB
2MLQ	NMR	-	A	310-318	PDB
5T1A	X-ray	281 A	A	2-313	PDB
7P8X	X-ray	140 A	M	25-29	PDB
7XA3	EM	290 A	R	1-318	PDB
AF-P41597-F1	Predicted				AlphaFoldDB

293 variants for P41597

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA119415 VAR_014339 rs1799864 RCV000008756	64	V>I	Susceptibility to HIV infection confers relative resistance to infection by HIV-1; delay in disease progression in African Americans but not in Caucasians [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV003224394 RCV000767917 rs368150580 CA2354498	352	D>N	Susceptibility to HIV infection [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs773632891 CA2354266	2	L>M		No	ClinGen ExAC TOPMed gnomAD
rs749369525 CA2354267	2	L>P		No	ClinGen ExAC gnomAD
rs373872490 COSM1485219 CA2354268	6	R>C	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA2354269 rs368615088	6	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA2354270 rs759923582	7	S>P		No	ClinGen ExAC gnomAD
rs1331436286 CA352465888	7	S>Y		No	ClinGen gnomAD
CA2354271 rs372648667	8	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA352465890 rs1355689842	8	R>W		No	ClinGen gnomAD
CA2354272 rs775776254	10	I>V		No	ClinGen ExAC gnomAD
rs761033901 CA2354273	11	R>G		No	ClinGen ExAC gnomAD
CA352465932 rs1283636260	14	N>S		No	ClinGen gnomAD
rs199666836 CA2354275	15	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199666836 CA352465935	15	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs75236779 CA2354278 COSM1284001	17	G>S	autonomic_ganglia [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA352465973 rs1432766750	20	V>I		No	ClinGen TOPMed
rs758208616 CA2354279	21	T>A		No	ClinGen ExAC gnomAD
CA352466000 rs1274809697	24	F>C		No	ClinGen TOPMed gnomAD
CA2354281 rs746791976	24	F>L		No	ClinGen ExAC TOPMed gnomAD
CA352466008 rs369390916 CA2354283	25	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2354282 rs754874220	25	D>N		No	ClinGen ExAC gnomAD
CA352466004 rs754874220	25	D>Y		No	ClinGen ExAC gnomAD
rs1301541790 CA352466049	29	G>D		No	ClinGen TOPMed
rs771219113 CA2354285	29	G>S		No	ClinGen ExAC gnomAD
CA352466057 rs1306511610	30	A>T		No	ClinGen gnomAD
rs1388071603 CA352466063	30	A>V		No	ClinGen TOPMed
rs1377688031 CA352466088	32	C>S		No	ClinGen gnomAD
rs1397019491 CA352466135	35	F>I		No	ClinGen gnomAD
rs778812407 CA352466158	36	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1448697134 CA352466167	37	V>L		No	ClinGen TOPMed gnomAD
CA352466165 rs1448697134	37	V>M		No	ClinGen TOPMed gnomAD
rs769904472 CA73697450	38	K>R		No	ClinGen gnomAD
CA2354288 rs772502682	41	G>R		No	ClinGen ExAC gnomAD
CA352466239 rs776044125	42	A>G		No	ClinGen ExAC TOPMed gnomAD
rs776044125 CA2354289	42	A>V		No	ClinGen ExAC TOPMed gnomAD
rs910295273 CA73697465	43	Q>H		No	ClinGen Ensembl
CA2354290 rs761015332	44	L>V		No	ClinGen ExAC TOPMed gnomAD
CA73697471 rs4987052 VAR_020066	45	L>V		No	ClinGen UniProt TOPMed dbSNP
rs777084052 CA73697483	47	P>A		No	ClinGen ExAC gnomAD
rs200099906 CA2354293	47	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs777084052 CA2354292	47	P>S		No	ClinGen ExAC gnomAD
rs749834579 CA2354295	48	L>F		No	ClinGen ExAC gnomAD
CA2354296 rs762615152 COSM1593755	50	S>L	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs929504805 CA73697496	53	F>S		No	ClinGen Ensembl
CA352466387 rs1254516472	54	I>L		No	ClinGen TOPMed
CA352466391 rs1449356333	54	I>T		No	ClinGen gnomAD
rs754794357 CA2354299	55	F>L		No	ClinGen ExAC gnomAD
rs781098683 CA2354300	57	F>C		No	ClinGen ExAC gnomAD
rs766201549 CA73697515	58	V>A		No	ClinGen TOPMed
CA352466467 rs766201549	58	V>G		No	ClinGen TOPMed
rs1483777755 CA352466478	59	G>D		No	ClinGen TOPMed
rs1466859213 CA352466492	60	N>K		No	ClinGen gnomAD
rs1400248989 CA352466509	61	M>I		No	ClinGen gnomAD
CA2354301 rs752561542	61	M>R		No	ClinGen ExAC gnomAD
CA73697517 rs928262971	61	M>V		No	ClinGen Ensembl
rs757366142 CA2354302	63	V>I		No	ClinGen ExAC TOPMed gnomAD
rs780507473 CA2354305	65	L>F		No	ClinGen ExAC gnomAD
CA352466563 rs1373191489	66	I>S		No	ClinGen gnomAD
CA73697537 rs1042578153	66	I>V		No	ClinGen TOPMed gnomAD
rs747475266 CA2354307	69	N>D		No	ClinGen ExAC gnomAD
rs762717036 CA2354306	70	C>*		No	ClinGen ExAC gnomAD
rs769171687 CA73697553	70	C>S		No	ClinGen ExAC TOPMed gnomAD
rs769171687 CA2354308	70	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA352466634 rs1206564341	72	K>T		No	ClinGen TOPMed gnomAD
CA2354309 rs200575131	75	C>R		No	ClinGen 1000Genomes ExAC
rs762239858 CA352466658	75	C>W		No	ClinGen ExAC TOPMed gnomAD
CA73697560 rs1055084032	76	L>W		No	ClinGen Ensembl
rs893818700 CA73697565	78	D>N		No	ClinGen Ensembl
CA73697569 rs1010908334	79	I>V		No	ClinGen gnomAD
CA73697581 rs767602057	83	N>S		No	ClinGen gnomAD
rs1575273131 CA352466716	85	A>T		No	ClinGen Ensembl
CA2354314 rs766030490	87	S>T		No	ClinGen ExAC TOPMed gnomAD
CA352466742 rs1455709306	89	L>M		No	ClinGen TOPMed gnomAD
rs751150214 CA2354315	90	L>P		No	ClinGen ExAC gnomAD
rs759501183 CA2354316	92	L>V		No	ClinGen ExAC gnomAD
CA2354318 rs752368994	93	I>T		No	ClinGen ExAC TOPMed gnomAD
rs778990367 CA2354320	95	L>P		No	ClinGen ExAC TOPMed
CA2354319 rs756006925	95	L>V		No	ClinGen ExAC TOPMed gnomAD
CA352466791 rs1230058872	97	L>S		No	ClinGen gnomAD
CA352466824 rs752821656	102	A>P		No	ClinGen ExAC TOPMed gnomAD
CA2354322 rs752821656	102	A>T		No	ClinGen ExAC TOPMed gnomAD
rs780059438 CA2354323	104	N>K		No	ClinGen ExAC gnomAD
rs755409798 CA2354325	105	E>K		No	ClinGen ExAC gnomAD
CA352466849 rs1489062912	106	W>R		No	ClinGen gnomAD
CA352466868 rs1209802498	108	F>C		No	ClinGen gnomAD
rs1258650932 CA352466881	110	N>T		No	ClinGen TOPMed
rs748444969 CA2354327	111	A>T		No	ClinGen ExAC gnomAD
rs1411428565 CA352466892	112	M>L		No	ClinGen gnomAD
CA352466903 rs1471741242	113	C>Y		No	ClinGen TOPMed gnomAD
CA73697669 rs1030658938	118	G>R		No	ClinGen Ensembl
rs1167133420 CA352466942	119	L>M		No	ClinGen gnomAD
rs113340633 CA73697674	119	L>P		No	ClinGen Ensembl
rs748913404 CA352466970	123	G>C		No	ClinGen ExAC TOPMed gnomAD
CA352466969 rs748913404	123	G>R		No	ClinGen ExAC TOPMed gnomAD
rs748913404 CA2354330	123	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1411421663 CA352466987	125	F>C		No	ClinGen gnomAD
CA2354331 rs371121141	125	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2354332 rs773943704	126	G>A		No	ClinGen ExAC gnomAD
rs1349428151 CA352466989	126	G>S		No	ClinGen gnomAD
CA2354334 rs756172205	127	G>*		No	ClinGen ExAC TOPMed gnomAD
CA2354335 rs756172205	127	G>R		No	ClinGen ExAC TOPMed gnomAD
rs373211972 CA2354336	127	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA352467000 rs1264188741	128	I>N		No	ClinGen gnomAD
CA352467001 rs1264188741	128	I>T		No	ClinGen gnomAD
CA2354337 rs763990194	129	F>L		No	ClinGen ExAC gnomAD
CA2354338 rs753655538	130	F>L		No	ClinGen ExAC gnomAD
rs758555738 CA2354339	131	I>V		No	ClinGen ExAC gnomAD
CA2354340 rs766591105	132	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1190295120 CA352467032	133	L>I		No	ClinGen TOPMed gnomAD
CA352467040 rs1411780396	134	L>R		No	ClinGen TOPMed
rs1423307592 CA352467045	135	T>K		No	ClinGen gnomAD
rs781525332 CA352467052	136	I>M		No	ClinGen ExAC TOPMed gnomAD
rs796453205 CA73697769	136	I>V		No	ClinGen Ensembl
CA352467055 rs1458820009	137	D>A		No	ClinGen TOPMed
CA2354344 rs748725992	137	D>N		No	ClinGen ExAC TOPMed gnomAD
rs778154963 CA2354346	138	R>K		No	ClinGen ExAC gnomAD
CA2354347 rs374045702	141	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA2354348 rs376867283	142	I>V		No	ClinGen ESP ExAC gnomAD
rs774215151 CA2354349	145	A>V		No	ClinGen ExAC gnomAD
rs1575273297 CA352467146	151	A>S		No	ClinGen Ensembl
CA73697809 rs370278890	153	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA2354350 rs370278890	153	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA2354353 rs567951143	155	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA352467171 rs567951143	155	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA352467184 rs1212756427	157	G>V		No	ClinGen gnomAD
CA73697824 rs982343072	158	V>M		No	ClinGen gnomAD
rs532078003 CA2354354	159	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs532078003 CA352467191	159	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA352467214 rs1167265831	162	V>A		No	ClinGen Ensembl
CA352467212 rs1356881023	162	V>M		No	ClinGen TOPMed
CA352467219 rs199838068	163	I>N		No	ClinGen 1000Genomes TOPMed
rs199838068 CA73697828	163	I>T		No	ClinGen 1000Genomes TOPMed
CA73697829 rs958407661	165	W>S		No	ClinGen TOPMed gnomAD
rs1451205983 CA352467251	168	A>S		No	ClinGen gnomAD
rs1261120929 CA352467269	171	A>S		No	ClinGen gnomAD
rs1559562115 CA352467281	173	V>I		No	ClinGen Ensembl
rs761661605 CA2354356	182	Q>R		No	ClinGen ExAC gnomAD
rs375466820 CA2354357	183	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs928199844 CA73697833	183	K>R		No	ClinGen TOPMed gnomAD
CA352467358 rs1575273357	184	E>*		No	ClinGen Ensembl
CA352467380 rs1559562128	187	V>F		No	ClinGen Ensembl
rs368754451 CA2354359	188	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs752746746 CA2354361	189	V>I		No	ClinGen ExAC gnomAD
CA352467399 rs1559562142	190	C>Y		No	ClinGen Ensembl
CA2354363 rs778431432	192	P>L		No	ClinGen ExAC gnomAD
rs1322904635 CA352467438	196	R>*		No	ClinGen TOPMed
rs372424162 CA2354364	196	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA73697851 rs868594655	197	G>E		No	ClinGen Ensembl
rs1221231670 CA352467454	198	W>*		No	ClinGen TOPMed gnomAD
CA352467494 rs1157571256	204	I>V		No	ClinGen TOPMed
rs201670838 CA2354369	205	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2354368 rs771654222	205	M>T		No	ClinGen ExAC gnomAD
CA352467502 rs1485744383	205	M>V		No	ClinGen TOPMed gnomAD
CA352467524 rs1575273401	208	I>F		No	ClinGen Ensembl
CA352467536 rs776605382 CA2354372	210	G>R		No	ClinGen ExAC TOPMed gnomAD
CA352467548 rs1173494619	212	V>A		No	ClinGen gnomAD
rs773018725 CA2354375	212	V>F		No	ClinGen ExAC gnomAD
rs1173494619 CA352467549	212	V>G		No	ClinGen gnomAD
CA73697920 rs773018725	212	V>L		No	ClinGen ExAC gnomAD
CA2354377 rs767651209	214	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1439242955 CA352467572	217	I>V		No	ClinGen gnomAD
rs921975876 CA73697942	219	V>F		No	ClinGen TOPMed gnomAD
CA352467587 rs921975876	219	V>I		No	ClinGen TOPMed gnomAD
CA352467614 rs1225694981	222	Y>*		No	ClinGen TOPMed
rs1367302726 CA352467608	222	Y>H		No	ClinGen TOPMed gnomAD
rs375821125 CA2354382	223	S>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2354381 rs375821125	223	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764685687 CA2354380	223	S>P		No	ClinGen ExAC gnomAD
rs1373258745 CA352467618	224	G>R		No	ClinGen TOPMed
rs1208111702 CA352467647	228	T>N		No	ClinGen gnomAD
CA2354385 rs758002439	230	L>F		No	ClinGen ExAC TOPMed gnomAD
rs758002439 CA2354386	230	L>I		No	ClinGen ExAC TOPMed gnomAD
rs746514238 CA2354387	231	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM1723502 rs746514238 CA2354388	231	R>Q	NS [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs934480642 CA73697981	231	R>W		No	ClinGen TOPMed
rs1247269230 CA352467662	232	C>R		No	ClinGen gnomAD
CA352467670 COSM1600264 rs1454368903	233	R>*	large_intestine central_nervous_system [Cosmic]	No	ClinGen cosmic curated TOPMed
CA73697995 rs539087679	233	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2354389 rs539087679 COSM3427646	233	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA2354390 rs371859867	234	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA73698002 rs866454124	235	E>K		No	ClinGen Ensembl
CA73698008 rs553980827	236	K>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376895493 CA2354394	237	K>*		No	ClinGen ESP ExAC gnomAD
rs1406639552 CA352467715	240	R>G		No	ClinGen gnomAD
CA352467717 rs1201218616	240	R>K		No	ClinGen TOPMed
CA352467718 rs1201218616	240	R>T		No	ClinGen TOPMed
CA352467740 rs1349866826	243	R>S		No	ClinGen gnomAD
CA352467737 rs1296559902	243	R>T		No	ClinGen gnomAD
CA2354397 rs760787891	247	T>A		No	ClinGen ExAC gnomAD
rs200491743 CA2354398	249	M>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA2354399 rs200491743	249	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1228048261 CA352467788	251	V>L		No	ClinGen TOPMed gnomAD
rs1286734255 CA352467811	254	L>V		No	ClinGen gnomAD
rs762362055 CA2354400	257	T>A		No	ClinGen ExAC gnomAD
rs1272419160 CA352467851	259	Y>*		No	ClinGen TOPMed
CA352467864 rs1290502925	261	I>S		No	ClinGen TOPMed gnomAD
rs1290502925 CA352467865	261	I>T		No	ClinGen TOPMed gnomAD
rs1434902072 CA352467891	266	N>H		No	ClinGen TOPMed
CA352467917 rs1376761439	269	Q>R		No	ClinGen TOPMed
rs1253730691 CA352467927	270	E>D		No	ClinGen gnomAD
rs1166098549 CA352467935 COSM3823971	271	F>L	breast [Cosmic]	No	ClinGen cosmic curated TOPMed
CA2354403 rs758746375	272	F>L		No	ClinGen ExAC gnomAD
rs201184651 CA2354406	273	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2354405 rs201184651	273	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780628400 CA2354407	273	G>V		No	ClinGen ExAC gnomAD
rs751438454 CA2354409	277	C>*		No	ClinGen ExAC TOPMed gnomAD
CA352467969 rs1347835785	277	C>R		No	ClinGen Ensembl
CA73698112 rs866870826	279	S>N		No	ClinGen Ensembl
rs1024376744 CA73698117	282	Q>K		No	ClinGen TOPMed gnomAD
CA352468038 rs1170831340	286	A>V		No	ClinGen gnomAD
rs183084727 CA73698123	287	T>K		No	ClinGen 1000Genomes gnomAD
CA73698125 rs183084727	287	T>M		No	ClinGen 1000Genomes gnomAD
rs775750288 CA2354414	289	V>A		No	ClinGen ExAC gnomAD
CA2354416 rs769023852	292	T>A		No	ClinGen ExAC gnomAD
CA352468073 rs1355497798	292	T>I		No	ClinGen TOPMed gnomAD
rs1243719646 CA352468079	293	L>P		No	ClinGen gnomAD
rs762049291 CA73698152	295	M>L		No	ClinGen ExAC TOPMed gnomAD
CA2354419 rs765825679	295	M>R		No	ClinGen ExAC TOPMed gnomAD
rs762049291 CA2354418	295	M>V		No	ClinGen ExAC TOPMed gnomAD
rs199884389 CA73698159	296	T>A		No	ClinGen 1000Genomes
rs772785853 CA2354420	298	C>R		No	ClinGen ExAC TOPMed
CA352468125 rs1204246801	300	I>T		No	ClinGen gnomAD
CA73698165 rs749255253	301	N>S		No	ClinGen Ensembl
rs1378932341 CA352468130	301	N>Y		No	ClinGen TOPMed
rs763342847 CA2354421	302	P>L		No	ClinGen ExAC gnomAD
rs751973385 CA2354423	303	I>N		No	ClinGen ExAC gnomAD
CA2354422 rs766608058	303	I>V		No	ClinGen ExAC
CA352468155 rs1187567520	305	Y>C		No	ClinGen gnomAD
rs946714547 CA73698197	308	V>A		No	ClinGen gnomAD
rs376135179 CA73698195	308	V>I		No	ClinGen ESP TOPMed gnomAD
rs767163559 CA2354425	310	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1166524398 CA352468206	312	F>L		No	ClinGen gnomAD
rs752202072 CA2354426	313	R>K		No	ClinGen ExAC TOPMed gnomAD
rs752202072 CA2354427	313	R>T		No	ClinGen ExAC TOPMed gnomAD
rs777747275 CA2354428	314	S>G		No	ClinGen ExAC gnomAD
rs369549053 CA2354429	314	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2354479 rs140816549	316	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA352468553 rs1290268809	318	I>T		No	ClinGen gnomAD
CA352468550 rs1462806380	318	I>V		No	ClinGen TOPMed
CA2354480 rs747406014	319	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2354481 rs768179177	321	G>C		No	ClinGen ExAC gnomAD
rs776392870 CA73698738	322	C>F		No	ClinGen ExAC gnomAD
rs776392870 CA2354482	322	C>Y		No	ClinGen ExAC gnomAD
rs1183627388 CA352468581	323	R>T		No	ClinGen gnomAD
rs764799796 CA2354484	329	K>T		No	ClinGen ExAC gnomAD
rs1192318524 CA352468627	330	P>S		No	ClinGen TOPMed
rs772867652 CA2354485	331	V>L		No	ClinGen ExAC gnomAD
CA352468641 rs1254174953	332	C>F		No	ClinGen TOPMed
rs1182893606 CA352468637	332	C>R		No	ClinGen gnomAD
CA73698751 rs368219093	333	G>R		No	ClinGen ESP TOPMed gnomAD
rs1485085933 CA352468649	334	G>S		No	ClinGen TOPMed
rs766421784 CA2354487	335	P>A		No	ClinGen ExAC TOPMed gnomAD
rs751305081 CA2354488	338	R>K		No	ClinGen ExAC gnomAD
CA2354489 rs549990114	339	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA352468685 rs1287456627	340	G>E		No	ClinGen TOPMed
CA2354491 rs754133368	340	G>R		No	ClinGen ExAC gnomAD
CA352468701 rs1313550195	342	N>I		No	ClinGen gnomAD
CA352468705 rs1405899707	343	V>M		No	ClinGen Ensembl
CA352468718 rs1229525004	345	V>M		No	ClinGen gnomAD
CA2354493 rs778916097	346	T>I		No	ClinGen ExAC TOPMed gnomAD
rs757455917 CA2354492	346	T>P		No	ClinGen ExAC gnomAD
CA2354494 rs374682253	348	Q>R		No	ClinGen ESP ExAC gnomAD
CA352468741 rs1460914436	349	G>R		No	ClinGen gnomAD
rs758836764 CA2354495	350	L>F		No	ClinGen ExAC gnomAD
CA352468748 rs758836764	350	L>V		No	ClinGen ExAC gnomAD
CA2354496 rs780607505	351	L>V		No	ClinGen ExAC gnomAD
CA2354499 rs371790080	353	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA352468769 rs1177764009	354	R>G		No	ClinGen gnomAD
CA2354501 rs762326630	354	R>H		No	ClinGen ExAC TOPMed gnomAD
VAR_014340 rs3918387 CA2354502	355	G>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2354503 rs762616822	356	K>T		No	ClinGen ExAC gnomAD
rs1391405321 CA352468789	357	G>E		No	ClinGen gnomAD
rs766409398 CA2354504	358	K>R		No	ClinGen ExAC gnomAD
rs1575274509 CA352468811	360	I>M		No	ClinGen Ensembl
rs1434174167 CA352468809	360	I>T		No	ClinGen TOPMed
rs369188117 CA73698808	361	G>D		No	ClinGen ESP TOPMed
CA352468812 rs1396264399	361	G>S		No	ClinGen TOPMed
CA352468819 rs774399090	362	R>K		No	ClinGen ExAC gnomAD
CA2354505 rs774399090	362	R>T		No	ClinGen ExAC gnomAD
CA2354506 rs759224501	363	A>G		No	ClinGen ExAC gnomAD
CA352468830 rs1575274518	364	P>S		No	ClinGen Ensembl
rs767307595 CA2354507	367	S>G		No	ClinGen ExAC gnomAD
rs752458602 CA2354508	369	Q>*		No	ClinGen ExAC gnomAD
CA352468874 rs993589500	370	D>E		No	ClinGen TOPMed gnomAD
CA352468872 rs1559563249	370	D>G		No	ClinGen Ensembl
rs1361190411 CA352468896	373	G>A		No	ClinGen gnomAD
rs1216371766 CA352468900	374	A>D		No	ClinGen TOPMed gnomAD
CA352468898 rs757413973	374	A>S		No	ClinGen ExAC TOPMed gnomAD
rs757413973 CA2354509	374	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1216371766 CA352468902	374	A>V		No	ClinGen TOPMed gnomAD
CA352468907 rs1241496598	375	A>W		No	ClinGen TOPMed gnomAD
rs1484763146 CA352468909	375	A>Y		No	ClinGen gnomAD

No associated diseases with P41597

1 regional properties for P41597

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	59 - 305	IPR017452

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein	The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
fibrillar center	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perikaryon	The portion of the cell soma (neuronal cell body) that excludes the nucleus.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name	Definition
C-C chemokine binding	Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
C-C chemokine receptor activity	Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
CCR2 chemokine receptor binding	Binding to a CCR2 chemokine receptor.
chemokine receptor activity	Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
identical protein binding	Binding to an identical protein or proteins.

46 GO annotations of biological process

Name	Definition
blood vessel remodeling	The reorganization or renovation of existing blood vessels.
calcium-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
cell chemotaxis	The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
cellular defense response	A defense response that is mediated by cells.
cellular homeostasis	Any process involved in the maintenance of an internal steady state at the level of the cell.
chemokine-mediated signaling pathway	The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
chemotaxis	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cytokine-mediated signaling pathway	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
dendritic cell chemotaxis	The movement of a dendritic cell in response to an external stimulus.
immune response	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
inflammatory response to wounding	The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.
macrophage migration	The orderly movement of a macrophage from one site to another.
monocyte extravasation	The migration of a monocyte from the blood vessels into the surrounding tissue.
negative regulation of adenylate cyclase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.
negative regulation of angiogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of eosinophil degranulation	Any process that stops, prevents, or reduces the rate of eosinophil degranulation.
negative regulation of type 2 immune response	Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
positive regulation of alpha-beta T cell proliferation	Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
positive regulation of astrocyte chemotaxis	Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis.
positive regulation of CD8-positive, alpha-beta T cell extravasation	Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation.
positive regulation of cold-induced thermogenesis	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
positive regulation of cytosolic calcium ion concentration	Any process that increases the concentration of calcium ions in the cytosol.
positive regulation of hematopoietic stem cell migration	Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.
positive regulation of immune complex clearance by monocytes and macrophages	Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.
positive regulation of inflammatory response	Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of interferon-gamma production	Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
positive regulation of interleukin-2 production	Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
positive regulation of monocyte chemotaxis	Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
positive regulation of monocyte extravasation	Any process that activates or increases the frequency, rate or extent of monocyte extravasation.
positive regulation of NMDA glutamate receptor activity	Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity.
positive regulation of synaptic transmission, glutamatergic	Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
positive regulation of T cell activation	Any process that activates or increases the frequency, rate or extent of T cell activation.
positive regulation of T cell chemotaxis	Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
positive regulation of T-helper 1 type immune response	Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.
positive regulation of thymocyte migration	Any process that activates or increases the frequency, rate or extent of thymocyte migration.
positive regulation of tumor necrosis factor production	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
receptor signaling pathway via JAK-STAT	Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
regulation of inflammatory response	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
regulation of T cell cytokine production	Any process that modulates the frequency, rate, or extent of T cell cytokine production.
regulation of T cell differentiation	Any process that modulates the frequency, rate or extent of T cell differentiation.
regulation of vascular endothelial growth factor production	Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor.
response to wounding	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
sensory perception of pain	The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
T-helper 17 cell chemotaxis	The directed movement of a T-helper 17 cell in response to an external stimulus.

121 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2YDN1	GPR161	G protein-coupled receptor 161	Bos taurus (Bovine)	PR
Q0GBZ5	HCRTR1	Orexin/Hypocretin receptor type 1	Bos taurus (Bovine)	PR
Q17QD8	GPR37L1	G-protein coupled receptor 37-like 1	Bos taurus (Bovine)	PR
Q8SPN1	PROKR2	Prokineticin receptor 2	Bos taurus (Bovine)	PR
P46626	ADRB3	Beta-3 adrenergic receptor	Bos taurus (Bovine)	PR
O46639	TRHR	Thyrotropin-releasing hormone receptor	Bos taurus (Bovine)	PR
Q8SPN2	PROKR1	Prokineticin receptor 1	Bos taurus (Bovine)	PR
B9VR26	CMLKR1	Chemerin-like receptor 1	Bos taurus (Bovine)	PR
P18130	ADRA1A	Alpha-1A adrenergic receptor	Bos taurus (Bovine)	PR
B4XF06	GPR39	G-protein coupled receptor 39	Bos taurus (Bovine)	PR
O18913	OPN1LW	Long-wave-sensitive opsin 1	Felis catus (Cat) (Felis silvestris catus)	PR
P28683	PRA1	Green-sensitive opsin	Gallus gallus (Chicken)	PR
Q9N298	HTR1A	5-hydroxytryptamine receptor 1A	Pan troglodytes (Chimpanzee)	PR
P08099	Rh2	Opsin Rh2	Drosophila melanogaster (Fruit fly)	PR
P06002	ninaE	Opsin Rh1	Drosophila melanogaster (Fruit fly)	PR
Q4LBB9	Octbeta2R	Octopamine receptor beta-2R	Drosophila melanogaster (Fruit fly)	PR
Q8NFJ6	PROKR2	Prokineticin receptor 2	Homo sapiens (Human)	PR
Q13585	GPR50	Melatonin-related receptor	Homo sapiens (Human)	PR
Q9BZJ6	GPR63	Probable G-protein coupled receptor 63	Homo sapiens (Human)	PR
Q9H3N8	HRH4	Histamine H4 receptor	Homo sapiens (Human)	PR
P28336	NMBR	Neuromedin-B receptor	Homo sapiens (Human)	PR
Q9Y5Y3	GPR45	Probable G-protein coupled receptor 45	Homo sapiens (Human)	PR
P08913	ADRA2A	Alpha-2A adrenergic receptor	Homo sapiens (Human)	PR
Q8TCW9	PROKR1	Prokineticin receptor 1	Homo sapiens (Human)	PR
Q99788	CMKLR1	Chemerin-like receptor 1	Homo sapiens (Human)	PR
P08908	HTR1A	5-hydroxytryptamine receptor 1A	Homo sapiens (Human)	PR
P30559	OXTR	Oxytocin receptor	Homo sapiens (Human)	PR
P32239	CCKBR	Gastrin/cholecystokinin type B receptor	Homo sapiens (Human)	PR
O60883	GPR37L1	G-protein coupled receptor 37-like 1	Homo sapiens (Human)	PR
Q8TDU9	RXFP4	Relaxin-3 receptor 2	Homo sapiens (Human)	PR
P04000	OPN1LW	Long-wave-sensitive opsin 1	Homo sapiens (Human)	PR
Q6U736	OPN5	Opsin-5	Homo sapiens (Human)	PR
P34972	CNR2	Cannabinoid receptor 2	Homo sapiens (Human)	PR
P24530	EDNRB	Endothelin receptor type B	Homo sapiens (Human)	PR
P35348	ADRA1A	Alpha-1A adrenergic receptor	Homo sapiens (Human)	PR
Q6W5P4	NPSR1	Neuropeptide S receptor	Homo sapiens (Human)	PR
O43613	HCRTR1	Orexin/Hypocretin receptor type 1	Homo sapiens (Human)	PR
Q9BXC0	HCAR1	Hydroxycarboxylic acid receptor 1	Homo sapiens (Human)	PR
P30556	AGTR1	Type-1 angiotensin II receptor	Homo sapiens (Human)	PR
Q15761	NPY5R	Neuropeptide Y receptor type 5	Homo sapiens (Human)	PR
Q8N6U8	GPR161	G-protein coupled receptor 161	Homo sapiens (Human)	PR
Q6DWJ6	GPR139	Probable G-protein coupled receptor 139	Homo sapiens (Human)	PR
P21462	FPR1	fMet-Leu-Phe receptor	Homo sapiens (Human)	PR
P35414	APLNR	Apelin receptor	Homo sapiens (Human)	PR
P46091	CMKLR2	Chemerin-like receptor 2	Homo sapiens (Human)	PR
P32745	SSTR3	Somatostatin receptor type 3	Homo sapiens (Human)	PR
P41439	FOLR3	Folate receptor gamma	Homo sapiens (Human)	PR
P51681	CCR5	C-C chemokine receptor type 5	Homo sapiens (Human)	PR
P61073	CXCR4	C-X-C chemokine receptor type 4	Homo sapiens (Human)	PR
P32248	CCR7	C-C chemokine receptor type 7	Homo sapiens (Human)	PR
P19973	Lsp1	Lymphocyte-specific protein 1	Mus musculus (Mouse)	PR
O54799	Nmbr	Neuromedin-B receptor	Mus musculus (Mouse)	PR
Q64264	Htr1a	5-hydroxytryptamine receptor 1A	Mus musculus (Mouse)	PR
P51675	Ccr1	C-C chemokine receptor type 1	Mus musculus (Mouse)	PR
Q5U431	Gpr39	G-protein coupled receptor 39	Mus musculus (Mouse)	PR
Q99JG2	Gpr37l1	G-protein coupled receptor 37-like 1	Mus musculus (Mouse)	PR
P97295	Npy2r	Neuropeptide Y receptor type 2	Mus musculus (Mouse)	PR
O08786	Cckar	Cholecystokinin receptor type A	Mus musculus (Mouse)	PR
P56481	Cckbr	Gastrin/cholecystokinin type B receptor	Mus musculus (Mouse)	PR
P30731	Gpr83	G-protein coupled receptor 83	Mus musculus (Mouse)	PR
P97468	Cmklr1	Chemerin-like receptor 1	Mus musculus (Mouse)	PR
P21761	Trhr	Thyrotropin-releasing hormone receptor	Mus musculus (Mouse)	PR
Q5QD16	Taar3	Trace amine-associated receptor 3	Mus musculus (Mouse)	PR
P97292	Hrh2	Histamine H2 receptor	Mus musculus (Mouse)	PR
Q9EQQ3	Gpr63	Probable G-protein coupled receptor 63	Mus musculus (Mouse)	PR
Q924H0	Npffr2	Neuropeptide FF receptor 2	Mus musculus (Mouse)	PR
P34971	Adrb1	Beta-1 adrenergic receptor	Mus musculus (Mouse)	PR
Q91ZY2	Hrh4	Histamine H4 receptor	Mus musculus (Mouse)	PR
O88416	Gpr33	Probable G-protein coupled receptor 33	Mus musculus (Mouse)	PR
Q8K087	Cmklr2	Chemerin-like receptor 2	Mus musculus (Mouse)	PR
P70658	Cxcr4	C-X-C chemokine receptor type 4	Mus musculus (Mouse)	PR
Q9WV08	Aplnr	Apelin receptor	Mus musculus (Mouse)	PR
P97718	Adra1a	Alpha-1A adrenergic receptor	Mus musculus (Mouse)	PR
Q8BZP8	Npsr1	Neuropeptide S receptor	Mus musculus (Mouse)	PR
Q8K458	Prokr2	Prokineticin receptor 2	Mus musculus (Mouse)	PR
P58308	Hcrtr2	Orexin receptor type 2	Mus musculus (Mouse)	PR
Q7TQP3	Gpr119	Glucose-dependent insulinotropic receptor	Mus musculus (Mouse)	PR
Q8BGE9	Rxfp3	Relaxin-3 receptor 1	Mus musculus (Mouse)	PR
Q6VZZ7	Opn5	Opsin-5	Mus musculus (Mouse)	PR
Q8CIM5	Gpr84	G-protein coupled receptor 84	Mus musculus (Mouse)	PR
P25962	Adrb3	Beta-3 adrenergic receptor	Mus musculus (Mouse)	PR
Q80UC8	Gpr139	Probable G-protein coupled receptor 139	Mus musculus (Mouse)	PR
P0C5I1	Gpr25	Probable G-protein coupled receptor 25	Mus musculus (Mouse)	PR
P47936	Cnr2	Cannabinoid receptor 2	Mus musculus (Mouse)	PR
Q5QD13	Taar6	Trace amine-associated receptor 6	Mus musculus (Mouse)	PR
P35846	Folr1	Folate receptor alpha	Mus musculus (Mouse)	PR
P58307	Hcrtr1	Orexin/Hypocretin receptor type 1	Mus musculus (Mouse)	PR
Q8C131	Hcar1	Hydroxycarboxylic acid receptor 1	Mus musculus (Mouse)	PR
Q9EQQ4	Gpr45	Probable G-protein coupled receptor 45	Mus musculus (Mouse)	PR
B2RPY5	Gpr161	G-protein coupled receptor 161	Mus musculus (Mouse)	PR
Q764M9	CXCR4	C-X-C chemokine receptor type 4	Sus scrofa (Pig)	PR
Q9EQD2	Npffr2	Neuropeptide FF receptor 2	Rattus norvegicus (Rat)	PR
O08565	Cxcr4	C-X-C chemokine receptor type 4	Rattus norvegicus (Rat)	PR
Q01717	Trhr	Thyrotropin-releasing hormone receptor	Rattus norvegicus (Rat)	PR
P30936	Sstr3	Somatostatin receptor type 3	Rattus norvegicus (Rat)	PR
Q9JHG3	Aplnr	Apelin receptor	Rattus norvegicus (Rat)	PR
P43140	Adra1a	Alpha-1A adrenergic receptor	Rattus norvegicus (Rat)	PR
P19327	Htr1a	5-hydroxytryptamine receptor 1A	Rattus norvegicus (Rat)	PR
P56719	Hcrtr2	Orexin receptor type 2	Rattus norvegicus (Rat)	PR
P28564	Htr1b	5-hydroxytryptamine receptor 1B	Rattus norvegicus (Rat)	PR
P56718	Hcrtr1	Orexin/Hypocretin receptor type 1	Rattus norvegicus (Rat)	PR
P28647	Adora3	Adenosine receptor A3	Rattus norvegicus (Rat)	PR
P25102	Hrh2	Histamine H2 receptor	Rattus norvegicus (Rat)	PR
P23944	Adra1d	Alpha-1D adrenergic receptor	Rattus norvegicus (Rat)	PR
Q8R415	Prokr2	Prokineticin receptor 2	Rattus norvegicus (Rat)	PR
Q5QD24	Taar3	Trace amine-associated receptor 3	Rattus norvegicus (Rat)	PR
P0C0W8	Gpr139	Probable G-protein coupled receptor 139	Rattus norvegicus (Rat)	PR
P35370	Oprl1	Nociceptin receptor	Rattus norvegicus (Rat)	PR
P46090	Cmklr2	Chemerin-like receptor 2	Rattus norvegicus (Rat)	PR
O97664	CMKLR2	Chemerin-like receptor 2	Macaca mulatta (Rhesus macaque)	PR
O97666	APLNR	Apelin receptor	Macaca mulatta (Rhesus macaque)	PR
Q56H79	NPSR1	Neuropeptide S receptor	Macaca mulatta (Rhesus macaque)	PR
O18793	CCR2	C-C chemokine receptor type 2	Macaca mulatta (Rhesus macaque)	PR
Q18904	npr-8	Probable G-protein coupled receptor npr-8	Caenorhabditis elegans	PR
Q09388	gar-2	Muscarinic acetylcholine receptor gar-2	Caenorhabditis elegans	PR
B3DM66	gpr161	G-protein coupled receptor 161	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q9W6A6	opn1mw4	Green-sensitive opsin-4	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q9W6A5	opn1mw1	Green-sensitive opsin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q8AYM7	opn1mw3	Green-sensitive opsin-3	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q8AYN0	opn1lw2	Red-sensitive opsin-2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q90X46	gpr161	G-protein coupled receptor 161	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MLSTSRSRFI	RNTNESGEEV	TTFFDYDYGA	PCHKFDVKQI	GAQLLPPLYS	LVFIFGFVGN
70	80	90	100	110	120
MLVVLILINC	KKLKCLTDIY	LLNLAISDLL	FLITLPLWAH	SAANEWVFGN	AMCKLFTGLY
130	140	150	160	170	180
HIGYFGGIFF	IILLTIDRYL	AIVHAVFALK	ARTVTFGVVT	SVITWLVAVF	ASVPGIIFTK
190	200	210	220	230	240
CQKEDSVYVC	GPYFPRGWNN	FHTIMRNILG	LVLPLLIMVI	CYSGILKTLL	RCRNEKKRHR
250	260	270	280	290	300
AVRVIFTIMI	VYFLFWTPYN	IVILLNTFQE	FFGLSNCEST	SQLDQATQVT	ETLGMTHCCI
310	320	330	340	350	360
NPIIYAFVGE	KFRSLFHIAL	GCRIAPLQKP	VCGGPGVRPG	KNVKVTTQGL	LDGRGKGKSI
370
GRAPEASLQD	KEGA