P21462
PR
Gene name |
FPR1 |
Protein name |
fMet-Leu-Phe receptor |
Names |
fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:2357 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for P21462
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7EUO | EM | 290 A | R | 1-350 | PDB |
| 7T6T | EM | 320 A | R | 1-333 | PDB |
| 7VFX | EM | 280 A | R | 1-350 | PDB |
| 7WVU | EM | 330 A | R | 2-321 | PDB |
| AF-P21462-F1 | Predicted | AlphaFoldDB |
320 variants for P21462
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV002231220 rs148095693 RCV001703188 CA9616542 |
9 | T>M | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA9616539 RCV002230304 VAR_055915 rs5030878 RCV001824775 RCV000455423 |
11 | I>T | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1284082601 CA407121494 RCV002239298 |
14 | G>R | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
CA9616534 rs143088639 RCV002242267 |
27 | I>N | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA9616536 rs769777199 RCV002239358 |
27 | I>V | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
rs2083751098 RCV002242286 |
41 | V>I | Gingival disorder [ClinVar] | Yes |
ClinVar dbSNP |
|
CA9616517 RCV002241628 rs138475342 |
54 | R>W | Variant assessed as Somatic; 0.0 impact. Gingival disorder [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA9616507 RCV003166367 rs199534146 RCV002235094 |
69 | V>M | Gingival disorder Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
rs750324912 RCV003166318 CA9616499 RCV002235030 |
92 | P>T | Gingival disorder Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
CA9616493 RCV002233924 rs78488639 |
97 | L>M | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000455030 RCV001824774 RCV002230084 VAR_003476 CA9616489 rs2070745 |
101 | V>L | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV002240536 CA9616485 rs749737014 |
111 | G>R | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV002235847 rs149931707 COSM218594 RCV001529734 CA9616477 |
123 | R>H | Gingival disorder pancreas [ClinVar, Cosmic] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
COSM567272 CA9616474 RCV002235323 rs186613919 |
127 | V>I | lung Variant assessed as Somatic; 0.0 impact. Gingival disorder large_intestine [Cosmic, NCI-TCGA, ClinVar] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
RCV002233629 CA9616471 rs139132326 |
137 | R>C | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC dbSNP gnomAD |
|
RCV002239346 CA9616462 rs142367736 |
147 | I>T | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA9616463 rs183314714 RCV002235535 |
147 | I>V | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV002231004 CA9616453 rs111768566 |
163 | R>H | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV002563987 rs2083746502 |
166 | T>I | Gingival disorder [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV002234904 rs771064181 CA9616450 |
171 | T>P | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV002235101 COSM192562 CA9616441 rs146075164 |
181 | S>L | Variant assessed as Somatic; 0.0 impact. Gingival disorder large_intestine breast [NCI-TCGA, ClinVar, Cosmic] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
COSM94349 CA9616435 RCV002233855 rs139760904 |
187 | P>S | lung Gingival disorder [Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs773162997 RCV002240490 CA9616431 |
190 | R>S | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
VAR_055916 RCV001655668 RCV002239272 RCV001035430 rs5030880 CA9616432 |
190 | R>W | Gingival disorder N-FORMYLPEPTIDE RECEPTOR POLYMORPHISM [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV002230302 VAR_003477 rs1042229 RCV001618691 RCV000455271 CA9616428 |
192 | N>K | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA9616423 rs748893408 COSM3713152 RCV002241128 |
199 | T>M | upper_aerodigestive_tract Gingival disorder [Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs150239733 CA9616419 RCV002235844 |
203 | I>V | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1489945041 RCV002240265 CA407117900 |
205 | R>W | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
rs765164623 RCV002241504 CA9616413 |
212 | A>T | Variant assessed as Somatic; 0.0 impact. Gingival disorder [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA9616402 RCV002533174 RCV002234399 rs141913828 |
225 | A>V | Gingival disorder Inborn genetic diseases [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
rs1302309228 RCV002233871 CA407117162 |
237 | S>N | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
CA9616399 RCV002240186 rs368075541 |
238 | R>H | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA9616397 RCV002241289 rs752836535 |
241 | R>Q | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs147646924 RCV002241058 CA309808037 |
241 | R>W | Variant assessed as Somatic; 0.0 impact. Gingival disorder [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar ESP NCI-TCGA TOPMed dbSNP gnomAD |
|
rs2083743451 RCV002237134 |
246 | V>F | Gingival disorder [ClinVar] | Yes |
ClinVar dbSNP |
|
CA9616389 rs766818943 RCV002241585 |
251 | F>L | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV000149096 rs193920896 COSM1180045 CA174343 |
258 | Q>* | Malignant tumor of prostate prostate [ClinVar, Cosmic] | Yes |
ClinGen cosmic curated ClinVar Ensembl dbSNP |
|
rs771446051 RCV002233642 CA9616385 |
269 | R>C | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV002233923 CA9616384 rs142210016 |
269 | R>H | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA9616381 RCV002242167 rs746593681 |
275 | M>T | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs2083742597 RCV002241311 |
275 | M>V | Gingival disorder [ClinVar] | Yes |
ClinVar dbSNP |
|
rs1555796364 RCV002234398 CA407116329 |
276 | Y>C | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV002240341 CA9616380 rs553738020 |
276 | Y>H | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
RCV002239274 CA9616364 rs768241723 |
300 | L>V | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV002241487 rs2083741511 |
307 | D>N | Gingival disorder [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV002242470 rs555690623 CA9616360 |
309 | R>Q | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
CA9616356 RCV002241459 rs140083445 COSM1564264 |
315 | A>T | Variant assessed as Somatic; 0.0 impact. Gingival disorder large_intestine [NCI-TCGA, ClinVar, Cosmic] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
RCV002239335 CA9616351 rs201404212 |
318 | A>T | Variant assessed as Somatic; 0.0 impact. Gingival disorder [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA407114993 RCV002240319 rs1599806193 |
319 | S>R | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
CA9616346 rs551338523 RCV002241875 |
326 | E>K | Variant assessed as Somatic; 0.0 impact. Gingival disorder [NCI-TCGA, ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC NCI-TCGA dbSNP gnomAD |
|
VAR_003478 RCV000456087 RCV001824772 RCV002230300 CA9616335 rs867228 |
346 | E>A | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1555796329 CA658799307 RCV002528851 |
346 | E>A | Gingival disorder [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
| TCGA novel | 1 | M>? | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407121799 rs1178403168 |
2 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 4 | N>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9616544 rs757666229 |
6 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9616543 rs762396720 |
7 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407121559 rs5030878 |
11 | I>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA407121551 rs5030878 |
11 | I>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA407121566 rs1221745628 |
11 | I>V | No |
ClinGen gnomAD |
|
|
rs1369400642 CA407121456 |
15 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA407121455 rs1369400642 |
15 | T>K | No |
ClinGen TOPMed gnomAD |
|
|
CA407121452 rs1376878000 |
16 | P>T | No |
ClinGen TOPMed |
|
| TCGA novel | 17 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407121414 rs1286930729 |
17 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA9616538 rs770593902 |
18 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs1345693963 CA407121393 |
18 | V>I | No |
ClinGen gnomAD |
|
|
rs1568637657 CA407121364 |
19 | S>C | No |
ClinGen Ensembl |
|
|
rs749077776 CA9616537 |
20 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs931195222 CA309808931 |
21 | G>A | No |
ClinGen TOPMed |
|
| TCGA novel | 22 | Y>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407121260 rs1176636780 |
23 | L>F | No |
ClinGen gnomAD |
|
|
rs769777199 CA9616535 |
27 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs781251860 CA9616533 |
28 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1039474132 CA309808898 |
29 | T>I | No |
ClinGen TOPMed |
|
|
rs751640032 CA9616531 |
31 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs780182759 CA9616529 |
34 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407120958 rs1225536550 |
35 | V>A | No |
ClinGen gnomAD |
|
|
rs1213760476 CA407120911 |
37 | F>C | No |
ClinGen gnomAD |
|
|
rs1295188973 CA407120920 |
37 | F>L | No |
ClinGen gnomAD |
|
|
rs1013579949 CA309808884 |
39 | L>F | No |
ClinGen Ensembl |
|
| TCGA novel | 39 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407120860 rs1362480785 |
39 | L>R | No |
ClinGen gnomAD |
|
|
CA9616526 rs765639685 |
40 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs750811701 COSM3713153 CA9616527 |
40 | G>R | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA9616524 rs754359145 |
45 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA9616521 rs759165021 |
47 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773879518 CA9616520 |
48 | I>T | No |
ClinGen ExAC |
|
| TCGA novel | 49 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs770552297 CA9616519 |
49 | W>G | No |
ClinGen ExAC gnomAD |
|
|
CA9616518 rs762650605 |
51 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs145808420 CA9616516 COSM1494334 |
54 | R>Q | kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1205617235 CA407120471 |
55 | M>V | No |
ClinGen gnomAD |
|
|
rs748109117 CA9616515 |
56 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA407120402 rs1250967941 |
57 | H>N | No |
ClinGen gnomAD |
|
| TCGA novel | 59 | V>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1299580019 CA407120290 |
61 | T>I | No |
ClinGen gnomAD |
|
|
CA9616513 rs768554070 |
62 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407120237 rs1384967596 |
63 | S>N | No |
ClinGen TOPMed |
|
|
CA407120244 rs1315708653 |
63 | S>R | No |
ClinGen gnomAD |
|
|
rs1364719913 CA407120175 |
65 | L>R | No |
ClinGen TOPMed |
|
|
rs371282377 CA9616510 RCV000817481 |
66 | N>K | No |
ClinGen ClinVar ESP ExAC dbSNP gnomAD |
|
|
CA633902192 rs1297184486 |
66 | N>T | No |
ClinGen gnomAD |
|
|
CA407120121 rs199534146 |
69 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA309808762 rs1023206431 |
72 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA407120051 rs1254617519 |
73 | C>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs1190303798 CA407119986 |
77 | T>I | No |
ClinGen gnomAD |
|
|
rs1417326886 CA407119970 |
78 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 79 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1207471 rs754232242 CA9616506 |
79 | P>S | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs764738404 CA9616505 |
82 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407119911 rs1463080612 |
82 | M>V | No |
ClinGen TOPMed |
|
|
rs1481762038 CA407119898 |
83 | V>I | No |
ClinGen gnomAD |
|
|
rs1599807147 CA407119872 |
84 | R>S | No |
ClinGen Ensembl |
|
|
rs1599807152 CA407119879 |
84 | R>T | No |
ClinGen Ensembl |
|
|
rs1599807154 CA407119884 |
84 | R>W | No |
ClinGen Ensembl |
|
|
rs1599807143 CA407119856 |
85 | K>M | No |
ClinGen Ensembl |
|
|
CA407119849 rs1568637480 |
86 | A>T | No |
ClinGen Ensembl |
|
|
CA407119839 rs1197945289 |
86 | A>V | No |
ClinGen gnomAD |
|
| TCGA novel | 87 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs148846448 CA309808745 |
87 | M>R | No |
ClinGen ESP |
|
|
rs375049372 CA407119813 |
88 | G>* | No |
ClinGen TOPMed gnomAD |
|
|
rs375049372 CA309808740 |
88 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA9616504 rs756639389 |
89 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA407119781 rs1358544550 |
90 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs373383845 CA9616501 |
91 | W>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs765852801 CA9616502 |
91 | W>R | No |
ClinGen ExAC |
|
|
rs750324912 COSM1525896 CA407119736 |
92 | P>A | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs866198922 CA309808665 |
94 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs764850416 CA407119672 |
95 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9616495 COSM1737350 rs764850416 CA9616496 |
95 | W>C | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA407119675 rs1455632263 |
95 | W>L | No |
ClinGen TOPMed |
|
|
rs1015598098 CA309808655 |
96 | F>I | No |
ClinGen gnomAD |
|
|
rs1015598098 CA407119666 |
96 | F>V | No |
ClinGen gnomAD |
|
|
rs768642242 CA9616492 |
99 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA309808623 rs952836159 |
100 | F>L | No |
ClinGen gnomAD |
|
|
rs2070745 CA9616490 |
101 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA309808590 rs995333430 |
104 | I>M | No |
ClinGen TOPMed |
|
|
CA407119480 rs1366588879 |
104 | I>T | No |
ClinGen gnomAD |
|
|
rs896034471 CA309808583 |
107 | I>T | No |
ClinGen Ensembl |
|
|
rs1165447080 CA407119402 |
109 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs779324740 CA9616487 |
110 | F>I | No |
ClinGen ExAC gnomAD |
|
|
CA407119302 rs1268054986 |
116 | I>F | No |
ClinGen TOPMed |
|
|
CA9616482 rs547228145 |
117 | A>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs547228145 COSM475129 CA309808554 |
117 | A>T | kidney Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1290352179 CA407119282 |
117 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA9616481 rs190373580 |
118 | L>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs369354920 CA9616479 |
122 | D>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM1304982 CA9616478 rs764940294 |
123 | R>C | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA309808532 rs943366709 |
124 | C>F | No |
ClinGen TOPMed |
|
|
rs1599806978 CA407119158 |
125 | V>I | No |
ClinGen Ensembl |
|
|
rs776424230 CA407119129 |
126 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407119117 rs1325987699 |
127 | V>A | No |
ClinGen gnomAD |
|
|
rs186613919 CA407119120 |
127 | V>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA407119078 rs1348351358 |
129 | H>P | No |
ClinGen TOPMed |
|
| TCGA novel | 129 | H>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1436099285 CA407119010 |
132 | W>G | No |
ClinGen TOPMed |
|
|
CA407118895 rs775451540 |
136 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 136 | H>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9616472 rs775451540 |
136 | H>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745998725 CA9616470 |
137 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 137 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs774567273 CA9616469 |
138 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA309808439 COSM1000181 rs933017940 |
139 | V>M | Variant assessed as Somatic; impact. endometrium prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA407118842 rs1599806900 |
140 | S>G | No |
ClinGen Ensembl |
|
|
rs749458452 CA9616467 |
140 | S>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 140 | S>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407118826 rs1260952162 |
142 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA407118820 rs1599806876 |
143 | K>R | No |
ClinGen Ensembl |
|
|
CA9616466 rs562631943 |
144 | K>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA407118807 rs1465815944 |
145 | V>A | No |
ClinGen gnomAD |
|
|
rs1450551085 CA407118808 |
145 | V>L | No |
ClinGen TOPMed |
|
|
rs923151832 CA309808421 |
146 | I>N | No |
ClinGen Ensembl |
|
|
CA9616465 rs756459168 |
146 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9616464 rs183314714 |
147 | I>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA9616461 rs376781635 |
149 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1319489312 CA407118770 |
150 | W>* | No |
ClinGen gnomAD |
|
| TCGA novel | 152 | M>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9616456 rs763819355 |
159 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs113777346 CA309808381 |
160 | V>A | No |
ClinGen Ensembl |
|
|
rs564702916 CA9616454 |
163 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1311535690 CA407118532 |
165 | T>A | No |
ClinGen gnomAD |
|
|
CA407118500 rs1301820607 |
167 | V>I | No |
ClinGen gnomAD |
|
|
CA9616451 rs774585820 |
169 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201110935 CA9616449 |
171 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs866791532 CA309808327 |
172 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 172 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407118383 rs1381198012 |
174 | V>A | No |
ClinGen gnomAD |
|
|
CA9616445 rs781400810 |
175 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407118354 rs769223294 |
176 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 176 | C>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1293457909 CA407118346 |
177 | T>A | No |
ClinGen TOPMed |
|
|
CA9616443 rs747450344 RCV000686521 |
178 | F>L | No |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
|
rs778425990 CA9616442 |
180 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
rs145973159 CA9616438 |
185 | N>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA309808259 rs200667860 |
186 | D>E | No |
ClinGen 1000Genomes gnomAD |
|
|
CA407118177 rs1472804229 |
186 | D>G | No |
ClinGen gnomAD |
|
|
rs571987775 CA9616436 |
186 | D>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA407118155 rs1436828260 |
187 | P>L | No |
ClinGen gnomAD |
|
|
CA407118140 rs1178819366 |
188 | K>T | No |
ClinGen gnomAD |
|
| TCGA novel | 190 | R>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9616430 rs770113414 |
192 | N>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407118077 rs770113414 |
192 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768973228 CA9616427 |
193 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs201880162 CA9616425 |
195 | V>I | Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1341165144 CA407118024 |
196 | A>D | No |
ClinGen TOPMed |
|
|
CA407118026 rs1227141101 |
196 | A>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1341165144 CA407118020 |
196 | A>V | No |
ClinGen TOPMed |
|
|
rs1431399661 CA407118004 |
197 | M>I | No |
ClinGen gnomAD |
|
|
CA9616424 rs772539495 |
197 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA407117945 rs1461765570 |
201 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA407117926 rs1156279033 |
202 | G>D | No |
ClinGen gnomAD |
|
|
CA9616421 rs551377096 |
202 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9616418 rs375670055 |
203 | I>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA407117901 rs1489945041 |
205 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs751375183 CA9616417 |
205 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200464393 CA9616415 |
208 | I>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA309808142 rs991593657 |
209 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1282829962 CA407117810 |
210 | F>V | No |
ClinGen TOPMed gnomAD |
|
|
CA9616412 rs762131341 |
213 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372037824 CA9616409 |
216 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1399542796 CA407117615 |
217 | V>A | No |
ClinGen gnomAD |
|
|
rs772623174 CA9616407 |
217 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 217 | V>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs145775814 CA9616406 |
218 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA407117551 rs1428217009 |
220 | S>N | No |
ClinGen gnomAD |
|
|
CA9616404 rs772780081 |
220 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407117498 RCV001223564 rs1192119303 |
222 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ClinVar NCI-TCGA dbSNP gnomAD |
|
rs542658365 CA9616403 |
223 | L>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA407117405 rs1169625539 |
227 | K>E | No |
ClinGen gnomAD |
|
|
CA407117384 rs1599806485 |
227 | K>N | No |
ClinGen Ensembl |
|
|
rs1197760903 CA407117371 |
228 | I>F | No |
ClinGen TOPMed |
|
|
CA407117348 rs1431948869 |
229 | H>Y | No |
ClinGen gnomAD |
|
|
CA407117320 rs1391652948 |
230 | K>T | No |
ClinGen gnomAD |
|
| TCGA novel | 232 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1011722116 CA309808073 |
232 | G>S | No |
ClinGen Ensembl |
|
|
rs1599806467 CA407117276 |
233 | L>M | No |
ClinGen Ensembl |
|
|
rs1270124119 CA407117204 |
235 | K>M | No |
ClinGen gnomAD |
|
|
CA9616401 rs371524501 |
236 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA407117186 rs371524501 |
236 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1302309228 CA407117158 |
237 | S>I | No |
ClinGen gnomAD |
|
|
CA9616400 rs754643538 |
238 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA407117119 rs368075541 |
238 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs779937505 CA9616398 |
239 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 240 | L>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407117023 rs1176427712 |
243 | L>H | No |
ClinGen gnomAD |
|
|
CA309808012 rs755314613 |
244 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA309808009 rs901620615 |
245 | F>S | No |
ClinGen Ensembl |
|
|
CA9616392 rs764370052 |
247 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1386666411 CA407116914 |
248 | A>E | No |
ClinGen TOPMed |
|
|
CA407116889 rs1205639049 |
249 | A>D | No |
ClinGen gnomAD |
|
|
rs775843544 CA9616390 |
249 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA407116828 rs1345865143 |
251 | F>Y | No |
ClinGen TOPMed |
|
|
CA309807990 rs891068820 |
255 | S>C | No |
ClinGen TOPMed |
|
|
rs533709347 CA309807989 |
257 | Y>C | No |
ClinGen Ensembl |
|
|
CA407116617 rs1256741080 |
259 | V>A | No |
ClinGen gnomAD |
|
|
CA407116624 rs1460978960 |
259 | V>M | No |
ClinGen gnomAD |
|
|
CA407116528 rs201541948 |
263 | I>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs201541948 CA9616387 |
263 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs776269070 CA9616383 |
270 | E>A | No |
ClinGen ExAC gnomAD |
|
|
CA407116398 rs1238412189 |
272 | L>M | No |
ClinGen TOPMed |
|
|
rs1261451867 CA407116371 |
273 | Q>H | No |
ClinGen TOPMed |
|
|
rs535223217 CA309807904 |
276 | Y>* | No |
ClinGen 1000Genomes TOPMed |
|
|
CA407116332 rs553738020 |
276 | Y>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs771719466 CA9616379 |
280 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA9616378 rs745657784 |
282 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA407116242 rs1168324055 |
283 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA9616376 rs757217120 |
284 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA407116205 rs1444021071 |
285 | V>A | No |
ClinGen gnomAD |
|
|
CA309807887 rs903155050 |
285 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA407116190 rs1256978144 |
286 | T>I | No |
ClinGen gnomAD |
|
|
CA407116180 rs1479763315 |
287 | S>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1342695604 CA407116114 |
292 | F>L | No |
ClinGen gnomAD |
|
|
rs756329691 CA9616372 |
295 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA407116059 rs1312853445 |
295 | C>Y | No |
ClinGen gnomAD |
|
|
rs767891260 CA9616370 |
296 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759866243 CA9616369 |
296 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs571424983 CA9616368 |
297 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763461632 CA9616367 |
298 | P>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs763461632 CA9616366 |
298 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA309807842 rs529498075 |
299 | M>I | No |
ClinGen gnomAD |
|
|
CA407116004 rs1457870210 |
299 | M>T | No |
ClinGen gnomAD |
|
|
rs567895941 CA9616365 |
299 | M>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA9616363 rs760425963 |
301 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA9616362 rs775336229 COSM567274 |
304 | M>I | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA407115076 rs1183171485 COSM1129736 |
305 | G>V | Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA407115062 rs1220113532 |
307 | D>V | No |
ClinGen gnomAD |
|
| TCGA novel | 308 | F>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762250607 CA9616361 |
309 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA407115031 rs1314613984 |
312 | L>P | No |
ClinGen gnomAD |
|
| TCGA novel | 312 | L>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407115027 rs1599806230 |
313 | I>V | No |
ClinGen Ensembl |
|
|
rs770785167 CA407115018 |
314 | H>P | No |
ClinGen ExAC gnomAD |
|
|
CA9616358 rs770785167 |
314 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA407115014 rs140083445 |
315 | A>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA407115007 rs1301643254 |
316 | L>F | No |
ClinGen gnomAD |
|
|
CA9616353 rs781308895 |
317 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA9616354 rs752751969 |
317 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1160122325 CA407114995 |
318 | A>V | No |
ClinGen gnomAD |
|
| TCGA novel | 319 | S>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA407114981 rs1178238019 |
321 | E>Q | No |
ClinGen TOPMed |
|
|
CA407114963 rs1253311051 |
323 | A>V | No |
ClinGen TOPMed |
|
|
rs1599806178 CA407114953 |
325 | T>S | No |
ClinGen Ensembl |
|
|
rs775137735 CA9616345 |
327 | D>N | No |
ClinGen ExAC TOPMed |
|
|
rs1568636730 CA407114924 |
329 | T>N | No |
ClinGen Ensembl |
|
|
CA407114911 rs1166347902 |
331 | T>S | No |
ClinGen TOPMed |
|
|
CA407114873 rs1228513300 |
337 | N>H | No |
ClinGen gnomAD |
|
|
rs771713666 CA9616341 |
337 | N>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 338 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1232982137 CA407114855 |
339 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA9616338 rs769687769 |
341 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA9616339 rs773182339 |
341 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 342 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs974246861 CA309807730 |
344 | E>* | No |
ClinGen TOPMed |
|
|
CA407114822 rs1251033801 |
345 | V>L | No |
ClinGen gnomAD |
|
|
CA407114815 rs867228 |
346 | E>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1048756669 CA309807722 |
346 | E>K | No |
ClinGen Ensembl |
|
|
CA407114816 rs867228 |
346 | E>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs780304392 CA9616333 |
347 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA9616330 rs758884060 |
349 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
No associated diseases with P21462
1 regional properties for P21462
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 42 - 320 | IPR017452 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| azurophil granule membrane | The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| ficolin-1-rich granule membrane | The lipid bilayer surrounding a ficolin-1-rich granule. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| secretory granule membrane | The lipid bilayer surrounding a secretory granule. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| complement receptor activity | Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| G protein-coupled receptor binding | Binding to a G protein-coupled receptor. |
| N-formyl peptide receptor activity | Combining with an N-formyl peptide to initiate a change in cell activity. |
| RAGE receptor binding | Binding to a RAGE receptor, the receptor for advanced glycation end-products. |
| scavenger receptor binding | Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). |
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| complement receptor mediated signaling pathway | The series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| nitric oxide mediated signal transduction | Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
119 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METNSSLPTN | ISGGTPAVSA | GYLFLDIITY | LVFAVTFVLG | VLGNGLVIWV | AGFRMTHTVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TISYLNLAVA | DFCFTSTLPF | FMVRKAMGGH | WPFGWFLCKF | VFTIVDINLF | GSVFLIALIA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDRCVCVLHP | VWTQNHRTVS | LAKKVIIGPW | VMALLLTLPV | IIRVTTVPGK | TGTVACTFNF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPWTNDPKER | INVAVAMLTV | RGIIRFIIGF | SAPMSIVAVS | YGLIATKIHK | QGLIKSSRPL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RVLSFVAAAF | FLCWSPYQVV | ALIATVRIRE | LLQGMYKEIG | IAVDVTSALA | FFNSCLNPML |
| 310 | 320 | 330 | 340 | ||
| YVFMGQDFRE | RLIHALPASL | ERALTEDSTQ | TSDTATNSTL | PSAEVELQAK |