P34972
PR
Gene name |
CNR2 (CB2A, CB2B) |
Protein name |
Cannabinoid receptor 2 |
Names |
CB-2, CB2, hCB2, CX5 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:1269 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for P34972
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2KI9 | NMR | - | A | 240-272 | PDB |
| 5ZTY | X-ray | 280 A | PDB | ||
| 6KPC | X-ray | 320 A | PDB | ||
| 6KPF | EM | 290 A | R | 1-360 | PDB |
| 6PT0 | EM | 320 A | R | 1-360 | PDB |
| 8GUQ | EM | 308 A | R | 1-360 | PDB |
| 8GUR | EM | 284 A | R | 1-360 | PDB |
| 8GUS | EM | 297 A | R | 1-360 | PDB |
| 8GUT | EM | 298 A | R | 21-360 | PDB |
| AF-P34972-F1 | Predicted | AlphaFoldDB |
306 variants for P34972
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA686887 rs773689614 |
4 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA686886 rs202092094 |
5 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1356820488 CA339021668 |
9 | I>L | No |
ClinGen gnomAD |
|
|
CA686882 rs746669490 |
9 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA686883 rs370749734 |
9 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA339021678 rs1356820488 |
9 | I>V | No |
ClinGen gnomAD |
|
|
CA686881 rs775178577 |
11 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs201016971 CA19289698 |
13 | S>C | No |
ClinGen gnomAD |
|
|
rs201016971 CA339020807 |
13 | S>F | No |
ClinGen gnomAD |
|
|
rs1368227584 CA339020806 |
14 | K>Q | No |
ClinGen TOPMed |
|
|
CA19289687 rs199931185 |
15 | D>G | No |
ClinGen Ensembl |
|
|
COSM106383 rs142134658 CA19289688 |
15 | D>N | skin [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA686880 rs142134658 |
15 | D>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 16 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs745320779 CA686879 |
16 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs757147880 CA686877 |
18 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs1454280416 CA339020779 |
18 | D>Y | No |
ClinGen TOPMed |
|
|
CA19289652 rs900368894 |
20 | N>D | No |
ClinGen gnomAD |
|
|
CA686876 rs749046000 |
20 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs900368894 CA339020767 |
20 | N>Y | No |
ClinGen gnomAD |
|
|
CA339020762 rs1382764385 |
21 | P>T | No |
ClinGen gnomAD |
|
|
CA686873 rs751752206 |
22 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755226163 CA686875 |
22 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA686874 rs755226163 |
22 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1233783871 CA339020750 |
23 | K>E | No |
ClinGen TOPMed |
|
|
rs1223341048 CA339020726 |
26 | M>L | No |
ClinGen gnomAD |
|
| TCGA novel | 29 | S>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200121304 CA19289603 |
29 | S>R | No |
ClinGen Ensembl |
|
|
CA686870 rs750464246 |
29 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA686869 rs201821646 |
30 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA19289593 rs201821646 |
30 | G>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1239252701 CA339020694 |
31 | P>A | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1570699202 CA339020690 |
31 | P>L | No |
ClinGen Ensembl |
|
|
CA339020689 rs1288437535 |
32 | Q>* | No |
ClinGen gnomAD |
|
|
rs1217622625 CA339020664 |
35 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
CA339020666 rs1274481529 |
35 | A>P | No |
ClinGen TOPMed |
|
|
rs1350075547 CA339020661 |
36 | V>I | No |
ClinGen TOPMed |
|
|
CA339020655 rs1353512578 |
37 | A>T | No |
ClinGen gnomAD |
|
|
rs1307502753 CA339020645 |
38 | V>A | No |
ClinGen gnomAD |
|
|
rs754221879 CA686867 |
40 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs950189696 CA19289586 |
41 | T>I | No |
ClinGen TOPMed |
|
| TCGA novel | 43 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200666402 CA19289583 |
44 | G>R | No |
ClinGen gnomAD |
|
|
CA339020613 rs200666402 |
44 | G>S | No |
ClinGen gnomAD |
|
|
rs1302769261 CA339020594 |
47 | S>N | No |
ClinGen gnomAD |
|
|
CA686866 rs764487664 |
47 | S>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 49 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 50 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA339020563 rs775303358 |
52 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA686864 rs775303358 |
52 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339020552 rs1332210341 |
53 | A>S | No |
ClinGen gnomAD |
|
|
rs1279905726 CA339020544 |
54 | V>M | No |
ClinGen TOPMed |
|
|
rs111832243 CA19289543 |
55 | L>P | No |
ClinGen Ensembl |
|
|
rs1444034929 CA339020510 |
56 | Y>C | No |
ClinGen TOPMed |
|
| TCGA novel | 57 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA339020464 rs1307295654 |
59 | L>V | No |
ClinGen TOPMed |
|
|
CA686861 rs773937494 |
60 | S>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs770828039 CA686860 |
61 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339020443 rs1301116696 |
61 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
rs749247846 CA686859 |
62 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA686858 rs769611593 |
63 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA19289529 rs769611593 |
63 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA686857 rs769611593 |
63 | Q>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339020403 rs2501432 |
63 | Q>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
VAR_054310 CA686856 rs2501432 |
63 | Q>R | high incidence in Japanese depressed subjects [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs35761398 CA19289506 |
63 | Q>R | No |
ClinGen Ensembl |
|
|
rs528804725 CA686854 |
65 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA686853 rs200619419 |
65 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
RCV000967909 CA686850 rs61996280 |
66 | R>Q | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
COSM3804575 COSM3804576 rs757744382 CA686851 |
66 | R>W | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs761149846 CA686848 |
68 | P>H | No |
ClinGen ExAC |
|
|
rs141481878 CA686846 |
70 | Y>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA339020230 rs1427907785 |
73 | I>T | No |
ClinGen gnomAD |
|
|
rs1414556125 CA339020237 |
73 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA686844 rs773803426 |
74 | G>C | No |
ClinGen ExAC gnomAD |
|
|
rs1263418042 CA339020160 |
77 | A>V | No |
ClinGen gnomAD |
|
|
rs1484764426 CA339020150 |
79 | A>T | No |
ClinGen gnomAD |
|
|
rs200099315 CA339020097 |
82 | L>P | No |
ClinGen gnomAD |
|
|
rs200099315 CA19289455 |
82 | L>Q | No |
ClinGen gnomAD |
|
|
rs756316007 CA339020093 |
83 | A>P | No |
ClinGen Ensembl |
|
|
rs756316007 CA19289450 |
83 | A>S | No |
ClinGen Ensembl |
|
|
rs201650984 CA686842 |
84 | S>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA19289449 rs1008131094 |
84 | S>I | No |
ClinGen TOPMed |
|
|
CA19289433 rs955203366 |
87 | F>I | No |
ClinGen TOPMed |
|
| TCGA novel | 87 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA19289428 rs200068439 |
89 | C>* | No |
ClinGen Ensembl |
|
|
CA686840 rs773226744 |
89 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs769681479 CA686839 |
89 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs543855954 CA686838 |
90 | S>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs772338354 CA339019924 |
92 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA686836 rs772338354 |
92 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA339019865 rs1488942624 |
94 | F>L | No |
ClinGen Ensembl |
|
|
rs746058590 CA686835 |
95 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA19289420 rs866049734 |
95 | H>Y | No |
ClinGen Ensembl |
|
|
rs1449343871 CA339019765 |
97 | F>S | No |
ClinGen gnomAD |
|
|
rs1334169209 CA339019741 |
98 | H>R | No |
ClinGen gnomAD |
|
|
CA686831 rs778345235 |
101 | D>A | No |
ClinGen ExAC gnomAD |
|
|
CA339019685 rs778345235 |
101 | D>V | No |
ClinGen ExAC gnomAD |
|
|
rs1009950229 CA19289399 |
102 | S>F | No |
ClinGen Ensembl |
|
|
rs767985981 CA686828 |
110 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs139756160 CA686829 |
110 | I>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs754722865 CA686827 |
111 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339019527 rs1244080724 |
112 | S>R | No |
ClinGen TOPMed |
|
|
rs527797875 CA686825 |
113 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762556883 CA686824 |
114 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA339019441 rs1570698822 |
116 | T>P | No |
ClinGen Ensembl |
|
| TCGA novel | 117 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs772531845 CA686823 |
117 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA339019384 rs1315215453 |
118 | T>A | No |
ClinGen gnomAD |
|
|
rs1315215453 CA339019382 |
118 | T>P | No |
ClinGen gnomAD |
|
|
rs765174269 CA686822 |
119 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA339019269 rs1233888905 |
122 | G>D | No |
ClinGen TOPMed |
|
|
CA686816 rs774664120 |
128 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774664120 CA19289310 |
128 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA19289295 rs1006481868 |
129 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA686815 rs770989594 |
129 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA19289306 rs201688371 |
129 | I>V | No |
ClinGen Ensembl |
|
|
rs150233022 CA686814 |
131 | R>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs199691655 CA686813 |
131 | R>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
CA686812 rs199785089 |
132 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA686811 rs41311993 |
133 | L>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs930052487 CA19289265 |
134 | C>R | No |
ClinGen Ensembl |
|
|
rs781726068 CA686810 |
134 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM906509 COSM906510 CA686808 rs141989735 |
136 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
COSM533640 COSM533639 rs199631465 CA686807 |
136 | R>H | lung Variant assessed as Somatic; 0.0 impact. endometrium [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs757932522 CA686806 |
137 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs750007574 CA686805 |
139 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339018924 rs1316722407 |
140 | S>Y | No |
ClinGen Ensembl |
|
|
CA686803 rs201510809 |
142 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA339018863 rs1170811802 |
143 | A>S | No |
ClinGen gnomAD |
|
|
rs200635692 CA19289214 |
143 | A>V | No |
ClinGen Ensembl |
|
|
rs776572645 CA686802 |
144 | L>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339018845 rs1303369295 |
145 | L>F | No |
ClinGen gnomAD |
|
|
rs1423785471 CA339018821 |
146 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA339018815 rs1557521491 |
147 | R>C | No |
ClinGen Ensembl |
|
|
CA686801 rs542890327 |
147 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA686800 rs760521443 |
148 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1363136054 CA339018747 |
152 | V>M | No |
ClinGen gnomAD |
|
|
CA686796 rs145306214 |
154 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs769975822 CA686795 |
155 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs80131168 CA19289154 |
157 | M>R | No |
ClinGen Ensembl |
|
|
rs781772998 CA339018622 |
158 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs781772998 CA686793 |
158 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs1352082292 CA339018605 |
159 | V>A | No |
ClinGen gnomAD |
|
|
rs201087852 CA686792 |
159 | V>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 160 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1240581048 CA339018562 |
162 | A>T | No |
ClinGen gnomAD |
|
|
rs1307638165 CA339018543 |
163 | L>I | No |
ClinGen TOPMed |
|
|
rs780269365 CA686790 |
164 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 167 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 169 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1557521430 CA339018378 |
171 | G>E | No |
ClinGen Ensembl |
|
|
rs1299861030 CA339018346 |
173 | T>A | No |
ClinGen gnomAD |
|
|
rs776070030 CA686785 |
174 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA339018251 rs1451726101 |
178 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs372203029 CA339018259 |
178 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs372203029 COSM1284189 COSM1284188 CA686783 |
178 | P>T | Variant assessed as Somatic; 0.0 impact. autonomic_ganglia [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA339018158 rs1177444347 |
184 | P>S | No |
ClinGen gnomAD |
|
|
rs1320657768 CA339018138 |
185 | L>V | No |
ClinGen gnomAD |
|
|
rs767181446 CA686781 |
186 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339018090 rs1196382257 |
188 | N>S | No |
ClinGen gnomAD |
|
|
CA686780 rs763288928 |
190 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1259208364 CA339018026 |
192 | L>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA686777 rs761992110 |
194 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs375951786 CA19289043 |
196 | L>P | No |
ClinGen Ensembl |
|
|
rs201054712 CA19289018 |
198 | I>V | No |
ClinGen 1000Genomes gnomAD |
|
|
CA686774 rs747466044 |
199 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs142861964 CA19289013 |
199 | A>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs142861964 COSM906506 CA686775 COSM906505 |
199 | A>T | endometrium [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA19289011 rs747466044 |
199 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1557521335 CA339017875 |
201 | L>F | No |
ClinGen Ensembl |
|
|
rs1209223384 CA339017843 |
202 | F>L | No |
ClinGen TOPMed |
|
|
rs772344819 CA686772 |
203 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs201354527 CA686770 |
204 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339017788 rs1427539256 |
206 | I>T | No |
ClinGen gnomAD |
|
|
rs1169817581 CA339017752 |
208 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1169817581 CA339017756 |
208 | T>N | No |
ClinGen TOPMed gnomAD |
|
|
rs756844127 CA686769 |
210 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA686768 rs753400744 |
211 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA686767 rs777141896 |
211 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1687209 rs1244259465 COSM1687210 CA339017681 |
213 | L>F | skin [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA339017670 rs1202560631 |
214 | W>R | No |
ClinGen gnomAD |
|
|
CA339017651 rs1557521293 |
215 | K>E | No |
ClinGen Ensembl |
|
|
rs752550897 CA686765 |
216 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1330513364 CA339017599 |
217 | H>R | No |
ClinGen gnomAD |
|
|
rs1338529393 CA339017584 |
218 | Q>* | No |
ClinGen gnomAD |
|
|
rs751335953 CA686762 |
218 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA686763 rs759285584 |
218 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA19288956 rs764328610 |
221 | A>T | No |
ClinGen Ensembl |
|
|
CA19288946 rs201178693 |
223 | L>F | No |
ClinGen TOPMed |
|
|
CA686758 rs764050301 |
228 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA686759 rs200162708 |
228 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA686756 rs201612710 |
229 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200979413 CA19288889 |
231 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA686754 rs200979413 |
231 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA339017278 rs1166557653 |
231 | V>M | No |
ClinGen gnomAD |
|
|
rs770633754 CA686752 |
233 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA19288883 rs1016615550 |
233 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1197908587 CA339017194 |
235 | A>D | No |
ClinGen TOPMed |
|
|
CA339017209 rs1442272482 |
235 | A>T | No |
ClinGen gnomAD |
|
|
rs199945476 CA686750 |
236 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199945476 CA686751 |
236 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM906503 CA686749 COSM906504 rs567833720 |
236 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA19288866 rs747652812 |
239 | L>M | No |
ClinGen Ensembl |
|
|
CA339017023 rs1436901918 |
241 | V>M | No |
ClinGen gnomAD |
|
|
CA686748 rs747658837 |
242 | R>M | No |
ClinGen ExAC gnomAD |
|
|
CA686747 rs780999060 |
242 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs1179895832 CA339016953 |
243 | L>F | No |
ClinGen TOPMed |
|
|
CA686745 rs201829495 |
244 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1482465885 CA339016948 |
244 | A>S | No |
ClinGen TOPMed |
|
|
CA686746 rs201829495 |
244 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754091476 CA339016858 |
248 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA686743 rs200997121 |
248 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs754091476 CA686742 |
248 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764336476 CA686741 |
250 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs4649124 CA339016821 |
251 | L>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA339016790 rs1394295438 |
252 | A>T | No |
ClinGen TOPMed |
|
|
rs201916611 CA686739 |
254 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs201916611 CA339016712 |
254 | L>I | No |
ClinGen ExAC gnomAD |
|
|
CA339016436 rs1454163294 |
260 | P>L | No |
ClinGen TOPMed |
|
|
CA19288773 rs895889557 |
263 | A>T | No |
ClinGen TOPMed |
|
|
CA339016384 rs1258070138 |
264 | L>F | No |
ClinGen TOPMed |
|
|
rs199818268 CA686735 |
265 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774735405 CA339016351 |
266 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs774735405 CA686734 |
266 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA686733 rs771259098 |
270 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs371186526 CA686732 |
271 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201049279 CA686731 |
272 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA339016215 rs1291378690 |
272 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
rs780744054 CA686728 |
275 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs199680710 CA686727 |
275 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs146922938 COSM328043 COSM328042 CA686724 |
280 | A>V | pancreas [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA339015979 rs1336110702 |
282 | A>V | No |
ClinGen TOPMed |
|
| TCGA novel | 283 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201941905 CA339015874 |
285 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201941905 CA686722 |
285 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339015863 rs1557521037 |
286 | M>V | No |
ClinGen Ensembl |
|
|
rs1319274495 CA339015792 |
288 | C>Y | No |
ClinGen TOPMed |
|
|
rs764236604 CA686721 |
290 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA339015689 rs1160391158 |
291 | N>K | No |
ClinGen gnomAD |
|
|
rs144980121 CA686718 |
297 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1178172933 CA339015547 |
298 | I>N | No |
ClinGen gnomAD |
|
|
CA339015523 rs1307692881 |
299 | Y>H | No |
ClinGen Ensembl |
|
|
CA19288676 rs202124598 |
300 | A>V | No |
ClinGen Ensembl |
|
|
rs1352877241 CA339015478 |
301 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
CA19288668 rs191065191 |
302 | R>Q | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
COSM1638274 CA686717 COSM1638275 rs760083242 |
302 | R>W | bone [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1197100282 CA339015445 |
303 | S>G | No |
ClinGen gnomAD |
|
|
rs1367351756 CA339015408 |
305 | E>G | No |
ClinGen TOPMed |
|
|
CA686716 rs752079780 |
305 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs766834385 CA339015396 |
306 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766834385 CA686715 |
306 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA686713 rs773572627 |
307 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA686714 rs773572627 |
307 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs148656213 CA686712 |
307 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs148656213 CA339015375 |
307 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA686710 rs776045128 |
308 | S>F | No |
ClinGen ExAC |
|
|
CA339015329 rs923029792 |
310 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
CA19288627 rs954473721 |
310 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
rs923029792 CA19288623 |
310 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA339015263 rs201210941 |
313 | C>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA686709 rs550621200 |
313 | C>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs375133736 CA686707 |
315 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs2229579 CA686706 |
316 | H>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs2229579 VAR_029209 CA686705 |
316 | H>Y | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs761834077 CA19288583 |
319 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA19288575 rs201088433 |
320 | C>* | No |
ClinGen Ensembl |
|
|
rs778764026 CA686704 |
320 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA19288579 rs201974899 |
320 | C>S | No |
ClinGen ExAC gnomAD |
|
|
rs201974899 CA686703 |
320 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1469867086 CA339015130 |
321 | V>M | No |
ClinGen gnomAD |
|
|
CA19288569 rs962859442 |
323 | G>A | No |
ClinGen TOPMed |
|
|
CA19288558 rs988922624 |
324 | L>P | No |
ClinGen Ensembl |
|
|
rs781339227 CA686701 |
325 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA686702 CA339015070 rs752937607 |
325 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA19288537 rs985148888 |
327 | E>D | No |
ClinGen gnomAD |
|
|
rs201819496 CA339015016 |
328 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs201819496 CA686700 |
328 | A>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA686699 rs751574405 |
328 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1168010488 CA339014981 |
330 | E>A | No |
ClinGen TOPMed |
|
|
rs368692272 CA19288513 |
330 | E>D | No |
ClinGen ESP TOPMed |
|
|
rs372132839 CA686698 |
330 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA19288510 rs200157579 |
332 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs201633175 CA19288509 |
333 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201633175 CA686696 |
333 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761421274 CA686694 |
335 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs199612016 CA686693 |
338 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs541088933 CA339014825 |
339 | E>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA686689 rs541088933 |
339 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA339014805 rs1285005660 |
340 | T>S | No |
ClinGen gnomAD |
|
|
CA339014799 rs1317764755 |
341 | E>K | No |
ClinGen gnomAD |
|
|
rs778618350 CA686687 |
342 | A>T | No |
ClinGen ExAC TOPMed |
|
|
CA19288465 rs201546828 |
344 | G>E | No |
ClinGen Ensembl |
|
|
rs183583549 CA19288462 |
345 | K>E | No |
ClinGen 1000Genomes gnomAD |
|
|
rs1334308910 CA339014712 |
346 | I>T | No |
ClinGen gnomAD |
|
|
rs1237637123 CA339014700 |
347 | T>A | No |
ClinGen gnomAD |
|
|
CA686684 rs200710174 |
348 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1570697772 CA339014657 |
349 | W>S | No |
ClinGen Ensembl |
|
|
rs1426500834 CA339014641 |
350 | P>S | No |
ClinGen gnomAD |
|
|
rs191952641 CA686682 |
352 | S>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA339014537 rs1330595940 |
354 | D>G | No |
ClinGen gnomAD |
|
|
CA686681 rs199599665 |
354 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 356 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs148142264 CA686679 |
357 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 359 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA19288443 rs1000489968 |
360 | C>F | No |
ClinGen TOPMed |
No associated diseases with P34972
1 regional properties for P34972
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 55 - 302 | IPR017452 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cannabinoid receptor activity | Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| cannabinoid signaling pathway | A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. |
| immune response | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| leukocyte chemotaxis | The movement of a leukocyte in response to an external stimulus. |
| negative regulation of action potential | Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
| negative regulation of mast cell activation | Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. |
| negative regulation of nitric-oxide synthase activity | Any process that stops or reduces the activity of the enzyme nitric-oxide synthase. |
| negative regulation of synaptic transmission, GABAergic | Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
| regulation of metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. |
| response to amphetamine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| sensory perception of pain | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. |
119 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEECWVTEIA | NGSKDGLDSN | PMKDYMILSG | PQKTAVAVLC | TLLGLLSALE | NVAVLYLILS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SHQLRRKPSY | LFIGSLAGAD | FLASVVFACS | FVNFHVFHGV | DSKAVFLLKI | GSVTMTFTAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VGSLLLTAID | RYLCLRYPPS | YKALLTRGRA | LVTLGIMWVL | SALVSYLPLM | GWTCCPRPCS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELFPLIPNDY | LLSWLLFIAF | LFSGIIYTYG | HVLWKAHQHV | ASLSGHQDRQ | VPGMARMRLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VRLAKTLGLV | LAVLLICWFP | VLALMAHSLA | TTLSDQVKKA | FAFCSMLCLI | NSMVNPVIYA |
| 310 | 320 | 330 | 340 | 350 | |
| LRSGEIRSSA | HHCLAHWKKC | VRGLGSEAKE | EAPRSSVTET | EADGKITPWP | DSRDLDLSDC |