P32745
PR
Gene name |
SSTR3 |
Protein name |
Somatostatin receptor type 3 |
Names |
SS-3-R, SS3-R, SS3R, SST3, SSR-28 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6753 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P32745
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P32745-F1 | Predicted | AlphaFoldDB |
383 variants for P32745
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs146051676 CA10217430 |
3 | M>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1381736584 CA411436584 |
3 | M>V | No |
ClinGen TOPMed |
|
|
CA10217429 rs750747193 |
4 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1158593036 CA411436544 |
5 | H>P | No |
ClinGen TOPMed gnomAD |
|
|
CA10217428 rs781697449 |
5 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs887386610 CA324061151 |
7 | S>T | No |
ClinGen TOPMed |
|
|
CA10217426 rs142779764 |
8 | S>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1367539166 CA411436475 |
9 | V>M | No |
ClinGen TOPMed |
|
|
CA10217424 rs759139510 |
11 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411436336 rs1354652511 |
15 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs766123452 CA10217422 |
17 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs772935218 CA10217420 |
19 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs138252753 CA10217418 |
20 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs768604532 CA10217416 |
21 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749451006 CA10217415 |
23 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411436139 rs1310850669 |
24 | P>S | No |
ClinGen gnomAD |
|
|
rs1397804485 CA411436126 |
25 | D>H | No |
ClinGen gnomAD |
|
|
rs1356204498 CA411436115 |
26 | A>T | No |
ClinGen gnomAD |
|
|
rs145680119 CA10217413 |
27 | T>N | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1601654111 CA411436098 |
27 | T>P | No |
ClinGen Ensembl |
|
| TCGA novel | 28 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA324061096 rs952318206 |
29 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
rs781653219 CA10217410 |
29 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA324061093 rs952318206 |
29 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA10217406 rs754444767 |
31 | V>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs113507829 CA10217407 |
31 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10217405 rs150245926 |
32 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA411436010 rs4988466 |
33 | A>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10217402 VAR_029219 rs4988466 |
33 | A>V | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs761652974 CA10217400 |
36 | S>R | No |
ClinGen ExAC gnomAD |
|
|
VAR_049440 rs34943557 CA10217398 |
37 | P>L | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs774150809 CA10217399 |
37 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA10217396 rs372921356 |
38 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs777044647 CA10217393 |
42 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs147574177 CA10217391 |
45 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217390 rs778006551 |
46 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA411435704 rs1182778728 |
54 | V>A | No |
ClinGen TOPMed |
|
|
rs1269168300 CA411435710 |
54 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs142559355 CA10217385 |
55 | C>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs779577740 CA10217387 |
55 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs548257776 CA10217384 |
56 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1271244804 CA411435656 |
57 | V>A | No |
ClinGen gnomAD |
|
|
rs763813232 CA10217381 |
57 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs1004420444 CA324060976 |
61 | G>C | No |
ClinGen TOPMed gnomAD |
|
|
CA10217379 rs775327404 |
63 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs923070938 CA324060859 |
65 | V>F | No |
ClinGen TOPMed |
|
|
CA411435069 rs771215439 |
67 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA411435072 rs1281389124 |
67 | Y>F | No |
ClinGen gnomAD |
|
|
CA10217372 rs1027118721 |
69 | V>F | No |
ClinGen TOPMed |
|
|
CA10217371 rs773577020 |
71 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs995767572 CA324060818 |
71 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs562366809 CA324060811 |
72 | H>N | No |
ClinGen 1000Genomes |
|
|
CA10217370 rs772356909 |
72 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs748658683 CA10217369 |
73 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA324060773 rs894700326 |
74 | A>D | No |
ClinGen Ensembl |
|
|
rs866625896 CA324060799 |
74 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs755615522 CA10217367 |
75 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1569079635 CA411434978 |
75 | S>R | No |
ClinGen Ensembl |
|
|
rs370926465 CA324060758 |
79 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217364 rs144524580 |
79 | T>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217365 rs370926465 |
79 | T>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217366 rs370926465 |
79 | T>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217361 rs752669676 |
81 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752669676 CA10217360 |
81 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 82 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1448499165 CA411434882 |
84 | L>F | No |
ClinGen gnomAD |
|
|
rs1424916012 CA411434873 |
85 | N>I | No |
ClinGen TOPMed |
|
|
CA10217357 rs375736845 |
86 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA411434861 rs1332920981 |
87 | A>V | No |
ClinGen gnomAD |
|
|
rs1404188428 CA411434856 |
88 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
CA411434855 rs1333682959 |
89 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA411434849 rs1601653562 |
90 | D>N | No |
ClinGen Ensembl |
|
|
rs201547867 CA10217352 |
91 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA411434817 rs1601653516 |
94 | M>R | No |
ClinGen Ensembl |
|
|
CA411434819 rs1569079509 |
94 | M>V | No |
ClinGen Ensembl |
|
|
CA411434810 rs1376419910 |
95 | L>V | No |
ClinGen gnomAD |
|
| TCGA novel | 96 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10217351 rs774702592 |
96 | G>W | No |
ClinGen ExAC gnomAD |
|
|
rs139954208 CA10217349 |
102 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA324060706 rs1041799726 |
102 | A>V | No |
ClinGen TOPMed |
|
|
rs1054188776 CA324060690 |
106 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA10217346 rs4988467 |
111 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217344 rs572234753 |
112 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1219207470 CA411434695 |
113 | S>F | No |
ClinGen TOPMed |
|
|
CA411434684 rs1225894358 |
115 | M>T | No |
ClinGen gnomAD |
|
|
rs778868708 CA10217342 |
117 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10217340 rs146025994 |
117 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs146025994 CA10217341 |
117 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs778868708 CA324060675 |
117 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1478365821 CA411434662 |
119 | V>F | No |
ClinGen TOPMed |
|
|
CA411434657 rs1198477773 |
120 | M>V | No |
ClinGen gnomAD |
|
|
rs766537501 CA10217339 |
121 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1601653379 CA411434639 |
122 | V>G | No |
ClinGen Ensembl |
|
|
CA324060646 rs907657079 |
125 | I>L | No |
ClinGen gnomAD |
|
|
CA10217337 rs750652022 |
125 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA411434602 rs1401081053 |
128 | F>L | No |
ClinGen gnomAD |
|
|
CA411434588 rs1299790884 |
130 | S>G | No |
ClinGen TOPMed |
|
|
rs867629272 CA324060610 |
130 | S>N | No |
ClinGen gnomAD |
|
|
rs774649311 CA10217334 |
134 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs774649311 CA411434557 |
134 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1399165472 CA411434550 |
135 | T>I | No |
ClinGen TOPMed |
|
|
CA411434538 rs1228252578 |
137 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs769036687 CA10217332 |
137 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA411434542 rs1332782396 |
137 | M>V | No |
ClinGen TOPMed |
|
|
CA10217331 rs763415857 |
138 | S>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 138 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs776023604 CA10217330 |
138 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA10217328 rs746570552 |
139 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777345486 CA10217327 |
141 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373095766 CA10217325 |
141 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA10217326 rs373095766 |
141 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs754862054 CA10217323 |
142 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
rs35163011 CA10217324 |
142 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA324060552 rs933389010 |
144 | A>S | No |
ClinGen TOPMed |
|
|
CA10217320 rs142693615 |
145 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs974216924 CA324060550 |
147 | H>R | No |
ClinGen Ensembl |
|
|
rs556374239 CA10217315 |
150 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA10217314 rs763363171 |
150 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA10217313 rs201144344 |
151 | S>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs772552377 CA10217310 |
153 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs558818233 CA10217309 |
153 | R>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10217308 rs141443248 |
155 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217307 rs376489598 |
155 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA411434427 rs1168127761 |
157 | A>P | No |
ClinGen gnomAD |
|
|
rs752943068 CA324060496 |
158 | P>L | No |
ClinGen gnomAD |
|
|
rs1315556808 CA411434422 |
158 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs779911144 CA10217304 |
161 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA10217303 rs371788740 |
161 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA10217302 rs143323494 |
162 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA324060459 rs971111379 |
164 | S>R | No |
ClinGen TOPMed |
|
|
rs138495835 CA411434345 |
165 | A>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201367265 CA10217299 |
165 | A>T | Variant assessed as Somatic; 4.955e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA10217298 rs138495835 |
165 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA411434332 rs1429614547 |
166 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs147112799 CA10217296 |
167 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217295 rs765660582 |
168 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA411434284 rs1455865730 |
170 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA10217294 rs759921363 |
172 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10217292 rs35848389 |
173 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10217290 rs774000607 |
177 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA411434192 rs1286400150 |
178 | V>A | No |
ClinGen gnomAD |
|
|
rs201631765 CA411434196 |
178 | V>L | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs201631765 CA324060390 |
178 | V>M | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs1244531322 CA411434180 |
179 | V>A | No |
ClinGen TOPMed |
|
|
rs149879896 CA10217288 |
179 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs769666782 CA10217286 |
181 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA10217287 rs769666782 |
181 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA10217285 rs372511888 |
182 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 183 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs747027378 CA10217282 |
186 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747027378 CA324060372 |
186 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs552400624 CA10217280 |
186 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs552400624 CA10217281 |
186 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10217278 rs779117007 |
187 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs369189316 CA411434072 CA10217275 |
188 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs754289088 CA10217276 |
188 | M>R | No |
ClinGen ExAC |
|
|
rs1437423246 CA411434084 |
188 | M>V | No |
ClinGen gnomAD |
|
|
CA411434065 rs761276382 |
189 | S>N | No |
ClinGen ExAC TOPMed |
|
|
rs761276382 CA10217274 |
189 | S>T | No |
ClinGen ExAC TOPMed |
|
|
rs1415533488 CA411434055 |
190 | T>N | No |
ClinGen TOPMed |
|
|
CA10217273 rs751064098 |
190 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA411434014 rs1170753037 |
194 | Q>* | No |
ClinGen TOPMed |
|
|
rs376160893 CA324060325 |
197 | E>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs376160893 CA10217268 |
197 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1237771491 CA411433982 |
198 | P>L | No |
ClinGen gnomAD |
|
|
rs1237771491 CA411433984 |
198 | P>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA324060313 rs34092036 |
199 | A>T | No |
ClinGen Ensembl |
|
|
rs371258114 CA10217266 |
199 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA10217265 rs367840725 |
200 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 201 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA324060294 rs867001722 |
202 | W>L | No |
ClinGen Ensembl |
|
|
CA324060291 rs981153686 |
203 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1376657158 CA411433957 |
203 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1022755663 CA324060285 |
205 | G>A | No |
ClinGen TOPMed |
|
|
CA10217262 rs748297538 |
205 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 205 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10217261 rs779253764 |
206 | F>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 206 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs140167759 CA411433914 |
210 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs754171994 CA10217259 |
210 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10217260 rs140167759 |
210 | T>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1189513419 CA411433909 |
211 | A>T | No |
ClinGen gnomAD |
|
|
rs1262390020 CA411433905 |
212 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs376088723 CA10217255 |
214 | G>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376088723 CA10217254 |
214 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA324060259 rs13057124 |
215 | F>L | No |
ClinGen Ensembl |
|
|
CA10217252 rs764874654 CA411433875 |
217 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs530075945 CA324060252 |
218 | P>L | No |
ClinGen 1000Genomes gnomAD |
|
|
rs1311429410 CA411433868 |
218 | P>S | No |
ClinGen TOPMed |
|
|
CA411433863 rs1400998403 |
219 | L>P | No |
ClinGen TOPMed |
|
|
rs770747977 CA10217249 |
222 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1298140638 CA411433838 |
223 | C>Y | No |
ClinGen gnomAD |
|
|
rs773182636 CA10217247 |
224 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA324060245 rs868373029 |
225 | C>F | No |
ClinGen Ensembl |
|
|
CA411433815 CA411433816 rs1415294488 |
226 | Y>* | No |
ClinGen gnomAD |
|
|
rs1457082553 CA411433821 |
226 | Y>H | No |
ClinGen gnomAD |
|
|
rs1457082553 CA411433822 |
226 | Y>N | No |
ClinGen gnomAD |
|
|
rs774301903 CA10217244 |
230 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201174534 CA10217242 |
234 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1190974255 CA411433769 |
234 | R>S | No |
ClinGen gnomAD |
|
|
CA411433760 rs1569078670 |
236 | A>S | No |
ClinGen Ensembl |
|
|
rs13056958 CA324060226 |
236 | A>V | No |
ClinGen Ensembl |
|
|
CA10217241 rs749502598 |
237 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs192574257 CA10217240 |
238 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs756595845 CA10217239 |
238 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs756595845 CA411433747 |
238 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10217238 rs34690350 |
239 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA411433745 rs1215577249 |
239 | R>W | No |
ClinGen gnomAD |
|
|
rs577113986 CA10217236 |
242 | A>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs577113986 CA411433727 |
242 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs752191545 CA10217235 |
243 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA411433722 rs1296729984 |
243 | P>T | No |
ClinGen gnomAD |
|
|
CA10217234 rs201384387 |
244 | S>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA411433713 rs201384387 |
244 | S>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10217231 rs766144463 |
247 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs146500640 CA10217232 |
247 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760525038 CA10217230 |
248 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs913472800 CA411433689 |
249 | R>G | No |
ClinGen gnomAD |
|
|
rs988807314 CA324060145 |
249 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs913472800 CA324060161 |
249 | R>W | No |
ClinGen gnomAD |
|
|
CA10217229 rs773133158 |
250 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA10217228 rs767424186 |
250 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
VAR_020072 rs6413537 CA324060127 |
251 | S>F | No |
ClinGen UniProt Ensembl dbSNP |
|
|
rs6413537 CA411433679 |
251 | S>Y | No |
ClinGen Ensembl |
|
|
CA411433677 rs1469109472 |
252 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA10217225 rs774446220 |
253 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768655309 CA10217224 |
253 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774446220 CA10217226 |
253 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411433666 rs1341999879 |
254 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs370263249 CA411433650 |
256 | T>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217223 rs370263249 |
256 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217221 rs200603936 |
257 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10217219 rs202229747 |
257 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs202229747 CA10217220 |
257 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10217218 rs757736671 |
259 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1326277707 CA411433622 |
261 | A>V | No |
ClinGen gnomAD |
|
|
rs1171951853 CA411433616 |
262 | V>A | No |
ClinGen gnomAD |
|
|
CA10217216 rs778455559 |
262 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA10217213 rs139412786 |
264 | A>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217215 rs754495677 |
264 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA10217214 rs139412786 |
264 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA411433603 rs1454866571 |
265 | L>F | No |
ClinGen gnomAD |
|
|
rs767244611 CA411433591 |
267 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767244611 CA10217210 |
267 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761776296 CA10217209 |
269 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA10217208 rs2071710 CA411433535 |
274 | Y>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA411433533 rs376429760 |
275 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217206 rs376429760 |
275 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs373435292 CA324060041 |
279 | V>I | No |
ClinGen ESP TOPMed |
|
|
rs777016404 CA10217202 |
281 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA10217203 rs369840172 |
281 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1443685919 CA411433491 |
282 | V>M | No |
ClinGen gnomAD |
|
|
rs1332980411 CA411433475 |
284 | P>S | No |
ClinGen gnomAD |
|
| TCGA novel | 287 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10217198 rs200323878 |
287 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA411433448 rs748732628 |
288 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA324059978 rs1055168952 |
288 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1055168952 CA411433453 |
288 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs755721825 CA10217195 |
289 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs779556043 CA10217196 |
289 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA10217193 rs781015807 |
294 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA324059960 rs937792622 |
297 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA10217190 rs570846487 |
300 | A>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA324059935 rs901856630 |
300 | A>T | No |
ClinGen TOPMed |
|
|
CA10217189 rs570846487 |
300 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA10217186 rs759802711 |
302 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA324059919 rs760562953 |
303 | Y>* | No |
ClinGen Ensembl |
|
|
CA10217184 rs771313399 |
306 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA10217182 rs773634216 |
307 | C>W | No |
ClinGen ExAC gnomAD |
|
|
CA10217183 rs761016457 |
307 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA324059887 rs927684113 |
308 | A>V | No |
ClinGen TOPMed |
|
|
CA411433321 rs1320101698 |
309 | N>S | No |
ClinGen gnomAD |
|
|
CA411433311 rs1402653871 |
311 | I>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1402653871 CA411433310 |
311 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA324059882 rs866155133 |
312 | L>F | No |
ClinGen Ensembl |
|
|
rs1045927279 CA324059880 |
313 | Y>* | No |
ClinGen TOPMed |
|
| TCGA novel | 316 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs950212781 CA324059869 |
318 | Y>C | No |
ClinGen Ensembl |
|
|
CA10217180 rs748679410 |
319 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779505244 CA10217179 |
319 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA411433244 rs1475399498 |
321 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs745516978 CA10217177 |
322 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs879306511 CA324059862 |
323 | G>S | No |
ClinGen Ensembl |
|
|
CA411433223 rs1601651800 |
324 | F>V | No |
ClinGen Ensembl |
|
|
rs780770327 CA10217176 |
325 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA324059836 rs1049598972 |
325 | R>H | No |
ClinGen TOPMed |
|
|
rs1447146372 CA411433208 |
326 | R>S | No |
ClinGen gnomAD |
|
|
rs1569078158 CA411433194 |
329 | L>V | No |
ClinGen Ensembl |
|
|
rs1293416143 CA411433188 |
330 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs373712578 CA10217174 |
330 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA411433186 rs772937539 |
331 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
rs527832440 CA10217173 |
331 | P>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs772937539 CA324059820 |
331 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
rs752724021 CA10217171 |
332 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA10217168 rs375773160 |
333 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1459907072 CA411433175 |
333 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1459907072 CA411433173 |
333 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs766448009 CA10217167 |
334 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10217166 rs139709130 |
334 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
VAR_029220 rs4988469 CA10217165 |
336 | R>C | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs143937169 CA10217164 |
336 | R>H | Variant assessed as Somatic; 4.922e-05 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs762283089 CA10217163 |
337 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA411433139 rs1487541768 |
339 | E>G | No |
ClinGen gnomAD |
|
|
rs1174018190 CA411433133 |
340 | P>S | No |
ClinGen TOPMed |
|
|
CA10217161 rs200839217 |
341 | T>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10217160 rs745309656 |
342 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs1326983067 CA411433109 |
344 | P>H | No |
ClinGen TOPMed |
|
|
rs1299901450 CA411433112 |
344 | P>T | No |
ClinGen TOPMed |
|
|
CA10217158 rs202051882 |
345 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 345 | P>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA324059719 rs1055446333 |
350 | E>G | No |
ClinGen TOPMed |
|
|
rs544320915 CA10217156 |
351 | E>K | No |
ClinGen 1000Genomes ExAC |
|
|
rs748085660 CA10217152 |
352 | D>E | No |
ClinGen ExAC |
|
|
CA10217155 rs147091066 |
352 | D>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217150 rs532546526 |
355 | E>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs143269835 CA10217151 |
355 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217148 rs753806021 |
356 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA411433015 rs1601651487 |
357 | D>E | No |
ClinGen Ensembl |
|
|
rs1373543662 CA411433017 |
357 | D>G | No |
ClinGen gnomAD |
|
| TCGA novel | 358 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1294115807 CA411433011 |
358 | G>V | No |
ClinGen gnomAD |
|
|
rs199911328 CA10217140 |
363 | E>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10217141 rs767852546 |
363 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA324059613 CA411432971 rs1002263290 |
364 | G>R | No |
ClinGen gnomAD |
|
| TCGA novel | 365 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1172226396 CA411432961 |
365 | G>D | No |
ClinGen gnomAD |
|
|
rs763537466 CA411432956 |
366 | K>M | No |
ClinGen ExAC gnomAD |
|
|
CA10217136 rs763537466 |
366 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs775961405 CA10217135 |
369 | E>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 369 | E>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA411432927 rs1385546860 |
370 | M>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA411432913 rs1347085465 |
372 | G>D | No |
ClinGen gnomAD |
|
|
CA324059596 rs774669227 |
372 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs771988317 CA10217131 |
373 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA10217132 rs143429499 |
373 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1601651281 CA411432902 |
374 | V>G | No |
ClinGen Ensembl |
|
|
CA411432907 rs1390863926 |
374 | V>I | No |
ClinGen gnomAD |
|
|
CA324059581 rs891972987 |
376 | Q>K | No |
ClinGen Ensembl |
|
|
CA10217129 rs371635196 |
378 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1311437187 CA411432865 |
380 | P>A | No |
ClinGen gnomAD |
|
|
rs1311437187 CA411432864 |
380 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1311437187 CA411432866 |
380 | P>T | No |
ClinGen gnomAD |
|
|
CA324059565 rs926181113 |
381 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA10217127 rs554837429 |
382 | T>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs554837429 CA10217126 |
382 | T>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1416970859 CA411432843 |
384 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1177285164 CA411432824 |
386 | E>D | No |
ClinGen gnomAD |
|
|
CA10217124 rs750635599 |
386 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA10217122 rs749316868 |
387 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs145475895 CA10217123 |
387 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA10217120 rs764548986 |
388 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA324059528 rs764548986 |
388 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753297506 CA10217118 |
389 | P>L | No |
ClinGen ExAC |
|
| TCGA novel | 389 | P>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs386821181 CA324059519 |
389 | P>S | No |
ClinGen Ensembl |
|
|
rs868760451 CA324059515 |
390 | S>R | No |
ClinGen Ensembl |
|
|
rs765795872 CA10217117 |
390 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA10217116 rs760300421 |
393 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771796089 CA10217114 |
394 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA324059497 rs564655455 |
395 | K>N | No |
ClinGen Ensembl |
|
|
CA324059506 rs866849257 |
395 | K>Q | No |
ClinGen Ensembl |
|
|
CA10217113 rs575289966 |
396 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10217112 rs367707990 |
398 | Q>K | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10217111 rs768538578 |
401 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA10217109 rs780104150 |
402 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs746345730 CA324059481 |
403 | E>Q | No |
ClinGen Ensembl |
|
|
rs201953429 CA324059466 |
406 | T>N | No |
ClinGen Ensembl |
|
|
rs1415546356 CA411432650 |
407 | G>E | No |
ClinGen gnomAD |
|
|
rs1173505046 CA411432643 |
408 | E>G | No |
ClinGen gnomAD |
|
| TCGA novel | 408 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1189932737 CA411432647 |
408 | E>K | No |
ClinGen gnomAD |
|
|
CA411432626 rs1461472651 |
410 | S>F | No |
ClinGen TOPMed |
|
|
CA10217103 rs229568 |
411 | S>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10217102 rs229568 VAR_011853 |
411 | S>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA411432617 rs372352171 |
412 | T>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs372352171 CA10217100 |
412 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217101 rs758856246 |
412 | T>P | No |
ClinGen ExAC gnomAD |
|
|
rs144108226 CA10217098 |
414 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217097 rs4988471 VAR_029221 |
414 | R>H | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs368276792 CA10217096 |
415 | I>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10217095 rs368276792 |
415 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs774107520 CA10217094 |
418 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1459253495 CA411432573 |
419 | L>W | No |
ClinGen TOPMed |
No associated diseases with P32745
1 regional properties for P32745
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 61 - 313 | IPR017452 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| ciliary membrane | The portion of the plasma membrane surrounding a cilium. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| non-motile cilium | A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| neuropeptide binding | Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
| somatostatin receptor activity | Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell signaling | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
| cellular response to estradiol stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
| cellular response to glucocorticoid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. |
| cerebellum development | The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. |
| forebrain development | The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. |
| hormone-mediated apoptotic signaling pathway | The series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| neuropeptide signaling pathway | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| response to starvation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
120 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| Q9Y5Y4 | PTGDR2 | Prostaglandin D2 receptor 2 | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDMLHPSSVS | TTSEPENASS | AWPPDATLGN | VSAGPSPAGL | AVSGVLIPLV | YLVVCVVGLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GNSLVIYVVL | RHTASPSVTN | VYILNLALAD | ELFMLGLPFL | AAQNALSYWP | FGSLMCRLVM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AVDGINQFTS | IFCLTVMSVD | RYLAVVHPTR | SARWRTAPVA | RTVSAAVWVA | SAVVVLPVVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FSGVPRGMST | CHMQWPEPAA | AWRAGFIIYT | AALGFFGPLL | VICLCYLLIV | VKVRSAGRRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WAPSCQRRRR | SERRVTRMVV | AVVALFVLCW | MPFYVLNIVN | VVCPLPEEPA | FFGLYFLVVA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPYANSCANP | ILYGFLSYRF | KQGFRRVLLR | PSRRVRSQEP | TVGPPEKTEE | EDEEEEDGEE |
| 370 | 380 | 390 | 400 | 410 | |
| SREGGKGKEM | NGRVSQITQP | GTSGQERPPS | RVASKEQQLL | PQEASTGEKS | STMRISYL |