AiPD: Autoinhibited Protein Database

Q9Y5Y4

Gene name	PTGDR2 (CRTH2, DL1R, GPR44)
Protein name	Prostaglandin D2 receptor 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11251
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

296-395 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

296-395 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9Y5Y4

Entry ID	Method	Resolution	Chain	Position	Source
6D26	X-ray	280 A	A	1-339	PDB
6D27	X-ray	274 A	A	1-339	PDB
7M8W	X-ray	261 A	A	1-339	PDB
AF-Q9Y5Y4-F1	Predicted				AlphaFoldDB

378 variants for Q9Y5Y4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA222808428 rs899422732	3	A>D		No	ClinGen Ensembl
rs868723708 CA222808430	3	A>T		No	ClinGen gnomAD
rs749693737 CA6027127	4	N>S		No	ClinGen ExAC TOPMed gnomAD
rs756531361 CA6027125	5	A>D		No	ClinGen ExAC gnomAD
rs1331228556 CA380619563	5	A>T		No	ClinGen gnomAD
CA380619556 rs756531361	5	A>V		No	ClinGen ExAC gnomAD
rs1443887935 CA380619543	6	T>I		No	ClinGen gnomAD
CA380619513 rs1331888448	9	P>A		No	ClinGen TOPMed gnomAD
CA6027123 rs779367187	12	P>L		No	ClinGen ExAC gnomAD
CA380619464 rs1404978305	13	I>V		No	ClinGen TOPMed
rs1478468727 CA380619445	14	L>P		No	ClinGen gnomAD
CA380619442 rs1176877818	15	E>K		No	ClinGen gnomAD
rs1439098402 CA380619425	16	Q>E		No	ClinGen gnomAD
rs1439098402 CA380619423	16	Q>K		No	ClinGen gnomAD
CA380619401 rs1239319568	17	M>T		No	ClinGen gnomAD
rs1311971460 CA380619385	18	S>N		No	ClinGen TOPMed
CA6027121 rs140107997	19	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA380619361 rs1590579585	20	L>P		No	ClinGen Ensembl
CA380619352 rs1441103287	21	Q>*		No	ClinGen gnomAD
CA6027119 rs757092179	24	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA380619266 rs1345318629	26	T>I		No	ClinGen gnomAD
rs1590579567 CA380619274	26	T>P		No	ClinGen Ensembl
rs1305113045 CA380619242	28	I>N		No	ClinGen gnomAD
CA6027118 rs763977880	29	R>C		No	ClinGen ExAC gnomAD
rs974931539 CA222808409	29	R>H		No	ClinGen TOPMed gnomAD
CA380619225 rs974931539	29	R>P		No	ClinGen TOPMed gnomAD
CA6027117 rs763977880	29	R>S		No	ClinGen ExAC gnomAD
rs760460958 CA6027116	30	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1333292970 CA380619180	32	D>G		No	ClinGen gnomAD
CA380619187 rs1338537653	32	D>H		No	ClinGen TOPMed gnomAD
CA380619185 rs1338537653	32	D>Y		No	ClinGen TOPMed gnomAD
CA380619170 rs1377512340	33	H>N		No	ClinGen gnomAD
CA380619168 rs1377512340	33	H>Y		No	ClinGen gnomAD
rs759678740 CA6027114	34	A>G		No	ClinGen ExAC gnomAD
CA6027113 rs759678740	34	A>V		No	ClinGen ExAC gnomAD
CA380619129 rs1472077936	36	V>L		No	ClinGen gnomAD
rs1472077936 CA380619133	36	V>M		No	ClinGen gnomAD
rs1444433077 CA380619108	38	L>P		No	ClinGen gnomAD
rs1188709002 CA380619112	38	L>V		No	ClinGen TOPMed gnomAD
TCGA novel CA380619085 rs1214002175	40	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed gnomAD
rs1378201761 CA380619072	41	L>V		No	ClinGen TOPMed
CA6027110 rs749549015	42	A>S		No	ClinGen ExAC TOPMed gnomAD
CA222808397 rs749549015	42	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6027108 rs770201396	44	L>P		No	ClinGen ExAC gnomAD
CA380618980 rs1296644438	49	E>*		No	ClinGen gnomAD
CA380618974 rs1399606590	49	E>D		No	ClinGen gnomAD
CA380618932 rs1361294052	53	I>V		No	ClinGen gnomAD
rs1020410142 CA222808380	54	L>F		No	ClinGen TOPMed gnomAD
CA380618882 rs1164278891	56	V>L		No	ClinGen TOPMed gnomAD
rs1164278891 CA380618884	56	V>M		No	ClinGen TOPMed gnomAD
CA6027103 rs757981361	58	G>D		No	ClinGen ExAC TOPMed gnomAD
CA6027104 rs781753851	58	G>S		No	ClinGen ExAC gnomAD
rs1191130297 CA380618834	59	C>Y		No	ClinGen TOPMed gnomAD
CA222808364 rs942533419	60	R>C		No	ClinGen TOPMed
rs145143849 CA380618816	60	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs145143849 CA6027102	60	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA380618800 CA380618798 rs1263389045	61	M>I		No	ClinGen TOPMed gnomAD
CA6027101 rs756927031	62	R>C		No	ClinGen ExAC gnomAD
rs373319775 CA6027099	62	R>H		No	ClinGen ESP ExAC gnomAD
CA6027100 rs756927031	62	R>S		No	ClinGen ExAC gnomAD
rs989408283 CA222808353	65	V>M		No	ClinGen gnomAD
CA380618749 rs1276033280	66	V>I		No	ClinGen gnomAD
CA6027094 rs201972295	70	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1324851093 CA380618664	71	L>M		No	ClinGen gnomAD
CA6027092 rs150731729	72	H>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1590579336 CA380618643	72	H>P		No	ClinGen Ensembl
CA222808346 rs886432557	72	H>Q		No	ClinGen TOPMed
rs150731729 CA380618646	72	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs556535305 CA6027089	74	A>E		No	ClinGen 1000Genomes ExAC gnomAD
rs773499365 CA6027090	74	A>P		No	ClinGen ExAC gnomAD
rs556535305 CA222808337	74	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA222808331 rs1023425447	77	D>G		No	ClinGen TOPMed gnomAD
rs1222265973 CA380618575	77	D>N		No	ClinGen gnomAD
rs1318251339 CA380618522	80	A>V		No	ClinGen gnomAD
CA380618503 rs1298088096	81	S>F		No	ClinGen gnomAD
rs777269301 CA6027087	82	A>V		No	ClinGen ExAC gnomAD
CA380618463 rs1275484342	84	L>P		No	ClinGen TOPMed gnomAD
rs1275484342 CA380618465	84	L>Q		No	ClinGen TOPMed gnomAD
rs1331179942 CA380618448	85	P>L		No	ClinGen gnomAD
rs536997157 CA6027086	85	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA222808322 rs991379420	86	F>L		No	ClinGen Ensembl
CA380618400 rs1356626307	88	T>I		No	ClinGen gnomAD
CA380618389 rs1393363442	89	Y>H		No	ClinGen TOPMed
rs868760358 CA222808321	92	A>D		No	ClinGen gnomAD
rs868760358 CA380618324	92	A>V		No	ClinGen gnomAD
rs1193741895 CA380618318	93	V>M		No	ClinGen gnomAD
rs1236293106 CA380618285	95	H>Y		No	ClinGen gnomAD
CA380618257 rs1177929656	96	S>L		No	ClinGen gnomAD
rs1208337071 CA380618217	98	E>D		No	ClinGen gnomAD
rs1252834706 CA380618232	98	E>K		No	ClinGen gnomAD
rs1311864237 CA380618164	102	T>I		No	ClinGen gnomAD
CA380618172 rs1590579209	102	T>P		No	ClinGen Ensembl
CA6027083 rs567746955	104	C>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1448138536 CA380618095	106	L>P		No	ClinGen gnomAD
CA222808310 rs1016441688	107	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	113	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6027081 rs777522390	114	N>H		No	ClinGen ExAC gnomAD
CA380617990 CA6027080 rs755857823	115	M>L		No	ClinGen ExAC gnomAD
rs1436105635 CA380617974	117	A>T		No	ClinGen gnomAD
CA6027078 rs780977793	119	G>S		No	ClinGen ExAC TOPMed gnomAD
CA380617943 rs1267415201	121	L>R		No	ClinGen TOPMed
CA380617940 rs1482775174	122	L>F		No	ClinGen gnomAD
CA222808296 rs950681359	122	L>P		No	ClinGen TOPMed gnomAD
rs1030738989 CA222808293	124	A>T		No	ClinGen gnomAD
rs1565098380 CA380617921	125	I>N		No	ClinGen Ensembl
rs1285373730 CA380617923	125	I>V		No	ClinGen TOPMed gnomAD
CA380617906 rs1311123631	127	L>P		No	ClinGen gnomAD
CA380617908 rs1319286138	127	L>V		No	ClinGen gnomAD
CA380617901 rs1590579125	128	D>A		No	ClinGen Ensembl
rs766394399 CA6027076	129	R>H		No	ClinGen ExAC gnomAD
CA6027075 rs766394399	129	R>P		No	ClinGen ExAC gnomAD
CA380617888 rs1313183771	130	C>S		No	ClinGen TOPMed gnomAD
CA380617885 rs1416207905	130	C>W		No	ClinGen gnomAD
CA380617889 rs1313183771	130	C>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA222808288 rs997564963	131	L>P		No	ClinGen Ensembl
rs1187809995 CA380617880	132	Q>K		No	ClinGen TOPMed
rs1259013577 CA380617876	132	Q>R		No	ClinGen TOPMed
rs901904459 CA222808283	134	V>A		No	ClinGen TOPMed
rs180805093 CA6027072	134	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs571378284 CA6027068	135	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs571378284 CA6027069	135	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777073027 CA6027070	135	R>W		No	ClinGen ExAC gnomAD
CA6027067 rs148279533	136	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1487444524 CA380617855	137	V>M		No	ClinGen gnomAD
CA380617840 rs1565098345	139	A>T		No	ClinGen Ensembl
rs777277288 CA6027064	143	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6027063 rs531558021	143	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1244693162 CA380617801	144	T>I		No	ClinGen gnomAD
CA222808267 rs945653182	145	V>G		No	ClinGen TOPMed gnomAD
TCGA novel	145	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380617787 rs1338001903	147	A>T		No	ClinGen gnomAD
CA6027059 rs370596613	147	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs56067229 CA6027058	148	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1291758942 CA380617773	149	H>Q		No	ClinGen TOPMed gnomAD
rs1290727204 CA380617775	149	H>R		No	ClinGen TOPMed
RCV000971057 rs542817355	150	K>missing		No	ClinVar dbSNP
CA6027055 rs750463480	151	V>A		No	ClinGen ExAC TOPMed gnomAD
CA380617759 rs750463480	151	V>G		No	ClinGen ExAC TOPMed gnomAD
CA380617761 rs1485268895	151	V>I		No	ClinGen TOPMed
rs142523235 CA6027054	152	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	154	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6027052 rs754138332	155	L>I		No	ClinGen ExAC TOPMed gnomAD
CA6027050 rs761163934	159	A>P		No	ClinGen ExAC gnomAD
CA380617711 rs1430445362	159	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6027048 rs376767392	160	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA380617699 rs1275550027	162	N>H		No	ClinGen TOPMed gnomAD
CA380617694 rs1197146216	162	N>S		No	ClinGen gnomAD
CA380617682 rs1565098277	164	V>A		No	ClinGen Ensembl
rs777347417 CA6027044	167	F>L		No	ClinGen ExAC TOPMed gnomAD
CA6027046 rs772710890	167	F>S		No	ClinGen ExAC gnomAD
CA6027042 rs768406482	169	F>S		No	ClinGen ExAC gnomAD
CA380617644 rs1565098258	170	R>Q		No	ClinGen Ensembl
CA380617645 rs1298591078	170	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1452144922 CA380617637	171	D>G		No	ClinGen TOPMed
rs1439471564 CA380617641	171	D>Y		No	ClinGen gnomAD
rs1395134306 CA380617632	172	T>A		No	ClinGen gnomAD
CA380617628 rs1327769075	172	T>I		No	ClinGen gnomAD
CA222808255 rs769718905	174	S>A		No	ClinGen Ensembl
CA380617618 rs1310206144	174	S>W		No	ClinGen TOPMed
CA6027041 rs746868690	175	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1463700031 CA380617605	177	D>H		No	ClinGen TOPMed gnomAD
rs1376083041 CA380617596	178	G>R		No	ClinGen gnomAD
CA380617592 rs560069216	179	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA222808254 rs560069216	179	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs560069216 CA6027040	179	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758293056 CA6027039	181	M>V		No	ClinGen ExAC TOPMed gnomAD
CA6027038 rs745827224	182	C>R		No	ClinGen ExAC TOPMed gnomAD
rs540395712 CA6027037	182	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA599793430 rs1438630116	183	Y>*		No	ClinGen gnomAD
rs757463710 CA6027036	183	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs374186483 CA6027035	183	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6027034 rs764479126	184	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs886376440 CA222808253	185	N>K		No	ClinGen TOPMed
CA6027033 rs756534607	185	N>Y		No	ClinGen ExAC gnomAD
rs916305901 CA222808252	186	V>A		No	ClinGen gnomAD
CA6027032 rs753053259	187	L>P		No	ClinGen ExAC gnomAD
rs1334999027 CA380617522	188	L>P		No	ClinGen gnomAD
CA380617510 rs1407964527	189	L>P		No	ClinGen TOPMed
CA380617489 rs760047266 CA6027030	190	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1411406615 CA380617493	190	N>S		No	ClinGen gnomAD
rs774740653 CA6027029	191	P>L		No	ClinGen ExAC TOPMed gnomAD
rs774740653 CA380617473	191	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1173182171 CA380617479	191	P>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs761350678 CA6027027	192	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1439650279 CA380617443	193	P>H		No	ClinGen gnomAD
CA380617424 rs1233928252	194	D>E		No	ClinGen gnomAD
CA380617414 rs1184436768	195	R>C		No	ClinGen gnomAD
rs1440994969 CA380617411	195	R>H		No	ClinGen gnomAD
CA380617402 rs1253714262	196	D>N		No	ClinGen gnomAD
CA6027026 rs371086118	198	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs768351350 CA6027025	199	C>G		No	ClinGen ExAC
rs1281813783 CA380617351	199	C>Y		No	ClinGen gnomAD
CA380617337 rs746672454	200	N>D		No	ClinGen ExAC TOPMed gnomAD
rs746672454 CA6027024	200	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1444204137 CA380617307	201	S>L		No	ClinGen TOPMed
rs775318917 CA6027023	202	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA380617292 rs1444122926	203	Q>*		No	ClinGen gnomAD
CA6027020 rs2467642 VAR_063131	204	V>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs2467642 CA380617271	204	V>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6027021 rs745798810	204	V>L		No	ClinGen ExAC gnomAD
rs1296459878 CA380617269	205	A>T		No	ClinGen TOPMed gnomAD
rs749437828 CA6027018	205	A>V		No	ClinGen ExAC gnomAD
rs1222315528 CA380617256	207	A>G		No	ClinGen TOPMed
CA6027012 rs755345035	208	V>I		No	ClinGen ExAC gnomAD
rs1308877342 CA380617248	209	S>R		No	ClinGen TOPMed
rs1213827593 CA380617232	211	F>I		No	ClinGen gnomAD
CA380617217 rs1267311587	213	L>R		No	ClinGen TOPMed
CA380617197 rs1225386546	216	L>P		No	ClinGen gnomAD
CA380617184 rs1421994075	218	P>L		No	ClinGen TOPMed
CA6027010 rs766860087	219	L>P		No	ClinGen ExAC gnomAD
rs761295583 CA6027009	221	I>T		No	ClinGen ExAC gnomAD
CA380617160 rs1430177739	223	A>T		No	ClinGen gnomAD
rs753283471 CA6027008	225	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1166139910 CA380617129	227	A>G		No	ClinGen TOPMed gnomAD
TCGA novel	227	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA380617125 rs1419586482	228	A>S		No	ClinGen gnomAD
CA380617120 rs763629755	229	V>L		No	ClinGen ExAC TOPMed gnomAD
CA6027007 rs763629755	229	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1565098107 CA380617116	230	S>R		No	ClinGen Ensembl
CA6027006 rs760275552	232	R>L		No	ClinGen ExAC gnomAD
rs1217253964 CA380617090	234	Q>*		No	ClinGen gnomAD
rs1449827211 CA380617088	234	Q>R		No	ClinGen gnomAD
CA222808243 rs945630948	235	H>N		No	ClinGen TOPMed gnomAD
CA6027005 rs775057256	236	R>C		No	ClinGen ExAC TOPMed gnomAD
rs771871405 CA6027004	236	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1276617126 CA380617072	237	G>R		No	ClinGen gnomAD
rs1276617126 CA380617073	237	G>S		No	ClinGen gnomAD
CA380617062 rs1362808311	238	R>H		No	ClinGen gnomAD
CA380617067 rs1214175493	238	R>S		No	ClinGen gnomAD
CA380617059 rs774333725	239	R>P		No	ClinGen ExAC TOPMed gnomAD
COSM1208718 CA6027002 rs774333725	239	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA222808242 rs914134006	240	R>Q		No	ClinGen TOPMed gnomAD
rs1434343794 CA380617056	240	R>W		No	ClinGen gnomAD
CA6027001 rs770935570	242	G>V		No	ClinGen ExAC TOPMed gnomAD
CA6027000 rs749242968	243	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA380617041 rs749242968	243	R>G		No	ClinGen ExAC gnomAD
CA380617040 rs1290306509	243	R>H		No	ClinGen TOPMed
CA6026999 rs770014924	246	R>C		No	ClinGen ExAC gnomAD
CA6026998 rs770014924	246	R>G		No	ClinGen ExAC gnomAD
CA380617015 rs1409036697	247	L>R		No	ClinGen TOPMed gnomAD
CA380617012 rs1470677791	248	V>L		No	ClinGen TOPMed gnomAD
CA380616994 rs1590578493	251	V>A		No	ClinGen Ensembl
CA6026996 rs781308596	251	V>I		No	ClinGen ExAC gnomAD
rs755364144 CA6026995	254	A>D		No	ClinGen ExAC gnomAD
CA222808230 rs979811922	255	F>L		No	ClinGen TOPMed gnomAD
rs1255896071 CA380616695	256	A>T		No	ClinGen gnomAD
rs970239250 CA222808228	256	A>V		No	ClinGen TOPMed gnomAD
rs1275297676 CA380616675	257	L>P		No	ClinGen gnomAD
CA380616681 rs1308332947	257	L>V		No	ClinGen gnomAD
rs1283427410 CA380616672	258	C>S		No	ClinGen TOPMed gnomAD
CA380616646 rs1217558920	259	W>*		No	ClinGen gnomAD
rs1224137156 CA380616649	259	W>S		No	ClinGen gnomAD
TCGA novel	262	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758867069 CA6026992	264	V>L		No	ClinGen ExAC TOPMed gnomAD
CA380616583 rs758867069	264	V>M		No	ClinGen ExAC TOPMed gnomAD
rs985005190 CA380616522	268	L>P		No	ClinGen TOPMed
rs985005190 CA222808221	268	L>R		No	ClinGen TOPMed
rs1443303307 CA380616487	271	R>G		No	ClinGen gnomAD
CA380616481 rs575311239	271	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA380616483 rs575311239	271	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs575311239 CA6026990	271	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1565098020 CA380616474	272	A>E		No	ClinGen Ensembl
CA380616476 rs1590578403	272	A>S		No	ClinGen Ensembl
rs1393922316 CA380616452	274	A>T		No	ClinGen gnomAD
CA6026988 rs760146329	275	N>K		No	ClinGen ExAC gnomAD
rs763575164 CA380616432	275	N>S		No	ClinGen ExAC gnomAD
CA6026989 rs763575164	275	N>T		No	ClinGen ExAC gnomAD
CA380616415 rs1248276867	276	P>L		No	ClinGen gnomAD
rs1234869101 CA380616405	277	G>E		No	ClinGen gnomAD
CA380616412 rs1480802580	277	G>R		No	ClinGen TOPMed gnomAD
CA6026986 rs767136063	279	R>Q		No	ClinGen ExAC gnomAD
rs1281097090 CA380616374	280	P>L		No	ClinGen gnomAD
RCV000923710 CA380616366 rs1236541796	281	L>F		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs773952294 CA6026984	283	W>*		No	ClinGen ExAC gnomAD
CA380616338 rs1352162656	283	W>*		No	ClinGen TOPMed gnomAD
rs1446644693 CA380616326	284	R>C		No	ClinGen TOPMed
CA222808209 rs966032658	284	R>H		No	ClinGen TOPMed gnomAD
rs1382548962 CA380616318	285	G>R		No	ClinGen TOPMed gnomAD
rs770880210 CA6026983	286	L>M		No	ClinGen ExAC
rs1444878399 CA380616292	287	P>L		No	ClinGen Ensembl
rs762934437 CA6026981	288	F>L		No	ClinGen ExAC TOPMed
CA380616274 rs1299567960	289	V>I		No	ClinGen TOPMed gnomAD
rs1299567960 CA380616272	289	V>L		No	ClinGen TOPMed gnomAD
rs1312990492 CA380616221	293	A>T		No	ClinGen TOPMed gnomAD
rs1435967594 COSM397949 CA380616209	294	F>L	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA380616203 rs1362006501	294	F>S		No	ClinGen TOPMed gnomAD
rs769961680 CA380616155	297	S>N		No	ClinGen ExAC TOPMed gnomAD
CA6026979 rs769961680	297	S>T		No	ClinGen ExAC TOPMed gnomAD
rs748240414 CA6026978	298	V>A		No	ClinGen ExAC TOPMed gnomAD
CA222808199 rs1017653624	298	V>M		No	ClinGen TOPMed
CA222808196 rs867031959	299	A>T		No	ClinGen TOPMed gnomAD
CA6026977 rs776896074	299	A>V		No	ClinGen ExAC gnomAD
CA380616107 rs1258413807	301	P>A		No	ClinGen TOPMed gnomAD
CA380616105 rs1258413807	301	P>S		No	ClinGen TOPMed gnomAD
CA380616109 rs1258413807	301	P>T		No	ClinGen TOPMed gnomAD
rs1216395493 CA380616088	302	V>A		No	ClinGen TOPMed gnomAD
rs1216395493 CA380616086	302	V>G		No	ClinGen TOPMed gnomAD
rs1260724622 CA380616071	304	Y>H		No	ClinGen TOPMed gnomAD
CA222808191 rs768698494	305	V>L		No	ClinGen ExAC TOPMed gnomAD
CA6026976 rs768698494	305	V>M		No	ClinGen ExAC TOPMed gnomAD
rs747256636 CA6026975	306	L>V		No	ClinGen ExAC TOPMed gnomAD
CA6026974 rs41459145	308	C>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1293465766 CA380615988	310	D>E		No	ClinGen TOPMed gnomAD
CA222808183 rs12807053	310	D>G		No	ClinGen Ensembl
rs1157529005 CA380616000	310	D>N		No	ClinGen TOPMed
rs12807051 CA222808181	311	M>L		No	ClinGen gnomAD
CA380615984 rs12807051	311	M>V		No	ClinGen gnomAD
TCGA novel	312	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6026972 rs371953294	313	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA222808176 rs779466222	314	K>N		No	ClinGen ExAC gnomAD
CA222808174 rs892644625	315	L>P		No	ClinGen TOPMed gnomAD
rs755638586 CA380615916	316	R>P		No	ClinGen ExAC gnomAD
rs755638586 CA6026970	316	R>Q		No	ClinGen ExAC gnomAD
CA380615920 rs1302867940	316	R>W		No	ClinGen TOPMed gnomAD
CA6026969 rs368130260	317	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6026968 rs767058222	317	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1334551229 CA380615900	318	S>T		No	ClinGen TOPMed
TCGA novel	320	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1325774893 CA380615858	321	T>M		No	ClinGen TOPMed
CA380615855 rs1190331332	322	V>M		No	ClinGen gnomAD
CA222808168 rs939638183	324	E>G		No	ClinGen TOPMed
TCGA novel	324	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6026966 rs751278829	325	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1181398425 CA380615793	326	V>G		No	ClinGen TOPMed
rs1044475989 CA222808162	326	V>M		No	ClinGen TOPMed gnomAD
rs762879192 CA6026964	327	L>M		No	ClinGen ExAC TOPMed gnomAD
CA380615786 rs1481134746	327	L>P		No	ClinGen TOPMed
rs1401107499 CA380615775	328	V>A		No	ClinGen gnomAD
rs1428238084 CA380615754	329	D>E		No	ClinGen TOPMed
CA380615750 rs1335893919	330	D>H		No	ClinGen TOPMed gnomAD
rs1335893919 CA380615748	330	D>Y		No	ClinGen TOPMed gnomAD
rs773277258 CA380615718	332	E>*		No	ClinGen ExAC gnomAD
rs773277258 CA6026963	332	E>Q		No	ClinGen ExAC gnomAD
rs1169243737 CA380615706	333	L>M		No	ClinGen TOPMed
rs1246490105 CA380615702	333	L>P		No	ClinGen TOPMed gnomAD
rs1246490105 CA380615701	333	L>Q		No	ClinGen TOPMed gnomAD
rs983635490 CA380615690	334	G>A		No	ClinGen TOPMed gnomAD
rs983635490 CA222808156	334	G>D		No	ClinGen TOPMed gnomAD
rs1294257752 CA380615654	337	G>E		No	ClinGen TOPMed gnomAD
CA222808152 rs984564590	337	G>R		No	ClinGen TOPMed
rs765142335 CA6026962	339	S>C		No	ClinGen ExAC TOPMed gnomAD
CA380615634 rs1249791017	339	S>R		No	ClinGen TOPMed
rs1030605096 CA222808148	340	R>C		No	ClinGen Ensembl
CA6026961 rs761821276	340	R>H		No	ClinGen ExAC TOPMed gnomAD
rs776503511 CA6026960	341	R>C		No	ClinGen ExAC TOPMed gnomAD
rs776503511 CA222808145	341	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	342	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6026959 rs374184117	342	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA380615624 rs1394906734	342	R>S		No	ClinGen TOPMed gnomAD
CA6026958 rs747181485	343	R>C		No	ClinGen ExAC gnomAD
rs747181485 CA380615618	343	R>S		No	ClinGen ExAC gnomAD
rs571515921 CA6026954	346	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA380615568 rs1193552946	349	R>G		No	ClinGen TOPMed gnomAD
CA222808144 rs1011668064	352	S>P		No	ClinGen TOPMed
CA380615520 rs1194385684	353	P>T		No	ClinGen gnomAD
CA222808142 rs1017599685	354	L>S		No	ClinGen TOPMed
CA222808140 rs1007949943	355	A>G		No	ClinGen TOPMed
rs753507290 CA222808141	355	A>P		No	ClinGen TOPMed gnomAD
CA380615483 rs1227594925	356	L>F		No	ClinGen gnomAD
rs1383938130 CA380615433	360	P>A		No	ClinGen TOPMed
rs1293712891 CA380615413	361	E>G		No	ClinGen TOPMed
CA380615382 rs1440054560	363	P>R		No	ClinGen TOPMed gnomAD
CA380615364 rs1590577870	365	G>S		No	ClinGen Ensembl
rs780518762 CA6026949	368	R>C		No	ClinGen ExAC gnomAD
rs1396056866 CA380615322	368	R>L		No	ClinGen gnomAD
CA222808135 rs1009657951	371	G>D		No	ClinGen TOPMed
CA6026948 rs754566001	371	G>R		No	ClinGen ExAC TOPMed gnomAD
rs751223841 CA6026947	373	L>P		No	ClinGen ExAC TOPMed gnomAD
rs751223841 CA380615265	373	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA222808131 rs1003730997	384	G>D		No	ClinGen TOPMed
CA380615124 rs1590577787	387	N>I		No	ClinGen Ensembl
CA380615123 rs1164709984	387	N>K		No	ClinGen TOPMed
CA380615121 rs1046341416	388	R>G		No	ClinGen gnomAD
CA222808128 rs1046341416	388	R>W		No	ClinGen gnomAD
CA222808125 rs199514968	392	S>R		No	ClinGen gnomAD
CA380615088 rs1287180867	393	T>I		No	ClinGen TOPMed
rs1249466813 CA380615082	394	S>*		No	ClinGen gnomAD
CA222808123 rs949045758	395	S>T		No	ClinGen TOPMed gnomAD

No associated diseases with Q9Y5Y4

2 regional properties for Q9Y5Y4

Type	Name	Position	InterPro Accession
domain	Activity-regulated cytoskeleton-associated protein, C-terminal domain	274 - 356	IPR040814
domain	Activity-regulated cytoskeleton-associated protein, N-terminal domain	45 - 151	IPR045557

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein	Internalized receptors colocalized with RAB11A
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name	Definition
G protein-coupled receptor activity	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
neuropeptide binding	Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).
peptide binding	Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
prostaglandin D receptor activity	Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.
prostaglandin F receptor activity	Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.
prostaglandin J receptor activity	Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.

8 GO annotations of biological process

Name	Definition
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
calcium-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
chemotaxis	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
immune response	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
negative regulation of male germ cell proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation.
neuropeptide signaling pathway	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
positive regulation of G protein-coupled receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P46091	CMKLR2	Chemerin-like receptor 2	Homo sapiens (Human)	PR
P32745	SSTR3	Somatostatin receptor type 3	Homo sapiens (Human)	PR
Q9Z2J6	Ptgdr2	Prostaglandin D2 receptor 2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSANATLKPL	CPILEQMSRL	QSHSNTSIRY	IDHAAVLLHG	LASLLGLVEN	GVILFVVGCR
70	80	90	100	110	120
MRQTVVTTWV	LHLALSDLLA	SASLPFFTYF	LAVGHSWELG	TTFCKLHSSI	FFLNMFASGF
130	140	150	160	170	180
LLSAISLDRC	LQVVRPVWAQ	NHRTVAAAHK	VCLVLWALAV	LNTVPYFVFR	DTISRLDGRI
190	200	210	220	230	240
MCYYNVLLLN	PGPDRDATCN	SRQVALAVSK	FLLAFLVPLA	IIASSHAAVS	LRLQHRGRRR
250	260	270	280	290	300
PGRFVRLVAA	VVAAFALCWG	PYHVFSLLEA	RAHANPGLRP	LVWRGLPFVT	SLAFFNSVAN
310	320	330	340	350	360
PVLYVLTCPD	MLRKLRRSLR	TVLESVLVDD	SELGGAGSSR	RRRTSSTARS	ASPLALCSRP
370	380	390
EEPRGPARLL	GWLLGSCAAS	PQTGPLNRAL	SSTSS