P46091
PR
Gene name |
CMKLR2 |
Protein name |
Chemerin-like receptor 2 |
Names |
Chemerin chemokine-like receptor 2, Chemokine-like receptor 2, G-protein coupled receptor 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:2825 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P46091
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P46091-F1 | Predicted | AlphaFoldDB |
286 variants for P46091
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA2071551 rs773595228 |
2 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs772384045 CA350149776 |
6 | E>A | No |
ExAC gnomAD ClinGen |
|
|
rs148641154 CA2071549 |
6 | E>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772384045 CA2071550 |
6 | E>V | No |
ExAC gnomAD ClinGen |
|
|
rs149464246 CA2071548 |
7 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs749401195 CA2071546 |
9 | F>Y | No |
ExAC gnomAD ClinGen |
|
|
rs374619664 CA2071545 |
11 | E>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs3755227 CA2071544 |
13 | E>D | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs1432816269 CA350149728 |
13 | E>G | No |
gnomAD ClinGen |
|
|
CA64427779 rs755322647 |
15 | Y>C | No |
ClinGen gnomAD |
|
|
rs751443641 CA2071540 |
17 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs781030355 CA2071541 |
17 | Y>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ExAC TOPMed gnomAD ClinGen NCI-TCGA |
|
rs764046928 CA350149675 |
20 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350149678 rs1187401676 |
20 | D>G | No |
ClinGen gnomAD |
|
|
rs1576030719 CA350149646 |
25 | E>Q | No |
Ensembl ClinGen |
|
|
rs375035771 CA64427773 |
26 | S>A | No |
Ensembl ClinGen |
|
|
CA2071535 rs752177604 |
30 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs1468991627 CA350149587 |
33 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs764766251 CA2071534 |
37 | V>L | No |
ClinGen ExAC TOPMed |
|
|
CA2071533 rs759221878 |
38 | H>R | No |
ClinGen ExAC gnomAD |
|
|
rs1321277765 CA350149538 |
40 | V>A | No |
gnomAD ClinGen |
|
|
CA350149543 rs1474069293 |
40 | V>I | No |
TOPMed ClinGen |
|
|
CA350149526 rs1359575548 |
43 | V>M | No |
gnomAD ClinGen |
|
|
rs1441496491 CA350149504 |
46 | C>R | No |
gnomAD ClinGen |
|
|
CA2071529 rs774874796 |
46 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749853120 CA2071527 |
50 | V>A | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA350149476 rs149251931 |
50 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs149251931 CA2071528 |
50 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1212324573 CA350149455 |
53 | I>M | No |
TOPMed gnomAD ClinGen |
|
|
CA64427763 rs1031558191 |
55 | G>E | No |
ClinGen gnomAD |
|
|
rs1000237242 CA350149434 |
57 | A>S | No |
TOPMed gnomAD ClinGen |
|
|
rs1000237242 CA64427761 |
57 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs904518205 CA64427759 |
57 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs770060810 CA350149426 |
58 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs141873416 CA2071526 |
58 | I>N | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs781277858 COSM1326499 CA2071524 |
59 | V>I | Variant assessed as Somatic; 9.24e-05 impact. ovary [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs781277858 CA2071523 |
59 | V>L | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA350149416 rs1216593796 |
60 | I>M | No |
TOPMed ClinGen |
|
|
rs1576030500 CA350149418 |
60 | I>S | No |
Ensembl ClinGen |
|
|
rs757034566 CA2071522 |
60 | I>V | No |
ExAC gnomAD ClinGen |
|
|
rs746797584 CA2071521 |
61 | W>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 62 | F>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs368825572 CA2071520 |
63 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1060384 CA2071518 |
65 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2071517 rs201695021 |
65 | F>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1206851602 CA350149377 |
66 | K>M | No |
ClinGen gnomAD |
|
|
rs1233716962 CA350149382 |
66 | K>Q | No |
ClinGen gnomAD |
|
|
rs1273589576 CA350149372 |
67 | W>* | No |
ClinGen gnomAD |
|
|
rs754458819 CA2071516 |
67 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA350149365 rs1443713571 |
68 | K>E | No |
TOPMed ClinGen |
|
|
CA2071515 rs143724527 |
68 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350149350 rs1349876354 |
70 | T>A | No |
ClinGen gnomAD |
|
|
rs1349876354 CA350149349 |
70 | T>S | No |
ClinGen gnomAD |
|
|
rs1373055371 CA350149335 |
72 | T>S | No |
TOPMed ClinGen |
|
|
rs1439512899 CA350149325 |
74 | L>Q | No |
gnomAD ClinGen |
|
|
rs774826672 CA2071512 |
75 | W>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 77 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA350149296 rs1435725486 |
78 | N>S | No |
ClinGen gnomAD |
|
|
CA2071510 rs138835154 |
80 | A>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1559081655 CA350149287 |
80 | A>T | No |
ClinGen Ensembl |
|
|
rs763544932 CA2071509 |
81 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA64427744 rs973621193 |
81 | I>V | No |
ClinGen Ensembl |
|
|
rs140409125 CA2071508 |
82 | A>E | No |
ESP ExAC gnomAD ClinGen |
|
|
rs140409125 CA2071507 COSM1015313 |
82 | A>V | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ESP ExAC gnomAD ClinGen cosmic curated NCI-TCGA |
|
rs1179192321 CA350149271 |
83 | D>N | No |
ClinGen gnomAD |
|
|
rs1482163820 CA350149263 |
84 | F>V | No |
ClinGen gnomAD |
|
|
rs771032609 CA2071504 |
85 | I>L | No |
ExAC gnomAD ClinGen |
|
|
rs771032609 CA2071505 |
85 | I>V | No |
ExAC gnomAD ClinGen |
|
|
rs941064280 CA64427737 |
88 | L>V | No |
gnomAD ClinGen |
|
|
rs747291714 CA2071502 |
89 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA350149219 rs1232393144 |
91 | P>S | No |
gnomAD ClinGen |
|
|
CA2071501 rs777539632 |
93 | Y>S | No |
ExAC gnomAD ClinGen |
|
|
CA2071500 rs758246603 |
94 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA2071498 rs778824583 |
96 | Y>C | No |
ExAC gnomAD ClinGen |
|
|
CA2071497 rs754464282 |
98 | A>T | No |
ExAC gnomAD ClinGen |
|
|
rs1469493921 CA350149167 |
99 | M>I | No |
ClinGen TOPMed |
|
|
rs753268123 CA2071496 |
100 | N>H | No |
ClinGen ExAC gnomAD |
|
|
CA2071495 rs779655651 |
103 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs868820125 CA64427729 |
104 | P>S | No |
ClinGen Ensembl |
|
|
rs1335038546 CA350149124 |
105 | F>S | No |
TOPMed ClinGen |
|
| TCGA novel | 106 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA64427726 rs979898365 |
107 | I>V | No |
ClinGen Ensembl |
|
|
rs755718806 CA2071494 |
112 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1471646461 CA350149070 |
113 | N>S | No |
gnomAD ClinGen |
|
| TCGA novel | 114 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA64427723 rs372858527 |
115 | F>L | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA2071493 rs750162244 |
119 | L>S | No |
ExAC gnomAD ClinGen |
|
|
CA2071491 rs763418055 |
120 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs765681623 CA2071489 |
121 | M>T | No |
ExAC gnomAD ClinGen |
|
|
rs753218684 CA2071490 |
121 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs529464072 CA64427714 |
122 | F>C | No |
ClinGen Ensembl |
|
|
CA2071488 rs138365581 |
124 | S>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2071487 rs776538578 |
126 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs1327844140 CA350148986 |
126 | F>I | No |
ClinGen gnomAD |
|
|
CA2071485 rs760872653 |
127 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA2071484 rs771786296 |
127 | F>S | No |
ExAC gnomAD ClinGen |
|
| rs759796967 | 127 | F>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2071483 rs771786296 |
127 | F>Y | No |
ClinGen ExAC gnomAD |
|
|
CA64427707 rs201014131 |
128 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2071480 rs201014131 |
128 | L>R | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs1291127448 CA350148964 |
130 | V>M | No |
gnomAD ClinGen |
|
|
rs539447013 CA2071478 |
131 | I>M | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
CA2071479 rs778730470 |
131 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA350148958 rs1346483722 |
131 | I>V | No |
ClinGen TOPMed |
|
|
CA2071477 rs749315120 |
132 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 135 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs774765099 CA64427701 |
136 | Y>C | No |
Ensembl ClinGen |
|
| TCGA novel | 137 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA350148918 rs1186663240 |
137 | I>L | No |
ClinGen gnomAD |
|
|
CA2071476 rs779420589 |
137 | I>N | No |
ExAC gnomAD ClinGen |
|
|
CA2071474 rs750031706 |
138 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2071473 rs140764131 |
139 | L>S | No |
ESP ExAC TOPMed ClinGen |
|
|
CA2071472 rs758783890 |
140 | I>T | No |
ExAC gnomAD ClinGen |
|
|
CA350148892 rs1467692061 |
141 | H>Y | No |
gnomAD ClinGen |
|
|
CA64427696 rs769016501 |
142 | P>H | No |
gnomAD ClinGen |
|
|
CA350148865 rs993078046 |
145 | S>C | No |
ClinGen TOPMed |
|
|
rs993078046 CA64427691 |
145 | S>F | No |
TOPMed ClinGen |
|
|
rs150952559 CA2071471 |
145 | S>P | No |
ESP ExAC TOPMed ClinGen |
|
|
rs759952214 CA2071469 |
146 | H>Q | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs765670533 CA2071470 COSM1208567 |
146 | H>R | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA350148864 rs1466582146 |
146 | H>Y | No |
ClinGen TOPMed |
|
|
rs766309138 CA2071467 |
147 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763256948 CA2071468 |
147 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2071466 rs760747839 |
148 | H>Y | No |
ExAC gnomAD ClinGen |
|
|
COSM1326501 CA2071465 rs150274953 |
149 | R>* | ovary [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs150274953 CA350148848 |
149 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA64427684 rs1000101925 |
149 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA2071464 rs558470352 |
151 | L>F | No |
1000Genomes ExAC gnomAD ClinGen |
|
|
rs762062191 CA2071463 |
152 | K>R | No |
ExAC gnomAD ClinGen |
|
|
rs372527355 CA350148826 |
153 | N>D | No |
ClinGen ESP ExAC TOPMed |
|
|
CA2071460 rs775713404 |
153 | N>I | No |
ExAC gnomAD ClinGen |
|
|
rs775713404 CA2071461 |
153 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs372527355 CA2071462 |
153 | N>Y | No |
ESP ExAC TOPMed ClinGen |
|
|
CA2071458 rs144883816 |
156 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs147291301 CA2071456 |
157 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350148802 rs147291301 |
157 | V>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA350148799 rs1449364415 |
158 | I>L | No |
ClinGen gnomAD |
|
|
rs535009332 CA64427673 |
158 | I>T | No |
ClinGen 1000Genomes gnomAD |
|
|
CA350148798 rs1449364415 |
158 | I>V | No |
gnomAD ClinGen |
|
|
CA2071455 rs780894474 |
159 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs756935085 CA2071454 |
160 | F>I | No |
ExAC gnomAD ClinGen |
|
|
rs756935085 CA350148788 COSM209719 |
160 | F>L | large_intestine [Cosmic] | No |
ExAC gnomAD ClinGen cosmic curated |
|
CA2071453 rs746722419 |
162 | W>* | No |
ExAC gnomAD ClinGen |
|
|
rs779131200 CA2071452 |
162 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 163 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA350148750 rs1342159018 |
165 | A>G | No |
ClinGen gnomAD |
|
|
rs1304791236 CA350148741 COSM1306345 |
167 | L>V | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
gnomAD ClinGen cosmic curated NCI-TCGA |
| TCGA novel | 168 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2071449 rs755382525 |
168 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs147720275 CA2071447 |
170 | G>S | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA2071446 rs138788057 |
171 | P>H | No |
ESP ExAC gnomAD ClinGen |
|
|
rs1433999001 CA350148713 |
172 | A>S | No |
TOPMed ClinGen |
|
|
CA350148710 rs1392133952 |
172 | A>V | Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA2071445 rs750471925 |
173 | L>P | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs1307594094 CA350148698 |
174 | Y>* | No |
TOPMed gnomAD ClinGen |
|
|
rs569840690 COSM3425978 CA2071443 |
176 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA2071444 rs202007589 |
176 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs762841542 CA2071440 |
179 | V>M | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA64427659 rs200101630 |
182 | N>H | No |
ClinGen TOPMed |
|
|
CA2071438 rs769828775 |
185 | T>I | No |
ExAC ClinGen |
|
|
rs1171427181 CA350148614 |
187 | C>R | No |
ClinGen gnomAD |
|
|
rs745836396 CA2071437 |
188 | Y>C | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs770620691 CA2071435 |
189 | N>S | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA2071434 rs746582947 |
190 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA350148562 rs1281722003 |
194 | H>D | No |
gnomAD ClinGen |
|
|
rs1241746877 CA350148558 |
194 | H>R | No |
ClinGen TOPMed |
|
|
CA350148551 rs1363916494 |
195 | D>A | No |
gnomAD ClinGen |
|
|
rs755257238 CA2071432 |
197 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs755257238 CA2071433 |
197 | D>G | No |
ExAC gnomAD ClinGen |
|
|
CA64427651 rs113939423 |
198 | L>P | No |
Ensembl ClinGen |
|
|
rs1359358234 CA350148517 |
200 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
TOPMed ClinGen NCI-TCGA |
|
CA2071430 rs780322833 |
201 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA2071428 rs145032684 |
203 | H>D | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs145032684 CA2071427 |
203 | H>N | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA2071429 rs145032684 |
203 | H>Y | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs1409038492 CA350148450 |
208 | W>* | No |
ClinGen gnomAD |
|
|
rs763136844 CA2071423 |
212 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA2071422 rs775320834 |
213 | I>F | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA2071420 rs759530133 |
215 | Y>C | No |
ExAC gnomAD ClinGen |
|
|
rs776720871 CA2071419 |
217 | F>L | No |
ExAC TOPMed gnomAD ClinGen |
|
|
CA2071417 rs760263677 |
218 | P>S | No |
ExAC gnomAD ClinGen |
|
|
rs772691120 CA2071416 |
221 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA350148272 rs1576029146 |
222 | M>V | No |
ClinGen Ensembl |
|
|
rs1472488659 CA350148252 |
223 | S>C | No |
gnomAD ClinGen |
|
|
CA350148247 rs1380759764 |
223 | S>N | No |
TOPMed ClinGen |
|
|
rs1212879940 CA350148193 |
227 | L>S | No |
gnomAD ClinGen |
|
|
rs1441120973 CA350148181 |
228 | C>Y | No |
gnomAD ClinGen |
|
|
rs141742272 CA350148160 |
230 | I>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs141742272 CA2071415 |
230 | I>T | No |
1000Genomes ExAC TOPMed gnomAD ClinGen |
|
|
COSM3407500 rs34685097 CA2071413 |
236 | R>* | central_nervous_system [Cosmic] | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen cosmic curated |
|
rs34685097 CA2071414 |
236 | R>G | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
CA2071412 rs144224629 |
236 | R>Q | No |
ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs957036197 CA64427636 |
237 | S>N | No |
TOPMed ClinGen |
|
|
CA2071411 rs746310435 |
238 | I>T | No |
ExAC gnomAD ClinGen |
|
|
rs151283587 CA2071408 |
240 | I>T | No |
1000Genomes ExAC gnomAD ClinGen |
|
|
rs1339865297 COSM1015312 CA350147981 |
243 | R>G | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs369746651 CA64427631 |
243 | R>K | No |
ESP TOPMed gnomAD ClinGen |
|
|
rs542082936 CA2071407 |
244 | H>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA64427628 rs979278947 |
246 | W>R | No |
ClinGen TOPMed gnomAD |
|
|
CA2071406 rs758637443 |
247 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1210503671 CA350147897 |
248 | I>M | No |
gnomAD ClinGen |
|
|
CA350147901 rs1385761839 |
248 | I>T | No |
gnomAD ClinGen |
|
|
rs765063604 CA2071404 |
250 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1322676990 CA2071402 |
251 | V>L | No |
ClinGen TOPMed |
|
|
CA350147853 rs1184026287 |
253 | V>M | No |
ClinGen gnomAD |
|
|
rs1227187364 CA350147830 |
254 | A>S | No |
TOPMed ClinGen |
|
|
CA64427622 rs200520559 |
256 | V>A | No |
1000Genomes gnomAD ClinGen |
|
|
CA350147812 rs1256355804 |
256 | V>M | No |
ClinGen TOPMed |
|
|
rs924422899 CA64427620 |
259 | W>G | No |
Ensembl ClinGen |
|
|
rs753785690 CA2071400 |
260 | T>I | No |
ExAC gnomAD ClinGen |
|
|
rs760577634 CA2071398 |
261 | P>S | No |
ExAC gnomAD ClinGen |
|
|
CA350147729 rs1335817851 |
263 | H>Q | No |
TOPMed gnomAD ClinGen |
|
|
CA64427615 rs771185033 |
263 | H>R | No |
Ensembl ClinGen |
|
|
rs1482354373 CA350147705 |
266 | S>G | No |
ClinGen TOPMed |
|
|
CA2071395 rs761473728 |
266 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs865775052 CA64427610 |
267 | I>N | No |
ClinGen Ensembl |
|
|
rs773998045 CA2071394 |
267 | I>V | No |
ExAC gnomAD ClinGen |
|
|
CA2071393 rs187311851 |
268 | W>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA350147652 rs1576028822 |
269 | E>Q | No |
Ensembl ClinGen |
|
|
CA350147650 rs1576028812 |
269 | E>V | No |
ClinGen Ensembl |
|
|
rs1437133238 CA350147636 |
270 | L>P | No |
ClinGen gnomAD |
|
|
CA350147627 rs1362421203 |
271 | T>I | No |
ClinGen gnomAD |
|
|
CA350147622 rs1576028778 |
272 | I>V | No |
ClinGen Ensembl |
|
|
rs746257146 CA2071392 |
274 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA350147564 rs1415934127 |
276 | S>N | No |
TOPMed ClinGen |
|
| TCGA novel | 277 | Y>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs747533227 COSM1015311 CA2071389 |
282 | M>I | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA |
|
CA2071388 rs777891254 |
285 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA350147453 rs777891254 |
285 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA350147427 rs1403989213 |
287 | P>H | No |
gnomAD ClinGen |
|
|
rs776449349 RCV000880999 |
288 | L>missing | No |
ClinVar dbSNP |
|
|
rs752897727 CA2071386 |
288 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA64427601 rs201030518 |
292 | L>W | No |
ClinGen 1000Genomes gnomAD |
|
|
rs142324185 CA2071383 |
293 | A>G | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen |
|
|
rs1017490140 CA64427599 |
293 | A>T | No |
ClinGen Ensembl |
|
|
CA2071382 rs374533476 |
294 | F>L | No |
ESP ExAC gnomAD ClinGen |
|
|
rs1320918560 CA350147334 |
295 | L>P | No |
ClinGen gnomAD |
|
|
CA2071381 rs766344244 |
296 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs750343149 CA2071379 |
299 | L>S | No |
ClinGen ExAC gnomAD |
|
|
rs750343149 CA350147280 |
299 | L>W | No |
ExAC gnomAD ClinGen |
|
|
rs766986682 CA2071378 |
300 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA64427592 rs371683882 |
301 | P>L | No |
ClinGen ESP TOPMed |
|
|
CA350147245 rs371683882 |
301 | P>R | No |
ESP TOPMed ClinGen |
|
|
rs1369055761 CA350147212 |
303 | L>P | No |
TOPMed gnomAD ClinGen |
|
|
rs1576028510 CA350147167 |
307 | I>T | No |
ClinGen Ensembl |
|
|
VAR_023839 CA2071376 rs3732083 |
307 | I>V | No |
1000Genomes ESP ExAC TOPMed gnomAD ClinGen UniProt dbSNP |
|
|
CA350147124 rs763717829 |
310 | K>R | No |
ExAC gnomAD ClinGen |
|
|
CA2071374 rs763717829 |
310 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs1432003400 CA350147102 |
312 | Q>E | No |
gnomAD ClinGen |
|
|
rs762637894 CA2071373 |
314 | R>C | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs776972032 CA2071372 |
314 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ExAC gnomAD ClinGen NCI-TCGA |
|
rs1006315490 CA64427583 |
315 | F>V | No |
gnomAD ClinGen |
|
|
rs1487749554 CA350147052 |
316 | R>L | No |
ClinGen TOPMed |
|
|
rs1487749554 CA2071368 |
316 | R>Q | No |
TOPMed ClinGen |
|
|
COSM1168925 CA2071370 rs142744381 |
316 | R>W | pancreas [Cosmic] | No |
ESP ExAC TOPMed gnomAD ClinGen cosmic curated |
|
CA2071367 rs773594709 |
319 | V>G | No |
ExAC gnomAD ClinGen |
|
|
CA64427578 rs13423662 |
320 | A>V | No |
ClinGen Ensembl |
|
|
rs772149134 CA2071366 |
323 | L>F | No |
ExAC gnomAD ClinGen |
|
|
rs1424059846 CA350146972 |
324 | K>N | No |
ClinGen TOPMed |
|
|
rs748259369 CA2071365 |
324 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA350146967 rs1273873581 |
325 | Y>C | No |
gnomAD ClinGen |
|
| TCGA novel | 325 | Y>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1412229689 CA350146955 |
327 | L>P | No |
TOPMed ClinGen |
|
|
rs368120852 CA64427573 |
330 | V>I | No |
ESP ClinGen |
|
|
CA350146927 rs1313463097 |
331 | S>N | No |
gnomAD ClinGen |
|
|
rs949694979 CA64427571 |
332 | C>F | No |
TOPMed gnomAD ClinGen |
|
|
rs749580664 COSM1669689 CA2071362 |
335 | T>R | ovary [Cosmic] | No |
ExAC TOPMed gnomAD ClinGen cosmic curated |
|
CA2071360 rs755868010 |
337 | S>N | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs755868010 CA350146889 |
337 | S>T | No |
ExAC TOPMed gnomAD ClinGen |
|
|
rs1412111402 CA350146883 |
338 | E>* | No |
TOPMed gnomAD ClinGen |
|
|
CA64427564 rs184432069 |
338 | E>G | No |
ClinGen 1000Genomes |
|
|
rs1412111402 CA350146885 |
338 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA2071359 rs572438977 |
339 | Q>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs757236817 CA2071357 |
340 | L>R | No |
ExAC gnomAD ClinGen |
|
|
CA350146862 rs1360975517 |
341 | R>K | No |
gnomAD ClinGen |
|
|
CA2071356 rs751042183 |
341 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs1365795644 CA350146851 |
343 | S>P | No |
ClinGen TOPMed |
|
|
CA2071354 rs141787369 |
349 | C>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2071353 rs762576602 |
349 | C>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 350 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 350 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA350146805 rs1559080292 |
350 | L>V | No |
ClinGen Ensembl |
|
|
CA2071349 rs760975303 |
352 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA2071350 rs760975303 |
352 | E>V | No |
ExAC gnomAD ClinGen |
|
|
CA2071348 rs773717933 |
354 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs934416716 CA64427551 |
355 | Q>R | No |
ClinGen Ensembl |
No associated diseases with P46091
1 regional properties for P46091
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 55 - 304 | IPR017452 |
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| adipokinetic hormone binding | Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. |
| adipokinetic hormone receptor activity | Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| neuropeptide binding | Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| neuropeptide signaling pathway | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
120 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| Q9Y5Y4 | PTGDR2 | Prostaglandin D2 receptor 2 | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDLEETLFE | EFENYSYDLD | YYSLESDLEE | KVQLGVVHWV | SLVLYCLAFV | LGIPGNAIVI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WFTGFKWKKT | VTTLWFLNLA | IADFIFLLFL | PLYISYVAMN | FHWPFGIWLC | KANSFTAQLN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MFASVFFLTV | ISLDHYIHLI | HPVLSHRHRT | LKNSLIVIIF | IWLLASLIGG | PALYFRDTVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FNNHTLCYNN | FQKHDPDLTL | IRHHVLTWVK | FIIGYLFPLL | TMSICYLCLI | FKVKKRSILI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSRHFWTILV | VVVAFVVCWT | PYHLFSIWEL | TIHHNSYSHH | VMQAGIPLST | GLAFLNSCLN |
| 310 | 320 | 330 | 340 | 350 | |
| PILYVLISKK | FQARFRSSVA | EILKYTLWEV | SCSGTVSEQL | RNSETKNLCL | LETAQ |