AiPD: Autoinhibited Protein Database

P04000

Gene name	OPN1LW (RCP)
Protein name	Long-wave-sensitive opsin 1
Names	Red cone photoreceptor pigment, Red-sensitive opsin, ROP
Species	Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-61 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P04000

Entry ID	Method	Resolution	Chain	Position	Source
AF-P04000-F1	Predicted				AlphaFoldDB

211 variants for P04000

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001528791 rs1557157655 RCV000011250 RCV001699100	180	A>=	RED CONE POLYMORPHISM [ClinVar]	Yes	ClinVar dbSNP
VAR_009298 CA121104 rs121434621 RCV002466398 RCV000011251 RCV000479007	203	C>R	Protan defect Cone monochromatism BCM [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV000011249 CA121100 rs104894912	247	R>*	Variant assessed as Somatic; impact. Cone monochromatism [NCI-TCGA, ClinVar]	Yes	ClinGen ClinVar Ensembl NCI-TCGA dbSNP
CA10558930 VAR_009299 rs782797093	307	P>L	BCM [UniProt]	Yes	ClinGen UniProt ExAC dbSNP gnomAD
RCV000011252 CA255281 rs104894913 VAR_064054	338	G>E	Protan defect CBP [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
CA10558725 rs782168842	2	A>V		No	ClinGen ExAC TOPMed gnomAD
CA415297167 rs1557156888	5	W>R		No	ClinGen gnomAD
CA415297232 rs1432802860	6	S>N		No	ClinGen TOPMed
CA415297244 rs1557156890	6	S>R		No	ClinGen gnomAD
CA10558726 rs782320360	10	L>F		No	ClinGen ExAC gnomAD
CA415297372 rs1179025423	11	A>E		No	ClinGen TOPMed
rs376687141 CA10558727	11	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA10558728 rs782255535	12	G>D		No	ClinGen ExAC gnomAD
rs1557156900 CA415297395	13	R>C		No	ClinGen gnomAD
rs782395128 CA10558729	14	H>P		No	ClinGen ExAC gnomAD
CA415297445 rs1557156902	14	H>Q		No	ClinGen gnomAD
CA10558730 rs782024126	15	P>L		No	ClinGen ExAC TOPMed gnomAD
rs781941716 CA10558733	16	Q>P		No	ClinGen ExAC gnomAD
TCGA novel	18	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1557156905 CA415297738	23	T>A		No	ClinGen gnomAD
rs782082005 CA10558734	23	T>I		No	ClinGen ExAC gnomAD
rs782744314 CA10558735	27	I>V		No	ClinGen ExAC gnomAD
CA337665472 rs368762233	29	T>I		No	ClinGen ESP
rs781989269 CA10558736	33	S>N		No	ClinGen ExAC gnomAD
CA10558737 rs782130602	34	N>D		No	ClinGen ExAC TOPMed gnomAD
CA415298142 rs1603344740	34	N>I		No	ClinGen Ensembl
CA10558738 rs782793124	35	S>F		No	ClinGen ExAC gnomAD
CA415298194 rs1603344745	36	T>P		No	ClinGen Ensembl
CA415298812 rs1557157390	38	G>D		No	ClinGen gnomAD
CA415298823 rs1557157393	39	P>S		No	ClinGen gnomAD
TCGA novel	41	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1117811 COSM1117812 rs1557157399 CA415298938	41	E>K	Variant assessed as Somatic; 0.0 impact. oesophagus endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs377209440 CA337665632	43	P>L		No	ClinGen ESP TOPMed gnomAD
rs781861633 CA10558757	47	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10558755 rs782693292	47	I>V		No	ClinGen ExAC gnomAD
CA415299425 rs1557157405	50	R>K		No	ClinGen gnomAD
rs1557157406 CA415299516	52	V>M		No	ClinGen gnomAD
rs782783558 CA10558758	54	H>Y		No	ClinGen ExAC gnomAD
rs1557157408 CA415299667	55	L>V		No	ClinGen gnomAD
CA10558759 rs369185568	58	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557157412 CA415299928	60	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1333366976 CA415299956	61	I>M		No	ClinGen TOPMed gnomAD
CA415299986 rs1557157415	62	F>S		No	ClinGen gnomAD
rs782550559 CA10558760	64	V>I		No	ClinGen ExAC gnomAD
CA10558761 rs782815809	65	T>I		No	ClinGen ExAC TOPMed gnomAD
CA10558762 rs781794536	66	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1603345202 CA415300147	66	A>V		No	ClinGen Ensembl
TCGA novel	67	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	68	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10558764 rs782786685	68	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA415300312 rs1387596834	72	G>R		No	ClinGen TOPMed
CA10558765 rs782228887	74	V>M		No	ClinGen ExAC gnomAD
rs782494665 CA10558767	76	A>E		No	ClinGen ExAC TOPMed gnomAD
CA10558766 rs782494665	76	A>V		No	ClinGen ExAC TOPMed gnomAD
CA10558769 rs782420318	78	T>I		No	ClinGen ExAC gnomAD
rs782420318 CA415300557	78	T>N		No	ClinGen ExAC gnomAD
rs868981933 CA415300628	79	M>I		No	ClinGen Ensembl
rs1557157437 CA415300589	79	M>V		No	ClinGen gnomAD
rs781915220 CA10558770	82	K>E		No	ClinGen ExAC gnomAD
rs1374912169 CA415300872	83	K>N		No	ClinGen TOPMed
COSM1117818 RCV000485633 COSM1117817 rs1064796643 CA16621250	85	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ClinVar NCI-TCGA dbSNP gnomAD
CA415300920 rs1557157441	85	R>H	Variant assessed as Somatic; 6.334e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA415300977 rs1186876810	87	P>L		No	ClinGen TOPMed gnomAD
CA415301225 rs1557157443	91	I>N		No	ClinGen gnomAD
rs782337911 CA10558772	96	A>V		No	ClinGen ExAC TOPMed gnomAD
rs376112729 CA415301515	97	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs376112729 CA10558774	97	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1450325118 CA415301535	98	A>S		No	ClinGen TOPMed gnomAD
CA415301562 rs1450325118	98	A>T		No	ClinGen TOPMed gnomAD
CA415301712 rs1339445760	101	A>G		No	ClinGen TOPMed gnomAD
CA10558776 rs782210449	101	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1339445760 CA415301713	101	A>V		No	ClinGen TOPMed gnomAD
rs371146776 CA10558778	104	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10558780 rs782102273	106	A>S		No	ClinGen ExAC
CA415302131 rs1065421	111	I>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_012010 CA10558781 rs1065421	111	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs781869198 CA10558782	112	V>L		No	ClinGen ExAC
VAR_012011 rs1065422 CA10558783	116	S>Y		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs2067072148 RCV001310756	118	Y>*		No	ClinVar dbSNP
rs782670567 COSM755697 CA415302530 COSM755696	119	F>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1557157468 CA415302714	125	M>L		No	ClinGen gnomAD
CA10558785 rs781787315	128	L>P		No	ClinGen ExAC gnomAD
CA415303013 rs1398682615	133	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10558803 rs782484270	138	I>V		No	ClinGen ExAC gnomAD
rs1557157619 CA415303811	151	R>I		No	ClinGen gnomAD
rs713 CA337665709 VAR_012012	153	M>L		No	ClinGen UniProt 1000Genomes ExAC dbSNP gnomAD
CA519322669 rs1557157624	155	V>L		No	ClinGen gnomAD
CA10558809 rs782340336	159	F>C		No	ClinGen ExAC gnomAD
CA10558811 rs782249764	162	V>E		No	ClinGen ExAC gnomAD
CA10558812 rs184047537	163	R>I		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA337665717 rs782526787	164	F>C		No	ClinGen Ensembl
COSM375503 rs373601495 CA10558813 COSM375502	165	D>G	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs1557157636 CA415304236	166	A>G		No	ClinGen gnomAD
rs782292865 CA415304230	166	A>S		No	ClinGen ExAC gnomAD
rs782292865 CA10558814	166	A>T		No	ClinGen ExAC gnomAD
CA10558815 rs782305369	168	L>M		No	ClinGen ExAC
CA415304307 rs1557157639	169	A>V		No	ClinGen gnomAD
CA10558816 rs781931953	170	I>V		No	ClinGen ExAC
rs5986963 CA10558819	171	V>L		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA10558818 rs5986963	171	V>M		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA415304400 rs1557157644	172	G>S		No	ClinGen gnomAD
rs1557157645 CA415304471	173	I>T		No	ClinGen gnomAD
CA10558822 rs149897670	174	A>V		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA10558823 rs150391359	177	W>R		No	ClinGen ESP ExAC gnomAD
rs781836898 CA10558825	178	I>N		No	ClinGen ExAC gnomAD
RCV000454776 rs145009674 CA10558824	178	I>V		No	ClinGen ClinVar 1000Genomes ESP ExAC dbSNP gnomAD
rs1557157653 CA415304630	179	W>*		No	ClinGen gnomAD
VAR_004842 rs1557157655 CA337665728	180	A>S	62% of the population [UniProt]	No	ClinGen UniProt 1000Genomes ExAC dbSNP gnomAD
CA10558826 rs375863094	182	V>L		No	ClinGen ESP ExAC
CA10558828 rs782549215	184	T>A		No	ClinGen ExAC gnomAD
rs782568898 CA10558829	185	A>T		No	ClinGen ExAC gnomAD
rs782197748 CA10558830	186	P>L		No	ClinGen ExAC gnomAD
CA10558832 rs782699550	188	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1557157668 CA415304975	190	G>A		No	ClinGen gnomAD
CA415305036 rs1557157669	192	S>G		No	ClinGen gnomAD
rs1380050111 CA415305479	196	P>A		No	ClinGen TOPMed
CA10558856 rs781989418	198	G>D		No	ClinGen ExAC TOPMed gnomAD
CA10558855 rs782361699	198	G>S		No	ClinGen ExAC TOPMed gnomAD
rs782028359 CA10558859	207	V>A		No	ClinGen ExAC
CA415305933 rs1557157806	207	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA415305956 rs1603345413	208	F>V		No	ClinGen Ensembl
rs782047119 CA10558860	209	S>R		No	ClinGen ExAC TOPMed gnomAD
CA10558861 rs782715468	210	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1159151639 CA415306174	211	S>R		No	ClinGen TOPMed
CA415306203 rs1399594374	212	S>L		No	ClinGen TOPMed
CA10558864 rs782755469	214	P>S		No	ClinGen ExAC gnomAD
CA415306261 rs782755469	214	P>T		No	ClinGen ExAC gnomAD
rs782523727 CA10558866	215	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1188983268 CA415306337	216	V>M		No	ClinGen TOPMed gnomAD
rs781810750 CA10558868	220	M>I		No	ClinGen ExAC gnomAD
CA10558870 rs782480227	221	I>N		No	ClinGen ExAC gnomAD
CA10558869 rs782480227	221	I>T		No	ClinGen ExAC gnomAD
CA10558871 rs782250157	222	V>I		No	ClinGen ExAC gnomAD
CA415306599 rs1557157826	224	M>L		No	ClinGen gnomAD
rs1557157827 CA415306626	224	M>R		No	ClinGen gnomAD
CA10558874 rs148583295 VAR_012014 COSM1557035 COSM1557034	230	I>T	lung [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10558873 rs144864828	230	I>V		No	ClinGen ESP ExAC gnomAD
rs781936473 CA415307007	233	A>S		No	ClinGen ExAC TOPMed gnomAD
rs781936473 CA10558876	233	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1292153674 CA415307013	233	A>V		No	ClinGen TOPMed
rs782079976 CA10558877	234	I>M		No	ClinGen ExAC gnomAD
TCGA novel	235	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782358874 CA10558878	235	I>V		No	ClinGen ExAC gnomAD
rs1065426 CA10558880 CA10558881	236	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1065426 CA10558879	236	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1363528484 CA415307123	237	L>V		No	ClinGen TOPMed
rs1288768228 CA415307159	238	C>F		No	ClinGen TOPMed
CA415307199 rs1437848284	240	L>R		No	ClinGen TOPMed
rs782070898 CA10558883	243	W>C		No	ClinGen ExAC gnomAD
CA415307304 rs1349908448	243	W>L		No	ClinGen TOPMed gnomAD
CA415307294 rs1349908448	243	W>S		No	ClinGen TOPMed gnomAD
CA415307336 rs1166314366 COSM1557032 COSM1557033	244	L>V	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA415307364 rs1557157843	245	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs782727254 CA415307349	245	A>P		No	ClinGen ExAC gnomAD
CA10558884 rs782727254	245	A>T		No	ClinGen ExAC gnomAD
rs781846140 CA10558885	247	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs139583770	248	A>=	Variant assessed as Somatic; 6.354e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA415307450 rs782506559	248	A>G		No	ClinGen ExAC TOPMed gnomAD
CA10558886 rs782506559	248	A>V		No	ClinGen ExAC TOPMed gnomAD
rs782291194 CA10558898	251	K>N		No	ClinGen ExAC gnomAD
rs782326320 CA10558899	253	Q>R		No	ClinGen ExAC gnomAD
rs1312545420 CA415307936	260	Q>E		No	ClinGen TOPMed
rs1451624086 CA415308002	262	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1557157969 CA415308017	263	E>Q		No	ClinGen gnomAD
TCGA novel	267	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10558903 rs782000011	268	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10558904 rs782151075	268	R>H		No	ClinGen ExAC TOPMed gnomAD
rs782151075 CA10558905	268	R>L		No	ClinGen ExAC TOPMed gnomAD
CA415308193 rs1557157977	269	M>I		No	ClinGen gnomAD
rs145097171 CA10558906	271	V>L		No	ClinGen ESP ExAC gnomAD
rs145097171 CA415308224	271	V>M		No	ClinGen ESP ExAC gnomAD
rs1557157979 CA415308248	272	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs2315122 CA415308304	274	I>L		No	ClinGen TOPMed gnomAD
CA415308325 rs1459580137	274	I>M		No	ClinGen TOPMed
CA415308307 rs2315122 VAR_050612	274	I>V		No	ClinGen UniProt TOPMed dbSNP gnomAD
rs2315124 CA10558910	275	F>L		No	ClinGen ExAC TOPMed gnomAD
CA337665818 rs2315123	275	F>L		No	ClinGen ExAC gnomAD
CA10558909 rs2315123	275	F>V		No	ClinGen ExAC gnomAD
COSM3390514 CA415308382 COSM3390513 rs1557157985	276	A>V	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
CA337665820 rs2315126	277	Y>F		No	ClinGen Ensembl
CA415308459 rs781838044	278	C>W		No	ClinGen ExAC TOPMed gnomAD
COSM1466738 COSM1466739 rs2315127 CA10558913	279	V>F	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA10558912 rs2315127	279	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	281	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA415308561 rs1557157993	283	P>S		No	ClinGen gnomAD
rs200528091 CA10558916	285	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA415308605 rs1361043870	285	T>S		No	ClinGen TOPMed
rs782365080 CA415308672	288	A>P		No	ClinGen ExAC TOPMed gnomAD
CA10558918 rs782365080	288	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA415308696 rs1342563936	289	C>S		No	ClinGen TOPMed
rs782260583 CA10558920	292	A>S		No	ClinGen ExAC gnomAD
CA10558922 rs782039891	296	G>A		No	ClinGen ExAC gnomAD
CA10558925 VAR_012015 rs1065440	298	A>P		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
COSM172391 CA10558926 rs1065440	298	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs782777199 CA10558927	301	P>R		No	ClinGen ExAC gnomAD
rs1557158004 CA415308966	303	M>I		No	ClinGen gnomAD
rs782540205 CA10558929	305	A>G		No	ClinGen ExAC gnomAD
TCGA novel	308	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10558932 rs145631912	309	Y>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782626484 CA10558933	310	F>I		No	ClinGen ExAC gnomAD
rs782520080 CA10558935	311	A>V		No	ClinGen ExAC gnomAD
rs1557158017 CA415309019	312	K>R		No	ClinGen gnomAD
CA415309035 rs1557158018	314	A>G		No	ClinGen gnomAD
CA415309040 rs1557158024	315	T>N		No	ClinGen gnomAD
CA415309080 rs782292319	321	I>F		No	ClinGen ExAC gnomAD
rs782292319 CA10558937	321	I>V		No	ClinGen ExAC gnomAD
CA10558938 rs782312823	322	Y>H		No	ClinGen ExAC
CA415309123 rs1201703999	327	R>G		No	ClinGen TOPMed gnomAD
CA415309125 rs1490687236	327	R>Q		No	ClinGen TOPMed gnomAD
CA415309124 rs1201703999	327	R>W		No	ClinGen TOPMed gnomAD
CA415309380 rs1557158115	362	S>L		No	ClinGen Ensembl

2 associated diseases with P04000

[MIM: 303900]: Colorblindness, partial, protan series (CBP)

A color vision defect characterized by a dichromasy in which red and green are confused, with loss of luminance and shift of brightness and hue curves toward the short wave end of the spectrum. Dichromasy is due to the use of only two types of photoreceptors, blue plus red in deuteranopia and blue plus green in protanopia. {ECO:0000269|PubMed:12051694}. Note=The disease is caused by variants affecting the gene represented in this entry.

[MIM: 303700]: Blue cone monochromacy (BCM)

A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia. {ECO:0000269|PubMed:8213841, ECO:0000269|PubMed:8666378}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A color vision defect characterized by a dichromasy in which red and green are confused, with loss of luminance and shift of brightness and hue curves toward the short wave end of the spectrum. Dichromasy is due to the use of only two types of photoreceptors, blue plus red in deuteranopia and blue plus green in protanopia. {ECO:0000269|PubMed:12051694}. Note=The disease is caused by variants affecting the gene represented in this entry.
A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia. {ECO:0000269|PubMed:8213841, ECO:0000269|PubMed:8666378}. Note=The disease is caused by variants affecting the gene represented in this entry.

1 regional properties for P04000

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	66 - 330	IPR017452

Functions

		Description
EC Number
Subcellular Localization	Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
photoreceptor disc membrane	Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
photoreceptor outer segment	The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.

2 GO annotations of molecular function

Name	Definition
G protein-coupled photoreceptor activity	Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
photoreceptor activity	The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation.

6 GO annotations of biological process

Name	Definition
cellular response to light stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
phototransduction	The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
positive regulation of cytokinesis	Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
visual perception	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

120 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2YDN1	GPR161	G protein-coupled receptor 161	Bos taurus (Bovine)	PR
Q0GBZ5	HCRTR1	Orexin/Hypocretin receptor type 1	Bos taurus (Bovine)	PR
Q17QD8	GPR37L1	G-protein coupled receptor 37-like 1	Bos taurus (Bovine)	PR
Q8SPN1	PROKR2	Prokineticin receptor 2	Bos taurus (Bovine)	PR
P46626	ADRB3	Beta-3 adrenergic receptor	Bos taurus (Bovine)	PR
O46639	TRHR	Thyrotropin-releasing hormone receptor	Bos taurus (Bovine)	PR
Q8SPN2	PROKR1	Prokineticin receptor 1	Bos taurus (Bovine)	PR
B9VR26	CMLKR1	Chemerin-like receptor 1	Bos taurus (Bovine)	PR
P18130	ADRA1A	Alpha-1A adrenergic receptor	Bos taurus (Bovine)	PR
B4XF06	GPR39	G-protein coupled receptor 39	Bos taurus (Bovine)	PR
O18913	OPN1LW	Long-wave-sensitive opsin 1	Felis catus (Cat) (Felis silvestris catus)	PR
P28683	PRA1	Green-sensitive opsin	Gallus gallus (Chicken)	PR
Q9N298	HTR1A	5-hydroxytryptamine receptor 1A	Pan troglodytes (Chimpanzee)	PR
P08099	Rh2	Opsin Rh2	Drosophila melanogaster (Fruit fly)	PR
P06002	ninaE	Opsin Rh1	Drosophila melanogaster (Fruit fly)	PR
Q4LBB9	Octbeta2R	Octopamine receptor beta-2R	Drosophila melanogaster (Fruit fly)	PR
Q8NFJ6	PROKR2	Prokineticin receptor 2	Homo sapiens (Human)	PR
Q13585	GPR50	Melatonin-related receptor	Homo sapiens (Human)	PR
Q9BZJ6	GPR63	Probable G-protein coupled receptor 63	Homo sapiens (Human)	PR
Q9H3N8	HRH4	Histamine H4 receptor	Homo sapiens (Human)	PR
P28336	NMBR	Neuromedin-B receptor	Homo sapiens (Human)	PR
Q9Y5Y3	GPR45	Probable G-protein coupled receptor 45	Homo sapiens (Human)	PR
P08913	ADRA2A	Alpha-2A adrenergic receptor	Homo sapiens (Human)	PR
P41597	CCR2	C-C chemokine receptor type 2	Homo sapiens (Human)	PR
P51681	CCR5	C-C chemokine receptor type 5	Homo sapiens (Human)	PR
Q8TCW9	PROKR1	Prokineticin receptor 1	Homo sapiens (Human)	PR
Q99788	CMKLR1	Chemerin-like receptor 1	Homo sapiens (Human)	PR
P08908	HTR1A	5-hydroxytryptamine receptor 1A	Homo sapiens (Human)	PR
P30559	OXTR	Oxytocin receptor	Homo sapiens (Human)	PR
P32239	CCKBR	Gastrin/cholecystokinin type B receptor	Homo sapiens (Human)	PR
O60883	GPR37L1	G-protein coupled receptor 37-like 1	Homo sapiens (Human)	PR
Q8TDU9	RXFP4	Relaxin-3 receptor 2	Homo sapiens (Human)	PR
P34972	CNR2	Cannabinoid receptor 2	Homo sapiens (Human)	PR
P24530	EDNRB	Endothelin receptor type B	Homo sapiens (Human)	PR
P35348	ADRA1A	Alpha-1A adrenergic receptor	Homo sapiens (Human)	PR
Q6W5P4	NPSR1	Neuropeptide S receptor	Homo sapiens (Human)	PR
O43613	HCRTR1	Orexin/Hypocretin receptor type 1	Homo sapiens (Human)	PR
P61073	CXCR4	C-X-C chemokine receptor type 4	Homo sapiens (Human)	PR
Q9BXC0	HCAR1	Hydroxycarboxylic acid receptor 1	Homo sapiens (Human)	PR
P30556	AGTR1	Type-1 angiotensin II receptor	Homo sapiens (Human)	PR
Q15761	NPY5R	Neuropeptide Y receptor type 5	Homo sapiens (Human)	PR
Q8N6U8	GPR161	G-protein coupled receptor 161	Homo sapiens (Human)	PR
Q6DWJ6	GPR139	Probable G-protein coupled receptor 139	Homo sapiens (Human)	PR
P21462	FPR1	fMet-Leu-Phe receptor	Homo sapiens (Human)	PR
P35414	APLNR	Apelin receptor	Homo sapiens (Human)	PR
P46091	CMKLR2	Chemerin-like receptor 2	Homo sapiens (Human)	PR
P32745	SSTR3	Somatostatin receptor type 3	Homo sapiens (Human)	PR
P41439	FOLR3	Folate receptor gamma	Homo sapiens (Human)	PR
Q6U736	OPN5	Opsin-5	Homo sapiens (Human)	PR
P04001	OPN1MW	Medium-wave-sensitive opsin 1	Homo sapiens (Human)	PR
P19973	Lsp1	Lymphocyte-specific protein 1	Mus musculus (Mouse)	PR
O54799	Nmbr	Neuromedin-B receptor	Mus musculus (Mouse)	PR
Q64264	Htr1a	5-hydroxytryptamine receptor 1A	Mus musculus (Mouse)	PR
P51675	Ccr1	C-C chemokine receptor type 1	Mus musculus (Mouse)	PR
Q5U431	Gpr39	G-protein coupled receptor 39	Mus musculus (Mouse)	PR
Q99JG2	Gpr37l1	G-protein coupled receptor 37-like 1	Mus musculus (Mouse)	PR
P97295	Npy2r	Neuropeptide Y receptor type 2	Mus musculus (Mouse)	PR
O08786	Cckar	Cholecystokinin receptor type A	Mus musculus (Mouse)	PR
P56481	Cckbr	Gastrin/cholecystokinin type B receptor	Mus musculus (Mouse)	PR
P30731	Gpr83	G-protein coupled receptor 83	Mus musculus (Mouse)	PR
P97468	Cmklr1	Chemerin-like receptor 1	Mus musculus (Mouse)	PR
P21761	Trhr	Thyrotropin-releasing hormone receptor	Mus musculus (Mouse)	PR
Q5QD16	Taar3	Trace amine-associated receptor 3	Mus musculus (Mouse)	PR
P97292	Hrh2	Histamine H2 receptor	Mus musculus (Mouse)	PR
Q9EQQ3	Gpr63	Probable G-protein coupled receptor 63	Mus musculus (Mouse)	PR
Q924H0	Npffr2	Neuropeptide FF receptor 2	Mus musculus (Mouse)	PR
P34971	Adrb1	Beta-1 adrenergic receptor	Mus musculus (Mouse)	PR
Q91ZY2	Hrh4	Histamine H4 receptor	Mus musculus (Mouse)	PR
O88416	Gpr33	Probable G-protein coupled receptor 33	Mus musculus (Mouse)	PR
Q8K087	Cmklr2	Chemerin-like receptor 2	Mus musculus (Mouse)	PR
P70658	Cxcr4	C-X-C chemokine receptor type 4	Mus musculus (Mouse)	PR
Q9WV08	Aplnr	Apelin receptor	Mus musculus (Mouse)	PR
P97718	Adra1a	Alpha-1A adrenergic receptor	Mus musculus (Mouse)	PR
Q8BZP8	Npsr1	Neuropeptide S receptor	Mus musculus (Mouse)	PR
Q8K458	Prokr2	Prokineticin receptor 2	Mus musculus (Mouse)	PR
P58308	Hcrtr2	Orexin receptor type 2	Mus musculus (Mouse)	PR
Q7TQP3	Gpr119	Glucose-dependent insulinotropic receptor	Mus musculus (Mouse)	PR
Q8BGE9	Rxfp3	Relaxin-3 receptor 1	Mus musculus (Mouse)	PR
Q6VZZ7	Opn5	Opsin-5	Mus musculus (Mouse)	PR
Q8CIM5	Gpr84	G-protein coupled receptor 84	Mus musculus (Mouse)	PR
P25962	Adrb3	Beta-3 adrenergic receptor	Mus musculus (Mouse)	PR
Q80UC8	Gpr139	Probable G-protein coupled receptor 139	Mus musculus (Mouse)	PR
P0C5I1	Gpr25	Probable G-protein coupled receptor 25	Mus musculus (Mouse)	PR
P47936	Cnr2	Cannabinoid receptor 2	Mus musculus (Mouse)	PR
Q5QD13	Taar6	Trace amine-associated receptor 6	Mus musculus (Mouse)	PR
P35846	Folr1	Folate receptor alpha	Mus musculus (Mouse)	PR
P58307	Hcrtr1	Orexin/Hypocretin receptor type 1	Mus musculus (Mouse)	PR
Q8C131	Hcar1	Hydroxycarboxylic acid receptor 1	Mus musculus (Mouse)	PR
Q9EQQ4	Gpr45	Probable G-protein coupled receptor 45	Mus musculus (Mouse)	PR
B2RPY5	Gpr161	G-protein coupled receptor 161	Mus musculus (Mouse)	PR
Q764M9	CXCR4	C-X-C chemokine receptor type 4	Sus scrofa (Pig)	PR
Q9EQD2	Npffr2	Neuropeptide FF receptor 2	Rattus norvegicus (Rat)	PR
O08565	Cxcr4	C-X-C chemokine receptor type 4	Rattus norvegicus (Rat)	PR
Q01717	Trhr	Thyrotropin-releasing hormone receptor	Rattus norvegicus (Rat)	PR
P30936	Sstr3	Somatostatin receptor type 3	Rattus norvegicus (Rat)	PR
Q9JHG3	Aplnr	Apelin receptor	Rattus norvegicus (Rat)	PR
P43140	Adra1a	Alpha-1A adrenergic receptor	Rattus norvegicus (Rat)	PR
P19327	Htr1a	5-hydroxytryptamine receptor 1A	Rattus norvegicus (Rat)	PR
P56719	Hcrtr2	Orexin receptor type 2	Rattus norvegicus (Rat)	PR
P28564	Htr1b	5-hydroxytryptamine receptor 1B	Rattus norvegicus (Rat)	PR
P56718	Hcrtr1	Orexin/Hypocretin receptor type 1	Rattus norvegicus (Rat)	PR
P28647	Adora3	Adenosine receptor A3	Rattus norvegicus (Rat)	PR
P25102	Hrh2	Histamine H2 receptor	Rattus norvegicus (Rat)	PR
P23944	Adra1d	Alpha-1D adrenergic receptor	Rattus norvegicus (Rat)	PR
Q8R415	Prokr2	Prokineticin receptor 2	Rattus norvegicus (Rat)	PR
Q5QD24	Taar3	Trace amine-associated receptor 3	Rattus norvegicus (Rat)	PR
P0C0W8	Gpr139	Probable G-protein coupled receptor 139	Rattus norvegicus (Rat)	PR
P35370	Oprl1	Nociceptin receptor	Rattus norvegicus (Rat)	PR
P46090	Cmklr2	Chemerin-like receptor 2	Rattus norvegicus (Rat)	PR
O97664	CMKLR2	Chemerin-like receptor 2	Macaca mulatta (Rhesus macaque)	PR
O97666	APLNR	Apelin receptor	Macaca mulatta (Rhesus macaque)	PR
Q56H79	NPSR1	Neuropeptide S receptor	Macaca mulatta (Rhesus macaque)	PR
Q18904	npr-8	Probable G-protein coupled receptor npr-8	Caenorhabditis elegans	PR
Q09388	gar-2	Muscarinic acetylcholine receptor gar-2	Caenorhabditis elegans	PR
B3DM66	gpr161	G-protein coupled receptor 161	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q9W6A6	opn1mw4	Green-sensitive opsin-4	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q9W6A5	opn1mw1	Green-sensitive opsin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q8AYM7	opn1mw3	Green-sensitive opsin-3	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q90X46	gpr161	G-protein coupled receptor 161	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q8AYN0	opn1lw2	Red-sensitive opsin-2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAQQWSLQRL	AGRHPQDSYE	DSTQSSIFTY	TNSNSTRGPF	EGPNYHIAPR	WVYHLTSVWM
70	80	90	100	110	120
IFVVTASVFT	NGLVLAATMK	FKKLRHPLNW	ILVNLAVADL	AETVIASTIS	IVNQVSGYFV
130	140	150	160	170	180
LGHPMCVLEG	YTVSLCGITG	LWSLAIISWE	RWMVVCKPFG	NVRFDAKLAI	VGIAFSWIWA
190	200	210	220	230	240
AVWTAPPIFG	WSRYWPHGLK	TSCGPDVFSG	SSYPGVQSYM	IVLMVTCCII	PLAIIMLCYL
250	260	270	280	290	300
QVWLAIRAVA	KQQKESESTQ	KAEKEVTRMV	VVMIFAYCVC	WGPYTFFACF	AAANPGYAFH
310	320	330	340	350	360
PLMAALPAYF	AKSATIYNPV	IYVFMNRQFR	NCILQLFGKK	VDDGSELSSA	SKTEVSSVSS

VSPA