P30556
PR
Gene name |
AGTR1 |
Protein name |
Type-1 angiotensin II receptor |
Names |
AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1 receptor |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:185 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
308 variants for P30556
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV001149670 rs138997091 RCV000907538 |
30 | M>= | Renal tubular dysgenesis [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV000019689 rs387906577 |
38 | I>missing | Renal tubular dysgenesis [ClinVar] | Yes |
ClinVar dbSNP |
|
rs751575775 RCV001149671 RCV002483880 CA2657277 |
38 | I>T | Renal tubular dysgenesis Essential hypertension, genetic [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
CA10617445 RCV000374387 rs886058069 |
51 | I>T | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
CA2657284 rs758161051 RCV000293905 |
57 | M>T | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV000901265 rs111980524 CA2657287 RCV001149672 |
65 | V>I | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA143693 rs398122935 RCV000043468 |
84 | W>* | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
CA2657307 RCV002520093 rs145708722 RCV000399815 |
103 | I>T | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV002502319 rs140542820 CA2657316 RCV000314268 RCV002520094 |
114 | A>T | Renal tubular dysgenesis Essential hypertension, genetic [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
rs397514687 RCV000043469 CA143696 |
126 | R>* | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs756951904 RCV000345798 CA2657331 |
143 | L>I | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
CA2657336 COSM149495 rs12721226 RCV000889099 RCV001145355 VAR_029206 |
163 | A>T | Renal tubular dysgenesis stomach [ClinVar, Cosmic] | Yes |
ClinGen cosmic curated ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
RCV001145356 COSM224879 rs200184769 RCV001543568 CA2657338 |
167 | R>Q | Renal tubular dysgenesis oesophagus large_intestine skin Variant assessed as Somatic; 4.621e-05 impact. [ClinVar, Cosmic, NCI-TCGA] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
RCV001356298 RCV002505719 CA2657366 RCV001145357 rs151206107 |
233 | P>T | Renal tubular dysgenesis Essential hypertension, genetic [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
rs12721225 VAR_029207 CA2657375 RCV001145358 RCV000953205 |
244 | A>S | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000365536 CA10617600 rs886058071 |
255 | P>L | Renal tubular dysgenesis [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
rs1218342417 RCV001145359 |
272 | R>P | Renal tubular dysgenesis [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV000019690 VAR_035086 rs104893677 CA127782 |
282 | T>M | Renal tubular dysgenesis RTD [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt TOPMed dbSNP |
|
RCV000266272 RCV001850823 CA2657409 rs368951368 RCV002487510 |
298 | N>S | Renal tubular dysgenesis Essential hypertension, genetic [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
rs372561921 CA2657266 |
2 | I>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs779475784 CA2657267 |
2 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372561921 CA2657265 |
2 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 3 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2657269 rs754942115 |
4 | N>H | No |
ClinGen ExAC gnomAD |
|
|
rs1261778963 CA354884843 |
4 | N>S | No |
ClinGen TOPMed |
|
|
CA354884904 rs1477901393 |
7 | T>I | No |
ClinGen gnomAD |
|
|
rs201574073 CA85497240 |
10 | G>S | No |
ClinGen 1000Genomes |
|
|
CA2657270 rs781030550 |
10 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA354885014 rs1165750203 |
11 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA2657272 rs769583495 |
11 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA85497265 rs896587204 |
12 | K>T | No |
ClinGen gnomAD |
|
|
CA354885056 rs1358705034 |
13 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA354885107 rs1013672470 |
14 | I>M | No |
ClinGen gnomAD |
|
|
CA354885221 rs1330784410 |
17 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA354885286 rs1434001031 |
20 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA354885283 rs1434001031 |
20 | K>T | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 22 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA85497275 rs1047885033 |
23 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1362276045 CA354885397 |
25 | N>H | No |
ClinGen gnomAD |
|
|
CA2657273 rs773385210 |
27 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA2657274 rs749536273 |
28 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs1239347270 CA354885516 |
29 | V>I | No |
ClinGen gnomAD |
|
|
rs1453251109 CA354885622 |
31 | I>T | No |
ClinGen gnomAD |
|
|
CA354885631 rs1283192114 |
32 | P>A | No |
ClinGen TOPMed gnomAD |
|
|
CA354885633 rs1283192114 |
32 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA354885658 rs1355208421 |
33 | T>I | No |
ClinGen gnomAD |
|
| TCGA novel | 34 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2657275 rs770976926 |
36 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA2657276 rs774334785 |
36 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1451621681 CA354885733 |
37 | I>T | No |
ClinGen TOPMed |
|
|
rs1559933743 CA354885729 |
37 | I>V | No |
ClinGen Ensembl |
|
|
rs1219761165 CA354885756 |
39 | F>S | No |
ClinGen TOPMed gnomAD |
|
|
CA85497310 rs13095608 |
41 | V>G | No |
ClinGen Ensembl |
|
|
rs374930715 CA85497340 |
42 | G>R | No |
ClinGen ESP |
|
|
rs1478603789 CA354885861 |
47 | S>R | No |
ClinGen gnomAD |
|
|
rs764573066 CA2657281 |
49 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA2657280 rs145575818 |
49 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1576541676 CA354885896 |
50 | V>G | No |
ClinGen Ensembl |
|
|
rs1450888240 CA354885887 |
50 | V>M | No |
ClinGen TOPMed |
|
|
CA354885917 rs150629733 |
52 | V>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2657282 rs150629733 |
52 | V>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 52 | V>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA354886003 rs1350271075 |
58 | K>E | No |
ClinGen gnomAD |
|
|
CA2657285 rs765903933 |
58 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs751092458 CA2657286 |
59 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1241893519 CA354886031 |
62 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1559933838 CA354886035 |
63 | A>S | No |
ClinGen Ensembl |
|
|
CA354886042 rs1240210108 |
64 | S>N | No |
ClinGen gnomAD |
|
|
CA354886047 rs111980524 |
65 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA354886059 rs1229680209 |
66 | F>L | No |
ClinGen gnomAD |
|
|
CA354886076 rs1334821430 |
69 | N>T | No |
ClinGen TOPMed gnomAD |
|
|
rs753149496 CA2657288 |
70 | L>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2657289 rs748117430 |
74 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs545751404 CA354886119 |
76 | C>G | No |
ClinGen Ensembl |
|
|
CA85497462 rs545751404 |
76 | C>R | No |
ClinGen Ensembl |
|
|
rs747975618 CA2657292 |
77 | F>C | No |
ClinGen ExAC gnomAD |
|
|
CA354886143 rs1239236626 |
79 | L>R | No |
ClinGen gnomAD |
|
|
CA85497464 rs968984924 |
82 | P>S | No |
ClinGen Ensembl |
|
|
rs745868057 CA2657296 |
85 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs774646145 CA354886175 |
85 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774646145 CA2657295 |
85 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA85497487 rs745868057 |
85 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA2657297 rs149809890 |
86 | V>L | No |
ClinGen ESP ExAC gnomAD |
|
|
CA2657298 rs775810028 |
87 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA354886191 rs1396490062 |
88 | T>A | No |
ClinGen TOPMed |
|
|
CA2657299 rs570903965 |
90 | M>V | No |
ClinGen 1000Genomes ExAC |
|
| TCGA novel | 91 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA354886226 rs1246422058 |
93 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA2657300 rs764518060 |
93 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA354886234 rs1342200710 |
94 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
RCV000722621 rs1431071473 |
95 | P>missing | No |
ClinVar dbSNP |
|
|
rs1320545424 CA354886340 |
100 | L>P | No |
ClinGen gnomAD |
|
|
rs751231086 CA2657305 |
101 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA2657306 rs201745152 |
103 | I>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1189751208 CA354886463 |
104 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA354886483 rs1258458257 |
105 | S>* | No |
ClinGen TOPMed gnomAD |
|
|
rs911154679 CA85497552 |
106 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1168216909 CA354886523 |
107 | S>G | No |
ClinGen gnomAD |
|
|
rs373362261 CA2657310 |
108 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs753570924 CA354886587 |
109 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs753570924 CA2657311 |
109 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs201151143 CA2657312 |
112 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1402676563 CA354886792 |
115 | S>G | No |
ClinGen TOPMed |
|
|
rs550259107 CA2657317 |
115 | S>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA354886831 rs1165414525 |
116 | V>A | No |
ClinGen TOPMed |
|
|
CA354886830 rs1165414525 |
116 | V>E | No |
ClinGen TOPMed |
|
|
CA354886885 rs1397758938 |
119 | L>F | No |
ClinGen gnomAD |
|
|
rs144141909 CA2657319 |
120 | T>M | No |
ClinGen ESP ExAC gnomAD |
|
|
rs144141909 CA2657320 |
120 | T>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA85497639 rs757886940 |
124 | I>T | No |
ClinGen Ensembl |
|
|
rs368534001 CA85497632 |
124 | I>V | No |
ClinGen Ensembl |
|
| TCGA novel | 125 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs397514687 CA354887054 |
126 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2657322 rs762020328 |
126 | R>Q | Variant assessed as Somatic; 0.0007489 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM3846463 CA2657323 rs770227887 |
127 | Y>C | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1450133165 CA354887072 |
127 | Y>H | No |
ClinGen TOPMed |
|
|
CA354887074 rs770227887 |
127 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
rs773829709 COSM1670630 CA2657324 |
132 | H>N | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
| TCGA novel | 133 | P>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA354887208 rs1197968073 |
134 | M>I | No |
ClinGen gnomAD |
|
|
CA354887201 rs369846514 |
134 | M>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2657325 rs369846514 |
134 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA2657326 rs766907479 |
136 | S>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 137 | R>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1182247 rs995803867 CA85497688 |
137 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA2657327 rs56257794 |
137 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1417391173 COSM175915 CA354887281 |
139 | R>* | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA2657328 rs760594254 |
139 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
COSM1039650 rs763952495 CA2657329 |
140 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs763952495 CA354887289 |
140 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs570056677 CA2657330 COSM291104 |
140 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA354887362 rs1329812513 |
143 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
CA354887368 rs1304179427 |
144 | V>I | No |
ClinGen gnomAD |
|
|
CA85497729 rs1020069665 |
149 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1288388541 CA354887523 |
150 | I>L | No |
ClinGen gnomAD |
|
|
CA354887544 rs1486330094 |
150 | I>M | No |
ClinGen gnomAD |
|
|
rs1222372059 CA354887565 |
151 | I>M | No |
ClinGen gnomAD |
|
|
rs1208979081 CA354887561 |
151 | I>T | No |
ClinGen gnomAD |
|
|
rs780264737 CA354887647 |
156 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780264737 CA2657335 |
156 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1434779519 CA354887654 |
156 | A>V | No |
ClinGen gnomAD |
|
|
rs968555821 CA85497736 |
157 | G>A | No |
ClinGen gnomAD |
|
|
CA354887660 rs1332504059 |
157 | G>S | No |
ClinGen TOPMed |
|
|
CA354887791 rs1559934144 |
166 | H>L | No |
ClinGen Ensembl |
|
|
rs768866306 CA2657337 |
167 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA2657340 rs748715507 |
172 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA85497764 rs979012840 |
173 | E>Q | No |
ClinGen Ensembl |
|
|
rs1413312331 CA354887885 |
174 | N>K | No |
ClinGen TOPMed |
|
|
CA354887882 rs1459236128 |
174 | N>S | No |
ClinGen TOPMed |
|
| TCGA novel | 176 | N>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2657342 rs202211101 |
176 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA85497775 rs533866995 |
177 | I>L | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA354887906 rs533866995 |
177 | I>V | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs369560166 CA2657343 |
179 | V>L | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 180 | C>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA354887970 rs868647200 |
182 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1327158479 CA354887984 |
183 | H>L | No |
ClinGen TOPMed gnomAD |
|
|
CA354887983 rs1327158479 |
183 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA2657345 rs775127751 |
184 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs553350297 CA2657346 |
185 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA354888033 rs1244351944 |
186 | S>F | No |
ClinGen gnomAD |
|
|
CA2657347 rs763613654 |
186 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs200844345 CA85497826 |
188 | N>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs200844345 CA2657348 |
188 | N>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA2657349 rs761847680 |
189 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA85497842 rs917905020 |
189 | S>P | No |
ClinGen Ensembl |
|
|
rs1576542214 CA354888086 |
190 | T>P | No |
ClinGen Ensembl |
|
|
rs949413715 CA85497856 |
190 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
rs764933525 CA2657350 |
191 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2657352 rs772616879 |
192 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA354888115 rs1179924232 |
192 | P>S | No |
ClinGen gnomAD |
|
|
rs1162242884 CA354888128 |
193 | I>L | No |
ClinGen gnomAD |
|
|
rs1369905389 CA354888137 |
193 | I>T | No |
ClinGen gnomAD |
|
|
CA85497882 rs1038279926 |
194 | G>A | No |
ClinGen Ensembl |
|
|
COSM582021 rs1400159105 CA354888169 |
196 | G>V | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs781474726 CA2657356 |
197 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA354888184 rs1576542281 |
198 | T>A | No |
ClinGen Ensembl |
|
| TCGA novel | 199 | K>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1226161583 CA354888225 |
201 | I>L | No |
ClinGen TOPMed |
|
| TCGA novel | 201 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1010369365 CA85497943 |
203 | G>D | No |
ClinGen TOPMed |
|
|
CA354888294 rs1323787639 |
205 | L>P | No |
ClinGen gnomAD |
|
|
CA2657359 rs777986489 |
208 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs1429999499 CA354888398 |
213 | T>A | No |
ClinGen gnomAD |
|
|
CA354888403 rs1390102655 |
213 | T>K | No |
ClinGen TOPMed |
|
| TCGA novel | 214 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA85498039 rs202215841 |
214 | S>T | No |
ClinGen Ensembl |
|
|
COSM1693564 CA85498062 rs867471763 |
216 | T>I | skin [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs1315912957 CA354888460 |
217 | L>P | No |
ClinGen gnomAD |
|
|
rs771316000 CA2657361 |
218 | I>S | No |
ClinGen ExAC gnomAD |
|
|
CA354888488 rs1233443416 |
219 | W>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA2657362 rs775074631 |
221 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA85498087 rs1020042180 |
221 | A>T | No |
ClinGen TOPMed |
|
|
rs17852013 CA85498101 VAR_070375 |
222 | L>V | No |
ClinGen UniProt dbSNP gnomAD |
|
|
rs1576542376 CA354888523 |
223 | K>Q | No |
ClinGen Ensembl |
|
|
rs1481397980 CA354888551 |
224 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA85498120 rs968846002 |
230 | K>E | No |
ClinGen TOPMed |
|
|
rs776269256 CA2657365 |
231 | N>T | No |
ClinGen ExAC gnomAD |
|
|
CA85498189 rs963961250 |
234 | R>T | No |
ClinGen TOPMed gnomAD |
|
|
CA2657369 rs762800866 |
236 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs766301385 CA2657370 |
236 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs370495451 CA2657368 |
236 | D>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370495451 CA354888722 |
236 | D>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 237 | D>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2657371 rs761069030 |
237 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1216176664 CA354888738 |
237 | D>Y | No |
ClinGen gnomAD |
|
|
CA2657372 rs375320868 TCGA novel |
240 | K>N | Variant assessed as Somatic; 0.0 impact. Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1278671622 CA354888806 |
241 | I>T | No |
ClinGen TOPMed |
|
|
rs767703245 CA2657373 |
242 | I>T | No |
ClinGen ExAC |
|
|
rs752880266 CA2657374 |
243 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs1339679912 CA354888848 |
244 | A>E | No |
ClinGen TOPMed |
|
|
rs749780887 CA2657377 |
245 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA2657376 rs377357687 |
245 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs188281474 CA2657378 |
246 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
CA2657381 rs746657746 |
248 | F>C | No |
ClinGen ExAC gnomAD |
|
|
CA2657380 rs541786585 |
248 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1414427195 CA354888964 |
252 | S>F | No |
ClinGen gnomAD |
|
| TCGA novel | 255 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2657384 COSM335633 rs776157396 |
256 | H>N | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA2657385 rs150330554 |
257 | Q>* | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 257 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA354889058 rs1432609682 |
258 | I>M | No |
ClinGen gnomAD |
|
|
rs769221844 CA2657386 |
258 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2657387 rs773017244 |
260 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA354889096 rs1559934478 |
262 | L>V | No |
ClinGen Ensembl |
|
|
rs763035960 CA2657388 |
263 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1034593197 CA85498405 |
267 | Q>R | No |
ClinGen Ensembl |
|
|
rs762651737 CA2657390 |
269 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs759821283 CA2657391 |
270 | I>V | No |
ClinGen ExAC |
|
|
CA354889213 rs1283415503 |
271 | I>T | No |
ClinGen gnomAD |
|
|
CA2657392 rs767722134 |
272 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1218342417 CA354889224 |
272 | R>H | No |
ClinGen gnomAD |
|
|
rs760757555 CA2657394 |
278 | D>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 279 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs764126581 CA354889332 |
279 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA354889334 rs1397503282 |
280 | V>L | No |
ClinGen gnomAD |
|
|
rs757827237 CA2657397 COSM728837 |
283 | A>T | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA354889373 rs1576542565 |
286 | I>V | No |
ClinGen Ensembl |
|
|
CA2657399 rs750724789 |
287 | T>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 288 | I>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2657401 rs780860717 |
288 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA2657400 rs758763207 |
288 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1064533 VAR_011847 CA85498607 |
289 | C>W | No |
ClinGen UniProt ExAC dbSNP gnomAD |
|
|
rs747780318 CA2657402 |
289 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA2657404 rs777193000 |
290 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749234826 CA2657405 |
292 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA2657407 rs774446445 |
293 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs1224002017 CA354889497 |
295 | N>Y | No |
ClinGen gnomAD |
|
|
rs374541305 CA2657408 |
297 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs374541305 CA354889538 |
297 | L>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs374541305 CA354889547 |
297 | L>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 298 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1236450037 CA354889577 |
299 | P>H | No |
ClinGen gnomAD |
|
|
rs1178054956 CA354889575 |
299 | P>S | No |
ClinGen gnomAD |
|
|
COSM1419809 CA354889598 rs1225940534 |
300 | L>P | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1481777694 CA354889588 |
300 | L>V | No |
ClinGen TOPMed |
|
|
CA2657411 rs760846471 |
302 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs907915344 CA85498649 |
303 | G>D | No |
ClinGen Ensembl |
|
|
rs1159364990 CA354889656 |
303 | G>S | No |
ClinGen gnomAD |
|
| TCGA novel | 307 | K>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1343355046 CA354889722 |
307 | K>R | No |
ClinGen TOPMed |
|
|
rs1413395918 CA354889749 CA354889747 |
308 | K>N | No |
ClinGen gnomAD |
|
|
CA85498670 rs549928178 |
309 | F>C | No |
ClinGen 1000Genomes gnomAD |
|
|
CA2657412 rs764229950 |
309 | F>I | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs1205343354 | 309 | F>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA85498664 rs764229950 |
309 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 311 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2657413 RCV000734441 rs199541646 |
314 | L>R | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs750956179 CA2657416 |
315 | Q>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs529403958 CA2657418 |
318 | K>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs758743626 CA2657417 |
318 | K>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 320 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 322 | P>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA85498824 rs1020848540 |
325 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA2657423 rs200411216 |
325 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 326 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2657424 rs374146740 |
327 | H>P | No |
ClinGen ESP ExAC gnomAD |
|
|
CA2657425 rs778954862 |
334 | M>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1182686592 CA354890255 |
334 | M>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1439602978 CA354890245 |
334 | M>V | No |
ClinGen gnomAD |
|
|
CA354890263 rs1474368913 |
335 | S>N | No |
ClinGen gnomAD |
|
|
CA354890270 rs767462753 |
336 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767462753 CA2657426 |
336 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1801021 VAR_011848 CA85498873 |
336 | T>P | No |
ClinGen UniProt Ensembl dbSNP |
|
|
rs147106220 CA2657428 |
339 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs548345422 CA2657430 |
340 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2657431 rs377193123 |
340 | R>H | Variant assessed as Somatic; 9.245e-05 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA354890292 rs377193123 |
340 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA85498909 rs548345422 |
340 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs17852012 VAR_070376 CA85498920 |
341 | P>H | No |
ClinGen UniProt TOPMed dbSNP |
|
|
rs17852012 CA354890298 |
341 | P>L | No |
ClinGen TOPMed |
|
|
CA354890300 rs1576542776 |
342 | S>P | No |
ClinGen Ensembl |
|
|
rs765319802 CA2657433 |
344 | N>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1428962420 CA354890337 |
346 | S>T | No |
ClinGen gnomAD |
|
|
rs773689751 CA2657434 |
347 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773689751 CA354890350 |
347 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs568213686 CA2657436 |
349 | T>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2657437 rs766765776 |
350 | K>R | No |
ClinGen ExAC |
|
|
CA2657438 rs751927459 |
351 | K>M | No |
ClinGen ExAC gnomAD |
|
|
CA2657439 rs755384581 |
352 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs533828937 CA2657440 |
354 | P>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA354890431 rs1229064157 |
354 | P>T | No |
ClinGen TOPMed |
|
|
CA85498958 rs201891355 |
355 | C>Y | No |
ClinGen Ensembl |
|
|
rs1438356001 CA354890465 |
356 | F>L | No |
ClinGen TOPMed |
|
|
CA2657442 rs144333873 |
356 | F>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA85498973 rs761220426 |
357 | E>K | No |
ClinGen Ensembl |
|
| TCGA novel | 360 | E>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778604981 CA2657443 |
360 | E>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
1 associated diseases with P30556
[MIM: 267430]: Renal tubular dysgenesis (RTD)
Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269|PubMed:16116425}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269|PubMed:16116425}. Note=The disease is caused by variants affecting the gene represented in this entry.
1 regional properties for P30556
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 45 - 302 | IPR017452 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| angiotensin type I receptor activity | An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. |
| angiotensin type II receptor activity | An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. |
| bradykinin receptor binding | Binding to a bradykinin receptor. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
30 GO annotations of biological process
| Name | Definition |
|---|---|
| angiotensin-activated signaling pathway | A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| blood vessel diameter maintenance | Any process that modulates the diameter of blood vessels. |
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
| cell chemotaxis | The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| kidney development | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. |
| low-density lipoprotein particle remodeling | The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. |
| maintenance of blood vessel diameter homeostasis by renin-angiotensin | The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system. |
| phospholipase C-activating angiotensin-activated signaling pathway | A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. |
| positive regulation of CoA-transferase activity | Any process that activates or increases the frequency, rate or extent of CoA-transferase activity. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway | Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. |
| positive regulation of inflammatory response | Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
| positive regulation of macrophage derived foam cell differentiation | Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. |
| positive regulation of NAD(P)H oxidase activity | Any process that activates or increases the activity of the enzyme NAD(P)H oxidase. |
| positive regulation of phospholipase A2 activity | Any process that activates or increases the activity of the enzyme phospholipase A2. |
| positive regulation of protein metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. |
| positive regulation of reactive oxygen species metabolic process | Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. |
| regulation of cell growth | Any process that modulates the frequency, rate, extent or direction of cell growth. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
| regulation of renal sodium excretion | Any process that modulates the amount of sodium excreted in urine over a unit of time. |
| regulation of systemic arterial blood pressure by renin-angiotensin | The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. |
| regulation of vasoconstriction | Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. |
| renin-angiotensin regulation of aldosterone production | The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone. |
| Rho protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. |
| viral entry into host cell | The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. |
120 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| P30411 | BDKRB2 | B2 bradykinin receptor | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MILNSSTEDG | IKRIQDDCPK | AGRHNYIFVM | IPTLYSIIFV | VGIFGNSLVV | IVIYFYMKLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVASVFLLNL | ALADLCFLLT | LPLWAVYTAM | EYRWPFGNYL | CKIASASVSF | NLYASVFLLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CLSIDRYLAI | VHPMKSRLRR | TMLVAKVTCI | IIWLLAGLAS | LPAIIHRNVF | FIENTNITVC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AFHYESQNST | LPIGLGLTKN | ILGFLFPFLI | ILTSYTLIWK | ALKKAYEIQK | NKPRNDDIFK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IIMAIVLFFF | FSWIPHQIFT | FLDVLIQLGI | IRDCRIADIV | DTAMPITICI | AYFNNCLNPL |
| 310 | 320 | 330 | 340 | 350 | |
| FYGFLGKKFK | RYFLQLLKYI | PPKAKSHSNL | STKMSTLSYR | PSDNVSSSTK | KPAPCFEVE |