P30411
PR
Gene name |
BDKRB2 (BKR2) |
Protein name |
B2 bradykinin receptor |
Names |
27 kDa diphtheria toxin receptor-associated protein, DRAP27, B2R, BK-2 receptor |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:624 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P30411
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7F2O | EM | 290 A | R | 40-370 | PDB |
| 7F6H | EM | 290 A | A | 25-391 | PDB |
| 7F6I | EM | 280 A | A | 25-391 | PDB |
| AF-P30411-F1 | Predicted | AlphaFoldDB |
346 variants for P30411
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs979441683 CA266035957 |
2 | F>I | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 2 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA266035963 rs777673155 |
5 | W>C | No |
ClinGen Ensembl |
|
| TCGA novel | 5 | W>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 6 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1210196872 CA390898795 |
7 | I>L | No |
ClinGen TOPMed |
|
|
CA390898809 rs1566695406 |
9 | M>T | No |
ClinGen Ensembl |
|
|
CA7334837 rs751935351 |
9 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA390898822 rs924868565 COSM171141 |
11 | L>M | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA266035978 rs924868565 |
11 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
VAR_003457 CA7334839 rs1046248 |
14 | R>C | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
COSM1741704 rs200131401 CA7334841 |
14 | R>H | urinary_tract [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs200131401 CA7334840 |
14 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7334843 rs753954087 |
15 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs201351531 CA7334842 |
15 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7334844 rs140696405 |
16 | D>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs992787256 CA266036010 COSM1707856 |
16 | D>N | Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA7334846 rs377705294 |
18 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7334847 rs770712432 |
19 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA7334848 rs200061371 |
21 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390898880 rs532210447 |
22 | A>P | No |
ClinGen gnomAD |
|
|
CA266036046 rs532210447 |
22 | A>T | No |
ClinGen gnomAD |
|
|
CA390898889 rs1195038299 |
23 | S>C | No |
ClinGen TOPMed |
|
| TCGA novel | 23 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7334851 rs199499079 |
25 | S>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7334890 rs199739317 |
25 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390898914 rs200693201 |
26 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7334892 rs200693201 |
26 | A>T | Variant assessed as Somatic; 6.026e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs765360779 CA7334896 |
27 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA7334895 rs199704308 |
27 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7334894 COSM959336 rs776833029 |
27 | D>N | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1402372389 CA390898929 |
28 | M>I | No |
ClinGen gnomAD |
|
|
CA7334897 rs775702998 |
28 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775702998 CA390898928 |
28 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762874297 CA7334898 |
29 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA390898939 rs1374640374 |
30 | N>D | No |
ClinGen gnomAD |
|
|
rs750309210 CA7334900 |
33 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7334901 rs755933062 |
34 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390898978 rs1277230957 |
36 | P>S | No |
ClinGen gnomAD |
|
|
rs753563291 CA7334903 |
37 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7334904 rs200814940 |
38 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs757938037 CA7334907 |
40 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA7334906 rs199956553 |
40 | G>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs201987499 CA7334908 |
42 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA7334910 rs557017882 |
43 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs200146501 CA266037789 |
43 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA7334913 rs746210702 |
45 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs770056184 CA7334914 |
46 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA266037801 rs201100139 |
47 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390899048 rs201100139 |
47 | C>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775517421 CA7334915 |
47 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs138633013 CA7334917 |
48 | P>L | No |
ClinGen ESP ExAC gnomAD |
|
|
CA266037808 rs562698090 |
49 | Q>R | No |
ClinGen gnomAD |
|
|
rs202026817 CA7334919 |
50 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA390899066 rs1203280196 |
51 | E>K | No |
ClinGen TOPMed |
|
|
rs1240156584 CA390899071 |
51 | E>V | No |
ClinGen gnomAD |
|
|
rs1347730800 CA390899082 |
52 | W>C | No |
ClinGen gnomAD |
|
|
CA390899090 rs1595265981 |
54 | G>S | No |
ClinGen Ensembl |
|
|
rs1010944578 CA266037820 |
55 | W>* | No |
ClinGen Ensembl |
|
|
rs1595265991 CA390899118 |
58 | T>P | No |
ClinGen Ensembl |
|
|
rs759195610 CA7334922 |
61 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1195457784 CA390899139 |
61 | P>S | No |
ClinGen gnomAD |
|
|
rs1195457784 CA390899137 |
61 | P>T | No |
ClinGen gnomAD |
|
|
rs764968612 CA390899146 |
62 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764968612 CA7334923 |
62 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA390899145 rs764968612 |
62 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390899157 rs1252355336 COSM138947 |
64 | L>F | skin [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA390899156 rs1252355336 |
64 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1230747543 CA390899167 |
65 | W>C | No |
ClinGen TOPMed |
|
|
rs777477855 CA7334926 |
65 | W>S | No |
ClinGen ExAC gnomAD |
|
|
CA390899169 rs1178045383 |
66 | V>M | No |
ClinGen gnomAD |
|
|
CA390899178 rs1461241929 |
67 | L>P | No |
ClinGen gnomAD |
|
|
rs368495707 CA7334927 |
69 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs368495707 CA266037874 |
69 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1324607649 CA390899195 |
70 | L>P | No |
ClinGen gnomAD |
|
|
CA390899208 rs1324159651 |
72 | T>I | No |
ClinGen TOPMed |
|
| TCGA novel | 74 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1439328562 CA390899215 |
74 | E>Q | No |
ClinGen gnomAD |
|
|
rs757903530 CA7334928 |
77 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201041317 CA7334929 |
77 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs746256717 CA7334930 |
78 | V>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 79 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs202213026 CA266037901 |
80 | S>G | No |
ClinGen Ensembl |
|
|
CA7334934 rs200683377 COSM266091 |
81 | V>I | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1190697892 CA390899294 |
85 | H>Q | No |
ClinGen gnomAD |
|
|
rs1427735913 CA390899289 |
85 | H>Y | No |
ClinGen gnomAD |
|
|
CA390899301 rs1566696864 |
86 | K>N | No |
ClinGen Ensembl |
|
|
CA390899306 rs1239669339 |
87 | S>I | No |
ClinGen TOPMed |
|
|
CA390899308 rs1239669339 |
87 | S>N | No |
ClinGen TOPMed |
|
|
CA390899322 rs1465789260 |
89 | C>Y | No |
ClinGen gnomAD |
|
|
CA7334937 rs201448595 |
90 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7334936 rs201448595 |
90 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390899330 rs201448595 |
90 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390899354 rs1566696880 |
94 | I>N | No |
ClinGen Ensembl |
|
|
CA7334943 rs763831238 |
97 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA390899382 rs1342685085 |
98 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1595266110 CA390899379 |
98 | N>T | No |
ClinGen Ensembl |
|
|
rs751115238 CA7334944 |
100 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7334946 rs781733145 |
101 | A>T | Variant assessed as Somatic; 5.539e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1265982604 CA390899429 |
106 | L>R | No |
ClinGen gnomAD |
|
|
CA390899426 rs1301390843 |
106 | L>V | No |
ClinGen TOPMed |
|
|
CA7334948 rs756610849 |
109 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1415161438 CA390899459 |
111 | P>L | No |
ClinGen gnomAD |
|
|
rs1186789152 CA390899456 |
111 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA390899463 rs1320975078 |
112 | F>S | No |
ClinGen TOPMed |
|
|
CA390899478 rs1425065664 |
114 | A>T | No |
ClinGen gnomAD |
|
|
rs779049358 CA7334952 |
115 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs748250276 CA7334953 |
116 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs772009524 CA7334954 |
117 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA266037954 rs867353437 |
120 | N>D | No |
ClinGen gnomAD |
|
|
CA7334955 rs773315270 |
120 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA390899515 rs867353437 |
120 | N>Y | No |
ClinGen gnomAD |
|
|
rs1158322515 CA390899533 |
122 | D>E | No |
ClinGen TOPMed |
|
|
CA7334957 rs143890409 |
122 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7334958 rs775489416 |
123 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA266037971 rs898472314 |
125 | F>S | No |
ClinGen TOPMed |
|
|
rs762765957 CA7334959 |
126 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA390899570 rs1287992867 |
128 | T>A | No |
ClinGen gnomAD |
|
|
rs183386880 CA7334960 COSM959340 |
128 | T>M | large_intestine endometrium [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs563494871 CA266037984 |
131 | R>C | No |
ClinGen gnomAD |
|
|
rs766976697 CA7334963 |
131 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM1678240 CA266037988 rs766976697 |
131 | R>L | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1008727566 CA266037992 |
132 | V>E | No |
ClinGen TOPMed |
|
|
CA390899591 rs201909453 |
132 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7334964 rs201909453 |
132 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368510407 CA7334965 |
135 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA390899636 rs1382656122 |
139 | M>L | No |
ClinGen gnomAD |
|
|
CA390899635 rs1382656122 |
139 | M>V | No |
ClinGen gnomAD |
|
|
CA7334966 rs766805624 |
140 | N>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 140 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7334968 rs755289030 |
141 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA266038019 rs547136020 |
145 | I>L | No |
ClinGen Ensembl |
|
|
CA266038022 rs547136020 |
145 | I>V | No |
ClinGen Ensembl |
|
|
rs781770613 CA266038033 |
147 | F>Y | No |
ClinGen Ensembl |
|
|
CA7334972 rs777777245 |
149 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA266038039 rs200839127 |
149 | M>V | No |
ClinGen Ensembl |
|
|
CA266038043 rs201523214 |
152 | S>G | No |
ClinGen gnomAD |
|
|
CA390899726 rs1313650979 |
152 | S>R | No |
ClinGen gnomAD |
|
|
CA7334974 rs769618803 |
153 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs749114824 CA7334976 |
154 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA266038045 rs777611379 |
154 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA390899742 rs1240626421 |
155 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs768529413 CA7334977 |
158 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390899769 rs1173476065 |
160 | V>L | No |
ClinGen gnomAD |
|
|
rs1566697002 CA390899783 |
162 | T>P | No |
ClinGen Ensembl |
|
|
CA266038053 rs200137610 |
165 | M>R | No |
ClinGen Ensembl |
|
|
rs774254602 CA390899818 |
167 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA266038055 rs201092575 |
167 | R>Q | No |
ClinGen gnomAD |
|
|
rs774254602 CA7334978 |
167 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs139076079 CA7334979 CA266038058 |
168 | M>I | No |
ClinGen ESP ExAC gnomAD |
|
|
rs964993900 CA266038056 |
168 | M>R | No |
ClinGen TOPMed |
|
|
rs1464178755 COSM959346 CA390899828 |
169 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA7334980 rs141412276 |
169 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs202134620 CA7334984 |
170 | G>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1272946587 CA390899833 |
170 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs202134620 CA390899832 |
170 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs202134620 CA7334983 |
170 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA7334988 rs201329154 |
171 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs139401938 CA7334987 |
171 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs140161378 CA7334990 |
172 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7334991 COSM1749054 rs201474162 |
172 | R>H | urinary_tract [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA390899843 rs201474162 |
172 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1258138680 CA390899850 |
173 | W>* | No |
ClinGen gnomAD |
|
|
rs977838309 CA266038075 |
174 | A>V | No |
ClinGen TOPMed |
|
|
CA390899868 rs1193564678 |
176 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
rs199642464 CA266038078 |
177 | Y>* | No |
ClinGen gnomAD |
|
|
CA390899873 rs1595266297 |
177 | Y>H | No |
ClinGen Ensembl |
|
|
CA390899880 rs1252323377 |
178 | S>G | No |
ClinGen gnomAD |
|
|
rs1479223093 CA390899884 |
178 | S>I | No |
ClinGen gnomAD |
|
|
CA7334992 rs780168746 |
182 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs1210181426 CA390899920 |
183 | G>V | No |
ClinGen TOPMed |
|
|
rs939563124 CA390899924 |
184 | C>S | No |
ClinGen TOPMed gnomAD |
|
|
rs939563124 CA266038092 |
184 | C>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs749275929 CA7334993 |
185 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1436987223 CA390899967 |
191 | P>L | No |
ClinGen gnomAD |
|
|
CA390899971 rs1269345234 |
192 | M>V | No |
ClinGen gnomAD |
|
|
rs546829915 CA7334996 |
194 | V>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs747911761 CA390899995 |
195 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM69815 CA266038119 rs201760673 |
196 | R>Q | ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA266038116 rs962382149 |
196 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 198 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA390900020 COSM699705 rs199831344 |
199 | K>N | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
| TCGA novel | 200 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7334999 rs772874206 |
203 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA390900070 rs1311014558 |
206 | H>R | No |
ClinGen TOPMed |
|
|
rs760136048 CA7335000 |
206 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1196125459 CA390900075 |
207 | N>D | No |
ClinGen gnomAD |
|
|
CA7335002 rs200470118 |
207 | N>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA390900074 rs1196125459 |
207 | N>Y | No |
ClinGen gnomAD |
|
|
CA7335003 rs139203012 |
208 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA390900082 rs139203012 |
208 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7335005 rs200062156 |
209 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7335004 rs200062156 |
209 | T>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs183204823 CA7335006 |
210 | A>T | Variant assessed as Somatic; 4.904e-05 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA266038161 rs199803197 |
212 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs751762638 CA390900119 |
214 | S>I | No |
ClinGen ExAC gnomAD |
|
|
CA7335008 rs751762638 |
214 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs757519944 CA7335009 |
215 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA7335010 rs781468888 |
218 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA390900156 rs1416268650 |
220 | W>* | No |
ClinGen TOPMed |
|
|
CA390900153 rs1354409040 |
220 | W>R | No |
ClinGen gnomAD |
|
|
rs750517955 CA7335012 |
221 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA266038191 rs1019206771 |
222 | V>A | No |
ClinGen TOPMed |
|
|
CA7335013 rs778853908 |
226 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7335014 rs188092400 |
230 | V>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs192953717 CA7335016 |
231 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs202072945 CA7335018 |
238 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1185595154 CA390900293 |
241 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA390900291 rs1185595154 |
241 | T>N | No |
ClinGen TOPMed gnomAD |
|
|
CA390900315 COSM3690268 rs1239271323 |
244 | T>M | Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA390900314 rs1239271323 |
244 | T>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1336713927 CA390900321 |
245 | M>I | No |
ClinGen TOPMed |
|
|
rs772538359 CA7335019 |
245 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA390900326 rs1291250850 |
246 | Q>K | No |
ClinGen TOPMed |
|
|
CA7335020 rs758983716 |
247 | I>S | No |
ClinGen ExAC gnomAD |
|
|
CA266038232 rs200532207 |
248 | M>I | No |
ClinGen Ensembl |
|
|
CA390900355 rs1227299587 |
250 | V>M | No |
ClinGen gnomAD |
|
|
rs776011947 CA7335022 |
252 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA7335021 rs770296029 |
252 | R>W | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 255 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs144066261 CA7335024 |
255 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1308513453 CA390900388 |
255 | E>V | No |
ClinGen TOPMed |
|
|
CA390900406 rs1335720129 |
257 | Q>H | No |
ClinGen gnomAD |
|
|
CA390900438 rs1340560260 |
261 | E>D | No |
ClinGen gnomAD |
|
|
rs774556385 CA7335025 |
262 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs1279563252 CA390900443 |
262 | I>N | No |
ClinGen gnomAD |
|
|
CA7335026 rs146453096 COSM335024 |
264 | T>I | lung [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
| TCGA novel | 265 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1259795095 CA390900464 |
265 | E>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 266 | R>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs199749772 CA7335029 COSM1240890 |
269 | T>M | oesophagus [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs142053211 CA7335028 |
269 | T>S | No |
ClinGen ESP ExAC TOPMed |
|
|
rs765119910 CA7335030 |
270 | V>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 271 | L>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs752721113 CA7335031 |
271 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200761934 CA266038291 |
281 | I>F | No |
ClinGen gnomAD |
|
|
CA390900554 rs200761934 |
281 | I>V | No |
ClinGen gnomAD |
|
|
CA390900586 rs1195696280 |
285 | P>L | No |
ClinGen TOPMed |
|
|
CA266038298 rs544336047 |
288 | I>M | No |
ClinGen 1000Genomes |
|
|
rs146985256 CA7335035 |
288 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA390900616 rs1595266573 |
290 | T>P | No |
ClinGen Ensembl |
|
|
rs200643742 CA7335036 |
291 | F>L | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1043378552 CA266038313 |
293 | D>G | No |
ClinGen Ensembl |
|
|
CA7335037 rs745400008 |
294 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA7335038 COSM198832 rs201732624 |
294 | T>M | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA266038324 rs1001773730 |
296 | H>P | No |
ClinGen Ensembl |
|
|
CA7335040 rs749848603 |
297 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1310557751 CA390900661 |
297 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1310557751 CA390900659 |
297 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs373071105 CA266038330 |
299 | G>D | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA7335042 rs769027698 |
299 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7335041 rs769027698 |
299 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 301 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1256223562 CA390900702 |
304 | C>F | No |
ClinGen gnomAD |
|
|
rs771091903 CA7335043 |
304 | C>G | No |
ClinGen ExAC gnomAD |
|
|
CA7335044 rs200077235 |
306 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7335046 rs138076769 |
307 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM3377485 rs766530842 CA7335047 |
308 | R>C | Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs766530842 CA390900728 |
308 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201166893 CA7335048 |
308 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA390900729 COSM1371887 rs201166893 |
308 | R>P | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA390900733 rs1477286619 |
309 | I>V | No |
ClinGen gnomAD |
|
|
CA7335050 rs763874568 |
311 | D>N | Variant assessed as Somatic; 9.256e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs763874568 CA7335051 |
311 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390900756 rs1192713371 |
312 | V>G | No |
ClinGen TOPMed |
|
|
rs1252615530 CA390900751 |
312 | V>I | No |
ClinGen TOPMed |
|
|
rs745556740 CA266038380 |
316 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745556740 CA7335055 |
316 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7335054 rs780850861 |
316 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs146650268 CA266038397 |
317 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs146650268 CA7335058 |
317 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1022206251 CA266038410 |
319 | F>S | No |
ClinGen TOPMed |
|
|
rs748555729 CA7335062 |
320 | M>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748555729 CA7335061 |
320 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1312528542 CA390900800 |
320 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs761018120 CA7335064 |
326 | C>G | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 328 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7335067 rs776780847 |
329 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs1258882849 CA390900867 |
329 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1376663729 CA390900874 |
330 | L>R | No |
ClinGen TOPMed |
|
|
rs1425275963 CA390900885 |
332 | Y>C | No |
ClinGen gnomAD |
|
|
CA390900882 rs1314751517 |
332 | Y>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs201791629 CA7335069 |
333 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs149359477 CA7335073 |
335 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA390900913 rs1366590295 |
337 | K>E | No |
ClinGen gnomAD |
|
|
rs144659195 CA7335074 |
337 | K>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7335075 rs200627214 |
338 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390900920 rs200627214 |
338 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM959348 CA7335076 rs148172749 |
338 | R>H | endometrium [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA266038506 rs988013396 |
340 | R>* | No |
ClinGen TOPMed gnomAD |
|
|
rs201521050 CA7335078 |
340 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA266038510 rs199686931 |
341 | K>R | No |
ClinGen TOPMed |
|
|
CA266038512 rs200826300 |
342 | K>N | No |
ClinGen Ensembl |
|
|
CA390900986 rs1265886726 |
343 | S>C | No |
ClinGen gnomAD |
|
|
CA390900978 rs1363659698 |
343 | S>P | No |
ClinGen gnomAD |
|
|
CA390901000 rs1214117912 COSM1371888 |
344 | W>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA7335079 rs748715230 |
344 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA266038517 rs201675002 |
346 | V>L | No |
ClinGen Ensembl |
|
|
rs201675002 CA266038519 |
346 | V>M | No |
ClinGen Ensembl |
|
|
CA7335081 rs146150661 |
349 | G>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 349 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs141974118 CA7335080 |
349 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs146150661 CA390901067 |
349 | G>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs778592206 CA7335083 |
350 | V>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA390901072 rs747273570 |
350 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747273570 CA7335082 |
350 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200182006 CA266038529 |
351 | C>R | No |
ClinGen Ensembl |
|
|
VAR_012284 rs2227279 CA7335084 RCV000970276 |
354 | G>E | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1424976476 CA390901125 |
354 | G>R | No |
ClinGen gnomAD |
|
|
CA390901141 rs1419536397 |
355 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
CA390901139 rs1419536397 |
355 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA266038532 rs374332188 |
355 | G>R | No |
ClinGen ESP TOPMed |
|
|
CA390901135 rs374332188 |
355 | G>S | No |
ClinGen ESP TOPMed |
|
|
CA390901201 rs1165932459 |
360 | P>A | No |
ClinGen TOPMed |
|
|
rs200078302 CA7335087 |
360 | P>L | No |
ClinGen ESP ExAC gnomAD |
|
|
CA266038539 rs1056000198 |
363 | M>T | No |
ClinGen Ensembl |
|
|
rs1474991980 CA390901238 |
363 | M>V | No |
ClinGen TOPMed |
|
|
COSM959350 rs930223969 CA266038542 |
364 | E>D | endometrium [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
| TCGA novel | 368 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA390901309 rs1302420548 |
368 | G>R | No |
ClinGen gnomAD |
|
|
rs201021538 CA7335088 |
368 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs896082320 CA266038546 |
369 | T>I | No |
ClinGen Ensembl |
|
|
CA266038548 rs983008064 |
370 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
CA7335090 rs201864766 |
371 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7335092 rs147570529 |
371 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201864766 CA7335091 |
371 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200843057 CA7335093 |
372 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778625682 CA7335095 |
374 | I>N | No |
ClinGen ExAC gnomAD |
|
|
CA390901356 rs778625682 |
374 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1595266790 CA390901349 |
374 | I>V | No |
ClinGen Ensembl |
|
|
CA266038563 rs201367171 |
376 | V>A | No |
ClinGen TOPMed |
|
|
CA7335096 rs141958164 |
376 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 376 | V>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7335097 rs751331696 |
378 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA7335098 rs778370159 COSM3386768 |
378 | R>H | pancreas [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
COSM433560 rs778370159 CA266038568 |
378 | R>L | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs747426571 CA7335099 |
383 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
rs199655832 COSM1678241 CA7335100 |
385 | D>H | lung [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA390901549 rs1444534694 COSM95579 |
386 | W>* | breast [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA7335101 rs200260828 |
386 | W>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA390901540 rs1401578997 |
386 | W>R | No |
ClinGen gnomAD |
|
|
rs1357593533 CA390901565 |
387 | A>V | No |
ClinGen gnomAD |
|
|
CA390901592 rs1175807356 |
389 | S>N | No |
ClinGen gnomAD |
|
|
rs746121575 CA7335102 |
390 | R>K | No |
ClinGen ExAC |
|
|
CA266038587 rs769987281 |
391 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA266038590 rs796213533 |
392 | Q>G | No |
ClinGen Ensembl |
No associated diseases with P30411
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| bradykinin receptor activity | Combining with bradykinin to initiate a change in cell activity. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). |
| protease binding | Binding to a protease or a peptidase. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| type 1 angiotensin receptor binding | Binding to a type 1 angiotensin receptor. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| arachidonic acid secretion | The controlled release of arachidonic acid from a cell or a tissue. |
| blood circulation | The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. |
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered. |
| negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator | Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. |
| negative regulation of peptidyl-serine phosphorylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| regulation of vascular permeability | Any process that modulates the extent to which blood vessels can be pervaded by fluid. |
| regulation of vasoconstriction | Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
| smooth muscle contraction | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vasoconstriction | A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. |
| vasodilation | An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P25023 | Bdkrb2 | B2 bradykinin receptor | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFSPWKISMF | LSVREDSVPT | TASFSADMLN | VTLQGPTLNG | TFAQSKCPQV | EWLGWLNTIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPFLWVLFVL | ATLENIFVLS | VFCLHKSSCT | VAEIYLGNLA | AADLILACGL | PFWAITISNN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FDWLFGETLC | RVVNAIISMN | LYSSICFLML | VSIDRYLALV | KTMSMGRMRG | VRWAKLYSLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IWGCTLLLSS | PMLVFRTMKE | YSDEGHNVTA | CVISYPSLIW | EVFTNMLLNV | VGFLLPLSVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TFCTMQIMQV | LRNNEMQKFK | EIQTERRATV | LVLVVLLLFI | ICWLPFQIST | FLDTLHRLGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSSCQDERII | DVITQIASFM | AYSNSCLNPL | VYVIVGKRFR | KKSWEVYQGV | CQKGGCRSEP |
| 370 | 380 | 390 | |||
| IQMENSMGTL | RTSISVERQI | HKLQDWAGSR | Q |