P35414
PR
Gene name |
APLNR (AGTRL1, APJ) |
Protein name |
Apelin receptor |
Names |
Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:187 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
13 structures for P35414
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2LOT | NMR | - | A | 1-55 | PDB |
| 2LOU | NMR | - | A | 1-55 | PDB |
| 2LOV | NMR | - | A | 1-55 | PDB |
| 2LOW | NMR | - | A | 1-55 | PDB |
| 5VBL | X-ray | 260 A | PDB | ||
| 6KNM | X-ray | 320 A | PDB | ||
| 7SUS | X-ray | 270 A | PDB | ||
| 7W0L | EM | 357 A | Q/R | 2-330 | PDB |
| 7W0M | EM | 371 A | R | 2-330 | PDB |
| 7W0N | EM | 421 A | Q/R | 2-330 | PDB |
| 7W0O | EM | 378 A | R | 2-330 | PDB |
| 7W0P | EM | 316 A | R | 2-330 | PDB |
| AF-P35414-F1 | Predicted | AlphaFoldDB |
353 variants for P35414
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs897353100 CA222674832 |
4 | G>R | No |
ClinGen TOPMed |
|
|
CA6002958 rs760885266 |
9 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1036113404 CA222674798 |
9 | N>I | No |
ClinGen TOPMed |
|
| TCGA novel | 9 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380544900 rs1372426063 |
11 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1461556030 CA380544906 |
11 | Y>H | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 13 | A>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs184417795 CA222674757 |
14 | D>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6002955 rs749004527 |
15 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1192596408 CA380544822 |
17 | S>T | No |
ClinGen TOPMed |
|
|
rs747713707 CA6002952 |
18 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs769341289 CA6002953 |
18 | E>V | No |
ClinGen ExAC |
|
|
rs1565021402 CA380544769 |
20 | E>D | No |
ClinGen Ensembl |
|
|
CA380544742 rs1480062263 |
22 | T>I | No |
ClinGen gnomAD |
|
|
rs1193505336 CA380544748 |
22 | T>S | No |
ClinGen gnomAD |
|
|
CA222674736 rs866747209 |
23 | D>N | No |
ClinGen Ensembl |
|
|
CA6002950 rs754947275 |
23 | D>V | No |
ClinGen ExAC gnomAD |
|
|
CA380544711 rs1201123037 |
24 | W>* | No |
ClinGen gnomAD |
|
|
CA380544691 rs564912523 |
25 | K>N | No |
ClinGen 1000Genomes TOPMed |
|
|
rs780061917 CA6002948 |
27 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA380544649 rs1332991096 |
29 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA222674703 rs1050060678 |
30 | L>F | No |
ClinGen TOPMed |
|
|
rs1288585000 CA380544622 |
31 | I>N | No |
ClinGen TOPMed |
|
|
CA6002945 COSM1746338 rs765581418 |
33 | A>T | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs765076382 CA222674685 |
36 | M>I | No |
ClinGen Ensembl |
|
|
rs757373811 CA6002944 |
36 | M>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 36 | M>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA222674684 rs192352340 |
38 | V>I | No |
ClinGen 1000Genomes TOPMed |
|
|
rs923143520 CA222674679 |
40 | L>F | No |
ClinGen TOPMed |
|
|
rs764453655 CA6002942 |
41 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002939 rs767906014 |
44 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 47 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1238295474 CA380544414 |
47 | G>S | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 48 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380544395 rs1460332643 |
49 | V>M | No |
ClinGen gnomAD |
|
|
rs776263345 CA6002934 |
50 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA6002933 rs768473688 |
51 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA380544343 rs145108815 CA380544342 |
53 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs145108815 CA6002931 RCV000906400 |
53 | V>M | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs745691280 CA222674591 |
55 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002929 rs745691280 |
55 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs200201854 CA6002930 |
55 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6002928 rs779214361 |
56 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs753846480 CA6002926 COSM3415989 |
58 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs370702287 CA6002927 |
58 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA380544251 rs1156413531 |
60 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA380544242 rs1452552982 |
61 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1380549490 CA380544239 |
61 | R>K | No |
ClinGen gnomAD |
|
|
CA6002925 rs142394789 |
62 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs756545642 CA6002924 |
64 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA6002923 rs753248942 |
67 | F>S | No |
ClinGen ExAC gnomAD |
|
|
CA6002921 rs376527330 |
72 | A>E | No |
ClinGen ESP ExAC gnomAD |
|
|
CA6002920 rs376527330 |
72 | A>V | No |
ClinGen ESP ExAC gnomAD |
|
|
CA380544081 rs1308815903 |
74 | A>V | No |
ClinGen gnomAD |
|
|
rs761594364 CA6002917 |
77 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs138423122 CA380544027 |
78 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs144634263 CA6002914 |
79 | V>M | No |
ClinGen ESP ExAC gnomAD |
|
|
rs538356535 CA6002913 |
81 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs994466745 CA222674531 |
86 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA222674526 rs752803395 |
89 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002905 rs752803395 |
89 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752803395 CA6002906 |
89 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002902 rs751917695 |
90 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
CA222674520 rs751917695 |
90 | Y>N | No |
ClinGen ExAC gnomAD |
|
|
CA6002900 rs374221224 |
91 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6002901 rs200935550 |
91 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 92 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs763688175 CA6002898 |
93 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs753483177 CA6002899 |
93 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
rs760167700 CA6002897 |
94 | D>A | No |
ClinGen ExAC gnomAD |
|
|
CA6002896 rs767552266 |
94 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380543802 rs763318766 |
96 | P>A | No |
ClinGen Ensembl |
|
|
CA380543800 rs763318766 |
96 | P>S | No |
ClinGen Ensembl |
|
|
rs374473031 CA6002894 |
99 | T>N | No |
ClinGen ESP ExAC gnomAD |
|
|
rs527725306 CA222674451 |
104 | L>F | No |
ClinGen 1000Genomes |
|
|
rs749056077 CA6002891 |
105 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA6002890 rs773442045 |
106 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA380543650 rs1590545274 |
107 | Y>S | No |
ClinGen Ensembl |
|
|
CA380543629 rs1173064610 |
109 | I>N | No |
ClinGen TOPMed |
|
| TCGA novel | 111 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs748168275 CA6002888 |
111 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA380543564 rs1296542035 |
113 | M>I | No |
ClinGen TOPMed |
|
|
CA6002887 rs781306328 |
113 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA380543571 rs1394966975 |
113 | M>T | No |
ClinGen gnomAD |
|
|
CA6002886 rs755448440 |
114 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
rs1197749607 CA380543541 |
115 | A>D | No |
ClinGen gnomAD |
|
|
CA6002884 rs780449482 |
115 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs750760773 CA6002882 COSM1245187 |
117 | V>I | Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs772810549 CA6002881 |
121 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs752254107 CA6002879 |
122 | G>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs753116544 CA6002878 |
123 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA380543433 rs1590545209 |
124 | S>R | No |
ClinGen Ensembl |
|
| TCGA novel | 126 | D>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs766255831 CA6002875 |
126 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA6002874 rs762740856 |
127 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM93871 CA6002873 rs772893901 |
127 | R>H | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
| TCGA novel | 130 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380543325 rs1466560631 |
132 | V>A | No |
ClinGen gnomAD |
|
|
CA6002871 rs562689168 |
132 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776670797 CA380543317 |
133 | R>K | No |
ClinGen ExAC gnomAD |
|
|
CA6002870 rs776670797 |
133 | R>M | No |
ClinGen ExAC gnomAD |
|
|
CA380543291 rs1469614549 |
136 | A>S | No |
ClinGen gnomAD |
|
|
rs1193200316 CA380543272 |
138 | A>V | No |
ClinGen gnomAD |
|
|
rs780546020 CA6002867 |
139 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA6002868 rs770716889 |
139 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1458114226 CA380543265 |
140 | L>P | No |
ClinGen gnomAD |
|
|
CA380543263 rs1590545160 |
141 | R>G | No |
ClinGen Ensembl |
|
|
CA6002866 rs200833984 |
143 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA380543250 rs1201535000 COSM1704007 |
143 | R>W | skin [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA380543242 rs1590545135 |
144 | V>G | No |
ClinGen Ensembl |
|
|
rs1424540556 CA380543230 |
146 | G>E | No |
ClinGen TOPMed |
|
|
CA6002863 rs755793037 |
146 | G>R | Variant assessed as Somatic; 4.813e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs576092494 CA222674311 |
148 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs576092494 CA6002861 |
148 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 149 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs751033294 CA6002859 |
150 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA6002857 rs373482292 |
151 | A>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 151 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380543197 rs1590545094 |
152 | V>G | No |
ClinGen Ensembl |
|
|
CA380543195 rs747848269 |
153 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs747848269 CA222674297 |
153 | L>I | No |
ClinGen gnomAD |
|
|
CA380543177 rs1590545089 |
155 | V>G | No |
ClinGen Ensembl |
|
|
CA6002856 rs552008634 |
157 | A>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 157 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs761618705 CA6002854 |
158 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002853 rs776795599 |
158 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA6002851 rs760691556 |
159 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772632870 CA6002849 |
160 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA380543156 rs1237794048 |
160 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs746406904 CA6002848 |
161 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
rs1280191295 CA380543141 |
162 | M>I | No |
ClinGen TOPMed |
|
|
CA222674235 rs771369044 |
163 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380543136 rs1219170438 |
163 | P>L | No |
ClinGen TOPMed |
|
|
CA6002846 rs771369044 |
163 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380543135 rs1410486842 |
164 | V>I | No |
ClinGen Ensembl |
|
|
CA6002845 rs749698318 |
165 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA6002844 rs780922972 |
166 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA380543117 rs780922972 |
166 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs373170562 COSM1354728 CA6002843 |
168 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6002842 rs746176980 |
168 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746176980 CA222674209 |
168 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002841 rs746176980 |
168 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380543104 rs1297186852 |
169 | T>N | No |
ClinGen gnomAD |
|
|
CA222674202 rs867095656 |
170 | T>I | No |
ClinGen Ensembl |
|
|
CA380543095 rs761532425 |
171 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761532425 CA6002837 |
171 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs369317042 CA222674190 CA6002838 |
171 | G>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA6002835 rs764290440 |
172 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs771174826 CA222674167 |
173 | L>V | No |
ClinGen Ensembl |
|
|
CA380543066 rs760876917 |
175 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 175 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775613142 CA6002833 |
177 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA6002832 rs200422749 |
178 | K>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA6002831 rs759679942 |
179 | V>E | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 180 | Q>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6002830 rs147862659 |
180 | Q>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA380543041 rs1367901533 |
180 | Q>K | No |
ClinGen TOPMed |
|
|
CA222674099 rs1005685932 |
180 | Q>R | No |
ClinGen TOPMed |
|
|
CA380543016 rs1219421947 |
183 | M>T | No |
ClinGen TOPMed |
|
|
rs778339271 CA6002827 |
183 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA6002826 rs768419160 |
184 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746680863 CA6002825 |
186 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA380542982 rs1288897691 |
188 | V>M | No |
ClinGen gnomAD |
|
|
rs1322779715 CA380542969 |
190 | T>A | No |
ClinGen gnomAD |
|
|
rs1366574383 CA380542966 |
190 | T>S | No |
ClinGen gnomAD |
|
|
CA380542927 rs1315517697 |
196 | A>P | No |
ClinGen gnomAD |
|
|
rs757807794 CA6002823 |
196 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs201345085 CA6002822 |
197 | W>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs61731623 CA380542907 |
198 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002820 rs748878685 |
199 | V>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1214148172 CA380542905 |
199 | V>M | No |
ClinGen TOPMed |
|
|
rs375325181 CA222673967 |
201 | L>V | No |
ClinGen ESP |
|
|
CA222673963 rs987592819 |
202 | G>R | No |
ClinGen Ensembl |
|
|
rs763920197 CA6002818 |
203 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs202019294 CA6002816 |
204 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6002817 rs202019294 |
204 | S>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs759463806 CA6002814 |
205 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380542871 rs1590544856 |
206 | T>P | No |
ClinGen Ensembl |
|
|
rs766977824 CA6002812 |
206 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA6002809 rs376646370 |
208 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6002810 COSM429269 rs376646370 |
208 | V>M | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1000614668 CA222673906 |
209 | G>V | No |
ClinGen gnomAD |
|
|
CA6002808 rs748576901 |
211 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs532639542 COSM429268 CA222673897 |
215 | T>I | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs1354695548 CA380542812 |
216 | I>V | No |
ClinGen gnomAD |
|
|
rs1565194332 CA380542790 |
219 | T>S | No |
ClinGen Ensembl |
|
|
CA6002805 rs771771159 |
220 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1565194327 CA599792486 |
221 | Y>* | No |
ClinGen Ensembl |
|
|
rs538012075 CA6002804 |
222 | F>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6002803 rs778464649 |
223 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380542751 rs144399813 |
224 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs749277146 CA6002801 |
225 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA6002800 rs140463390 |
225 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA380542733 rs1280620140 |
227 | T>I | No |
ClinGen TOPMed |
|
|
rs755821341 CA6002799 |
228 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA380542726 rs767575528 |
229 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002797 rs767575528 |
229 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs755284432 CA6002796 |
230 | G>C | No |
ClinGen ExAC gnomAD |
|
|
rs200672348 COSM192517 CA6002795 |
233 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs147193169 CA6002794 |
233 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs147193169 COSM93870 CA222673824 |
233 | R>L | lung [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA222673819 rs771201022 |
235 | E>D | No |
ClinGen gnomAD |
|
|
rs763530854 CA6002793 |
235 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM4165836 CA6002792 rs758461358 |
236 | R>C | kidney [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA380542682 rs758461358 |
236 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199589565 CA6002790 |
236 | R>H | Variant assessed as Somatic; 0.0005552 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs199589565 CA6002791 |
236 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs777114356 CA6002789 |
237 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs745562987 CA6002787 |
238 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA6002785 rs373939726 |
239 | G>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1446138644 CA380542666 |
239 | G>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs373939726 CA6002786 |
239 | G>S | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1164709176 CA380542663 |
240 | L>M | No |
ClinGen TOPMed |
|
|
CA6002782 rs139313864 COSM1289575 |
241 | R>Q | Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6002783 rs150001803 |
241 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6002780 rs781106110 |
242 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751878030 CA6002778 |
243 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751878030 CA222673782 |
243 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755123915 CA6002779 |
243 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs150819843 CA6002777 |
244 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6002776 rs758486436 |
244 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373852614 CA6002775 |
245 | R>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
CA380542641 rs1181111316 |
245 | R>W | No |
ClinGen gnomAD |
|
|
CA6002774 rs765646849 |
248 | S>I | No |
ClinGen ExAC gnomAD |
|
|
rs376442198 CA6002770 |
251 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376442198 CA6002771 |
251 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1590544659 CA380542597 |
252 | V>G | No |
ClinGen Ensembl |
|
|
CA380542587 rs1590544646 |
254 | V>G | No |
ClinGen Ensembl |
|
|
CA380542590 rs761642013 |
254 | V>L | No |
ClinGen gnomAD |
|
|
rs761642013 CA222673714 |
254 | V>M | No |
ClinGen gnomAD |
|
|
rs1590544645 CA380542581 |
255 | V>G | No |
ClinGen Ensembl |
|
|
CA222673698 rs998772870 |
256 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs770578460 CA6002768 |
256 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA380542572 rs1233100457 |
257 | F>S | No |
ClinGen TOPMed |
|
|
CA380542564 rs1296027554 |
258 | A>G | No |
ClinGen gnomAD |
|
|
CA6002767 rs762395563 |
258 | A>S | No |
ClinGen ExAC TOPMed |
|
| TCGA novel | 260 | C>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 262 | M>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs772839486 CA6002766 |
264 | Y>H | No |
ClinGen ExAC TOPMed |
|
|
rs192803923 CA6002764 |
266 | L>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA380542502 rs1590544597 |
267 | V>G | No |
ClinGen Ensembl |
|
|
rs140178173 COSM1746337 CA6002761 |
269 | T>M | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs780827696 CA6002762 |
269 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA380542480 rs1444551373 |
271 | Y>D | No |
ClinGen TOPMed gnomAD |
|
|
CA380542470 rs1216211812 |
272 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs953514421 CA222673625 |
272 | M>L | No |
ClinGen TOPMed |
|
|
CA222673622 rs953514421 |
272 | M>V | No |
ClinGen TOPMed |
|
|
COSM1509128 CA380542462 rs1288189384 |
274 | G>S | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA6002755 rs757679361 |
275 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA380542444 rs754319102 |
277 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs754319102 CA6002754 |
277 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA222673607 rs759267329 |
278 | H>Y | No |
ClinGen TOPMed |
|
|
CA380542420 rs1565194211 |
280 | P>L | No |
ClinGen Ensembl |
|
|
rs764535445 CA6002753 |
280 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs373559419 CA6002751 |
282 | D>E | No |
ClinGen ESP ExAC gnomAD |
|
|
rs143772778 CA6002752 |
282 | D>Y | No |
ClinGen ESP ExAC TOPMed |
|
|
rs1590544516 CA380542393 |
284 | D>A | No |
ClinGen Ensembl |
|
|
CA6002750 rs766005445 |
284 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1275880431 CA380542388 |
285 | L>F | No |
ClinGen gnomAD |
|
|
CA380542383 rs1356693715 |
286 | F>L | No |
ClinGen TOPMed |
|
|
rs762662661 CA6002749 |
286 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs1360794864 CA380542375 |
287 | L>F | No |
ClinGen gnomAD |
|
|
CA6002747 rs769396825 |
290 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 292 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1029675040 CA222673518 |
294 | C>Y | No |
ClinGen Ensembl |
|
|
rs200012705 CA6002742 |
295 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200012705 CA6002741 |
295 | T>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA380542318 rs746785866 |
295 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA6002743 rs746785866 |
295 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA380542316 rs1193417962 |
296 | C>S | No |
ClinGen gnomAD |
|
|
CA380542305 rs1478236158 |
297 | I>N | No |
ClinGen gnomAD |
|
|
CA678577390 rs1277723533 COSM399639 |
299 | Y>* | lung [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA222673470 rs187940540 |
299 | Y>H | No |
ClinGen 1000Genomes |
|
|
COSM1354726 CA6002739 VAR_049375 RCV000967201 rs7943508 |
300 | V>I | large_intestine [Cosmic] | No |
ClinGen cosmic curated ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
| TCGA novel | 302 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1020310646 CA222673440 |
303 | C>G | No |
ClinGen Ensembl |
|
|
CA380542254 rs1208391519 |
304 | L>P | No |
ClinGen TOPMed |
|
|
rs749336314 CA6002737 |
306 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002738 rs749336314 |
306 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002736 rs778198836 |
308 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA380542216 rs1192010648 |
310 | A>G | No |
ClinGen TOPMed |
|
|
rs1478425596 CA380542219 |
310 | A>T | No |
ClinGen Ensembl |
|
|
CA380542212 rs1217801777 |
311 | F>L | No |
ClinGen gnomAD |
|
|
rs1371023630 CA380542204 |
312 | F>L | No |
ClinGen TOPMed |
|
|
rs1590544456 CA380542195 |
313 | D>A | No |
ClinGen Ensembl |
|
|
CA6002733 rs767911833 |
313 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA6002731 rs764829178 |
314 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002730 rs764829178 |
314 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002728 rs137997556 COSM928532 |
315 | R>C | endometrium central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs137997556 CA6002729 |
315 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760732461 CA6002726 |
315 | R>H | Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs760732461 CA6002727 |
315 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA380542183 rs1170323244 |
316 | F>I | No |
ClinGen gnomAD |
|
|
CA6002725 COSM1354725 rs777561476 |
317 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
COSM192516 CA6002724 rs200854787 |
317 | R>H | Variant assessed as Somatic; 4.624e-05 impact. large_intestine breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 319 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380542155 rs1324943024 |
320 | C>S | No |
ClinGen TOPMed |
|
|
rs771075684 CA6002721 |
321 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA380542150 rs1590544407 |
321 | T>P | No |
ClinGen Ensembl |
|
| TCGA novel | 323 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6002720 rs749377510 |
324 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs377391271 CA222673362 |
326 | C>Y | No |
ClinGen ESP TOPMed |
|
|
CA380542096 rs1318397404 |
329 | S>G | No |
ClinGen gnomAD |
|
|
rs748705793 CA6002717 |
330 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA6002716 rs755331397 |
330 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs755331397 CA6002715 |
330 | R>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1590544368 CA380542084 |
331 | C>G | No |
ClinGen Ensembl |
|
|
CA380542075 rs764929700 |
332 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002713 rs764929700 |
332 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs140133715 CA6002711 |
333 | G>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs140133715 CA6002710 |
333 | G>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1590544343 CA380542067 |
334 | T>P | No |
ClinGen Ensembl |
|
|
CA6002708 rs775524444 |
336 | H>L | No |
ClinGen ExAC gnomAD |
|
|
rs767562498 CA6002707 |
337 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs759321946 CA6002706 |
338 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA222673328 rs1003344965 |
339 | S>C | No |
ClinGen TOPMed |
|
|
rs1590544308 CA380542019 |
341 | E>G | No |
ClinGen Ensembl |
|
|
rs866459668 CA222673326 |
341 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs544631342 CA6002704 |
343 | S>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA380542001 rs1278754872 |
344 | A>T | No |
ClinGen gnomAD |
|
|
CA380541996 rs1174323988 |
344 | A>V | No |
ClinGen gnomAD |
|
|
CA222673286 rs899069343 |
345 | S>G | No |
ClinGen Ensembl |
|
|
CA380541976 rs1565194104 |
347 | S>C | No |
ClinGen Ensembl |
|
|
CA6002702 rs369393051 |
348 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA380541973 rs1378380084 |
348 | S>P | No |
ClinGen gnomAD |
|
|
CA6002700 rs748258607 |
351 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002699 rs781612967 |
352 | Q>E | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 352 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1382995541 CA380541935 |
354 | P>S | No |
ClinGen TOPMed |
|
|
CA222673271 rs987154596 |
355 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA222673268 rs1048402746 COSM1509129 |
356 | P>T | lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA380541909 rs1309136222 |
358 | M>L | No |
ClinGen gnomAD |
|
|
CA6002695 rs146062493 |
360 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs753489933 CA6002694 |
361 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6002693 rs777596520 |
364 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA380541855 rs1336454338 |
365 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1359961228 CA380541860 |
365 | M>K | No |
ClinGen gnomAD |
|
|
CA380541848 rs142294759 |
366 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs755614745 CA6002692 |
366 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA6002690 rs767481092 COSM96302 |
367 | E>K | lung Variant assessed as Somatic; 0.0 impact. skin [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA380541833 rs1213912764 |
368 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA380541824 rs1252038071 |
370 | I>F | No |
ClinGen TOPMed |
|
|
rs1375964948 CA380541814 |
371 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA380541815 rs1375964948 |
371 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA380541799 rs1410072622 |
373 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs375912159 CA222673230 |
374 | Q>* | No |
ClinGen ESP TOPMed |
|
|
CA380541796 rs375912159 |
374 | Q>E | No |
ClinGen ESP TOPMed |
|
|
CA380541794 rs1179892614 |
374 | Q>R | No |
ClinGen gnomAD |
|
| TCGA novel | 375 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380541786 rs1472375388 |
375 | E>G | No |
ClinGen gnomAD |
|
| TCGA novel | 376 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1237677209 CA380541773 |
377 | L>P | No |
ClinGen gnomAD |
|
|
CA6002687 rs766139270 |
379 | V>G | No |
ClinGen ExAC gnomAD |
No associated diseases with P35414
1 regional properties for P35414
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 63 - 358 | IPR017452 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| apelin receptor activity | Combining with the peptide apelin to initiate a change in cell activity. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| signaling receptor activity | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
27 GO annotations of biological process
| Name | Definition |
|---|---|
| adult heart development | The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. |
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| aorta development | The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. |
| apelin receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by apelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| atrioventricular valve development | The progression of the atrioventricular valve over time, from its formation to the mature structure. |
| blood vessel development | The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. |
| coronary vasculature development | The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. |
| endocardial cushion formation | The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| gastrulation | A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| heart looping | The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. |
| negative regulation of cAMP-mediated signaling | Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. |
| positive regulation of histone deacetylation | Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. |
| positive regulation of inhibitory G protein-coupled receptor phosphorylation | Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation. |
| positive regulation of release of sequestered calcium ion into cytosol | Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. |
| regulation of body fluid levels | Any process that modulates the levels of body fluids. |
| regulation of gap junction assembly | Any process that modulates the frequency, rate or extent of gap junction assembly. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| vascular associated smooth muscle cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. |
| vasculature development | The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. |
| vasculogenesis | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
| venous blood vessel development | The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. |
| ventricular septum morphogenesis | The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. |
120 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| P30411 | BDKRB2 | B2 bradykinin receptor | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEGGDFDNY | YGADNQSECE | YTDWKSSGAL | IPAIYMLVFL | LGTTGNGLVL | WTVFRSSREK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRSADIFIAS | LAVADLTFVV | TLPLWATYTY | RDYDWPFGTF | FCKLSSYLIF | VNMYASVFCL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TGLSFDRYLA | IVRPVANARL | RLRVSGAVAT | AVLWVLAALL | AMPVMVLRTT | GDLENTTKVQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CYMDYSMVAT | VSSEWAWEVG | LGVSSTTVGF | VVPFTIMLTC | YFFIAQTIAG | HFRKERIEGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKRRRLLSII | VVLVVTFALC | WMPYHLVKTL | YMLGSLLHWP | CDFDLFLMNI | FPYCTCISYV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSCLNPFLYA | FFDPRFRQAC | TSMLCCGQSR | CAGTSHSSSG | EKSASYSSGH | SQGPGPNMGK |
| 370 | |||||
| GGEQMHEKSI | PYSQETLVVD |