O43613
PR
Gene name |
HCRTR1 |
Protein name |
Orexin/Hypocretin receptor type 1 |
Names |
Hypocretin receptor type 1, Orexin receptor type 1, Ox-1-R, Ox1-R, Ox1R |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:3061 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
15 structures for O43613
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4ZJ8 | X-ray | 275 A | PDB | ||
| 4ZJC | X-ray | 283 A | PDB | ||
| 6TO7 | X-ray | 226 A | A/B | 28-380 | PDB |
| 6TOD | X-ray | 211 A | A/B | 28-380 | PDB |
| 6TOS | X-ray | 213 A | A/B | 28-380 | PDB |
| 6TOT | X-ray | 222 A | A/B | 28-380 | PDB |
| 6TP3 | X-ray | 304 A | A/B | 28-380 | PDB |
| 6TP4 | X-ray | 301 A | A/B | 28-380 | PDB |
| 6TP6 | X-ray | 234 A | A/B | 28-380 | PDB |
| 6TQ4 | X-ray | 230 A | A/B | 28-380 | PDB |
| 6TQ6 | X-ray | 255 A | A/B | 28-380 | PDB |
| 6TQ7 | X-ray | 266 A | A/B | 28-380 | PDB |
| 6TQ9 | X-ray | 265 A | A/B | 28-381 | PDB |
| 6V9S | X-ray | 350 A | PDB | ||
| AF-O43613-F1 | Predicted | AlphaFoldDB |
349 variants for O43613
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA339581932 rs1313372688 |
4 | S>L | No |
ClinGen TOPMed |
|
|
CA339581940 rs1459296580 |
5 | A>V | No |
ClinGen gnomAD |
|
|
CA731801 rs761959271 |
6 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs111829370 CA20170600 |
7 | P>L | No |
ClinGen Ensembl |
|
|
CA339581954 rs1409834318 |
8 | G>E | No |
ClinGen gnomAD |
|
|
CA339581952 rs1315649201 |
8 | G>R | No |
ClinGen TOPMed |
|
|
CA339581970 rs1309331576 |
10 | Q>H | No |
ClinGen gnomAD |
|
|
CA731802 rs766478266 |
12 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs759338759 CA731806 |
13 | V>A | No |
ClinGen ExAC |
|
|
CA731803 rs751534374 |
13 | V>F | No |
ClinGen ExAC |
|
|
CA339581988 rs759338759 |
13 | V>G | No |
ClinGen ExAC |
|
| TCGA novel | 14 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA731808 rs752397479 |
15 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs768602707 | 15 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA20170626 rs752397479 |
15 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339582002 rs1557575618 |
16 | G>D | No |
ClinGen Ensembl |
|
|
CA731809 rs755833014 |
17 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs763715743 CA731810 |
18 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs753404874 CA731811 |
19 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA339582028 rs1482342936 |
20 | P>L | No |
ClinGen gnomAD |
|
|
CA731813 rs778327712 |
20 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA339582030 rs1269592384 |
21 | S>T | No |
ClinGen TOPMed |
|
|
rs1257155351 CA339582042 |
22 | P>R | No |
ClinGen gnomAD |
|
|
CA339582038 rs1414591897 |
22 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs11806980 CA731815 |
23 | V>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA339582054 rs1389417121 |
24 | P>L | No |
ClinGen gnomAD |
|
|
CA339582072 rs1170485085 |
27 | Y>C | No |
ClinGen gnomAD |
|
|
CA731816 rs147617240 |
27 | Y>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA731817 rs199831745 |
28 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs867602036 CA20170648 |
29 | D>N | No |
ClinGen Ensembl |
|
| TCGA novel | 29 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201961314 CA20170652 |
31 | F>L | No |
ClinGen 1000Genomes |
|
|
rs201585344 CA731818 |
33 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 34 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA731820 rs748302073 |
35 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs776977016 CA731819 |
35 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA731822 rs773381518 |
37 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM3400667 rs200094994 CA731823 COSM2077187 |
37 | R>H | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA339582188 rs1386882985 |
38 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA339582212 rs1338039681 |
39 | Y>F | No |
ClinGen TOPMed |
|
|
rs775406708 CA731825 |
41 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA731826 rs200964238 |
42 | P>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs991617465 CA20170714 |
44 | Q>P | No |
ClinGen TOPMed |
|
|
CA339582294 rs753494411 |
45 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763803560 CA731827 |
45 | Y>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 46 | E>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1186974313 CA339582318 |
47 | W>R | No |
ClinGen gnomAD |
|
| TCGA novel | 49 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA20170727 rs200330803 |
49 | L>P | No |
ClinGen Ensembl |
|
|
CA731833 rs780400386 |
51 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs749859402 CA731832 |
51 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs749859402 CA731831 |
51 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1413340269 CA339582426 |
52 | A>V | No |
ClinGen gnomAD |
|
|
CA339582452 rs1193127266 |
54 | V>M | No |
ClinGen TOPMed |
|
|
rs893440057 CA20170765 |
56 | V>A | No |
ClinGen TOPMed |
|
|
rs893440057 CA339582469 |
56 | V>G | No |
ClinGen TOPMed |
|
|
rs977613822 CA20170759 |
56 | V>M | No |
ClinGen TOPMed |
|
|
CA731837 rs748408361 |
58 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748408361 CA731838 |
58 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731839 rs773384656 |
59 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339582491 rs1570246099 |
60 | A>G | No |
ClinGen Ensembl |
|
|
rs1162394477 CA339582497 |
61 | L>R | No |
ClinGen TOPMed |
|
|
CA731841 rs749309295 |
62 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA339582505 rs1570246142 |
63 | G>C | No |
ClinGen Ensembl |
|
|
rs148898250 CA731842 |
63 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA731843 COSM1502485 rs775286747 |
65 | T>M | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA731845 rs137870169 |
67 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 70 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA20170947 rs973396791 |
70 | A>T | No |
ClinGen TOPMed |
|
|
rs201319457 CA731864 |
71 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs144638017 CA731866 |
73 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA731865 rs776448786 |
73 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731868 rs769541965 |
75 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA339582715 rs1400464628 |
76 | H>R | No |
ClinGen gnomAD |
|
|
CA20170976 rs200691518 |
76 | H>Y | No |
ClinGen Ensembl |
|
|
CA731870 rs762595710 CA339582722 |
77 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA731871 rs765816307 |
77 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1212423671 CA339582746 |
78 | R>S | No |
ClinGen TOPMed |
|
|
CA731873 rs372750162 |
80 | V>I | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1412039491 CA339582784 |
81 | T>I | No |
ClinGen gnomAD |
|
| TCGA novel | 82 | N>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA20170992 rs1046702865 |
82 | N>Y | No |
ClinGen Ensembl |
|
|
CA339582805 rs1557576061 |
83 | Y>D | No |
ClinGen Ensembl |
|
|
CA731874 rs768118872 |
85 | I>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 87 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1368005577 CA339582844 |
87 | N>Y | No |
ClinGen gnomAD |
|
|
rs1177748766 CA339582859 |
89 | S>C | No |
ClinGen TOPMed |
|
|
rs1307483513 CA339582856 |
89 | S>P | No |
ClinGen gnomAD |
|
|
CA731876 rs188180909 |
90 | L>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs778134490 CA731877 |
92 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339582878 rs778134490 |
92 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339582891 rs1228707208 |
93 | V>D | No |
ClinGen gnomAD |
|
|
rs75232948 CA731879 |
93 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA731880 rs778890336 |
98 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs200024185 COSM1687320 CA20171054 |
101 | P>L | Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA731881 rs745916428 |
101 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA339583028 rs1412406186 |
105 | L>P | No |
ClinGen TOPMed |
|
|
CA339583033 rs1557576174 |
106 | V>M | No |
ClinGen Ensembl |
|
|
rs545611444 CA731885 |
107 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339583068 rs1446574530 |
109 | T>P | No |
ClinGen TOPMed |
|
|
CA339583094 rs1472634746 |
111 | S>P | No |
ClinGen gnomAD |
|
|
CA339583117 rs1340646124 |
112 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
CA20171070 rs954874190 |
112 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
CA339583144 rs1387534892 |
114 | F>L | No |
ClinGen gnomAD |
|
|
rs1272754440 CA339583152 |
115 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs772997908 CA731886 |
115 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731889 rs774057685 |
122 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs374268108 CA731891 |
124 | Y>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1316880316 CA339583291 |
126 | Q>* | No |
ClinGen gnomAD |
|
|
rs200336907 CA731892 |
126 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA731912 rs201495028 |
127 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA20171694 rs201495028 |
127 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1480833211 CA339583422 |
127 | A>V | No |
ClinGen gnomAD |
|
|
rs762221684 CA731913 |
128 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199934518 COSM1254003 CA731915 |
130 | V>M | oesophagus [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs758555572 CA731916 |
132 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1384975368 CA339583488 |
133 | A>T | No |
ClinGen gnomAD |
|
|
CA20171730 rs201018126 |
134 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs201018126 CA731918 |
134 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs766465690 CA731917 |
134 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA339583520 rs1383440418 |
136 | T>A | No |
ClinGen gnomAD |
|
|
rs201877636 CA20171740 |
136 | T>S | No |
ClinGen Ensembl |
|
|
CA731922 rs757082425 |
141 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1487077579 CA339583585 |
141 | A>V | No |
ClinGen gnomAD |
|
|
rs778794988 CA731923 |
144 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs1267298387 CA339583601 |
144 | R>H | No |
ClinGen gnomAD |
|
|
CA339583603 rs1267298387 |
144 | R>L | No |
ClinGen gnomAD |
|
|
rs745537980 CA731924 |
145 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs201925923 CA20171807 |
147 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
CA339583623 rs201925923 |
147 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA339583628 rs1160159351 |
148 | I>N | No |
ClinGen gnomAD |
|
|
rs1233604992 CA339583646 |
150 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA20171840 rs200634924 |
151 | P>L | No |
ClinGen Ensembl |
|
|
rs1004014305 CA20171839 |
151 | P>T | No |
ClinGen Ensembl |
|
|
CA20171848 rs1056564939 |
152 | L>P | No |
ClinGen Ensembl |
|
|
rs1406187931 CA339583675 |
154 | F>S | No |
ClinGen gnomAD |
|
|
rs770155110 CA339583698 |
155 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs773512118 CA731932 |
156 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA731933 rs201449126 |
157 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA339583739 rs1308759789 |
158 | A>V | No |
ClinGen gnomAD |
|
|
rs767432563 CA731937 |
159 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA731935 rs751652807 |
159 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs757214467 CA731939 |
160 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731938 rs202061731 |
160 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA339583772 rs1239300181 |
161 | A>D | No |
ClinGen gnomAD |
|
|
CA731940 rs201910139 |
162 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201910139 CA339583781 |
162 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200191728 CA731941 |
162 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs758173191 CA731942 |
163 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA20171881 rs1023671004 |
165 | I>M | No |
ClinGen TOPMed |
|
|
rs1261571020 CA339583836 |
166 | L>P | No |
ClinGen Ensembl |
|
|
VAR_044505 CA731943 rs144603792 |
167 | G>S | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1245566334 CA339583889 |
170 | A>P | No |
ClinGen TOPMed |
|
|
rs1334589329 CA339583908 |
171 | V>A | No |
ClinGen TOPMed |
|
|
CA339583916 rs1032824028 |
172 | S>A | No |
ClinGen TOPMed |
|
|
rs1032824028 CA20171887 |
172 | S>P | No |
ClinGen TOPMed |
|
|
CA731944 rs746566291 |
172 | S>W | No |
ClinGen ExAC gnomAD |
|
|
CA339583936 rs780506804 |
174 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA731946 rs780506804 |
174 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA339583953 rs1426474145 |
175 | I>V | No |
ClinGen gnomAD |
|
|
CA731948 rs770241325 |
176 | M>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA20171923 rs770241325 |
176 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200440142 CA731947 |
176 | M>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1462071961 CA339583981 |
177 | V>M | No |
ClinGen gnomAD |
|
|
rs1322976043 CA339584013 |
179 | Q>* | No |
ClinGen TOPMed |
|
|
rs1322976043 CA339584011 |
179 | Q>E | No |
ClinGen TOPMed |
|
|
CA20171934 rs919621513 |
180 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA20171935 rs929860902 |
180 | A>V | No |
ClinGen Ensembl |
|
|
CA731953 rs774639908 |
183 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs199572096 CA731952 |
183 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 183 | M>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs982714218 CA20171939 |
184 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
CA731954 rs759622920 |
185 | C>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 187 | S>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1268188631 CA339584125 |
188 | V>E | No |
ClinGen TOPMed |
|
|
CA339584159 rs1200162931 |
191 | E>G | No |
ClinGen gnomAD |
|
|
rs1438264979 CA339584179 |
193 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
CA20171958 rs974804393 |
193 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs921646358 CA20171971 |
194 | N>S | No |
ClinGen TOPMed |
|
|
CA20171981 rs530187593 |
195 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs752681555 CA731956 |
195 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs530187593 CA731955 |
195 | R>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA339584236 rs199680510 |
197 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731960 rs199680510 |
197 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs61749523 CA731958 |
197 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA731962 rs751234904 |
200 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA20172004 rs751234904 |
200 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731963 rs754534724 |
203 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA339584398 rs1295959296 |
205 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA731964 rs147546381 |
205 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA339584412 rs147546381 |
205 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1160946715 CA339584463 |
208 | D>H | No |
ClinGen gnomAD |
|
|
rs201964385 CA731980 |
212 | P>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 213 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA731981 rs199860096 |
217 | S>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731982 rs201200117 |
218 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731983 rs202151567 |
223 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777211156 CA731984 |
225 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1372493121 CA339584834 |
228 | L>V | No |
ClinGen TOPMed |
|
|
rs370407845 CA731986 |
229 | G>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1404351736 CA339584903 |
233 | M>I | No |
ClinGen gnomAD |
|
|
rs1348655561 CA339584898 |
233 | M>T | No |
ClinGen gnomAD |
|
|
rs974710591 CA20176608 |
234 | A>T | No |
ClinGen TOPMed |
|
| TCGA novel | 235 | Y>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA339584973 rs1300966648 |
238 | I>M | No |
ClinGen TOPMed |
|
|
rs779375975 CA731987 |
238 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA731988 rs143860521 |
239 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA731989 rs772394538 |
240 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA731990 rs200954759 |
240 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs139788392 CA731992 |
241 | K>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1358624247 CA339585066 |
245 | R>C | No |
ClinGen gnomAD |
|
|
CA731993 rs200636229 |
245 | R>H | Variant assessed as Somatic; 0.0009877 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs374843159 CA732017 |
248 | P>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772807472 CA20177573 |
249 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1204720614 CA339585984 |
251 | T>I | No |
ClinGen gnomAD |
|
|
CA339585996 rs1245415639 |
252 | S>L | No |
ClinGen gnomAD |
|
|
CA732021 rs144550848 |
256 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs187526271 CA732020 |
256 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
rs1193144603 CA339586095 |
259 | K>E | No |
ClinGen gnomAD |
|
|
CA732022 rs368420650 |
260 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM1209369 CA732023 rs199553543 |
260 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed |
|
CA339586179 rs1570252927 |
263 | D>A | No |
ClinGen Ensembl |
|
|
CA20177597 rs372900989 |
264 | Q>H | No |
ClinGen ESP TOPMed |
|
|
CA339586205 rs1275214049 |
264 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
CA732025 rs41501244 |
265 | L>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA732026 rs751937138 |
267 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1470075123 CA339586271 |
268 | L>V | No |
ClinGen gnomAD |
|
|
rs1255400312 CA339586295 |
269 | E>G | No |
ClinGen Ensembl |
|
|
CA20177605 rs926530473 |
269 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA339586364 rs1178311951 |
273 | S>N | No |
ClinGen gnomAD |
|
|
CA339586377 rs1570253042 |
273 | S>R | No |
ClinGen Ensembl |
|
|
CA732027 rs755298261 |
274 | G>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA339586408 CA339586410 rs1318913475 |
275 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs140296272 CA20177621 |
275 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA732028 rs140296272 |
275 | E>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs370775411 CA732029 |
276 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs7516785 CA732032 VAR_033480 RCV000964805 |
279 | R>Q | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs200965303 CA732030 |
279 | R>W | Variant assessed as Somatic; 4.625e-05 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs771966404 CA732033 |
281 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
VAR_044506 rs41439244 CA732034 |
281 | R>H | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs202201419 CA20177652 COSM1209368 |
282 | A>T | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs768365681 CA732036 |
283 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA522360184 rs1448742634 |
287 | V>* | No |
ClinGen gnomAD |
|
|
CA732039 rs764675757 |
288 | K>* | No |
ClinGen ExAC gnomAD |
|
|
rs1042170102 CA20177665 |
289 | Q>R | No |
ClinGen TOPMed |
|
|
rs1265191087 CA339586688 |
290 | M>I | No |
ClinGen TOPMed |
|
|
CA732040 rs749907621 |
290 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA339586703 rs1361829354 |
291 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs200295984 CA732041 |
291 | R>H | Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA732044 rs202152090 |
293 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201360185 CA732043 |
293 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA732045 rs767939002 |
297 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200285087 CA20177694 |
298 | K>E | No |
ClinGen Ensembl |
|
|
rs1406367764 CA339586863 |
301 | M>K | No |
ClinGen gnomAD |
|
|
CA20177699 rs201077101 |
302 | V>M | No |
ClinGen Ensembl |
|
|
rs752887984 CA732046 |
303 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1570253349 CA339586949 |
306 | V>G | No |
ClinGen Ensembl |
|
|
rs200023428 CA732050 |
308 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs912860799 CA20177735 |
310 | C>S | No |
ClinGen Ensembl |
|
|
CA20177738 rs1005780357 |
311 | Y>C | No |
ClinGen TOPMed |
|
|
rs1291095889 CA339587085 |
312 | L>Q | No |
ClinGen gnomAD |
|
|
CA339587102 rs746884559 |
313 | P>H | No |
ClinGen ExAC gnomAD |
|
|
rs746884559 CA732052 |
313 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA339587121 rs1248689404 |
314 | I>T | No |
ClinGen gnomAD |
|
|
rs1418226779 CA339587143 |
315 | S>I | No |
ClinGen gnomAD |
|
|
rs1418226779 CA339587146 |
315 | S>T | No |
ClinGen gnomAD |
|
|
rs776437941 CA732054 |
316 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1365606335 CA339587191 |
318 | N>K | No |
ClinGen gnomAD |
|
|
CA732056 rs769453898 |
318 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA20177752 rs921867316 |
318 | N>Y | No |
ClinGen TOPMed |
|
|
CA732057 rs772642320 |
320 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs762535862 CA732058 |
322 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs139306009 CA732086 |
323 | V>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs188717453 CA732085 |
323 | V>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs781172049 COSM426068 CA732088 |
325 | G>R | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs752499424 CA732089 |
327 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA732090 rs541388873 |
328 | R>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA732091 rs541388873 |
328 | R>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA732092 rs200961371 |
328 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 330 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs564822689 CA732093 |
330 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA20178492 rs77421038 |
332 | D>N | No |
ClinGen Ensembl |
|
|
CA732094 rs145995425 |
333 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA339587612 rs1025311928 |
333 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA20178501 rs1025311928 |
333 | R>P | No |
ClinGen TOPMed gnomAD |
|
|
CA732096 COSM1748348 rs201416198 COSM3930747 |
334 | E>K | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA339587679 rs769086072 |
338 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA732099 rs769086072 |
338 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA732100 rs776939387 |
338 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs980564251 CA20178519 |
341 | T>S | No |
ClinGen Ensembl |
|
|
rs76538520 CA20178520 |
345 | W>* | No |
ClinGen TOPMed gnomAD |
|
|
rs202147376 CA732101 |
347 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs1213500568 CA339587778 |
348 | Y>H | No |
ClinGen gnomAD |
|
|
rs200448936 CA20178528 |
349 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA732103 rs201393960 |
350 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA20178545 rs958763496 |
351 | S>R | No |
ClinGen Ensembl |
|
|
rs763080324 CA339587805 |
352 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA732104 rs763080324 |
352 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1479886483 CA339587822 |
354 | N>K | No |
ClinGen gnomAD |
|
|
rs1199758263 CA339587823 |
355 | P>T | No |
ClinGen gnomAD |
|
|
rs766300509 CA732105 |
357 | I>L | No |
ClinGen ExAC |
|
|
rs1416548546 CA339587855 |
359 | N>T | No |
ClinGen gnomAD |
|
|
CA732106 rs181149943 |
362 | S>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs200880759 CA20178552 |
362 | S>R | No |
ClinGen 1000Genomes |
|
|
rs202193411 CA732128 |
366 | R>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA732127 rs202193411 |
366 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA732126 rs143453875 |
366 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs542908338 CA732129 |
367 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA20179618 rs200921333 |
367 | E>V | No |
ClinGen Ensembl |
|
|
CA732130 rs142508339 |
369 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs759858553 CA732131 |
371 | A>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1435714128 CA339588475 |
372 | A>D | No |
ClinGen gnomAD |
|
| TCGA novel | 373 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1035124863 CA20179633 |
375 | C>Y | No |
ClinGen gnomAD |
|
|
CA732132 rs201493869 |
376 | C>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1383934109 CA339588542 |
378 | P>S | No |
ClinGen gnomAD |
|
|
CA339588571 rs1469311937 |
381 | G>S | No |
ClinGen Ensembl |
|
|
rs75004619 CA20179659 COSM3934666 |
383 | C>* | oesophagus Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs199920679 CA732136 |
384 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA732137 rs781659400 |
388 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs770155053 CA732139 |
390 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA732140 rs553580629 |
390 | S>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs142044591 COSM2077208 CA20179691 |
392 | R>C | lung [Cosmic] | No |
ClinGen cosmic curated ESP TOPMed gnomAD |
|
CA732142 rs201590353 |
392 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs201590353 CA732143 |
392 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs1213578053 CA339588706 |
393 | S>F | No |
ClinGen gnomAD |
|
|
rs977769549 CA339588717 |
395 | A>P | No |
ClinGen gnomAD |
|
|
rs977769549 CA20179694 |
395 | A>T | No |
ClinGen gnomAD |
|
|
rs200071124 CA732144 |
396 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1180591467 CA339588780 |
400 | L>S | No |
ClinGen TOPMed |
|
|
CA732145 rs767638273 |
403 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA732146 rs202108275 |
405 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs201726958 CA732148 |
405 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA732147 rs201726958 |
405 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 408 | I>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs2271933 CA732150 VAR_022063 |
408 | I>V | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs751147274 CA732152 |
409 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1156714789 CA339588886 |
410 | K>T | No |
ClinGen gnomAD |
|
|
rs890640656 CA20179733 |
411 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA732156 rs748673480 |
414 | H>D | No |
ClinGen ExAC gnomAD |
|
|
CA732157 rs756585030 |
415 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756585030 CA339588918 |
415 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778162269 CA732158 |
418 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs377345441 CA732159 |
420 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs377345441 CA339588948 |
420 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA339588962 rs532128130 |
422 | T>K | No |
ClinGen gnomAD |
|
|
CA20179767 rs532128130 |
422 | T>R | No |
ClinGen gnomAD |
|
|
rs774441073 CA732161 |
423 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA339588982 rs1264078522 |
426 | P>R | No |
ClinGen gnomAD |
No associated diseases with O43613
1 regional properties for O43613
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 71 - 396 | IPR017452 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| orexin receptor activity | Combining with orexin to initiate a change in cell activity. |
| peptide hormone binding | Binding to a peptide with hormonal activity in animals. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| feeding behavior | Behavior associated with the intake of food. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| neuropeptide signaling pathway | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| regulation of cytosolic calcium ion concentration | Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. |
119 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPSATPGAQ | MGVPPGSREP | SPVPPDYEDE | FLRYLWRDYL | YPKQYEWVLI | AAYVAVFVVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVGNTLVCLA | VWRNHHMRTV | TNYFIVNLSL | ADVLVTAICL | PASLLVDITE | SWLFGHALCK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VIPYLQAVSV | SVAVLTLSFI | ALDRWYAICH | PLLFKSTARR | ARGSILGIWA | VSLAIMVPQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVMECSSVLP | ELANRTRLFS | VCDERWADDL | YPKIYHSCFF | IVTYLAPLGL | MAMAYFQIFR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLWGRQIPGT | TSALVRNWKR | PSDQLGDLEQ | GLSGEPQPRA | RAFLAEVKQM | RARRKTAKML |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MVVLLVFALC | YLPISVLNVL | KRVFGMFRQA | SDREAVYACF | TFSHWLVYAN | SAANPIIYNF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSGKFREQFK | AAFSCCLPGL | GPCGSLKAPS | PRSSASHKSL | SLQSRCSISK | ISEHVVLTSV |
| TTVLP |