AiPD: Autoinhibited Protein Database

O60883

Gene name	GPR37L1 (ETBRLP2)
Protein name	G-protein coupled receptor 37-like 1
Names	Endothelin B receptor-like protein 2, ETBR-LP-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9283
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-86 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

4-86 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O60883

Entry ID	Method	Resolution	Chain	Position	Source
AF-O60883-F1	Predicted				AlphaFoldDB

436 variants for O60883

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA1329934 rs139398911	2	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139398911 CA1329933	2	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs749150035 CA1329931	2	R>W		No	ClinGen ExAC gnomAD
rs541324374 CA1329935	3	W>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772725811 CA1329936	4	L>R		No	ClinGen ExAC gnomAD
CA344227458 rs1571709431	6	P>A		No	ClinGen Ensembl
rs370527613 CA35466409	6	P>L		No	ClinGen ESP TOPMed
rs1571709444 CA344227464	7	L>P		No	ClinGen Ensembl
rs1400520092 CA344227489	11	L>P		No	ClinGen gnomAD
CA35466455 rs976408606	16	A>V		No	ClinGen Ensembl
rs1311221310 CA344227530	18	G>E		No	ClinGen gnomAD
rs758706461 CA1329943	18	G>R		No	ClinGen ExAC gnomAD
CA1329946 rs147716769	20	S>N		No	ClinGen ESP ExAC gnomAD
CA1329945 rs747153569	20	S>R		No	ClinGen ExAC gnomAD
CA1329947 rs377674188	21	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1571709494 CA344227551	22	V>G		No	ClinGen Ensembl
CA1329949 rs561115649	22	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs561115649 CA1329950	22	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs267598306 CA35466481	24	G>E		No	ClinGen Ensembl
rs771774196 CA1329952	25	G>A		No	ClinGen ExAC gnomAD
rs145080702 CA1329951	25	G>S		No	ClinGen ESP ExAC gnomAD
CA344227581 rs770447580	28	L>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	28	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759964243 CA1329957	29	H>P		No	ClinGen ExAC gnomAD
CA1329956 rs201014592	29	H>Y		No	ClinGen 1000Genomes ExAC
rs753061610 CA1329959	34	R>K		No	ClinGen ExAC gnomAD
rs143016403 CA35466598	35	A>V		No	ClinGen ESP TOPMed gnomAD
rs369524183 CA344227630	36	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369524183 COSM1337879 CA1329961	36	E>K	large_intestine Variant assessed as Somatic; 4.675e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA1329962 rs546366311	37	T>I		No	ClinGen ExAC TOPMed gnomAD
CA1329963 rs546366311	37	T>N		No	ClinGen ExAC TOPMed gnomAD
rs781163292 CA1329964	38	Q>*		No	ClinGen ExAC gnomAD
CA344227658 rs1354886217	40	Q>E		No	ClinGen gnomAD
TCGA novel	40	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344227666 rs1296550711	40	Q>R		No	ClinGen TOPMed
CA1329965 rs750453293	42	S>R		No	ClinGen ExAC gnomAD
rs373409302 CA1329966	43	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs373409302 CA344227713	43	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA344227722 rs778901003	43	R>L		No	ClinGen ExAC TOPMed gnomAD
CA1329967 rs778901003	43	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA35466670 rs553879439	46	R>W		No	ClinGen Ensembl
rs747974048 CA1329968	47	G>S		No	ClinGen ExAC gnomAD
TCGA novel	48	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771829131 CA1329969	49	E>K		No	ClinGen ExAC gnomAD
CA1329970 rs777492681	50	D>G		No	ClinGen ExAC TOPMed gnomAD
CA1329971 rs746692737	51	E>K		No	ClinGen ExAC gnomAD
rs1405764903 CA344227869	52	E>K		No	ClinGen gnomAD
rs776016622 CA1329973	53	A>V		No	ClinGen ExAC gnomAD
rs759064184 CA1329974	54	K>*		No	ClinGen ExAC gnomAD
TCGA novel	55	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1329976 rs140390018	56	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1329977 rs376395326	58	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1169381888 CA344228010	59	Y>C		No	ClinGen gnomAD
TCGA novel	59	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344228036 rs1441983160	61	P>T		No	ClinGen gnomAD
rs1278122389 CA344228068	63	E>K		No	ClinGen TOPMed gnomAD
CA344228099 rs1229386614	64	W>*		No	ClinGen gnomAD
rs764564961 CA1329978	64	W>C		No	ClinGen ExAC gnomAD
rs370435464 CA1329979	65	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1329982 rs750514265	66	E>K		No	ClinGen ExAC gnomAD
CA344228188 COSM1127189 rs1230960248	68	P>L	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA1329983 rs201065708	68	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1329986 rs552502015	69	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1219056911 CA1329984	69	R>W		No	ClinGen TOPMed
CA35466744 rs200257132	70	P>L		No	ClinGen 1000Genomes gnomAD
CA1329987 rs752647832	70	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1329989 rs777578390	71	I>T		No	ClinGen ExAC gnomAD
rs758268638 CA1329988	71	I>V		No	ClinGen ExAC gnomAD
CA344228300 rs1571709710	72	H>P		No	ClinGen Ensembl
rs746759896 CA1329990	73	P>S		No	ClinGen ExAC gnomAD
rs1276612235 CA344228314	74	A>G		No	ClinGen TOPMed
CA344228311 rs1327345863	74	A>P		No	ClinGen TOPMed gnomAD
rs1327345863 CA344228310	74	A>T		No	ClinGen TOPMed gnomAD
CA344228319 rs1449134349	75	G>D		No	ClinGen gnomAD
rs756909328 CA1329991	77	Q>*		No	ClinGen ExAC gnomAD
CA344228341 rs1220598170	78	P>S		No	ClinGen gnomAD
CA1329992 rs780866798	79	T>A		No	ClinGen ExAC gnomAD
rs3795594 CA1329993 VAR_047455	81	P>A		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA1329994 rs769333411	81	P>L		No	ClinGen ExAC gnomAD
CA344228415 rs3795594	81	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs3795594 CA344228411	81	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1329996 rs749815014	83	V>M		No	ClinGen ExAC gnomAD
CA35466774 rs965126149	84	A>D		No	ClinGen gnomAD
CA1329997 rs373957619	86	S>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	87	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344228576 rs1412792519	87	P>T		No	ClinGen TOPMed
CA344228628 rs1195281218	89	P>S		No	ClinGen gnomAD
rs3795595 CA344228652	90	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144676177 CA344228644	90	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs3795595 VAR_047456 CA1330001	90	G>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs144676177 CA1329999	90	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144676177 CA1330000	90	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA35466840 rs17854616 VAR_047457	91	K>R		No	ClinGen UniProt Ensembl dbSNP
CA344228704 rs1426770371	92	D>N		No	ClinGen TOPMed gnomAD
rs1426770371 CA344228699	92	D>Y		No	ClinGen TOPMed gnomAD
CA344228770 rs1415435388	94	G>D		No	ClinGen gnomAD
rs1571709807 CA344228781	95	T>P		No	ClinGen Ensembl
rs147299257 CA1330002	97	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA344228837 rs1374237352	97	D>H		No	ClinGen gnomAD
rs766487840 CA1330003	98	S>R		No	ClinGen ExAC gnomAD
CA344228921 rs1325946224	99	G>A		No	ClinGen TOPMed gnomAD
rs1325946224 CA344228923	99	G>V		No	ClinGen TOPMed gnomAD
rs1199184380 CA344230369	103	R>K		No	ClinGen TOPMed
CA344230387 rs1319818125	104	G>C		No	ClinGen TOPMed
CA35466856 rs932305623	104	G>D		No	ClinGen TOPMed gnomAD
rs1217734000 CA344230415	105	N>K		No	ClinGen TOPMed
rs1345944074	105	N>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs77385011 CA35466857	106	L>M		No	ClinGen Ensembl
CA1330006 rs763997864	106	L>Q		No	ClinGen ExAC gnomAD
CA344230479 rs1558300619	109	A>G		No	ClinGen Ensembl
CA1330009 rs199819568	109	A>T		No	ClinGen ExAC TOPMed gnomAD
CA344230495 rs1262270748	110	P>R		No	ClinGen gnomAD
CA344230507 rs1190345812	111	G>E		No	ClinGen gnomAD
rs890859338 CA35466867	111	G>W		No	ClinGen TOPMed gnomAD
rs745545701 CA1330010	112	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs755653579 CA1330011	113	R>S		No	ClinGen ExAC gnomAD
rs1173477831 CA344230574	115	Q>*		No	ClinGen gnomAD
rs1421845147 CA344230586 COSM902284	115	Q>H	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
CA344230580 rs1393664714	115	Q>R		No	ClinGen gnomAD
TCGA novel	117	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1230316659 CA344230656	118	N>K		No	ClinGen gnomAD
CA1330012 rs779739235	119	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1332709059 CA344230665	119	P>S		No	ClinGen TOPMed
CA1330014 rs368393555	122	P>L		No	ClinGen ESP TOPMed gnomAD
rs368393555 CA344230732	122	P>R		No	ClinGen ESP TOPMed gnomAD
rs143588813 CA1330017	123	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA344230798 rs1241988625	125	E>D		No	ClinGen TOPMed
rs748522786 CA1330019 COSM299676	125	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA344230811 rs1558300665	126	S>N		No	ClinGen Ensembl
rs1558300668 CA344230820	126	S>R		No	ClinGen Ensembl
CA1330020 rs772504070	129	S>G		No	ClinGen ExAC gnomAD
rs772504070 CA1330021	129	S>R		No	ClinGen ExAC gnomAD
CA1330022 rs371020139	130	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	130	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766541854 CA1330023	132	A>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1203606918 CA344230963	133	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA1330024 rs776742546	135	L>I		No	ClinGen ExAC TOPMed gnomAD
CA1330026 rs558628333	137	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1330025 rs558628333	137	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1032560572 CA35467023	142	A>V		No	ClinGen TOPMed gnomAD
rs755810635 CA1330031	146	V>M		No	ClinGen ExAC TOPMed gnomAD
CA1330032 rs758210195	148	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1437696930 COSM3803468 CA344231267	150	S>L	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA344231306 rs1321908863	152	M>I		No	ClinGen TOPMed
rs1391547715 CA344231348	154	I>N		No	ClinGen gnomAD
rs778513085 CA1330035	155	V>M		No	ClinGen ExAC gnomAD
CA344231393 rs1318246970	156	W>*		No	ClinGen gnomAD
CA1330037 rs772421932	156	W>R		No	ClinGen ExAC gnomAD
CA344231459 rs1307411352	159	Y>C		No	ClinGen TOPMed gnomAD
CA344231482 rs1236799325	160	Y>*		No	ClinGen gnomAD
CA344231479 rs1335169132	160	Y>C		No	ClinGen gnomAD
TCGA novel	162	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344231519 rs1285825370	163	S>G		No	ClinGen gnomAD
rs778224488 CA1330038	163	S>I		No	ClinGen ExAC TOPMed gnomAD
rs778224488 CA1330039	163	S>N		No	ClinGen ExAC TOPMed gnomAD
rs776830420 CA1330041	164	A>S		No	ClinGen ExAC TOPMed gnomAD
rs776830420 CA1330042	164	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1458802529 CA344231656	171	S>R		No	ClinGen gnomAD
CA1330043 rs769875162	173	A>V		No	ClinGen ExAC TOPMed gnomAD
CA344231692 rs1490254759	175	W>*		No	ClinGen TOPMed
TCGA novel	176	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344231704 rs1558300726	176	D>Y		No	ClinGen Ensembl
rs946048338 CA35467142	179	V>A		No	ClinGen TOPMed
rs1417629822 CA344231756	179	V>I		No	ClinGen gnomAD
rs1043285712 CA35467145	184	L>F		No	ClinGen Ensembl
CA35467169 rs201945470	187	V>I		No	ClinGen gnomAD
CA1330047 rs375369601	188	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1402791658 CA344231961	190	N>S		No	ClinGen gnomAD
CA1330049 rs766197024	191	E>K		No	ClinGen ExAC TOPMed gnomAD
rs753561712 CA1330050	192	I>F		No	ClinGen ExAC
CA1330051 rs202014773	195	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs563639400 CA1330053	196	R>S		No	ClinGen 1000Genomes ExAC gnomAD
CA1330054 rs758994621	198	L>P		No	ClinGen ExAC TOPMed gnomAD
rs778113340 CA1330055	200	D>N		No	ClinGen ExAC TOPMed gnomAD
rs973969932 CA35467215	200	D>V		No	ClinGen TOPMed gnomAD
CA344232134 rs1358069069	201	V>D		No	ClinGen TOPMed
CA1330057 rs532678314	201	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373102358 CA1330058	204	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs147508343 CA1330059	204	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762917385 CA344232195	205	A>D		No	ClinGen ExAC TOPMed gnomAD
CA1330061 rs376800623	205	A>T		No	ClinGen ESP ExAC gnomAD
CA1330062 rs762917385	205	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1330064 COSM1127188 rs773015725	206	V>M	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA344232257 rs1314468156	208	F>L		No	ClinGen gnomAD
rs997931594 CA35467291	209	M>L		No	ClinGen gnomAD
rs766286719 CA1330066	209	M>T		No	ClinGen ExAC gnomAD
rs997931594 CA344232288	209	M>V		No	ClinGen gnomAD
CA35470585 rs902090125	211	V>I		No	ClinGen TOPMed gnomAD
rs1287757644 CA344234724	212	S>C		No	ClinGen gnomAD
CA344234725 rs1287757644	212	S>F		No	ClinGen gnomAD
rs1442641947 CA344234731	213	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344234726 rs1484697726	213	S>T		No	ClinGen TOPMed
rs746978054 CA1330082	215	G>*		No	ClinGen ExAC gnomAD
rs1370746288 CA344234742	216	V>I		No	ClinGen gnomAD
CA1330083 rs143981483	217	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1558302187 CA344234770	220	S>N		No	ClinGen Ensembl
rs1259038187 CA344234779	221	L>R		No	ClinGen gnomAD
rs776619571 CA1330084	221	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1311743691 CA344234785	222	C>F		No	ClinGen gnomAD
rs1489469372 CA344234791	223	A>D		No	ClinGen gnomAD
TCGA novel	224	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs551560424 CA1330085	225	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs368701564 CA1330086	227	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs565062364 CA1330088	228	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344234820 rs1401203532	228	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs763515533 CA1330089	230	H>D		No	ClinGen ExAC gnomAD
CA344234833 rs1571713020	230	H>P		No	ClinGen Ensembl
CA1330091 rs775034100	231	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA344234862 rs1416547590	234	S>R		No	ClinGen TOPMed
rs1022706697 CA35470648	237	P>R		No	ClinGen Ensembl
rs762545189 CA35470643	237	P>T		No	ClinGen Ensembl
CA1330094 rs750823234	238	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1223723351 CA344234890	239	V>E		No	ClinGen gnomAD
rs969865817 CA344234894	240	R>M		No	ClinGen TOPMed gnomAD
CA35470656 rs969865817	240	R>T		No	ClinGen TOPMed gnomAD
rs780376473 CA1330095	241	P>T		No	ClinGen ExAC gnomAD
CA1330099 rs763751843	242	I>M		No	ClinGen ExAC TOPMed gnomAD
rs376572507 CA1330097 COSM1208712	242	I>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA344234909 rs1234390465	243	E>G		No	ClinGen gnomAD
rs547892938 CA1330100	243	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1330101 rs547892938	243	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs146526098 CA344234913	244	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs369520081 CA1330103	244	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1330102 rs146526098	244	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs928279517 CA35470681	249	L>V		No	ClinGen gnomAD
rs371689702 CA35470685	250	A>T		No	ClinGen ESP gnomAD
CA344234953 rs1330398940	250	A>V		No	ClinGen gnomAD
rs1355498776 CA344234973	253	A>G		No	ClinGen gnomAD
rs1474511475 CA344234976	254	V>L		No	ClinGen TOPMed
rs904152052 CA35470694	255	I>T		No	ClinGen TOPMed gnomAD
CA1330106 rs768305437	257	V>A		No	ClinGen ExAC TOPMed gnomAD
CA344235013 rs1234027497	260	M>L		No	ClinGen gnomAD
CA1330108 rs374873137	261	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1571713116 CA344235024	261	T>P		No	ClinGen Ensembl
CA344235030 rs1571713135	262	L>P		No	ClinGen Ensembl
CA344235031 rs1571713135	262	L>R		No	ClinGen Ensembl
rs1216554604 CA344235032	263	A>T		No	ClinGen TOPMed gnomAD
rs1571713144 CA344235042	264	V>G		No	ClinGen Ensembl
rs750912841 CA1330110	264	V>L		No	ClinGen ExAC gnomAD
rs1438214844 CA344235044	265	P>A		No	ClinGen gnomAD
TCGA novel	265	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA35470713 rs914510410	267	L>P		No	ClinGen TOPMed
CA344235075 rs1231151613	270	W>*		No	ClinGen gnomAD
rs1571713157 CA344235074	270	W>G		No	ClinGen Ensembl
rs1486602361 CA344235089	272	L>M		No	ClinGen gnomAD
CA344235093 rs1571713171	272	L>R		No	ClinGen Ensembl
rs1188127909 CA344235094	273	A>T		No	ClinGen gnomAD
CA1330111 rs761183427	274	Q>H		No	ClinGen ExAC gnomAD
CA35470743 rs958885781	275	E>V		No	ClinGen TOPMed
CA1330113 rs766689444	276	P>S		No	ClinGen ExAC gnomAD
rs1459589660 CA1330114	277	A>T		No	ClinGen gnomAD
rs536616624 CA1330116	277	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1353456959 CA344235123	278	P>A		No	ClinGen TOPMed
CA1330117 rs755206179	279	T>I		No	ClinGen ExAC gnomAD
TCGA novel	280	M>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	281	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344235153 rs1352094996	282	T>N		No	ClinGen Ensembl
CA1330118 rs779249097	282	T>P		No	ClinGen ExAC
rs1377859726 CA344235157	283	L>P		No	ClinGen gnomAD
CA35470792 rs1024544392	287	I>V		No	ClinGen TOPMed
CA1330120 rs758541490	288	M>T		No	ClinGen ExAC gnomAD
CA344235201 rs1571713234	289	K>N		No	ClinGen Ensembl
rs1238421521 CA344235198	289	K>T		No	ClinGen gnomAD
CA344235209 rs1312734504	291	S>A		No	ClinGen gnomAD
CA1330121 rs200559622	293	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344235233 rs1432928335	295	P>S		No	ClinGen gnomAD
CA344235241 rs1391089854	296	E>A		No	ClinGen TOPMed
CA1330125 rs767987863	296	E>K	Variant assessed as Somatic; 0.0001387 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs772639629 CA1330130	303	M>I		No	ClinGen ExAC gnomAD
rs771579982 CA1330129	303	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1571713294 CA344235291	304	T>P		No	ClinGen Ensembl
rs368966314 CA1330131	307	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA1330134 rs754197349	308	A>S		No	ClinGen ExAC gnomAD
CA1330133 rs754197349 COSM902289	308	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA1330135 rs765614906	309	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1330136 rs752983537	309	R>H		No	ClinGen ExAC TOPMed gnomAD
CA1330137 rs752983537	309	R>P		No	ClinGen ExAC TOPMed gnomAD
rs778030980 CA1330138	310	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1330139 rs751607627	311	W>*		No	ClinGen ExAC gnomAD
CA344235339 rs1289284034	311	W>C		No	ClinGen Ensembl
CA344235353 rs1571713320	313	Y>S		No	ClinGen Ensembl
CA344235365 rs1571713321	314	F>L		No	ClinGen Ensembl
CA1330140 rs201739565	316	C>R		No	ClinGen ExAC gnomAD
TCGA novel	320	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA35470900 rs901814689	323	L>F		No	ClinGen Ensembl
CA1330141 rs780009156	326	V>I		No	ClinGen ExAC gnomAD
CA344235440 rs780009156	326	V>L		No	ClinGen ExAC gnomAD
CA344235445 rs1571713353	327	T>P		No	ClinGen Ensembl
CA1330142 rs749101816	329	Q>*		No	ClinGen ExAC gnomAD
CA1330143 rs768424757	331	V>A		No	ClinGen ExAC gnomAD
rs1319049078 CA344235473	331	V>M		No	ClinGen gnomAD
CA1330144 rs778617718	332	T>I		No	ClinGen ExAC TOPMed gnomAD
CA344235483 rs1305823394	333	W>G		No	ClinGen gnomAD
CA35470952 rs931832242	333	W>L		No	ClinGen TOPMed
CA1330146 rs149159486	334	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1330145 rs747799937	334	R>W	Variant assessed as Somatic; 0.0001396 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1330147 rs772762294	335	V>G		No	ClinGen ExAC gnomAD
CA1330148 rs746499872	336	R>*		No	ClinGen ExAC gnomAD
CA344235497 rs746499872	336	R>G		No	ClinGen ExAC gnomAD
CA1330149 rs143693713	336	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs148090270 CA344235506	338	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1445852977 CA344235509	338	P>L		No	ClinGen gnomAD
rs148090270 CA35470989	338	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs148090270 CA1330150	338	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs759904993 CA1330151	339	P>S		No	ClinGen ExAC gnomAD
rs765701004 CA344235518	340	G>E		No	ClinGen ExAC TOPMed gnomAD
rs765701004 CA1330152	340	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1455011107 CA344235534	342	K>N		No	ClinGen gnomAD
rs139393448 CA35470994	343	S>A		No	ClinGen ESP TOPMed
rs775957712 CA1330153	344	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1393865057 CA344235556	346	R>G		No	ClinGen gnomAD
CA35471004 rs1041603646	346	R>S		No	ClinGen TOPMed
rs763290313 CA1330154	347	A>S		No	ClinGen ExAC TOPMed gnomAD
CA1330155 rs764389112	348	S>C		No	ClinGen ExAC gnomAD
rs751628518 CA1330156	348	S>N		No	ClinGen ExAC gnomAD
rs1398970687 CA344235570	348	S>R		No	ClinGen gnomAD
CA1330157 rs372386575 RCV000625728 VAR_080868	349	K>N	found in siblings with a novel form of progressive myoclonus epilepsy; unknown pathological significance; no effect on expression levels, cell surface location, signaling activity or ubiquitination [UniProt]	No	ClinGen ClinVar UniProt ESP ExAC TOPMed dbSNP gnomAD
rs766282284 CA1330158	350	H>R		No	ClinGen ExAC gnomAD
CA1330161 rs778707802	351	E>G		No	ClinGen ExAC gnomAD
rs553415739 CA1330160	351	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344235586 rs553415739	351	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	352	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758090990 CA1330163	355	S>G		No	ClinGen ExAC TOPMed gnomAD
CA1330164 rs777479575	356	Q>L		No	ClinGen ExAC gnomAD
rs970631725 CA35471167	357	L>F		No	ClinGen gnomAD
rs1192005321 CA344235633	357	L>P		No	ClinGen TOPMed
TCGA novel	357	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344235635 rs1321263982	358	N>H		No	ClinGen TOPMed gnomAD
rs1200013258 CA344235640	358	N>S		No	ClinGen gnomAD
CA344235637 rs1321263982	358	N>Y		No	ClinGen TOPMed gnomAD
CA344235652 rs1265711648	360	T>A		No	ClinGen gnomAD
rs1345149082 CA344235661	361	V>A		No	ClinGen TOPMed
CA1330168 rs114687119	361	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776045297 CA1330170	362	V>A		No	ClinGen ExAC gnomAD
CA344235667 rs1288475868	363	G>S		No	ClinGen TOPMed
CA1330176 COSM1337883 rs200878639	366	V>M	large_intestine Variant assessed as Somatic; 4.662e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1330178 rs765131475	369	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA35471273 rs1024429607	370	F>S		No	ClinGen TOPMed
CA1330179 rs752559897	371	C>G		No	ClinGen ExAC gnomAD
CA344235727 rs1335072527	372	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA344235725 rs1335072527	372	T>N		No	ClinGen TOPMed gnomAD
rs1571713585 CA344235722	372	T>P		No	ClinGen Ensembl
CA35471293 rs199709819	375	E>G		No	ClinGen 1000Genomes
COSM209492 CA1330181 rs777374958	377	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1330182 rs746678071	380	I>V		No	ClinGen ExAC
CA1330183 rs115745935	381	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1330185 rs745348108	383	A>V		No	ClinGen ExAC TOPMed gnomAD
CA344235801 rs1571713620	384	Y>S		No	ClinGen Ensembl
rs770461543 CA1330186	387	T>I		No	ClinGen ExAC TOPMed gnomAD
CA1330189 rs201244518	388	E>K	Variant assessed as Somatic; 4.64e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs377493703 CA1330190	390	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA344235837 rs1571713633	390	T>P		No	ClinGen Ensembl
rs377493703 CA1330191	390	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs772132535 CA1330192	391	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773384673 CA1330193	391	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA35471409 rs773384673	391	R>L		No	ClinGen ExAC TOPMed gnomAD
CA344235851 rs1474889380	393	T>A		No	ClinGen gnomAD
rs151200634 CA1330194	393	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1302249943 CA344235858	394	L>P		No	ClinGen gnomAD
rs1374963667 CA344235856	394	L>V		No	ClinGen gnomAD
CA1330196 rs752647896	398	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA344235886 rs1220361595	399	L>F		No	ClinGen gnomAD
CA344235897 rs1346674380	401	N>H		No	ClinGen TOPMed
CA344235923 rs1407923537	404	S>A		No	ClinGen gnomAD
rs145269048 CA35471437	404	S>F		No	ClinGen ESP TOPMed
CA1330197 rs762811498	405	T>N		No	ClinGen ExAC gnomAD
CA344235928 rs1216647834	405	T>S		No	ClinGen TOPMed
CA1330198 rs763981644	407	F>L		No	ClinGen ExAC gnomAD
rs945874015 CA35471460	408	K>E		No	ClinGen TOPMed
CA1330202 rs143800455 COSM1337884	410	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA1330203 rs561408193	412	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1228691400 CA344235973	412	T>P		No	ClinGen TOPMed gnomAD
CA344235972 rs1228691400	412	T>S		No	ClinGen TOPMed gnomAD
rs141962107 CA1330205 CA1330204	414	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs141962107 CA344235982	414	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA1330206 rs769001087	416	L>F		No	ClinGen ExAC gnomAD
CA344235998 rs1485404167	417	L>F		No	ClinGen gnomAD
TCGA novel	417	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776209629 CA1330209 COSM3710506	419	I>M	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs773413931 CA1330210 COSM1668373	422	P>L	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1571713724 CA344236040	423	L>R		No	ClinGen Ensembl
CA1330213 rs138003036	424	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	424	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs138003036 CA344236041	424	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs762972110 CA1330214	425	Q>E		No	ClinGen ExAC gnomAD
rs1465148456 CA344236072	429	D>N		No	ClinGen gnomAD
CA344236077 rs1558302634	429	D>V		No	ClinGen Ensembl
TCGA novel	429	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1300558792 CA344236095	431	C>*		No	ClinGen gnomAD
CA35471543 rs747666563	434	C>S		No	ClinGen Ensembl
rs751408912 CA1330219	435	C>F		No	ClinGen ExAC gnomAD
CA344236137 rs1294340594	437	E>*		No	ClinGen TOPMed gnomAD
rs761506972 CA1330220	438	E>G		No	ClinGen ExAC gnomAD
rs1306056701 CA344236157	439	C>G		No	ClinGen TOPMed
rs1306056701 CA344236156	439	C>R		No	ClinGen TOPMed
rs1272741485 CA344236158	439	C>Y		No	ClinGen TOPMed
CA344236166 rs1208189972	440	G>A		No	ClinGen gnomAD
CA1330223 rs755756498	440	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1208189972 CA344236167	440	G>V		No	ClinGen gnomAD
rs61734417 CA1330226	441	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA344236174 rs1571713827	442	A>S		No	ClinGen Ensembl
rs748607219 CA1330228	443	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1246374793 CA344236180	443	S>P		No	ClinGen TOPMed gnomAD
CA344236198 rs1395673793	446	S>T		No	ClinGen gnomAD
CA1330231 rs747264401	447	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1330232 rs139797932	448	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA344236218 rs774140568	449	N>K		No	ClinGen ExAC TOPMed gnomAD
rs745906677 CA1330234	449	N>S		No	ClinGen ExAC TOPMed gnomAD
CA1330235 rs745906677	449	N>T		No	ClinGen ExAC TOPMed gnomAD
rs767423544 CA344236228	451	S>*		No	ClinGen ExAC TOPMed gnomAD
rs767423544 CA1330238	451	S>L		No	ClinGen ExAC TOPMed gnomAD
CA1330237 rs761751995	451	S>T		No	ClinGen ExAC gnomAD
rs1214677040 CA344236236	452	D>E		No	ClinGen TOPMed
rs760421842 CA1330240	453	N>S		No	ClinGen ExAC TOPMed gnomAD
CA1330241 rs766104125	454	K>R		No	ClinGen ExAC gnomAD
rs753467741 CA1330242	455	L>F		No	ClinGen ExAC gnomAD
rs1469979555 CA344236258	456	K>E		No	ClinGen gnomAD
rs764750408 CA1330244	458	E>*		No	ClinGen ExAC TOPMed gnomAD
CA344236271 rs764750408	458	E>K		No	ClinGen ExAC TOPMed gnomAD
rs764750408 CA344236272	458	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA35471648 rs148475636	459	V>M		No	ClinGen ESP TOPMed gnomAD
CA344236283 rs1410022765	460	S>P		No	ClinGen TOPMed gnomAD
CA1330245 rs753151926	462	S>C		No	ClinGen ExAC gnomAD
CA344236299 rs753151926	462	S>F		No	ClinGen ExAC gnomAD
rs1291579316 CA344236304	463	I>T		No	ClinGen gnomAD
CA344236316 rs1222185973	465	F>L		No	ClinGen TOPMed
rs1462694660 CA344236339	468	P>S		No	ClinGen TOPMed gnomAD
CA344236340 rs1462694660	468	P>T		No	ClinGen TOPMed gnomAD
CA344236370 rs1441297595	472	P>R		No	ClinGen TOPMed
rs1300458708 CA344236375	473	P>L		No	ClinGen gnomAD
rs747354319 CA1330248	473	P>T		No	ClinGen ExAC gnomAD
CA1330249 rs534860277	474	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781386235 CA1330251	477	L>P		No	ClinGen ExAC gnomAD
CA344236408 rs1571713992	479	T>I		No	ClinGen Ensembl
rs769776658 CA1330253	480	P>A		No	ClinGen ExAC gnomAD
rs1364373847 CA344236418	481	C>S		No	ClinGen TOPMed

No associated diseases with O60883

1 regional properties for O60883

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	43 - 301	IPR017452

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Cell projection, cilium membrane ; Multi-pass membrane protein	Associates with the basal membrane of Bergmann glia cell primary cilia
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
ciliary membrane	The portion of the plasma membrane surrounding a cilium.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of molecular function

Name	Definition
G protein-coupled peptide receptor activity	Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G protein-coupled receptor activity	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
peptide binding	Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
prosaposin receptor activity	Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D).

10 GO annotations of biological process

Name	Definition
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
Bergmann glial cell differentiation	The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate.
negative regulation of astrocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation.
negative regulation of hydrogen peroxide-induced cell death	Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
negative regulation of neuron differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
negative regulation of smoothened signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
negative regulation of systemic arterial blood pressure	The process that reduces the force with which blood travels through the systemic arterial circulatory system.
positive regulation of cerebellar granule cell precursor proliferation	The process that activates or increases the rate or extent of granule cell precursor proliferation.
positive regulation of MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
smoothened signaling pathway	The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

119 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2YDN1	GPR161	G protein-coupled receptor 161	Bos taurus (Bovine)	PR
Q0GBZ5	HCRTR1	Orexin/Hypocretin receptor type 1	Bos taurus (Bovine)	PR
Q8SPN1	PROKR2	Prokineticin receptor 2	Bos taurus (Bovine)	PR
P46626	ADRB3	Beta-3 adrenergic receptor	Bos taurus (Bovine)	PR
O46639	TRHR	Thyrotropin-releasing hormone receptor	Bos taurus (Bovine)	PR
Q8SPN2	PROKR1	Prokineticin receptor 1	Bos taurus (Bovine)	PR
B9VR26	CMLKR1	Chemerin-like receptor 1	Bos taurus (Bovine)	PR
P18130	ADRA1A	Alpha-1A adrenergic receptor	Bos taurus (Bovine)	PR
B4XF06	GPR39	G-protein coupled receptor 39	Bos taurus (Bovine)	PR
Q17QD8	GPR37L1	G-protein coupled receptor 37-like 1	Bos taurus (Bovine)	PR
O18913	OPN1LW	Long-wave-sensitive opsin 1	Felis catus (Cat) (Felis silvestris catus)	PR
P28683	PRA1	Green-sensitive opsin	Gallus gallus (Chicken)	PR
Q9N298	HTR1A	5-hydroxytryptamine receptor 1A	Pan troglodytes (Chimpanzee)	PR
P08099	Rh2	Opsin Rh2	Drosophila melanogaster (Fruit fly)	PR
P06002	ninaE	Opsin Rh1	Drosophila melanogaster (Fruit fly)	PR
Q4LBB9	Octbeta2R	Octopamine receptor beta-2R	Drosophila melanogaster (Fruit fly)	PR
Q8NFJ6	PROKR2	Prokineticin receptor 2	Homo sapiens (Human)	PR
Q13585	GPR50	Melatonin-related receptor	Homo sapiens (Human)	PR
Q9BZJ6	GPR63	Probable G-protein coupled receptor 63	Homo sapiens (Human)	PR
Q9H3N8	HRH4	Histamine H4 receptor	Homo sapiens (Human)	PR
P28336	NMBR	Neuromedin-B receptor	Homo sapiens (Human)	PR
Q9Y5Y3	GPR45	Probable G-protein coupled receptor 45	Homo sapiens (Human)	PR
P08913	ADRA2A	Alpha-2A adrenergic receptor	Homo sapiens (Human)	PR
P41597	CCR2	C-C chemokine receptor type 2	Homo sapiens (Human)	PR
P51681	CCR5	C-C chemokine receptor type 5	Homo sapiens (Human)	PR
Q8TCW9	PROKR1	Prokineticin receptor 1	Homo sapiens (Human)	PR
Q99788	CMKLR1	Chemerin-like receptor 1	Homo sapiens (Human)	PR
P08908	HTR1A	5-hydroxytryptamine receptor 1A	Homo sapiens (Human)	PR
P30559	OXTR	Oxytocin receptor	Homo sapiens (Human)	PR
P32239	CCKBR	Gastrin/cholecystokinin type B receptor	Homo sapiens (Human)	PR
Q8TDU9	RXFP4	Relaxin-3 receptor 2	Homo sapiens (Human)	PR
P04000	OPN1LW	Long-wave-sensitive opsin 1	Homo sapiens (Human)	PR
Q6U736	OPN5	Opsin-5	Homo sapiens (Human)	PR
P34972	CNR2	Cannabinoid receptor 2	Homo sapiens (Human)	PR
P24530	EDNRB	Endothelin receptor type B	Homo sapiens (Human)	PR
P35348	ADRA1A	Alpha-1A adrenergic receptor	Homo sapiens (Human)	PR
Q6W5P4	NPSR1	Neuropeptide S receptor	Homo sapiens (Human)	PR
O43613	HCRTR1	Orexin/Hypocretin receptor type 1	Homo sapiens (Human)	PR
P61073	CXCR4	C-X-C chemokine receptor type 4	Homo sapiens (Human)	PR
Q9BXC0	HCAR1	Hydroxycarboxylic acid receptor 1	Homo sapiens (Human)	PR
P30556	AGTR1	Type-1 angiotensin II receptor	Homo sapiens (Human)	PR
Q15761	NPY5R	Neuropeptide Y receptor type 5	Homo sapiens (Human)	PR
Q8N6U8	GPR161	G-protein coupled receptor 161	Homo sapiens (Human)	PR
Q6DWJ6	GPR139	Probable G-protein coupled receptor 139	Homo sapiens (Human)	PR
P21462	FPR1	fMet-Leu-Phe receptor	Homo sapiens (Human)	PR
P35414	APLNR	Apelin receptor	Homo sapiens (Human)	PR
P46091	CMKLR2	Chemerin-like receptor 2	Homo sapiens (Human)	PR
P32745	SSTR3	Somatostatin receptor type 3	Homo sapiens (Human)	PR
P41439	FOLR3	Folate receptor gamma	Homo sapiens (Human)	PR
P19973	Lsp1	Lymphocyte-specific protein 1	Mus musculus (Mouse)	PR
O54799	Nmbr	Neuromedin-B receptor	Mus musculus (Mouse)	PR
Q64264	Htr1a	5-hydroxytryptamine receptor 1A	Mus musculus (Mouse)	PR
P51675	Ccr1	C-C chemokine receptor type 1	Mus musculus (Mouse)	PR
Q5U431	Gpr39	G-protein coupled receptor 39	Mus musculus (Mouse)	PR
P97295	Npy2r	Neuropeptide Y receptor type 2	Mus musculus (Mouse)	PR
O08786	Cckar	Cholecystokinin receptor type A	Mus musculus (Mouse)	PR
P56481	Cckbr	Gastrin/cholecystokinin type B receptor	Mus musculus (Mouse)	PR
P30731	Gpr83	G-protein coupled receptor 83	Mus musculus (Mouse)	PR
P97468	Cmklr1	Chemerin-like receptor 1	Mus musculus (Mouse)	PR
P21761	Trhr	Thyrotropin-releasing hormone receptor	Mus musculus (Mouse)	PR
Q5QD16	Taar3	Trace amine-associated receptor 3	Mus musculus (Mouse)	PR
P97292	Hrh2	Histamine H2 receptor	Mus musculus (Mouse)	PR
Q9EQQ3	Gpr63	Probable G-protein coupled receptor 63	Mus musculus (Mouse)	PR
Q924H0	Npffr2	Neuropeptide FF receptor 2	Mus musculus (Mouse)	PR
P34971	Adrb1	Beta-1 adrenergic receptor	Mus musculus (Mouse)	PR
Q91ZY2	Hrh4	Histamine H4 receptor	Mus musculus (Mouse)	PR
O88416	Gpr33	Probable G-protein coupled receptor 33	Mus musculus (Mouse)	PR
Q8K087	Cmklr2	Chemerin-like receptor 2	Mus musculus (Mouse)	PR
P70658	Cxcr4	C-X-C chemokine receptor type 4	Mus musculus (Mouse)	PR
Q9WV08	Aplnr	Apelin receptor	Mus musculus (Mouse)	PR
P97718	Adra1a	Alpha-1A adrenergic receptor	Mus musculus (Mouse)	PR
Q8BZP8	Npsr1	Neuropeptide S receptor	Mus musculus (Mouse)	PR
Q8K458	Prokr2	Prokineticin receptor 2	Mus musculus (Mouse)	PR
P58308	Hcrtr2	Orexin receptor type 2	Mus musculus (Mouse)	PR
Q7TQP3	Gpr119	Glucose-dependent insulinotropic receptor	Mus musculus (Mouse)	PR
Q8BGE9	Rxfp3	Relaxin-3 receptor 1	Mus musculus (Mouse)	PR
Q6VZZ7	Opn5	Opsin-5	Mus musculus (Mouse)	PR
Q8CIM5	Gpr84	G-protein coupled receptor 84	Mus musculus (Mouse)	PR
P25962	Adrb3	Beta-3 adrenergic receptor	Mus musculus (Mouse)	PR
Q80UC8	Gpr139	Probable G-protein coupled receptor 139	Mus musculus (Mouse)	PR
P0C5I1	Gpr25	Probable G-protein coupled receptor 25	Mus musculus (Mouse)	PR
P47936	Cnr2	Cannabinoid receptor 2	Mus musculus (Mouse)	PR
Q5QD13	Taar6	Trace amine-associated receptor 6	Mus musculus (Mouse)	PR
P35846	Folr1	Folate receptor alpha	Mus musculus (Mouse)	PR
P58307	Hcrtr1	Orexin/Hypocretin receptor type 1	Mus musculus (Mouse)	PR
Q8C131	Hcar1	Hydroxycarboxylic acid receptor 1	Mus musculus (Mouse)	PR
Q9EQQ4	Gpr45	Probable G-protein coupled receptor 45	Mus musculus (Mouse)	PR
B2RPY5	Gpr161	G-protein coupled receptor 161	Mus musculus (Mouse)	PR
Q99JG2	Gpr37l1	G-protein coupled receptor 37-like 1	Mus musculus (Mouse)	PR
Q764M9	CXCR4	C-X-C chemokine receptor type 4	Sus scrofa (Pig)	PR
Q9EQD2	Npffr2	Neuropeptide FF receptor 2	Rattus norvegicus (Rat)	PR
O08565	Cxcr4	C-X-C chemokine receptor type 4	Rattus norvegicus (Rat)	PR
Q01717	Trhr	Thyrotropin-releasing hormone receptor	Rattus norvegicus (Rat)	PR
P30936	Sstr3	Somatostatin receptor type 3	Rattus norvegicus (Rat)	PR
Q9JHG3	Aplnr	Apelin receptor	Rattus norvegicus (Rat)	PR
P43140	Adra1a	Alpha-1A adrenergic receptor	Rattus norvegicus (Rat)	PR
P19327	Htr1a	5-hydroxytryptamine receptor 1A	Rattus norvegicus (Rat)	PR
P56719	Hcrtr2	Orexin receptor type 2	Rattus norvegicus (Rat)	PR
P28564	Htr1b	5-hydroxytryptamine receptor 1B	Rattus norvegicus (Rat)	PR
P56718	Hcrtr1	Orexin/Hypocretin receptor type 1	Rattus norvegicus (Rat)	PR
P28647	Adora3	Adenosine receptor A3	Rattus norvegicus (Rat)	PR
P25102	Hrh2	Histamine H2 receptor	Rattus norvegicus (Rat)	PR
P23944	Adra1d	Alpha-1D adrenergic receptor	Rattus norvegicus (Rat)	PR
Q8R415	Prokr2	Prokineticin receptor 2	Rattus norvegicus (Rat)	PR
Q5QD24	Taar3	Trace amine-associated receptor 3	Rattus norvegicus (Rat)	PR
P0C0W8	Gpr139	Probable G-protein coupled receptor 139	Rattus norvegicus (Rat)	PR
P35370	Oprl1	Nociceptin receptor	Rattus norvegicus (Rat)	PR
P46090	Cmklr2	Chemerin-like receptor 2	Rattus norvegicus (Rat)	PR
O97664	CMKLR2	Chemerin-like receptor 2	Macaca mulatta (Rhesus macaque)	PR
O97666	APLNR	Apelin receptor	Macaca mulatta (Rhesus macaque)	PR
Q56H79	NPSR1	Neuropeptide S receptor	Macaca mulatta (Rhesus macaque)	PR
Q18904	npr-8	Probable G-protein coupled receptor npr-8	Caenorhabditis elegans	PR
Q09388	gar-2	Muscarinic acetylcholine receptor gar-2	Caenorhabditis elegans	PR
B3DM66	gpr161	G-protein coupled receptor 161	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q9W6A6	opn1mw4	Green-sensitive opsin-4	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q9W6A5	opn1mw1	Green-sensitive opsin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q8AYM7	opn1mw3	Green-sensitive opsin-3	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q8AYN0	opn1lw2	Red-sensitive opsin-2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q90X46	gpr161	G-protein coupled receptor 161	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MRWLWPLAVS	LAVILAVGLS	RVSGGAPLHL	GRHRAETQEQ	QSRSKRGTED	EEAKGVQQYV
70	80	90	100	110	120
PEEWAEYPRP	IHPAGLQPTK	PLVATSPNPG	KDGGTPDSGQ	ELRGNLTGAP	GQRLQIQNPL
130	140	150	160	170	180
YPVTESSYSA	YAIMLLALVV	FAVGIVGNLS	VMCIVWHSYY	LKSAWNSILA	SLALWDFLVL
190	200	210	220	230	240
FFCLPIVIFN	EITKQRLLGD	VSCRAVPFME	VSSLGVTTFS	LCALGIDRFH	VATSTLPKVR
250	260	270	280	290	300
PIERCQSILA	KLAVIWVGSM	TLAVPELLLW	QLAQEPAPTM	GTLDSCIMKP	SASLPESLYS
310	320	330	340	350	360
LVMTYQNARM	WWYFGCYFCL	PILFTVTCQL	VTWRVRGPPG	RKSECRASKH	EQCESQLNST
370	380	390	400	410	420
VVGLTVVYAF	CTLPENVCNI	VVAYLSTELT	RQTLDLLGLI	NQFSTFFKGA	ITPVLLLCIC
430	440	450	460	470	480
RPLGQAFLDC	CCCCCCEECG	GASEASAANG	SDNKLKTEVS	SSIYFHKPRE	SPPLLPLGTP

C