P30559
PR
Gene name |
OXTR |
Protein name |
Oxytocin receptor |
Names |
OT-R |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:5021 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P30559
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6TPK | X-ray | 320 A | A | 35-356 | PDB |
| 7QVM | EM | 325 A | R | 1-359 | PDB |
| 7RYC | EM | 290 A | O | 1-389 | PDB |
| AF-P30559-F1 | Predicted | AlphaFoldDB |
382 variants for P30559
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA351667497 rs1370308186 |
4 | A>E | No |
ClinGen TOPMed |
|
| TCGA novel | 4 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA69854547 rs879072895 |
5 | L>F | No |
ClinGen Ensembl |
|
|
CA351667483 rs1406481579 |
6 | A>T | No |
ClinGen gnomAD |
|
|
rs237908 CA69854546 |
7 | A>S | No |
ClinGen Ensembl |
|
|
CA351667452 rs1396725263 |
8 | N>K | No |
ClinGen TOPMed |
|
|
rs1275152803 CA351667458 |
8 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1355563846 CA351667440 |
9 | W>C | No |
ClinGen gnomAD |
|
|
CA351667449 rs1228905385 |
9 | W>R | No |
ClinGen gnomAD |
|
|
CA69854544 rs1044054410 |
10 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA69854540 rs948430170 |
10 | S>R | No |
ClinGen TOPMed |
|
|
rs1364358733 CA351667424 |
11 | A>T | No |
ClinGen gnomAD |
|
|
CA69854525 rs953558316 |
12 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs953558316 CA69854523 |
12 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA351667413 rs1253330314 |
12 | E>V | No |
ClinGen TOPMed |
|
|
CA69854510 rs924822059 |
14 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
rs237907 CA69854520 |
14 | A>S | No |
ClinGen Ensembl |
|
|
rs921957230 CA69854507 |
15 | N>S | No |
ClinGen Ensembl |
|
|
rs1209332860 CA351667374 |
16 | A>G | No |
ClinGen TOPMed |
|
|
rs237906 CA69854501 VAR_031570 |
16 | A>S | No |
ClinGen UniProt Ensembl dbSNP |
|
| TCGA novel | 19 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA69854497 rs865871442 |
19 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA2236673 rs756453502 |
21 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs113718500 CA69854466 |
22 | G>A | No |
ClinGen TOPMed |
|
|
RCV000997975 CA351667323 rs113718500 |
22 | G>E | No |
ClinGen ClinVar TOPMed dbSNP |
|
|
rs189386 CA69854488 |
22 | G>W | No |
ClinGen Ensembl |
|
|
CA351667319 rs1222164801 |
23 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA2236672 rs752877652 |
24 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA351667297 rs1373308417 |
25 | G>S | No |
ClinGen TOPMed |
|
|
rs759817156 CA2236670 |
26 | N>S | No |
ClinGen ExAC |
|
|
CA351667273 rs1214214686 |
27 | R>C | No |
ClinGen gnomAD |
|
|
rs370955626 CA2236669 |
27 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1404237477 CA351667262 |
28 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA351667258 rs1404237477 |
28 | T>N | No |
ClinGen TOPMed gnomAD |
|
|
CA2236667 rs766535249 |
29 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs237903 CA69854433 |
29 | A>V | No |
ClinGen Ensembl |
|
|
CA2236664 rs769487361 |
30 | G>E | No |
ClinGen ExAC |
|
|
CA69854412 rs1015123659 |
31 | P>L | No |
ClinGen TOPMed |
|
|
rs761598751 CA2236662 |
31 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351667229 rs1370653078 |
32 | P>A | No |
ClinGen gnomAD |
|
|
CA69854409 rs200253138 |
32 | P>L | No |
ClinGen Ensembl |
|
|
CA351667218 rs1169252575 |
33 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1407892489 CA351667203 |
34 | R>L | No |
ClinGen gnomAD |
|
|
rs776288809 CA2236661 |
35 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA69854403 rs868112599 |
37 | A>G | No |
ClinGen TOPMed |
|
|
CA69854397 rs868112599 |
37 | A>V | No |
ClinGen TOPMed |
|
|
rs768357643 CA2236660 |
38 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA351667164 rs1184263778 |
39 | A>T | No |
ClinGen gnomAD |
|
|
rs527368267 CA69854387 |
39 | A>V | No |
ClinGen gnomAD |
|
|
rs779582872 CA2236657 |
40 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA2236658 rs746647506 |
40 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA351667144 rs1305951780 |
41 | V>L | No |
ClinGen gnomAD |
|
|
rs771532640 CA2236656 |
44 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201689053 CA69854369 |
45 | V>G | No |
ClinGen Ensembl |
|
|
CA2236655 rs202094106 |
45 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs778287635 CA2236654 |
46 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236653 rs376898672 |
47 | C>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1297077827 CA351667059 |
48 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 49 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA351667043 rs1466839874 |
50 | L>P | No |
ClinGen Ensembl |
|
|
rs753162423 CA2236652 |
51 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA351667018 rs1426958629 |
53 | A>S | No |
ClinGen gnomAD |
|
|
CA2236647 rs763066550 COSM229992 |
56 | G>W | NS [Cosmic] | No |
ClinGen cosmic curated ExAC |
|
CA351666963 rs1239366031 |
58 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs369623125 CA69854326 |
58 | A>V | No |
ClinGen Ensembl |
|
|
CA351666956 rs1323218977 |
59 | C>G | No |
ClinGen gnomAD |
|
|
rs993633205 CA69854323 |
59 | C>Y | No |
ClinGen TOPMed |
|
|
CA351666928 rs1463724617 |
61 | L>P | No |
ClinGen gnomAD |
|
|
CA69854314 rs171114 |
63 | A>G | No |
ClinGen gnomAD |
|
|
CA2236645 rs765288088 |
63 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA351666902 rs171114 |
63 | A>V | No |
ClinGen gnomAD |
|
|
rs776541412 CA2236643 |
65 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA351666870 rs1221569192 |
66 | T>P | No |
ClinGen gnomAD |
|
|
CA351666867 rs1380712691 |
66 | T>S | No |
ClinGen gnomAD |
|
|
CA2236642 rs569235363 |
68 | R>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs202023509 CA2236640 |
68 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236641 rs202023509 |
68 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1451101452 CA351666814 |
69 | Q>H | No |
ClinGen gnomAD |
|
|
rs905569921 CA69854288 |
71 | H>Q | No |
ClinGen gnomAD |
|
|
rs1363142055 CA351666728 |
73 | R>C | No |
ClinGen gnomAD |
|
|
rs143644523 CA69854287 |
74 | L>F | No |
ClinGen ESP TOPMed |
|
|
CA2236637 rs745319976 |
77 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA351666640 rs1184402768 |
78 | M>K | No |
ClinGen gnomAD |
|
|
rs1559681481 CA351666594 |
82 | S>R | No |
ClinGen Ensembl |
|
| TCGA novel | 84 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA351666533 rs1241587080 |
85 | D>H | No |
ClinGen gnomAD |
|
|
CA351666509 rs1210956948 |
86 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs770380982 CA2236634 |
87 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs1216229201 CA351666446 |
90 | V>M | No |
ClinGen gnomAD |
|
|
CA351666370 rs1322946487 |
94 | L>P | No |
ClinGen gnomAD |
|
|
rs748571597 CA2236633 |
95 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs748571597 CA351666362 |
95 | P>R | No |
ClinGen ExAC gnomAD |
|
|
rs1315175260 CA351666365 |
95 | P>S | No |
ClinGen gnomAD |
|
|
CA351666339 rs1380090835 |
97 | L>F | No |
ClinGen gnomAD |
|
|
rs200175095 CA69854266 |
100 | D>H | No |
ClinGen Ensembl |
|
|
rs755341345 CA2236631 |
101 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA69854255 rs1002718410 |
104 | R>H | No |
ClinGen TOPMed |
|
|
CA2236627 rs750576790 |
106 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs758686063 CA2236628 |
106 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
rs1296613616 CA351666154 |
107 | G>E | No |
ClinGen gnomAD |
|
|
rs1164269056 CA351666157 |
107 | G>R | No |
ClinGen gnomAD |
|
|
rs202138705 CA2236626 |
108 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236624 rs753682593 |
110 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA351666125 rs1203860631 |
112 | C>Y | No |
ClinGen gnomAD |
|
|
CA351666119 rs1489734213 |
113 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA351666120 rs1489734213 |
113 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1176182011 CA351666113 |
114 | L>P | No |
ClinGen TOPMed |
|
|
rs1293739076 CA351666107 |
115 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
CA2236620 rs767226551 |
115 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201043268 CA2236619 |
116 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs948376504 CA69854230 |
116 | K>T | No |
ClinGen TOPMed |
|
|
CA2236618 rs773950877 |
117 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs748707544 CA2236616 |
119 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA69854222 rs866438046 |
119 | Q>H | No |
ClinGen Ensembl |
|
|
rs1388350557 CA351666082 |
119 | Q>L | No |
ClinGen gnomAD |
|
|
rs1054609908 CA69854211 |
120 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs769144418 CA2236614 |
121 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA2236613 rs747441975 |
122 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA2236611 rs758698708 |
123 | M>T | No |
ClinGen ExAC |
|
|
rs201263513 CA69854182 |
123 | M>V | No |
ClinGen gnomAD |
|
|
CA351666049 rs1279073369 |
125 | A>T | No |
ClinGen TOPMed |
|
|
CA2236610 rs746051105 |
128 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1372756615 CA351666024 |
128 | Y>H | No |
ClinGen gnomAD |
|
|
CA2236607 rs201782300 |
133 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1253391808 CA351665957 |
134 | S>F | No |
ClinGen gnomAD |
|
|
CA351665955 rs1195917449 |
135 | L>M | No |
ClinGen gnomAD |
|
|
rs1338320549 CA351665931 |
137 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA351665933 rs1338320549 |
137 | R>G | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 137 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA351665935 rs1338320549 |
137 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
CA2236606 rs763954675 |
138 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs910787340 CA69854163 |
141 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs932090848 CA69854158 |
143 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
CA69854152 rs921988343 |
144 | P>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA351665856 rs921988343 |
144 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA351665861 rs1452481964 |
144 | P>T | No |
ClinGen TOPMed |
|
|
rs767267625 CA2236603 |
146 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA351665843 rs1435629334 |
146 | R>S | No |
ClinGen TOPMed |
|
|
CA351665830 rs759262978 |
147 | S>* | No |
ClinGen ExAC gnomAD |
|
|
COSM1538647 CA2236602 rs759262978 |
147 | S>L | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs765922696 CA351665827 |
148 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351665821 rs1430458196 |
149 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
COSM1669937 CA351665814 rs1479726969 |
150 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs547238576 CA2236599 |
150 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs772841181 CA2236598 |
151 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs772841181 CA69854123 |
151 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs199632156 CA69854114 |
153 | D>N | No |
ClinGen Ensembl |
|
|
rs776041271 CA351665791 |
154 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776041271 CA2236595 |
154 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351665765 rs1205191304 |
158 | L>F | No |
ClinGen gnomAD |
|
|
CA351665766 rs1205191304 |
158 | L>V | No |
ClinGen gnomAD |
|
|
CA351665760 rs1262310800 |
159 | A>P | No |
ClinGen gnomAD |
|
| TCGA novel | 159 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs746128164 CA2236593 |
160 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA2236591 rs757364243 |
161 | W>* | No |
ClinGen ExAC gnomAD |
|
|
CA351665740 rs1239852605 |
162 | L>I | No |
ClinGen gnomAD |
|
|
rs199792796 CA69854080 |
163 | G>R | No |
ClinGen Ensembl |
|
|
CA2236589 rs777819616 |
164 | C>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1454813911 CA351665721 |
165 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
CA351665702 rs1336464834 |
168 | S>I | No |
ClinGen gnomAD |
|
|
CA351665701 CA351665700 rs1468623065 |
168 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1251826737 CA351665697 |
169 | A>T | No |
ClinGen TOPMed |
|
|
CA351665690 rs1410796366 |
170 | P>Q | No |
ClinGen gnomAD |
|
|
CA351665691 rs1559680657 |
170 | P>S | No |
ClinGen Ensembl |
|
|
CA2236585 RCV000946712 rs115324487 |
172 | V>A | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA351665678 rs1559680615 |
172 | V>M | No |
ClinGen Ensembl |
|
|
rs1444832306 CA351665666 |
173 | H>D | No |
ClinGen gnomAD |
|
|
rs1027825190 CA351665623 |
176 | S>C | No |
ClinGen TOPMed |
|
|
CA69854029 rs1027825190 |
176 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1027825190 CA351665625 |
176 | S>Y | No |
ClinGen TOPMed |
|
|
CA69854028 rs1023312431 |
178 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
rs202006989 CA69854010 |
179 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1575491727 CA351665583 |
180 | V>G | No |
ClinGen Ensembl |
|
|
CA2236582 rs762650827 |
180 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1284782583 CA351665562 |
182 | D>E | No |
ClinGen gnomAD |
|
|
CA69854005 rs530470900 |
182 | D>G | No |
ClinGen 1000Genomes |
|
|
CA351665553 rs1268771830 |
183 | G>D | No |
ClinGen TOPMed |
|
|
CA351665559 rs1204489418 |
183 | G>S | No |
ClinGen gnomAD |
|
|
CA351665524 rs1277824401 |
185 | F>L | No |
ClinGen gnomAD |
|
|
rs761299103 CA2236579 |
186 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA2236580 rs761299103 |
186 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs998463848 CA2236576 |
187 | C>F | No |
ClinGen TOPMed |
|
|
CA2236578 rs776096405 |
187 | C>G | No |
ClinGen ExAC |
|
|
CA351665491 rs1272039752 |
188 | W>* | No |
ClinGen TOPMed |
|
|
rs373458355 CA2236574 |
188 | W>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs772500085 CA2236575 |
188 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA2236572 rs771118483 |
192 | I>L | No |
ClinGen ExAC gnomAD |
|
|
CA351665428 rs1319504719 |
193 | Q>K | No |
ClinGen gnomAD |
|
|
CA69853966 rs369626093 |
194 | P>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA2236571 rs369626093 |
194 | P>T | No |
ClinGen ESP ExAC gnomAD |
|
|
CA351665399 rs1164911719 |
195 | W>* | No |
ClinGen gnomAD |
|
|
CA351665379 rs1231433000 |
197 | P>A | No |
ClinGen TOPMed |
|
|
rs1231433000 CA351665378 |
197 | P>S | No |
ClinGen TOPMed |
|
|
CA351665356 rs1444773152 |
199 | A>S | No |
ClinGen gnomAD |
|
|
rs1384214115 CA351665319 |
202 | T>R | No |
ClinGen gnomAD |
|
|
rs867264431 CA69853959 |
203 | W>* | No |
ClinGen Ensembl |
|
|
rs200498154 CA2236569 CA351665312 |
203 | W>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236568 rs748090771 |
204 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs1192258696 CA351665288 |
205 | T>R | No |
ClinGen gnomAD |
|
|
RCV000973327 CA2236565 rs150746704 |
206 | L>V | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs758167206 CA2236563 |
208 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750064097 CA2236562 |
209 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
CA2236561 rs764865506 |
210 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236558 rs533560280 CA2236559 |
211 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA351665223 rs544737187 |
212 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs544737187 CA2236557 |
212 | P>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs544737187 CA351665224 |
212 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 213 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs774630023 CA351665204 |
214 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351665197 rs1424666216 |
214 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA69853934 rs201174307 |
214 | I>S | No |
ClinGen Ensembl |
|
|
rs774630023 CA2236556 |
214 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236555 rs771284722 |
215 | V>L | No |
ClinGen ExAC gnomAD |
|
|
VAR_031571 rs4686302 CA2236552 |
218 | A>T | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
COSM180137 TCGA novel rs755337435 CA351665159 |
219 | C>G | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
rs755337435 CA69853921 |
219 | C>R | No |
ClinGen TOPMed |
|
|
rs143908202 CA2236549 |
221 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA351665115 rs1490520588 |
222 | L>R | No |
ClinGen gnomAD |
|
|
rs1219514510 CA351665106 |
223 | I>T | No |
ClinGen gnomAD |
|
|
CA69853918 rs922060423 |
224 | S>G | No |
ClinGen Ensembl |
|
|
rs201379765 CA2236546 |
224 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201379765 CA2236547 |
224 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201379765 CA351665100 |
224 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351665089 rs1203280085 |
225 | F>C | No |
ClinGen TOPMed |
|
|
rs1274051168 CA351665085 |
225 | F>L | No |
ClinGen gnomAD |
|
|
rs1214342103 CA351665081 |
226 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs1316448422 CA351665078 |
226 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA2236544 rs376480209 |
227 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 228 | W>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2236543 rs145921539 |
228 | W>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1406112175 CA351665049 |
228 | W>R | No |
ClinGen gnomAD |
|
|
rs755469490 CA351664998 |
231 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs763639717 CA2236541 |
231 | L>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351664995 rs769955516 |
232 | R>G | No |
ClinGen gnomAD |
|
|
CA69853889 rs769955516 |
232 | R>W | No |
ClinGen gnomAD |
|
|
CA2236538 rs766740134 |
233 | L>I | No |
ClinGen ExAC gnomAD |
|
|
CA69853878 rs184175311 |
234 | K>E | No |
ClinGen 1000Genomes |
|
|
CA2236534 rs762072495 |
236 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1189532457 CA351664951 |
236 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1189532457 CA351664953 |
236 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA2236533 rs61740241 |
238 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1456681036 CA351664925 |
238 | A>V | No |
ClinGen gnomAD |
|
|
rs1224562853 CA351664919 |
239 | A>E | No |
ClinGen gnomAD |
|
|
CA351664915 rs1224562853 |
239 | A>V | No |
ClinGen gnomAD |
|
|
CA351664906 rs1299902978 |
240 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA2236528 rs745728119 |
241 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA69853841 rs757022912 |
242 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757022912 CA2236526 |
242 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757022912 CA2236525 |
242 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201563390 CA69853838 |
244 | P>S | No |
ClinGen Ensembl |
|
|
rs970194601 CA69853837 |
246 | G>D | No |
ClinGen Ensembl |
|
|
rs1559679735 CA351664852 |
246 | G>S | No |
ClinGen Ensembl |
|
|
rs748942469 CA2236524 |
247 | A>E | No |
ClinGen ExAC |
|
|
rs200392966 CA2236521 |
251 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236520 rs151141371 |
252 | G>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA351664792 rs1213254805 |
252 | G>R | No |
ClinGen TOPMed |
|
|
CA69853832 rs1031339175 |
253 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
CA2236519 rs139854982 |
254 | R>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs144366756 CA2236515 |
255 | V>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200237017 CA2236516 |
255 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA69853807 rs201462004 |
256 | A>V | No |
ClinGen Ensembl |
|
|
CA351664736 rs1254716341 |
258 | A>E | No |
ClinGen gnomAD |
|
|
CA2236511 rs200362197 |
259 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351664712 rs1303090976 |
260 | V>G | No |
ClinGen TOPMed |
|
|
rs1395236568 CA351664687 |
262 | S>R | No |
ClinGen TOPMed |
|
|
CA2236509 rs745781173 |
263 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA351664669 rs1384523315 |
264 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
rs774330237 CA2236508 |
265 | L>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs770798571 CA2236507 |
266 | I>T | No |
ClinGen ExAC gnomAD |
|
|
COSM262713 CA351664617 rs1399813211 |
272 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA351664612 rs1290507073 |
272 | R>L | No |
ClinGen gnomAD |
|
|
rs237901 CA2236505 |
273 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs237901 CA2236504 |
273 | T>R | No |
ClinGen ExAC gnomAD |
|
|
rs367766502 CA2236502 |
274 | V>I | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1254552364 CA351664587 |
276 | M>I | No |
ClinGen gnomAD |
|
|
CA2236500 rs750888333 |
276 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs1301038975 CA351664592 |
276 | M>T | No |
ClinGen TOPMed |
|
|
rs1349808427 CA351664574 |
278 | F>L | No |
ClinGen TOPMed |
|
|
CA69853729 rs201019367 |
279 | I>V | No |
ClinGen Ensembl |
|
|
CA69853727 rs996717779 |
280 | I>V | No |
ClinGen Ensembl |
|
|
rs144814761 CA2236499 |
281 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1256819423 CA351664547 |
283 | A>V | No |
ClinGen TOPMed |
|
|
CA69853722 rs201783860 |
284 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1291973512 CA351664479 |
288 | W>R | No |
ClinGen gnomAD |
|
|
CA351664452 rs1244817296 |
289 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA351664359 rs1575491210 |
294 | V>L | No |
ClinGen Ensembl |
|
|
rs760799201 CA2236494 |
295 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770976075 CA351664263 |
298 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236491 rs759580901 |
299 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236492 rs767677011 |
299 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs886491242 CA69853704 |
300 | W>R | No |
ClinGen Ensembl |
|
|
rs774370884 CA2236490 |
301 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA351664208 rs1164411475 |
302 | A>T | No |
ClinGen gnomAD |
|
|
CA2236489 rs201169406 |
303 | N>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2236487 CA2236486 rs769535684 |
303 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs762869788 CA2236488 |
303 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1457871248 CA351664184 |
304 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1261559119 CA351664173 |
305 | P>L | No |
ClinGen gnomAD |
|
|
CA2236484 rs199821534 |
307 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1169182654 CA351664160 |
307 | E>V | No |
ClinGen TOPMed |
|
|
rs774850560 CA2236462 |
308 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776264651 CA2236461 |
309 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756500024 CA2236458 |
312 | I>S | No |
ClinGen ExAC gnomAD |
|
|
rs778234588 CA2236459 |
312 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA69846841 rs941027352 |
313 | I>V | No |
ClinGen gnomAD |
|
|
CA2236456 rs201415673 |
314 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236454 rs751733420 |
320 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA2236452 rs140488139 |
321 | N>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 322 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA351662582 rs1454863747 |
323 | C>G | No |
ClinGen gnomAD |
|
|
rs750277604 CA2236450 |
324 | C>* | No |
ClinGen ExAC gnomAD |
|
|
rs1186395524 CA351662563 |
325 | N>I | No |
ClinGen TOPMed |
|
|
rs1240621057 CA351662558 |
326 | P>H | No |
ClinGen TOPMed |
|
|
CA2236449 rs765091883 |
326 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA2236448 rs761532456 |
328 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1158630940 CA351662541 |
328 | I>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA351662536 rs1575482900 |
329 | Y>C | No |
ClinGen Ensembl |
|
|
CA2236447 rs199499721 |
330 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1418638465 CA351662531 |
330 | M>L | No |
ClinGen gnomAD |
|
|
rs1378025564 CA351662528 |
330 | M>T | No |
ClinGen gnomAD |
|
|
rs201778590 CA2236446 |
331 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA69846795 rs200483617 |
333 | T>A | No |
ClinGen Ensembl |
|
|
rs200966415 CA2236444 |
333 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs927827511 CA69846774 |
334 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA2236440 rs151257822 |
334 | G>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1284089041 CA351662482 |
337 | F>L | No |
ClinGen gnomAD |
|
|
rs1457085651 CA351662475 |
338 | H>R | No |
ClinGen TOPMed |
|
|
CA351662466 rs1322917559 |
339 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
CA2236437 rs143927655 COSM276580 RCV000950098 |
339 | E>K | large_intestine [Cosmic] | No |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA2236435 rs201093607 |
341 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs201093607 CA2236434 |
341 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs913313090 CA69846739 |
342 | Q>* | No |
ClinGen Ensembl |
|
|
rs200035437 CA2236433 |
343 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA69846735 rs201981901 |
343 | R>H | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs757173355 CA2236431 |
346 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA351662414 rs1412682845 |
348 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
rs200007890 CA2236427 |
349 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA351662406 rs1242575012 |
349 | A>V | No |
ClinGen gnomAD |
|
|
rs767070357 CA2236426 |
350 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1559664961 CA351662403 |
350 | S>T | No |
ClinGen Ensembl |
|
|
CA351662394 rs1447297271 |
351 | Y>C | No |
ClinGen TOPMed |
|
|
CA2236425 rs759031806 |
351 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773895891 CA2236424 |
353 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA69846704 rs201786482 |
354 | G>A | No |
ClinGen TOPMed |
|
|
rs762376033 CA2236422 |
356 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777166927 CA2236421 |
356 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs747266977 CA2236419 |
357 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA351662361 rs1575482720 |
357 | L>P | No |
ClinGen Ensembl |
|
|
CA2236417 rs370398181 |
358 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA351662351 rs1304406777 |
359 | E>G | No |
ClinGen gnomAD |
|
|
rs1405089360 CA351662345 |
360 | T>A | No |
ClinGen gnomAD |
|
|
CA2236416 rs199856198 |
360 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 364 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2236413 rs753739373 |
364 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA2236412 rs756315520 |
365 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA69846675 rs201856773 |
366 | S>G | No |
ClinGen TOPMed |
|
| TCGA novel | 366 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA2236411 rs148899442 |
367 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201446460 CA351662255 |
368 | S>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA2236410 COSM3392610 rs201446460 |
368 | S>L | Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs888143658 CA69846664 |
369 | S>P | No |
ClinGen Ensembl |
|
|
rs1559664690 CA351662236 |
370 | S>F | No |
ClinGen Ensembl |
|
|
rs759201253 CA2236408 |
371 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs751067770 CA2236407 |
373 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA2236406 rs144289031 |
374 | S>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA351662191 rs1199625461 |
375 | H>Y | No |
ClinGen TOPMed |
|
|
rs35062132 CA2236405 |
376 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA2236404 rs35062132 |
376 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs769146293 COSM1048790 CA2236403 |
376 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs769146293 CA351662168 |
376 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761012572 CA2236402 |
377 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs772232510 CA2236400 |
378 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775911728 CA2236401 |
378 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772232510 CA351662150 |
378 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1229510727 CA351662128 |
380 | Q>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1219236049 CA351662111 |
381 | R>S | No |
ClinGen gnomAD |
|
|
CA2236397 rs770954275 |
386 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1272678253 CA351662055 |
386 | P>S | No |
ClinGen gnomAD |
|
|
CA2236395 rs776881012 |
388 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201162889 CA351662020 |
389 | A>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201162889 COSM1669936 CA2236394 |
389 | A>V | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA351662011 rs1433792393 |
390 | A>L | No |
ClinGen gnomAD |
No associated diseases with P30559
1 regional properties for P30559
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 43 - 326 | IPR017452 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| oxytocin receptor activity | Combining with oxytocin to initiate a change in cell activity. |
| peptide binding | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. |
| peptide hormone binding | Binding to a peptide with hormonal activity in animals. |
| vasopressin receptor activity | Combining with vasopressin to initiate a change in cell activity. |
38 GO annotations of biological process
| Name | Definition |
|---|---|
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| digestive tract development | The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. |
| eating behavior | The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. |
| ERK1 and ERK2 cascade | An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| estrous cycle | A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. |
| female pregnancy | The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| lactation | The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. |
| maternal behavior | Female behaviors associated with the care and rearing of offspring. |
| maternal process involved in parturition | A reproductive process occurring in the mother that results in birth. |
| memory | The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). |
| muscle contraction | A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
| negative regulation of gastric acid secretion | Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. |
| positive regulation of blood pressure | Any process in which the force of blood traveling through the circulatory system is increased. |
| positive regulation of cold-induced thermogenesis | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of norepinephrine secretion | Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. |
| positive regulation of penile erection | Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. |
| positive regulation of synapse assembly | Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. |
| positive regulation of synaptic transmission, GABAergic | Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
| positive regulation of synaptic transmission, glutamatergic | Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. |
| positive regulation of uterine smooth muscle contraction | Any process that increases the frequency, rate or extent of uterine smooth muscle contraction. |
| positive regulation of vasoconstriction | Any process that activates or increases the frequency, rate or extent of vasoconstriction. |
| regulation of systemic arterial blood pressure by vasopressin | The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. |
| response to amphetamine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. |
| response to anoxia | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. |
| response to cocaine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. |
| response to cytokine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. |
| response to estradiol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
| response to peptide hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. |
| response to progesterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| sleep | Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. |
| social behavior | Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. |
| sperm ejaculation | The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. |
| suckling behavior | Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. |
| telencephalon development | The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. |
119 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGALAANWS | AEAANASAAP | PGAEGNRTAG | PPRRNEALAR | VEVAVLCLIL | LLALSGNACV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLALRTTRQK | HSRLFFFMKH | LSIADLVVAV | FQVLPQLLWD | ITFRFYGPDL | LCRLVKYLQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VGMFASTYLL | LLMSLDRCLA | ICQPLRSLRR | RTDRLAVLAT | WLGCLVASAP | QVHIFSLREV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ADGVFDCWAV | FIQPWGPKAY | ITWITLAVYI | VPVIVLAACY | GLISFKIWQN | LRLKTAAAAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AEAPEGAAAG | DGGRVALARV | SSVKLISKAK | IRTVKMTFII | VLAFIVCWTP | FFFVQMWSVW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DANAPKEASA | FIIVMLLASL | NSCCNPWIYM | LFTGHLFHEL | VQRFLCCSAS | YLKGRRLGET |
| 370 | 380 | ||||
| SASKKSNSSS | FVLSHRSSSQ | RSCSQPSTA |