Q6DWJ6
PR
Gene name |
GPR139 (GPRG1, PGR3) |
Protein name |
Probable G-protein coupled receptor 139 |
Names |
G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:124274 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q6DWJ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7VUG | EM | 320 A | R | 2-321 | PDB |
| 7VUH | EM | 322 A | R | 2-321 | PDB |
| 7VUI | EM | 330 A | R | 2-321 | PDB |
| 7VUJ | EM | 380 A | R | 2-321 | PDB |
| AF-Q6DWJ6-F1 | Predicted | AlphaFoldDB |
268 variants for Q6DWJ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA7938422 rs756461493 |
2 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA7938421 rs373852028 |
3 | H>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM1162476 rs781371656 CA7938420 |
4 | T>M | Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA395241777 rs1323835049 |
5 | H>Q | No |
ClinGen gnomAD |
|
| TCGA novel | 5 | H>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395241773 rs1316148314 |
6 | A>S | No |
ClinGen gnomAD |
|
|
rs1032517369 CA279353799 |
8 | L>F | No |
ClinGen TOPMed |
|
|
CA7938418 rs753981536 |
9 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA7938417 rs766414100 |
10 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1296624501 CA395241745 |
11 | N>D | No |
ClinGen gnomAD |
|
|
rs1460296053 CA395241735 |
12 | S>I | No |
ClinGen gnomAD |
|
|
rs1163977589 CA395241722 |
14 | L>P | No |
ClinGen gnomAD |
|
|
CA395241708 rs1443996024 |
16 | W>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1383243009 CA395241687 |
19 | P>A | Variant assessed as Somatic; 4.802e-05 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA395241683 rs1419112630 |
20 | G>S | No |
ClinGen gnomAD |
|
|
CA7938415 rs753759452 |
21 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395241674 rs753759452 |
21 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775328176 CA7938412 |
22 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs775328176 CA395241668 |
22 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA7938410 rs759200829 |
24 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs773750094 CA7938409 |
29 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1596473373 CA395241619 |
30 | V>G | No |
ClinGen Ensembl |
|
|
rs1335194838 CA395241620 |
30 | V>L | No |
ClinGen gnomAD |
|
|
CA395241613 rs1388812927 |
31 | V>A | No |
ClinGen gnomAD |
|
|
rs777664660 CA395241615 |
31 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395241612 rs1388812927 |
31 | V>G | No |
ClinGen gnomAD |
|
|
rs777664660 CA7938407 |
31 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1270041405 CA395241589 |
34 | S>R | No |
ClinGen TOPMed |
|
|
CA395241587 rs1346374230 |
35 | L>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7938406 rs376264932 |
36 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs949786082 CA279353765 |
39 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
CA395241512 rs1461790339 |
43 | A>G | No |
ClinGen gnomAD |
|
|
rs781461709 CA7938403 |
43 | A>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 44 | N>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395241510 rs1449456374 |
44 | N>Y | No |
ClinGen TOPMed |
|
|
rs747226563 CA7938380 |
45 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1596463016 CA395241485 |
47 | T>I | No |
ClinGen Ensembl |
|
|
rs1271769549 CA395241480 |
48 | V>A | No |
ClinGen gnomAD |
|
|
CA395241476 rs1596463013 |
49 | I>F | No |
ClinGen Ensembl |
|
|
rs1227813348 CA395241462 |
51 | L>F | No |
ClinGen gnomAD |
|
|
rs141495504 CA395241445 |
53 | Q>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA395241438 rs1463614016 |
55 | V>M | No |
ClinGen gnomAD |
|
|
rs1316083998 CA395241427 |
57 | R>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7938375 rs756136132 |
57 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395241393 rs1596462997 |
61 | S>F | No |
ClinGen Ensembl |
|
|
CA395241366 rs1421128326 |
65 | Y>C | No |
ClinGen gnomAD |
|
|
CA395241365 rs1421128326 |
65 | Y>F | No |
ClinGen gnomAD |
|
|
CA7938373 rs767455957 |
66 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA279332299 rs914959837 |
68 | A>T | No |
ClinGen TOPMed |
|
|
CA279332296 rs769475571 |
70 | A>T | No |
ClinGen Ensembl |
|
|
CA279332290 rs1000112063 COSM244761 |
71 | A>V | prostate [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA279332288 rs759247227 |
74 | I>L | No |
ClinGen gnomAD |
|
|
CA7938369 rs762439043 |
74 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs759247227 CA395241315 |
74 | I>V | No |
ClinGen gnomAD |
|
| TCGA novel | 76 | V>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395241301 rs1266629567 |
76 | V>I | No |
ClinGen TOPMed |
|
| TCGA novel | 78 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1464793851 CA395241275 |
80 | I>L | No |
ClinGen TOPMed |
|
|
CA279332257 rs895582965 |
80 | I>M | No |
ClinGen TOPMed |
|
|
rs1014304157 CA279332260 |
80 | I>T | No |
ClinGen Ensembl |
|
|
rs369158552 CA7938367 |
82 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs762328410 CA7938366 |
83 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA7938365 rs777082356 |
84 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1295098832 CA395241241 |
85 | F>S | No |
ClinGen gnomAD |
|
|
rs761075198 CA7938362 |
88 | E>V | No |
ClinGen ExAC |
|
|
CA7938361 rs376132502 |
89 | D>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA395241190 rs1313754000 |
92 | L>F | No |
ClinGen gnomAD |
|
|
rs772331191 CA7938360 |
93 | N>T | No |
ClinGen ExAC gnomAD |
|
|
CA7938359 rs746022625 |
94 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs1329060702 CA395241182 |
94 | M>L | No |
ClinGen gnomAD |
|
|
rs1394836405 CA395241173 |
95 | Q>E | No |
ClinGen gnomAD |
|
|
rs143074187 CA7938358 |
95 | Q>R | No |
ClinGen ESP ExAC |
|
|
CA279332201 rs941617485 |
96 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA395241166 rs1165860928 |
96 | M>V | No |
ClinGen gnomAD |
|
|
CA279332200 rs908747188 |
97 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs181415488 CA7938357 |
98 | Q>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs748140778 CA7938356 |
101 | D>N | Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA395241108 rs1385137171 |
104 | I>M | No |
ClinGen TOPMed |
|
|
CA7938355 rs781252777 |
104 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
TCGA novel CA7938353 rs751365983 |
106 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen ExAC TOPMed gnomAD |
|
CA395241098 rs751365983 |
106 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395241087 rs1226140747 |
108 | E>* | No |
ClinGen gnomAD |
|
| TCGA novel | 112 | I>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA395241057 rs1328940523 |
112 | I>T | No |
ClinGen TOPMed |
|
|
CA279332167 COSM302324 rs1015377222 |
114 | T>I | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs758080532 CA7938351 |
116 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs770710839 CA279332163 |
116 | I>V | No |
ClinGen Ensembl |
|
|
rs1003961744 CA279332160 |
117 | W>C | No |
ClinGen TOPMed |
|
|
CA395241014 rs1265354362 |
119 | T>A | No |
ClinGen gnomAD |
|
|
CA7938350 rs749993997 |
120 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs761281280 CA7938348 |
121 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
CA395241002 rs1425613899 |
121 | P>S | No |
ClinGen gnomAD |
|
|
CA279332121 rs538799671 |
123 | T>S | No |
ClinGen 1000Genomes |
|
|
rs975483612 CA279332114 |
124 | I>M | No |
ClinGen gnomAD |
|
|
CA7938346 rs142100378 |
124 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1032845174 CA279332101 |
129 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1490438746 CA395240946 |
130 | V>L | No |
ClinGen gnomAD |
|
|
rs770936651 CA395240925 |
133 | P>A | No |
ClinGen TOPMed |
|
|
rs759836680 CA7938342 |
133 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs759836680 CA7938343 |
133 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
rs770936651 CA279332100 |
133 | P>T | No |
ClinGen TOPMed |
|
|
CA395240916 rs1318655690 |
135 | K>Q | No |
ClinGen gnomAD |
|
|
rs137883582 CA7938340 |
137 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs749366228 CA7938339 |
138 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA7938338 rs146922265 |
138 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1345333213 CA395240887 |
139 | V>F | No |
ClinGen gnomAD |
|
|
rs1345333213 CA395240888 |
139 | V>L | No |
ClinGen gnomAD |
|
|
rs537730436 CA7938335 |
141 | Y>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA395240876 rs1292118687 |
141 | Y>N | No |
ClinGen gnomAD |
|
|
CA7938334 rs758087867 |
143 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA7938333 rs750115024 |
144 | R>C | Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs778511361 CA7938332 |
144 | R>H | No |
ClinGen ExAC gnomAD |
|
|
COSM557113 CA395240859 rs750115024 |
144 | R>S | lung Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs117796776 CA279332028 |
145 | T>S | No |
ClinGen 1000Genomes |
|
|
rs1177481050 CA395240852 |
145 | T>S | No |
ClinGen gnomAD |
|
|
CA7938331 rs756813774 COSM1253519 |
146 | R>Q | Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1000398834 CA279332020 |
146 | R>W | No |
ClinGen TOPMed |
|
|
rs779166553 CA395240828 |
149 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA7938329 rs371060930 |
149 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395240818 rs753106637 |
151 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756668514 CA7938328 |
151 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA7938327 rs753106637 |
151 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395240808 rs1244720077 |
153 | Y>H | No |
ClinGen TOPMed |
|
|
CA279332000 rs1013940734 |
156 | C>F | No |
ClinGen gnomAD |
|
|
CA7938326 rs767966063 |
161 | I>F | No |
ClinGen ExAC gnomAD |
|
|
CA7938325 rs759798192 |
164 | Y>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 165 | W>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 166 | W>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1009146155 CA279331980 |
166 | W>R | No |
ClinGen TOPMed |
|
|
rs1363307473 CA395240690 |
169 | I>M | No |
ClinGen gnomAD |
|
|
CA279331975 rs868806533 COSM1708825 |
170 | W>* | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs1272020019 CA395240688 |
170 | W>R | No |
ClinGen TOPMed |
|
|
CA279331951 rs890668532 |
174 | Y>* | No |
ClinGen TOPMed |
|
|
CA279331968 rs1001230865 |
174 | Y>S | No |
ClinGen Ensembl |
|
|
CA279331945 rs905407464 |
175 | I>T | No |
ClinGen gnomAD |
|
|
CA395240634 rs1408438853 |
177 | T>I | No |
ClinGen gnomAD |
|
|
rs1337462285 CA395240622 |
179 | V>A | No |
ClinGen gnomAD |
|
| TCGA novel | 179 | V>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1421932721 CA395240626 |
179 | V>M | No |
ClinGen TOPMed |
|
|
rs1373611772 CA395240614 |
180 | H>Q | No |
ClinGen TOPMed |
|
|
CA7938322 rs773441202 |
182 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7938321 rs773441202 |
182 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7938319 rs746995178 |
183 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1304900610 CA395240591 |
184 | I>M | No |
ClinGen TOPMed |
|
|
CA279331915 rs915011877 |
184 | I>S | No |
ClinGen TOPMed gnomAD |
|
|
CA7938317 rs771946888 |
184 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1244518828 CA395240588 |
185 | W>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1244518828 CA395240590 |
185 | W>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1460608621 CA395240545 |
190 | T>N | No |
ClinGen gnomAD |
|
|
COSM3787096 rs368847803 CA7938315 |
191 | V>I | pancreas [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA7938314 rs756905722 |
194 | V>E | No |
ClinGen ExAC gnomAD |
|
|
rs755549727 CA7938311 |
197 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA7938310 rs753297345 |
198 | I>N | No |
ClinGen ExAC |
|
|
rs1451916218 CA395240490 |
199 | F>L | No |
ClinGen gnomAD |
|
|
CA395240475 rs1377279993 |
201 | I>S | No |
ClinGen TOPMed gnomAD |
|
|
CA395240476 rs1377279993 |
201 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
rs767897247 CA7938308 |
203 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA7938306 rs145592899 |
205 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1386953566 CA395240437 |
207 | V>E | No |
ClinGen gnomAD |
|
|
rs934038967 CA279331862 |
208 | Y>N | No |
ClinGen Ensembl |
|
|
CA395240411 rs1462141768 |
211 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
rs763292683 CA7938304 |
212 | R>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395240388 rs1451326198 |
214 | S>T | No |
ClinGen TOPMed |
|
|
rs1480751019 CA395240369 |
216 | F>L | No |
ClinGen gnomAD |
|
|
rs942765597 COSM967969 CA279331812 |
217 | R>C | large_intestine Variant assessed as Somatic; impact. endometrium [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs761772877 CA7938302 |
217 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA7938301 rs761772877 |
217 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA7938300 rs775551797 |
218 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs771899095 CA7938299 |
219 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs372844926 CA7938298 |
219 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs374393252 CA279331771 |
221 | Y>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs144787739 CA7938295 |
223 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs144787739 CA7938296 COSM1563214 |
223 | T>M | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs199641856 CA7938292 |
224 | G>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs780690861 CA7938291 |
227 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA395240307 rs1314429704 |
228 | A>S | No |
ClinGen gnomAD |
|
|
rs1314429704 CA395240308 COSM271930 |
228 | A>T | Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA7938289 rs752066033 |
229 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs140826186 CA7938288 |
231 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs551069792 CA395240261 |
235 | S>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs551069792 CA7938286 |
235 | S>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA395240263 rs1366271799 |
235 | S>P | No |
ClinGen gnomAD |
|
|
rs1219343579 CA395240253 |
236 | I>M | No |
ClinGen TOPMed |
|
|
rs762019600 CA7938284 |
238 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs143674735 CA7938283 |
239 | T>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7938282 rs562935712 |
240 | L>F | No |
ClinGen 1000Genomes ExAC |
|
|
CA395240220 rs1310132792 |
242 | A>T | No |
ClinGen TOPMed |
|
|
rs1270027468 CA395240212 |
243 | P>S | No |
ClinGen gnomAD |
|
| TCGA novel | 243 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7938280 rs774243224 |
244 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
CA7938279 rs140063049 |
244 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA279331686 rs866286293 |
247 | M>I | No |
ClinGen Ensembl |
|
|
CA7938277 rs370101416 |
248 | I>V | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1567233885 CA621665006 |
250 | Y>* | No |
ClinGen Ensembl |
|
|
CA395240163 rs562419932 |
250 | Y>* | No |
ClinGen 1000Genomes ExAC |
|
|
CA395240162 rs1383056575 |
251 | H>N | No |
ClinGen gnomAD |
|
|
rs747782887 CA7938274 |
251 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs780592517 CA7938273 |
253 | Y>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 254 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7938272 rs768243680 |
255 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1388412861 CA395240118 |
258 | Q>K | No |
ClinGen gnomAD |
|
|
rs747556372 CA7938271 |
260 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs201301006 CA7938270 |
260 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747556372 CA395240102 |
260 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA7938269 rs758887814 |
261 | W>L | No |
ClinGen ExAC gnomAD |
|
|
CA395240097 rs1410793752 |
261 | W>R | No |
ClinGen gnomAD |
|
|
CA395240081 rs1423315743 |
263 | V>A | No |
ClinGen TOPMed |
|
|
rs373440031 CA279331629 |
265 | I>M | No |
ClinGen Ensembl |
|
|
rs1414678143 CA395240067 |
265 | I>T | No |
ClinGen TOPMed |
|
|
CA7938265 rs754041218 |
266 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395240062 rs1159032666 |
266 | M>T | No |
ClinGen TOPMed |
|
|
rs757433137 CA7938266 |
266 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760723072 CA7938263 |
268 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA7938261 rs374532990 |
269 | I>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA279331606 rs374532990 |
269 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1266281677 CA395240033 |
271 | N>D | No |
ClinGen gnomAD |
|
|
rs539936998 CA7938260 |
271 | N>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7938259 rs762886187 |
272 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA7938256 rs761406669 |
279 | A>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 280 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs776388655 CA7938255 |
282 | F>V | No |
ClinGen ExAC |
|
|
CA7938254 rs768327452 |
284 | L>F | No |
ClinGen ExAC |
|
| TCGA novel | 285 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7938252 rs144836581 |
291 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA7938253 rs556069972 COSM182607 |
291 | R>W | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
CA7938251 rs750639804 |
293 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746326530 CA7938250 |
293 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs746326530 CA395239882 |
293 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs1406283279 CA395239876 |
294 | T>I | No |
ClinGen gnomAD |
|
|
CA7938247 rs749523304 |
295 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM3736139 CA7938248 rs149441644 |
295 | M>V | skin [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA7938245 rs188626855 |
298 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7938244 rs752778755 |
299 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs767531379 CA395239849 |
299 | T>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA7938243 rs767531379 |
299 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1278131938 CA395239845 |
300 | L>F | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 300 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs533506374 CA395239838 |
301 | K>R | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs533506374 CA279331554 |
301 | K>T | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs1252825563 CA395239827 |
303 | F>L | No |
ClinGen gnomAD |
|
|
CA395239803 rs1471800860 |
306 | C>G | No |
ClinGen TOPMed |
|
|
CA279331550 rs770079261 |
310 | P>S | No |
ClinGen Ensembl |
|
|
rs1419204742 CA395239765 |
311 | V>E | No |
ClinGen TOPMed |
|
|
CA7938240 rs764984700 |
311 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7938239 rs761645297 |
312 | Q>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 313 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7938238 rs776481788 |
314 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA7938237 rs763831028 |
316 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs868621318 CA395239714 |
318 | N>K | No |
ClinGen gnomAD |
|
|
rs760333722 CA7938236 |
318 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395239708 rs1361698674 |
319 | F>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1399166045 CA395239710 |
319 | F>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1168838873 CA395239697 |
321 | I>V | No |
ClinGen gnomAD |
|
|
CA395239688 rs1429688515 |
322 | T>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1429688515 CA395239687 |
322 | T>R | No |
ClinGen TOPMed gnomAD |
|
|
CA395239642 rs1237205341 COSM3741808 |
328 | S>L | liver [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs904899563 COSM172181 CA279331519 |
329 | P>L | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
| TCGA novel | 331 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 333 | H>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1379723211 CA395239603 |
334 | C>F | No |
ClinGen TOPMed |
|
|
CA7938234 rs771560703 |
336 | K>* | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 345 | N>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7938231 rs771259684 |
348 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778045772 CA7938229 |
350 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA395239482 rs1247565139 |
351 | V>A | No |
ClinGen gnomAD |
|
|
CA7938228 rs756345987 |
351 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7938226 rs199929675 |
353 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs748325656 CA7938227 |
353 | P>S | No |
ClinGen ExAC gnomAD |
No associated diseases with Q6DWJ6
3 regional properties for Q6DWJ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | RPEL repeat | 63 - 88 | IPR004018-1 |
| repeat | RPEL repeat | 583 - 608 | IPR004018-2 |
| repeat | RPEL repeat | 621 - 646 | IPR004018-3 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| neuropeptide receptor activity | Combining with a neuropeptide to initiate a change in cell activity. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
119 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHTHAHLAA | NSSLSWWSPG | SACGLGFVPV | VYYSLLLCLG | LPANILTVII | LSQLVARRQK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSYNYLLALA | AADILVLFFI | VFVDFLLEDF | ILNMQMPQVP | DKIIEVLEFS | SIHTSIWITV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLTIDRYIAV | CHPLKYHTVS | YPARTRKVIV | SVYITCFLTS | IPYYWWPNIW | TEDYISTSVH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HVLIWIHCFT | VYLVPCSIFF | ILNSIIVYKL | RRKSNFRLRG | YSTGKTTAIL | FTITSIFATL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WAPRIIMILY | HLYGAPIQNR | WLVHIMSDIA | NMLALLNTAI | NFFLYCFISK | RFRTMAAATL |
| 310 | 320 | 330 | 340 | 350 | |
| KAFFKCQKQP | VQFYTNHNFS | ITSSPWISPA | NSHCIKMLVY | QYDKNGKPIK | VSP |