AiPD: Autoinhibited Protein Database

Q8TDU9

Gene name	RXFP4 (GPCR142, GPR100, RLN3R2)
Protein name	Relaxin-3 receptor 2
Names	RLN3 receptor 2, G-protein coupled receptor 100, G-protein coupled receptor GPCR142, Insulin-like peptide INSL5 receptor, Relaxin family peptide receptor 4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:339403
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

325-374 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

325-374 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q8TDU9

Entry ID	Method	Resolution	Chain	Position	Source
7YJ4	EM	319 A	R	1-374	PDB
7YK6	EM	303 A	R	1-374	PDB
7YK7	EM	275 A	R	1-374	PDB
AF-Q8TDU9-F1	Predicted				AlphaFoldDB

334 variants for Q8TDU9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA342792174 rs1298314630	2	P>L		No	ClinGen TOPMed
CA30971842 rs867046609	3	T>I		No	ClinGen TOPMed gnomAD
CA30971845 rs867046609	3	T>K		No	ClinGen TOPMed gnomAD
rs76232257 CA1152582	6	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs569415346 CA1152585	9	S>F		No	ClinGen 1000Genomes ExAC gnomAD
CA342792220 rs1178270313	9	S>P		No	ClinGen TOPMed
CA1152586 rs373839078	10	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs995618243 CA30971905	12	T>A		No	ClinGen Ensembl
CA342792259 rs1557975171	13	F>C		No	ClinGen Ensembl
rs777267179 COSM206809 CA1152588	13	F>L	large_intestine Variant assessed as Somatic; impact. endometrium [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA
CA342792255 COSM206809 rs1290810019	13	F>L	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs140938499 CA1152589	16	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152590 rs769282364	17	N>S		No	ClinGen ExAC TOPMed gnomAD
CA30971912 rs1042629858	19	S>A		No	ClinGen TOPMed
CA1152592 rs762715919	20	G>R		No	ClinGen ExAC TOPMed gnomAD
rs765914097 CA1152593	22	S>G		No	ClinGen ExAC TOPMed gnomAD
CA1152594 rs774268188	23	V>M		No	ClinGen ExAC gnomAD
CA342792371 rs1187026185	25	S>R		No	ClinGen gnomAD
rs759310694 CA1152595	26	A>T		No	ClinGen ExAC gnomAD
rs555038205 CA1152597	29	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1152599 rs142076460	30	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	32	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758690281 CA1152602	34	K>E		No	ClinGen ExAC gnomAD
rs1307008956 CA342792477	34	K>R		No	ClinGen TOPMed
rs780137826 CA1152603	36	L>P		No	ClinGen ExAC gnomAD
rs747437685 CA1152604	37	A>T		No	ClinGen ExAC gnomAD
TCGA novel	37	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs202144379 CA1152608	41	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770177977 CA30972001	42	V>I		No	ClinGen ExAC TOPMed gnomAD
rs770177977 CA1152609	42	V>L		No	ClinGen ExAC TOPMed gnomAD
CA342792561 rs1392900126	45	A>D		No	ClinGen gnomAD
CA30972003 rs1020092628	48	L>F		No	ClinGen Ensembl
CA342792588 rs1572019586	49	V>G		No	ClinGen Ensembl
CA342792584 rs1338265362	49	V>M		No	ClinGen TOPMed
CA1152611 rs748743202	52	I>T		No	ClinGen ExAC TOPMed
rs78565440 CA30972023	54	L>F		No	ClinGen Ensembl
CA1152612 rs770671414	55	L>R		No	ClinGen ExAC TOPMed gnomAD
rs759329075 CA1152614	58	L>S		No	ClinGen ExAC gnomAD
rs200985925 CA1152615	59	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200985925 COSM3748441 CA342792647	59	A>V	stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1572019601 CA342792653	60	V>G		No	ClinGen Ensembl
CA1152616 rs368685840	61	L>P		No	ClinGen ESP ExAC gnomAD
rs760717759 CA1152617	63	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1179313142 CA342792667	63	V>L		No	ClinGen gnomAD
rs1572019610 TCGA novel CA342792677	65	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA342792692 CA342792691 rs1378590532	66	N>K		No	ClinGen TOPMed
rs1432833866 CA342792705	68	A>V		No	ClinGen gnomAD
rs753357570 CA1152619	69	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1152618 rs763911312	69	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1435368139 CA342792710	70	R>G		No	ClinGen TOPMed gnomAD
rs746068181 CA1152620	71	A>T		No	ClinGen ExAC gnomAD
rs1368602924 CA342792727	72	P>L		No	ClinGen gnomAD
rs1356721731 CA342792728	73	G>S		No	ClinGen gnomAD
rs1389679306 CA342792739	74	P>L		No	ClinGen TOPMed gnomAD
CA342792744 rs1305105604	75	P>L		No	ClinGen gnomAD
CA30972063 rs377552488	75	P>S		No	ClinGen Ensembl
rs754514600 CA1152622	76	S>A		No	ClinGen ExAC gnomAD
CA1152624 rs138502753	77	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152623 rs755427096	77	D>H		No	ClinGen ExAC gnomAD
CA30972092 rs201292152	78	T>N		No	ClinGen 1000Genomes TOPMed
CA342792756 rs1572019647	78	T>P		No	ClinGen Ensembl
rs937005861 CA30972105	80	V>I		No	ClinGen gnomAD
rs992179508 CA30972135	82	N>K		No	ClinGen TOPMed
CA1152626 rs756711204	82	N>S		No	ClinGen ExAC gnomAD
CA342792807 rs770276231	86	A>E		No	ClinGen ExAC TOPMed gnomAD
rs770276231 CA1152629	86	A>V		No	ClinGen ExAC TOPMed gnomAD
CA342792820 rs1310231779	88	L>P		No	ClinGen TOPMed
CA342792837 rs1383737299	91	A>G		No	ClinGen TOPMed
rs931520740 CA30972183	92	L>F		No	ClinGen TOPMed gnomAD
rs931520740 CA342792840	92	L>V		No	ClinGen TOPMed gnomAD
CA342792845 rs1456175747	93	T>A		No	ClinGen gnomAD
rs1327544871 CA342792847	93	T>N		No	ClinGen gnomAD
CA342792844 rs1456175747	93	T>P		No	ClinGen gnomAD
CA1152636 rs768700062	95	P>S		No	ClinGen ExAC gnomAD
rs766529074 CA1152639	97	W>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA30972246 rs944131513	99	A>V		No	ClinGen TOPMed gnomAD
rs767845245 CA1152642	100	E>D		No	ClinGen ExAC gnomAD
CA1152641 rs371453354	100	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs753169719 CA1152643	101	S>L		No	ClinGen ExAC TOPMed gnomAD
CA30972319 rs367884988	103	L>R		No	ClinGen ESP
CA1152645 rs778343223	105	F>L		No	ClinGen ExAC gnomAD
CA1152648 rs778446357	106	H>L		No	ClinGen ExAC gnomAD
rs754256552 CA1152646	106	H>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1152647 rs754256552	106	H>Y		No	ClinGen ExAC gnomAD
CA30972363 rs1042988959	107	W>*		No	ClinGen TOPMed
CA342792930 rs1193573852	107	W>R		No	ClinGen TOPMed
TCGA novel	108	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1412936437 CA342792937	108	P>T		No	ClinGen gnomAD
CA342792944 rs1421903986	109	F>L		No	ClinGen gnomAD
rs1456381655 CA342792953	110	G>E		No	ClinGen gnomAD
COSM2211357 rs199683371 CA1152650	110	G>R	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs779671231 CA1152651	111	G>D		No	ClinGen ExAC gnomAD
rs1572019750 CA342792962	112	A>P		No	ClinGen Ensembl
CA342792968 rs1346477534	113	L>F		No	ClinGen gnomAD
CA1152652 rs746835195	115	K>E		No	ClinGen ExAC gnomAD
COSM1668044 CA1152653 rs768269224	115	K>N	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs761607398 CA1152655	116	M>I		No	ClinGen ExAC gnomAD
CA1152654 rs776663883	116	M>T		No	ClinGen ExAC gnomAD
CA342792988 rs1471045795	116	M>V		No	ClinGen gnomAD
rs1355160467 CA342793003	118	L>P		No	ClinGen TOPMed
COSM897075 rs375481936 CA1152656	119	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1572019769 CA342793005	119	T>P		No	ClinGen Ensembl
rs1228035079 CA342793010	120	A>T		No	ClinGen gnomAD
CA342793032 rs1216582572	123	L>P		No	ClinGen gnomAD
CA342793035 rs1398004474	124	N>D		No	ClinGen TOPMed
rs1347322647 CA342793039	124	N>S		No	ClinGen TOPMed
CA1152660 rs548554375	125	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1161651026 CA342793083	128	S>T		No	ClinGen TOPMed
CA1152663 rs150519113	129	I>N		No	ClinGen ESP ExAC gnomAD
rs1179633113 CA342793110	130	F>C		No	ClinGen gnomAD
rs764314560 CA1152664	134	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1433410461 CA342793169	136	S>N		No	ClinGen TOPMed gnomAD
rs149283693 CA1152668	136	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA342793171 rs1433410461	136	S>T		No	ClinGen TOPMed gnomAD
rs757849833 CA1152669	137	V>I		No	ClinGen ExAC TOPMed gnomAD
CA1152670 rs779687290	138	A>T		No	ClinGen ExAC gnomAD
rs201370533 CA1152671	139	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs754825959 CA1152672	139	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs146210789 CA1152673	140	Y>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs747969629 CA1152675	143	V>A		No	ClinGen ExAC gnomAD
CA30972524 rs200353483	143	V>L		No	ClinGen Ensembl
rs769809373 CA30972547	144	A>D		No	ClinGen Ensembl
CA342793246 rs1212964575	144	A>T		No	ClinGen gnomAD
CA30972549 rs958648993	145	M>I		No	ClinGen Ensembl
rs200703792 CA1152676	145	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745946606 CA1152678	147	A>T		No	ClinGen ExAC gnomAD
rs144073711 CA1152679	147	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1572019862 CA342793321	151	T>N		No	ClinGen Ensembl
rs1572019857 CA342793316	151	T>P		No	ClinGen Ensembl
CA342793331 rs1572019866	152	H>P		No	ClinGen Ensembl
rs760852516 CA1152682	152	H>Q		No	ClinGen ExAC TOPMed
rs1283827844 CA342793327	152	H>Y		No	ClinGen TOPMed
TCGA novel	153	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1152683 rs764348848	154	S>A		No	ClinGen ExAC gnomAD
CA30972568 rs866604436	155	L>P		No	ClinGen Ensembl
CA1152685 rs528071251	157	W>*		No	ClinGen 1000Genomes ExAC gnomAD
rs765749600 CA1152686	158	A>P		No	ClinGen ExAC gnomAD
rs750863836 CA1152687	159	R>*		No	ClinGen ExAC gnomAD
CA1152688 rs148682172	159	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751059271 CA1152690	160	I>R		No	ClinGen ExAC TOPMed gnomAD
rs751059271 CA342793417	160	I>T		No	ClinGen ExAC TOPMed gnomAD
CA1152689 rs765759252	160	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	163	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1152695 rs755905775	164	A>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1152696 rs777880605	165	V>A		No	ClinGen ExAC TOPMed gnomAD
CA1152697 rs749183955	166	W>*		No	ClinGen ExAC gnomAD
rs770968073 CA1152698	167	A>V		No	ClinGen ExAC gnomAD
CA1152700 rs532755231 COSM897077	168	A>V	Variant assessed as Somatic; 0.0003709 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs776859123 CA1152702	171	L>P		No	ClinGen ExAC TOPMed gnomAD
rs770104363 COSM897078 CA1152704	173	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA342793590 rs1218566562	176	T>I		No	ClinGen TOPMed
CA30972670 rs936900058	179	F>C		No	ClinGen TOPMed gnomAD
CA1152706 rs373128622	180	G>R		No	ClinGen ExAC gnomAD
rs1205025987 CA342793667	183	G>S		No	ClinGen gnomAD
rs1241317541 CA342793674	184	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA1152708 rs751086295	184	E>V		No	ClinGen ExAC gnomAD
CA1152709 rs759027160	185	V>A		No	ClinGen ExAC TOPMed gnomAD
CA30972699 rs991014923	186	C>R		No	ClinGen TOPMed
rs1326681523 CA342793703	187	G>D		No	ClinGen TOPMed gnomAD
rs1335288810 CA342793716	188	V>A		No	ClinGen TOPMed
CA342793708 rs1408739914	188	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs752357892 CA1152711	189	R>C	Variant assessed as Somatic; 4.676e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs145457936 CA1152712	189	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs752357892 CA342793719	189	R>S		No	ClinGen ExAC TOPMed gnomAD
CA342793756 rs1400728120	192	L>V		No	ClinGen TOPMed
CA1152713 rs146694614	194	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152714 rs202002819	194	R>H		No	ClinGen ExAC TOPMed gnomAD
rs377498954 CA30972720	198	R>S		No	ClinGen gnomAD
CA1152716 rs540076477	198	R>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA342793863 rs1444728293	199	Y>*		No	ClinGen gnomAD
TCGA novel rs886488341 CA30972727	200	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
rs1388083881 CA342793871	200	W>G		No	ClinGen Ensembl
rs940782121 CA30972740	202	G>V		No	ClinGen TOPMed gnomAD
CA30972775 rs1005036062	203	A>G		No	ClinGen gnomAD
CA1152718 rs747077235	203	A>T		No	ClinGen ExAC gnomAD
CA342793918 rs1005036062	203	A>V		No	ClinGen gnomAD
rs1164645602 CA342793948	205	Q>*		No	ClinGen gnomAD
rs1015058361 CA30972788	210	V>G		No	ClinGen Ensembl
rs781300834 CA1152721	210	V>M		No	ClinGen ExAC gnomAD
rs769983048 CA1152723	214	M>T		No	ClinGen ExAC gnomAD
rs996037825 CA30972828	215	V>A		No	ClinGen TOPMed
CA342794093 rs1320281246	215	V>M		No	ClinGen TOPMed gnomAD
CA342794104 rs1326936498	216	P>T		No	ClinGen gnomAD
rs773608274 CA1152724	217	L>F		No	ClinGen ExAC gnomAD
TCGA novel	217	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763288156 CA1152725	218	G>D		No	ClinGen ExAC gnomAD
TCGA novel	219	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1152727 rs370386081	219	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1152728 rs758999178	220	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1206367540 CA342794163	223	S>G		No	ClinGen gnomAD
rs752229371 CA1152730	224	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs376040799 CA1152734	233	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152732 rs148204679	233	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370390435 CA1152736	234	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152735 rs41264991	234	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1363429808 CA342794242	235	Q>*		No	ClinGen gnomAD
CA1152739 rs755034465	236	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs41264993 CA1152738	236	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1152742 rs112568920	237	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142579924 CA1152741	237	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs200267541 CA1152744	238	R>L		No	ClinGen ExAC gnomAD
rs200267541 CA1152745	238	R>Q		No	ClinGen ExAC gnomAD
rs556908637 CA1152743	238	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1152746 rs774742423	239	Q>K		No	ClinGen ExAC gnomAD
CA342794299 rs1279643036	240	D>E		No	ClinGen gnomAD
CA1152747 rs746432427	240	D>N		No	ClinGen ExAC gnomAD
rs772424024 CA1152748	241	S>G		No	ClinGen ExAC gnomAD
CA342794308 rs1210833562	241	S>N		No	ClinGen gnomAD
CA1152749 rs746011090	243	V>G		No	ClinGen ExAC TOPMed gnomAD
CA342794334 rs1194280056	243	V>I		No	ClinGen TOPMed
CA1152751 rs763855634	244	V>M		No	ClinGen ExAC TOPMed gnomAD
rs775696063 CA30973029	245	A>D		No	ClinGen gnomAD
rs776359823 CA1152752	246	R>C		No	ClinGen ExAC TOPMed gnomAD
rs201264364 CA1152753	246	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201264364 CA1152754	246	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1364492264 CA342794400	248	V>F		No	ClinGen gnomAD
CA1152755 rs200081325	249	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA342794412 rs200081325	249	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs758401880 CA1152757	249	R>H		No	ClinGen ExAC TOPMed gnomAD
rs758401880 CA1152756	249	R>P		No	ClinGen ExAC TOPMed gnomAD
CA342794447 rs1435176379 CA342794450	252	V>L		No	ClinGen TOPMed gnomAD
CA342794445 rs1435176379	252	V>M		No	ClinGen TOPMed gnomAD
rs1297397468 CA342794458	253	A>T		No	ClinGen gnomAD
rs749477537 CA342794541	258	C>S		No	ClinGen ExAC TOPMed gnomAD
rs749477537 CA1152761	258	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1301975565 CA342794565	259	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1350693722 CA342794595	261	P>A		No	ClinGen gnomAD
CA1152762 rs200889754	263	H>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779371942 CA1152763	263	H>R		No	ClinGen ExAC
CA342794671 rs772761389	265	V>F		No	ClinGen ExAC gnomAD
CA1152765 rs772761389	265	V>I		No	ClinGen ExAC gnomAD
CA30973138 rs1041358512	267	L>P		No	ClinGen TOPMed
CA30973140 rs976950671	269	G>D		No	ClinGen gnomAD
rs1557975749 CA342794732	269	G>S		No	ClinGen Ensembl
rs1201562885	270	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342794779 rs1433085344	272	V>A		No	ClinGen Ensembl
CA1152768 rs768245510	272	V>L		No	ClinGen ExAC TOPMed gnomAD
CA342794789 rs1247429133	273	K>T		No	ClinGen TOPMed
rs1417925715 CA342794799	274	F>I		No	ClinGen gnomAD
rs370986226 CA1152769	274	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs761576138 CA1152770	275	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1463300594 CA342794847	277	V>L		No	ClinGen gnomAD
CA1152772 rs773126950	279	W>*		No	ClinGen ExAC TOPMed gnomAD
CA1152773 rs762644934	279	W>*		No	ClinGen ExAC TOPMed gnomAD
rs1298437696 COSM1241693 CA342794863	279	W>R	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
CA1152776 rs756207171	283	F>S		No	ClinGen ExAC gnomAD
CA342794920 rs1317795062	284	Y>C		No	ClinGen TOPMed
CA1152779 rs186678827	288	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1367690169 CA342794960	290	V>I		No	ClinGen TOPMed
TCGA novel	292	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs148508637 CA1152781	295	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs148508637 CA342794991	295	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1211993494 CA342794996	296	C>R		No	ClinGen gnomAD
rs1468934986 CA342795002	296	C>W		No	ClinGen TOPMed gnomAD
rs1254985974 CA342794998	296	C>Y		No	ClinGen gnomAD
CA342795012 rs1259543208	298	A>E		No	ClinGen gnomAD
rs780741134 CA1152783	298	A>T		No	ClinGen ExAC gnomAD
CA1152784 rs747474355	300	S>N		No	ClinGen ExAC TOPMed gnomAD
rs915269552 CA30973228	301	N>S		No	ClinGen TOPMed
rs1327132291 CA342795048	303	C>Y		No	ClinGen gnomAD
CA1152785 rs142470296	309	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747608815 CA1152787	313	R>K		No	ClinGen ExAC TOPMed gnomAD
CA1152786 rs144700057	313	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152789 rs140546405	314	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152788 rs769550116	314	R>W		No	ClinGen ExAC TOPMed gnomAD
CA342795118 rs1487606905	315	E>K		No	ClinGen TOPMed
rs1279248117 CA342795130	316	P>L		No	ClinGen gnomAD
rs762766633 CA1152792	316	P>T		No	ClinGen ExAC TOPMed gnomAD
CA342795131 rs770662368	317	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1152795 rs145206873	317	R>L		No	ClinGen ExAC TOPMed gnomAD
CA1152794 rs145206873	317	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1152793 rs770662368	317	R>W		No	ClinGen ExAC TOPMed gnomAD
CA342795136 rs1572020262	318	Q>P		No	ClinGen Ensembl
rs202202296 CA1152798	322	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs202202296 CA1152799	322	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765504405 CA1152800	323	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1572020281 CA342795168	324	F>L		No	ClinGen Ensembl
CA342795180 rs1445664906	325	R>S		No	ClinGen TOPMed
rs1258956005 CA342795193	327	L>P		No	ClinGen gnomAD
CA342795195 rs780618490	328	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1152804 rs751945369	328	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1152803 rs780618490	328	R>W		No	ClinGen ExAC TOPMed gnomAD
rs2152051 CA342795200	329	L>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM424097 rs781539948 CA342795202	329	L>F	breast [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs2152051 CA1152806 VAR_021516	329	L>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1572020301 CA342795199	329	L>V		No	ClinGen Ensembl
rs2152051 CA342795201	329	L>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342795226 rs1156319945	333	P>A		No	ClinGen gnomAD
COSM424098 CA1152809 rs747709631	333	P>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA342795229 rs747709631	333	P>L		No	ClinGen ExAC TOPMed gnomAD
CA342795227 rs1156319945	333	P>S		No	ClinGen gnomAD
TCGA novel	336	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1152811 rs548910794	336	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1152812 rs748985812	337	G>V		No	ClinGen ExAC TOPMed gnomAD
CA342795268 rs1572020337	339	V>G		No	ClinGen Ensembl
rs1413297206 CA342795269	340	Q>K		No	ClinGen gnomAD
rs1295405595 CA342795278	341	Q>E		No	ClinGen gnomAD
rs1380152581 CA342795283	341	Q>H		No	ClinGen gnomAD
rs1295405595 CA342795277	341	Q>K		No	ClinGen gnomAD
CA342795281 rs1572020349	341	Q>R		No	ClinGen Ensembl
CA342795319 rs774198224	347	V>I		No	ClinGen ExAC gnomAD
rs774198224 CA1152814	347	V>L		No	ClinGen ExAC gnomAD
rs201479425 CA30973355	349	R>S		No	ClinGen 1000Genomes gnomAD
CA1152816 rs139728237	350	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152815 rs184082733	350	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342795338 rs1572020371	351	W>G		No	ClinGen Ensembl
CA342795352 rs1572020376	352	V>G		No	ClinGen Ensembl
rs1572020374 CA342795349	352	V>I		No	ClinGen Ensembl
rs201411556 CA1152819	353	A>E		No	ClinGen 1000Genomes ExAC gnomAD
rs761985012 CA1152818	353	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA30973370 rs879065343	355	N>K		No	ClinGen gnomAD
rs1572020392 CA342795368	355	N>T		No	ClinGen Ensembl
CA342795374 rs1175067298	356	P>L		No	ClinGen gnomAD
rs570812142 CA1152820	356	P>T		No	ClinGen 1000Genomes ExAC gnomAD
rs766708834 CA1152822	357	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs369005247 CA1152821	357	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA342795384 rs1572020412	358	E>G		No	ClinGen Ensembl
CA1152824 rs755339305	360	R>C		No	ClinGen ExAC TOPMed gnomAD
rs372963770 CA1152825	360	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1152826 rs372963770	360	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA342795400 rs765999466	361	P>A		No	ClinGen ExAC
rs777184840 COSM1738411 CA1152829	361	P>L	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs765999466 CA1152828	361	P>T		No	ClinGen ExAC
CA342795414 rs1360065854	363	T>I		No	ClinGen TOPMed gnomAD
rs1360065854 CA342795415	363	T>S		No	ClinGen TOPMed gnomAD
rs748791946 CA1152830	365	L>P		No	ClinGen ExAC gnomAD
CA1152831 rs756960746	368	L>V		No	ClinGen ExAC TOPMed gnomAD
CA342795447 rs1375686128	369	D>A		No	ClinGen gnomAD
TCGA novel	369	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342795456 rs1350933025	370	R>K		No	ClinGen gnomAD
rs753531450 CA342795459 CA30973429	371	G>R		No	ClinGen TOPMed
CA342795467 rs1240949841	372	T>I		No	ClinGen gnomAD
TCGA novel	373	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745665167 CA1152833	374	G>R		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q8TDU9

3 regional properties for Q8TDU9

Type	Name	Position	InterPro Accession
repeat	RPEL repeat	63 - 88	IPR004018-1
repeat	RPEL repeat	583 - 608	IPR004018-2
repeat	RPEL repeat	621 - 646	IPR004018-3

Functions

		Description
EC Number
Subcellular Localization	Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
G protein-coupled peptide receptor activity	Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

2 GO annotations of biological process

Name	Definition
neuropeptide signaling pathway	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
positive regulation of feeding behavior	Any process that activates or increases the frequency, rate or extent of feeding behavior.

119 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2YDN1	GPR161	G protein-coupled receptor 161	Bos taurus (Bovine)	PR
Q0GBZ5	HCRTR1	Orexin/Hypocretin receptor type 1	Bos taurus (Bovine)	PR
Q17QD8	GPR37L1	G-protein coupled receptor 37-like 1	Bos taurus (Bovine)	PR
Q8SPN1	PROKR2	Prokineticin receptor 2	Bos taurus (Bovine)	PR
P46626	ADRB3	Beta-3 adrenergic receptor	Bos taurus (Bovine)	PR
O46639	TRHR	Thyrotropin-releasing hormone receptor	Bos taurus (Bovine)	PR
Q8SPN2	PROKR1	Prokineticin receptor 1	Bos taurus (Bovine)	PR
B9VR26	CMLKR1	Chemerin-like receptor 1	Bos taurus (Bovine)	PR
P18130	ADRA1A	Alpha-1A adrenergic receptor	Bos taurus (Bovine)	PR
B4XF06	GPR39	G-protein coupled receptor 39	Bos taurus (Bovine)	PR
O18913	OPN1LW	Long-wave-sensitive opsin 1	Felis catus (Cat) (Felis silvestris catus)	PR
P28683	PRA1	Green-sensitive opsin	Gallus gallus (Chicken)	PR
Q9N298	HTR1A	5-hydroxytryptamine receptor 1A	Pan troglodytes (Chimpanzee)	PR
P08099	Rh2	Opsin Rh2	Drosophila melanogaster (Fruit fly)	PR
P06002	ninaE	Opsin Rh1	Drosophila melanogaster (Fruit fly)	PR
Q4LBB9	Octbeta2R	Octopamine receptor beta-2R	Drosophila melanogaster (Fruit fly)	PR
Q8NFJ6	PROKR2	Prokineticin receptor 2	Homo sapiens (Human)	PR
Q13585	GPR50	Melatonin-related receptor	Homo sapiens (Human)	PR
Q9BZJ6	GPR63	Probable G-protein coupled receptor 63	Homo sapiens (Human)	PR
Q9H3N8	HRH4	Histamine H4 receptor	Homo sapiens (Human)	PR
P28336	NMBR	Neuromedin-B receptor	Homo sapiens (Human)	PR
Q9Y5Y3	GPR45	Probable G-protein coupled receptor 45	Homo sapiens (Human)	PR
P08913	ADRA2A	Alpha-2A adrenergic receptor	Homo sapiens (Human)	PR
P41597	CCR2	C-C chemokine receptor type 2	Homo sapiens (Human)	PR
P51681	CCR5	C-C chemokine receptor type 5	Homo sapiens (Human)	PR
Q8TCW9	PROKR1	Prokineticin receptor 1	Homo sapiens (Human)	PR
Q99788	CMKLR1	Chemerin-like receptor 1	Homo sapiens (Human)	PR
P08908	HTR1A	5-hydroxytryptamine receptor 1A	Homo sapiens (Human)	PR
P30559	OXTR	Oxytocin receptor	Homo sapiens (Human)	PR
P32239	CCKBR	Gastrin/cholecystokinin type B receptor	Homo sapiens (Human)	PR
O60883	GPR37L1	G-protein coupled receptor 37-like 1	Homo sapiens (Human)	PR
P04000	OPN1LW	Long-wave-sensitive opsin 1	Homo sapiens (Human)	PR
Q6U736	OPN5	Opsin-5	Homo sapiens (Human)	PR
P34972	CNR2	Cannabinoid receptor 2	Homo sapiens (Human)	PR
P24530	EDNRB	Endothelin receptor type B	Homo sapiens (Human)	PR
P35348	ADRA1A	Alpha-1A adrenergic receptor	Homo sapiens (Human)	PR
Q6W5P4	NPSR1	Neuropeptide S receptor	Homo sapiens (Human)	PR
O43613	HCRTR1	Orexin/Hypocretin receptor type 1	Homo sapiens (Human)	PR
P61073	CXCR4	C-X-C chemokine receptor type 4	Homo sapiens (Human)	PR
Q9BXC0	HCAR1	Hydroxycarboxylic acid receptor 1	Homo sapiens (Human)	PR
P30556	AGTR1	Type-1 angiotensin II receptor	Homo sapiens (Human)	PR
Q15761	NPY5R	Neuropeptide Y receptor type 5	Homo sapiens (Human)	PR
Q8N6U8	GPR161	G-protein coupled receptor 161	Homo sapiens (Human)	PR
Q6DWJ6	GPR139	Probable G-protein coupled receptor 139	Homo sapiens (Human)	PR
P21462	FPR1	fMet-Leu-Phe receptor	Homo sapiens (Human)	PR
P35414	APLNR	Apelin receptor	Homo sapiens (Human)	PR
P46091	CMKLR2	Chemerin-like receptor 2	Homo sapiens (Human)	PR
P32745	SSTR3	Somatostatin receptor type 3	Homo sapiens (Human)	PR
P41439	FOLR3	Folate receptor gamma	Homo sapiens (Human)	PR
P19973	Lsp1	Lymphocyte-specific protein 1	Mus musculus (Mouse)	PR
O54799	Nmbr	Neuromedin-B receptor	Mus musculus (Mouse)	PR
Q64264	Htr1a	5-hydroxytryptamine receptor 1A	Mus musculus (Mouse)	PR
P51675	Ccr1	C-C chemokine receptor type 1	Mus musculus (Mouse)	PR
Q5U431	Gpr39	G-protein coupled receptor 39	Mus musculus (Mouse)	PR
Q99JG2	Gpr37l1	G-protein coupled receptor 37-like 1	Mus musculus (Mouse)	PR
P97295	Npy2r	Neuropeptide Y receptor type 2	Mus musculus (Mouse)	PR
O08786	Cckar	Cholecystokinin receptor type A	Mus musculus (Mouse)	PR
P56481	Cckbr	Gastrin/cholecystokinin type B receptor	Mus musculus (Mouse)	PR
P30731	Gpr83	G-protein coupled receptor 83	Mus musculus (Mouse)	PR
P97468	Cmklr1	Chemerin-like receptor 1	Mus musculus (Mouse)	PR
P21761	Trhr	Thyrotropin-releasing hormone receptor	Mus musculus (Mouse)	PR
Q5QD16	Taar3	Trace amine-associated receptor 3	Mus musculus (Mouse)	PR
P97292	Hrh2	Histamine H2 receptor	Mus musculus (Mouse)	PR
Q9EQQ3	Gpr63	Probable G-protein coupled receptor 63	Mus musculus (Mouse)	PR
Q924H0	Npffr2	Neuropeptide FF receptor 2	Mus musculus (Mouse)	PR
P34971	Adrb1	Beta-1 adrenergic receptor	Mus musculus (Mouse)	PR
Q91ZY2	Hrh4	Histamine H4 receptor	Mus musculus (Mouse)	PR
O88416	Gpr33	Probable G-protein coupled receptor 33	Mus musculus (Mouse)	PR
Q8K087	Cmklr2	Chemerin-like receptor 2	Mus musculus (Mouse)	PR
P70658	Cxcr4	C-X-C chemokine receptor type 4	Mus musculus (Mouse)	PR
Q9WV08	Aplnr	Apelin receptor	Mus musculus (Mouse)	PR
P97718	Adra1a	Alpha-1A adrenergic receptor	Mus musculus (Mouse)	PR
Q8BZP8	Npsr1	Neuropeptide S receptor	Mus musculus (Mouse)	PR
Q8K458	Prokr2	Prokineticin receptor 2	Mus musculus (Mouse)	PR
P58308	Hcrtr2	Orexin receptor type 2	Mus musculus (Mouse)	PR
Q7TQP3	Gpr119	Glucose-dependent insulinotropic receptor	Mus musculus (Mouse)	PR
Q8BGE9	Rxfp3	Relaxin-3 receptor 1	Mus musculus (Mouse)	PR
Q6VZZ7	Opn5	Opsin-5	Mus musculus (Mouse)	PR
Q8CIM5	Gpr84	G-protein coupled receptor 84	Mus musculus (Mouse)	PR
P25962	Adrb3	Beta-3 adrenergic receptor	Mus musculus (Mouse)	PR
Q80UC8	Gpr139	Probable G-protein coupled receptor 139	Mus musculus (Mouse)	PR
P0C5I1	Gpr25	Probable G-protein coupled receptor 25	Mus musculus (Mouse)	PR
P47936	Cnr2	Cannabinoid receptor 2	Mus musculus (Mouse)	PR
Q5QD13	Taar6	Trace amine-associated receptor 6	Mus musculus (Mouse)	PR
P35846	Folr1	Folate receptor alpha	Mus musculus (Mouse)	PR
P58307	Hcrtr1	Orexin/Hypocretin receptor type 1	Mus musculus (Mouse)	PR
Q8C131	Hcar1	Hydroxycarboxylic acid receptor 1	Mus musculus (Mouse)	PR
Q9EQQ4	Gpr45	Probable G-protein coupled receptor 45	Mus musculus (Mouse)	PR
B2RPY5	Gpr161	G-protein coupled receptor 161	Mus musculus (Mouse)	PR
Q764M9	CXCR4	C-X-C chemokine receptor type 4	Sus scrofa (Pig)	PR
Q9EQD2	Npffr2	Neuropeptide FF receptor 2	Rattus norvegicus (Rat)	PR
O08565	Cxcr4	C-X-C chemokine receptor type 4	Rattus norvegicus (Rat)	PR
Q01717	Trhr	Thyrotropin-releasing hormone receptor	Rattus norvegicus (Rat)	PR
P30936	Sstr3	Somatostatin receptor type 3	Rattus norvegicus (Rat)	PR
Q9JHG3	Aplnr	Apelin receptor	Rattus norvegicus (Rat)	PR
P43140	Adra1a	Alpha-1A adrenergic receptor	Rattus norvegicus (Rat)	PR
P19327	Htr1a	5-hydroxytryptamine receptor 1A	Rattus norvegicus (Rat)	PR
P56719	Hcrtr2	Orexin receptor type 2	Rattus norvegicus (Rat)	PR
P28564	Htr1b	5-hydroxytryptamine receptor 1B	Rattus norvegicus (Rat)	PR
P56718	Hcrtr1	Orexin/Hypocretin receptor type 1	Rattus norvegicus (Rat)	PR
P28647	Adora3	Adenosine receptor A3	Rattus norvegicus (Rat)	PR
P25102	Hrh2	Histamine H2 receptor	Rattus norvegicus (Rat)	PR
P23944	Adra1d	Alpha-1D adrenergic receptor	Rattus norvegicus (Rat)	PR
Q8R415	Prokr2	Prokineticin receptor 2	Rattus norvegicus (Rat)	PR
Q5QD24	Taar3	Trace amine-associated receptor 3	Rattus norvegicus (Rat)	PR
P0C0W8	Gpr139	Probable G-protein coupled receptor 139	Rattus norvegicus (Rat)	PR
P35370	Oprl1	Nociceptin receptor	Rattus norvegicus (Rat)	PR
P46090	Cmklr2	Chemerin-like receptor 2	Rattus norvegicus (Rat)	PR
O97664	CMKLR2	Chemerin-like receptor 2	Macaca mulatta (Rhesus macaque)	PR
O97666	APLNR	Apelin receptor	Macaca mulatta (Rhesus macaque)	PR
Q56H79	NPSR1	Neuropeptide S receptor	Macaca mulatta (Rhesus macaque)	PR
Q18904	npr-8	Probable G-protein coupled receptor npr-8	Caenorhabditis elegans	PR
Q09388	gar-2	Muscarinic acetylcholine receptor gar-2	Caenorhabditis elegans	PR
B3DM66	gpr161	G-protein coupled receptor 161	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q9W6A6	opn1mw4	Green-sensitive opsin-4	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q9W6A5	opn1mw1	Green-sensitive opsin-1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q8AYM7	opn1mw3	Green-sensitive opsin-3	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q8AYN0	opn1lw2	Red-sensitive opsin-2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q90X46	gpr161	G-protein coupled receptor 161	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MPTLNTSASP	PTFFWANASG	GSVLSADDAP	MPVKFLALRL	MVALAYGLVG	AIGLLGNLAV
70	80	90	100	110	120
LWVLSNCARR	APGPPSDTFV	FNLALADLGL	ALTLPFWAAE	SALDFHWPFG	GALCKMVLTA
130	140	150	160	170	180
TVLNVYASIF	LITALSVARY	WVVAMAAGPG	THLSLFWARI	ATLAVWAAAA	LVTVPTAVFG
190	200	210	220	230	240
VEGEVCGVRL	CLLRFPSRYW	LGAYQLQRVV	LAFMVPLGVI	TTSYLLLLAF	LQRRQRRRQD
250	260	270	280	290	300
SRVVARSVRI	LVASFFLCWF	PNHVVTLWGV	LVKFDLVPWN	STFYTIQTYV	FPVTTCLAHS
310	320	330	340	350	360
NSCLNPVLYC	LLRREPRQAL	AGTFRDLRLR	LWPQGGGWVQ	QVALKQVGRR	WVASNPRESR
370
PSTLLTNLDR	GTPG