Q8NFJ6
PR
Gene name |
PROKR2 (GPR73L1, PKR2) |
Protein name |
Prokineticin receptor 2 |
Names |
PK-R2, G-protein coupled receptor 73-like 1, G-protein coupled receptor I5E, GPR73b, GPRg2 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:128674 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8NFJ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8NFJ6-F1 | Predicted | AlphaFoldDB |
372 variants for Q8NFJ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV000022409 RCV000479789 RCV001818122 rs587777834 RCV000623831 RCV002288460 |
20 | H>missing | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 2 with or without anosmia Inborn genetic diseases [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV000256868 rs886037916 CA10590049 |
33 | Y>H | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV000861011 COSM1533981 RCV000405604 rs144994507 CA9754423 RCV000622788 RCV001699378 |
51 | A>T | lung Hypogonadotropic hypogonadism 3 with or without anosmia Inborn genetic diseases [Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001138033 CA9754418 rs201283126 |
57 | G>C | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
RCV001138032 CA9754407 rs764674615 |
70 | G>S | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
RCV000239076 RCV000144712 rs141090506 RCV000520900 VAR_030957 COSM72301 CA170931 RCV002247534 |
85 | R>C | Hypogonadotropic hypogonadism 3 with or without anosmia ovary liver oesophagus Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) Hypogonadotropic hypogonadism 3 without anosmia HH3; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; decreased signaling activity [ClinVar, Cosmic, Ensembl, UniProt] | Yes |
ClinGen cosmic curated ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000345795 CA9754396 RCV000413366 rs141090506 |
85 | R>G | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) [ClinVar, Ensembl] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV001849252 RCV002254257 rs74315418 VAR_030958 RCV000022408 CA259601 RCV000498536 |
85 | R>H | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadism with anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3; decreased signaling activity [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000305149 CA9754395 RCV001281470 rs74315418 RCV002520022 |
85 | R>L | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) [ClinVar, Ensembl] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
COSM233185 RCV001142775 RCV002559382 rs756998275 CA408167927 |
110 | E>K | Hypogonadotropic hypogonadism 3 with or without anosmia Variant assessed as Somatic; 0.0 impact. skin endometrium [ClinVar, NCI-TCGA, Cosmic] | Yes |
ClinGen cosmic curated ClinVar ExAC NCI-TCGA dbSNP gnomAD |
|
RCV000782204 rs914930539 RCV001542623 RCV001849439 CA311178755 |
111 | M>R | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) [ClinVar, Ensembl] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
RCV002248622 VAR_072173 RCV000404745 CA9754374 rs202203360 |
113 | Y>H | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3 [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
CA270916 COSM1028228 rs138672528 RCV000144713 VAR_069964 |
115 | V>M | Hypogonadotropic hypogonadism 3 with or without anosmia Variant assessed as Somatic; 0.0 impact. endometrium Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3; phenotype consistent with Kallmann syndrome [ClinVar, NCI-TCGA, Cosmic, Ensembl, UniProt] | Yes |
ClinGen cosmic curated ClinVar UniProt 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs200048973 CA9754368 RCV000340194 |
126 | V>M | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
RCV001819718 RCV001009616 RCV001759688 CA9754361 rs149396342 |
135 | R>C | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA9754334 rs368732206 VAR_072978 |
158 | V>I | Variant assessed as Somatic; 0.0 impact. HH3; phenotype consistent with Kallmann syndrome [NCI-TCGA, UniProt] | Yes |
ClinGen UniProt ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs751875578 CA311167332 COSM2157500 VAR_030959 |
164 | R>Q | Variant assessed as Somatic; 0.0 impact. central_nervous_system HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity [NCI-TCGA, Cosmic, UniProt] | Yes |
ClinGen cosmic curated UniProt ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
RCV001142773 rs527771034 COSM2763774 CA9754328 |
169 | T>M | Hypogonadotropic hypogonadism 3 with or without anosmia Variant assessed as Somatic; 0.0 impact. central_nervous_system [ClinVar, NCI-TCGA, Cosmic] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs74315416 RCV000516948 RCV000239273 VAR_030960 CA259599 RCV000022406 RCV001327944 |
173 | L>R | Hypogonadotropic hypogonadism 3 with or without anosmia Infertility Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000870421 VAR_030961 RCV000144714 CA270917 rs201835496 |
178 | W>S | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3; decreased signaling activity [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
rs543677594 RCV001140931 CA9754320 |
180 | V>M | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD |
|
RCV002505183 VAR_072174 RCV000156965 CA185891 rs376239580 RCV002250579 |
188 | S>L | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) Hypogonadotropic hypogonadism 7 with or without anosmia HH3 [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
CA9754309 rs200755554 VAR_069965 |
202 | S>G | HH3; triallelic inheritance; the patient also carries mutations in GNRH1 and FGFR1 [UniProt] | Yes |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
rs74315417 VAR_030962 RCV000022407 RCV001797584 CA259600 |
210 | Q>R | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity; abolished ligand binding [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt TOPMed dbSNP gnomAD |
|
CA408167147 RCV001007930 rs1600577387 |
229 | G>R | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
RCV001140930 CA408167068 RCV002559366 rs1404173625 |
242 | C>Y | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
RCV001009617 rs921084722 CA311166914 |
243 | Y>C | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP |
|
RCV001140929 RCV002514778 rs376142095 RCV000144715 VAR_072175 CA170932 |
248 | R>Q | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) Hypogonadotropic hypogonadism 3 without anosmia HH3 [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000087251 RCV002490755 rs483352766 CA229206 |
248 | R>W | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
RCV001140928 rs143647776 CA408166910 |
266 | R>L | Hypogonadotropic hypogonadism 3 with or without anosmia Variant assessed as Somatic; impact. [ClinVar, NCI-TCGA] | Yes |
ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
VAR_030963 RCV000712861 RCV000386257 CA9754278 rs78861628 RCV000330452 |
268 | R>C | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3; benign variant; signaling activity is impaired [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
COSM3371730 CA9754273 RCV001140170 RCV002559354 rs146544539 |
270 | R>H | Hypogonadotropic hypogonadism 3 with or without anosmia Variant assessed as Somatic; 0.0 impact. pancreas [ClinVar, NCI-TCGA, Cosmic] | Yes |
ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs149992595 RCV001140169 RCV001565285 VAR_030964 CA9754257 |
290 | P>S | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired; impaired cell surface-targeting [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
CA408166728 rs139399061 RCV000859991 |
297 | V>F | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) [ClinVar, Ensembl] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
COSM2153537 CA9754251 RCV002550615 RCV000990279 rs139399061 |
297 | V>I | Hypogonadotropic hypogonadism 3 with or without anosmia central_nervous_system Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) [ClinVar, Cosmic, Ensembl] | Yes |
ClinGen cosmic curated ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000388350 rs775755881 CA9754243 |
310 | H>Q | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
CA9754236 RCV000326819 rs754796297 |
319 | E>K | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
CA259603 VAR_030965 rs74315419 RCV000022410 |
323 | M>I | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired [ClinVar, Ensembl, UniProt] | Yes |
ClinGen ClinVar UniProt Ensembl dbSNP |
|
VAR_030966 CA9754228 rs117106081 RCV000860781 RCV001002764 RCV000435948 COSM84707 |
331 | V>M | Hypogonadotropic hypogonadism 3 with or without anosmia pancreas HH3; likely benign variant [ClinVar, Cosmic, UniProt] | Yes |
ClinGen cosmic curated ClinVar UniProt 1000Genomes ESP TOPMed dbSNP gnomAD |
|
VAR_072979 rs371564610 CA9754226 |
334 | V>M | HH3; phenotype consistent with Kallmann syndrome [UniProt] | Yes |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
rs1425069359 RCV001137929 CA408166367 |
351 | H>P | Hypogonadotropic hypogonadism 3 with or without anosmia [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
VAR_072176 CA9754208 rs375036628 |
357 | R>W | Variant assessed as Somatic; 0.0 impact. HH3 [NCI-TCGA, UniProt] | Yes |
ClinGen UniProt ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
rs201023639 RCV001137927 RCV001759899 CA9754197 CA9754196 RCV001137928 RCV001759900 |
371 | G>R | Hypogonadotropic hypogonadism 3 with or without anosmia Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) [ClinVar, Ensembl] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
rs764073408 CA9754455 |
2 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs758128077 CA9754454 |
3 | A>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs758128077 CA408168605 |
3 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs865860354 CA311179432 |
6 | G>E | No |
ClinGen Ensembl |
|
|
CA9754453 rs752490227 |
11 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754452 rs147773715 RCV000863186 |
12 | P>R | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA9754451 rs759092882 |
13 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs1226045380 CA408168540 |
13 | N>T | No |
ClinGen gnomAD |
|
|
rs1330236754 CA408168534 |
14 | F>V | No |
ClinGen TOPMed |
|
| TCGA novel | 16 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs776389568 CA9754449 |
17 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408168504 rs1327524485 |
18 | Q>P | No |
ClinGen gnomAD |
|
|
CA9754448 rs146062524 |
19 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760292647 CA9754447 |
21 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA408168475 rs1420863056 |
23 | S>P | No |
ClinGen gnomAD |
|
|
rs773798644 CA9754446 |
23 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
CA9754443 rs774879752 |
24 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774879752 CA9754444 |
24 | L>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408168433 rs1412520155 |
29 | S>N | No |
ClinGen TOPMed |
|
|
CA9754439 rs372654229 COSM4164765 |
30 | Y>C | kidney [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA311179275 rs267606007 |
32 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs777619161 CA9754437 |
33 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA408168400 rs1232678900 |
34 | D>N | No |
ClinGen gnomAD |
|
|
CA408168392 rs1431356735 |
35 | L>F | No |
ClinGen TOPMed |
|
|
rs752437197 CA9754435 |
37 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs758358943 CA9754436 |
37 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408168381 rs1414930601 |
37 | M>V | No |
ClinGen TOPMed |
|
|
CA9754433 rs754872933 |
40 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs766072229 CA9754431 |
41 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA311179221 rs920112026 |
42 | D>Y | No |
ClinGen Ensembl |
|
|
rs1194016064 CA408168312 |
46 | T>N | No |
ClinGen gnomAD |
|
|
CA9754425 rs548595273 |
47 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA9754426 rs548595273 |
47 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM322839 CA9754427 rs768088473 |
47 | R>W | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1326314892 CA408168277 |
52 | A>G | No |
ClinGen TOPMed |
|
|
CA408168260 rs770056339 |
54 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA9754420 rs146963803 COSM1737360 |
55 | V>I | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs781268393 CA9754419 |
56 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748078265 CA9754417 |
57 | G>V | No |
ClinGen ExAC |
|
|
CA9754416 rs778972307 |
58 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1362052727 CA408168238 |
59 | A>S | No |
ClinGen gnomAD |
|
| TCGA novel | 59 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 61 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9754414 rs753673244 |
62 | G>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA408168209 rs1174074708 |
64 | M>L | No |
ClinGen gnomAD |
|
|
CA408168205 rs1600588787 |
64 | M>T | No |
ClinGen Ensembl |
|
|
CA408168207 rs1174074708 |
64 | M>V | No |
ClinGen gnomAD |
|
|
rs201898089 CA408168184 |
67 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754413 rs779533141 |
67 | C>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 68 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs750150306 CA9754411 |
68 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA311179025 rs893198630 |
68 | G>V | No |
ClinGen Ensembl |
|
|
CA408168173 rs564287592 |
69 | I>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs372651342 CA9754410 |
69 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs764674615 CA9754408 |
70 | G>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs775950405 CA9754405 COSM1533982 |
71 | N>S | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA408168159 rs1337872140 |
72 | F>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1253383162 CA408168148 |
73 | V>D | No |
ClinGen gnomAD |
|
|
CA408168146 rs1229245355 |
74 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1229245355 CA408168145 |
74 | F>V | No |
ClinGen TOPMed gnomAD |
|
|
CA9754402 rs776908572 COSM1028229 |
76 | A>T | endometrium Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA408168127 rs1468315090 COSM248968 |
77 | A>T | pancreas [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs1437885706 CA408168111 |
79 | T>S | No |
ClinGen TOPMed |
|
|
CA9754400 rs774093318 |
80 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs768671137 CA9754398 COSM3785423 |
80 | R>H | pancreas [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs774093318 CA9754399 |
80 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs748986790 CA9754397 |
81 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA311178912 rs748986790 |
81 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA311178914 rs748986790 |
81 | Y>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756769389 CA9754394 |
86 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 86 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9754393 rs751081663 |
86 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 89 | N>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9754389 rs765584064 |
91 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA311178838 rs267606006 |
94 | N>S | No |
ClinGen Ensembl |
|
|
rs375763923 CA9754387 |
96 | A>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs766596975 CA408168000 |
98 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766596975 CA9754386 |
98 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773364376 COSM724121 CA9754384 |
99 | D>N | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1238325520 CA408167990 |
100 | F>L | No |
ClinGen gnomAD |
|
|
rs772095377 CA9754383 |
101 | L>P | No |
ClinGen ExAC |
|
|
rs749220846 CA9754382 |
103 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA9754381 rs775634673 |
103 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754380 rs769696958 |
104 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1324157232 CA408167935 |
108 | P>L | No |
ClinGen gnomAD |
|
|
COSM236548 CA9754379 rs780924864 |
109 | F>L | autonomic_ganglia [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs756998275 CA9754377 |
110 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs777312812 CA408167906 |
112 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM125602 CA9754376 rs746450179 |
112 | D>Y | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA408167894 rs1357242204 |
114 | Y>C | No |
ClinGen TOPMed |
|
| TCGA novel | 115 | V>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA311178725 rs866478382 |
116 | V>I | No |
ClinGen Ensembl |
|
|
rs755272935 CA408167878 |
117 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755272935 CA9754372 |
117 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754373 rs142008002 |
117 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 118 | Q>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA408167873 rs1246947954 |
118 | Q>R | No |
ClinGen TOPMed |
|
|
rs940223117 CA311178684 |
124 | G>S | No |
ClinGen Ensembl |
|
|
rs1262451568 CA408167825 |
125 | H>Y | No |
ClinGen gnomAD |
|
|
rs987465905 CA311178678 |
126 | V>A | No |
ClinGen Ensembl |
|
|
rs200048973 CA408167819 |
126 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 128 | C>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs367865350 CA9754366 |
129 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9754364 rs374021985 |
131 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA408167774 rs1600588369 |
133 | Y>S | No |
ClinGen Ensembl |
|
|
CA311178618 rs149396342 |
135 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9754360 COSM1028227 rs746638938 |
135 | R>H | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs746638938 CA408167762 |
135 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs1195880083 CA408167756 |
136 | T>I | No |
ClinGen gnomAD |
|
|
CA408167753 rs1600588328 |
137 | V>A | No |
ClinGen Ensembl |
|
|
CA9754358 rs139259742 |
137 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
COSM135866 rs374834120 CA311178574 |
138 | S>F | Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs1191972976 CA408167741 |
139 | L>P | No |
ClinGen gnomAD |
|
|
rs1341324218 CA408167729 |
141 | V>D | No |
ClinGen TOPMed |
|
|
CA9754356 rs573392596 |
141 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs754392293 CA9754354 |
147 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs370778947 CA9754353 |
148 | A>T | No |
ClinGen ESP ExAC gnomAD |
|
|
CA408167683 rs1282256826 |
149 | I>V | No |
ClinGen TOPMed |
|
|
rs368328895 CA9754352 |
151 | I>M | No |
ClinGen ESP ExAC gnomAD |
|
|
CA408167670 rs1345405168 |
151 | I>V | No |
ClinGen gnomAD |
|
|
rs768195924 CA9754338 |
155 | L>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754336 COSM1165239 rs200887188 |
156 | A>T | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
| TCGA novel | 156 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA408167617 rs1413706503 |
157 | I>T | No |
ClinGen TOPMed |
|
|
rs368732206 CA408167613 |
158 | V>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA9754333 rs781436398 |
159 | H>N | No |
ClinGen ExAC gnomAD |
|
|
CA311167346 rs749920543 |
160 | P>L | No |
ClinGen Ensembl |
|
|
rs1296562290 CA408167595 |
161 | L>S | No |
ClinGen TOPMed |
|
|
CA9754332 rs757441748 |
162 | K>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs975343046 CA311167334 |
162 | K>N | No |
ClinGen Ensembl |
|
|
CA634331701 rs1439817754 |
164 | R>* | No |
ClinGen gnomAD |
|
|
CA311167321 rs751875578 |
164 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751875578 CA9754331 |
164 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408167577 rs1385068308 |
164 | R>W | No |
ClinGen gnomAD |
|
|
CA408167574 rs1213243746 |
165 | M>L | No |
ClinGen gnomAD |
|
|
rs549212197 CA311167305 |
167 | Y>D | No |
ClinGen 1000Genomes gnomAD |
|
|
rs997908057 CA311167302 |
168 | Q>E | No |
ClinGen TOPMed |
|
|
CA408167541 rs527771034 |
169 | T>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA408167538 rs1401420410 |
170 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs760482505 CA9754326 |
170 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA408167514 rs1391735710 |
174 | I>T | No |
ClinGen gnomAD |
|
|
COSM1263144 rs761425593 CA9754324 |
175 | A>T | Variant assessed as Somatic; 0.0 impact. oesophagus large_intestine central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs748808249 CA9754322 |
176 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408167497 rs1471050027 |
177 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA9754321 rs770233566 |
179 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA408167457 rs1222362721 COSM3547984 |
183 | L>F | Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA408167441 rs1282796125 |
185 | A>V | No |
ClinGen gnomAD |
|
|
rs868432159 CA311167191 |
187 | P>S | No |
ClinGen Ensembl |
|
|
rs1415204683 CA408167414 |
190 | Y>C | No |
ClinGen TOPMed |
|
|
rs576303711 CA9754316 |
190 | Y>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs758488440 CA9754315 |
191 | F>I | No |
ClinGen ExAC gnomAD |
|
|
CA408167400 rs960872927 |
192 | A>E | No |
ClinGen gnomAD |
|
|
CA311167135 rs960872927 |
192 | A>V | No |
ClinGen gnomAD |
|
| TCGA novel | 194 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA311167112 rs1033836905 |
194 | E>K | No |
ClinGen Ensembl |
|
|
rs554736651 CA9754314 |
195 | T>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA9754312 rs755987251 |
196 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs572126852 CA9754311 |
197 | L>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1600577571 CA408167361 |
199 | I>V | No |
ClinGen Ensembl |
|
| TCGA novel | 200 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA408167355 rs1600577560 |
200 | V>I | No |
ClinGen Ensembl |
|
|
rs1172763024 CA408167335 |
202 | S>R | No |
ClinGen gnomAD |
|
|
CA408167332 rs1600577547 |
203 | Q>K | No |
ClinGen Ensembl |
|
|
CA408167319 rs1191945491 |
204 | E>D | No |
ClinGen gnomAD |
|
|
CA408167326 rs1255165303 |
204 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1240364075 CA408167304 |
206 | I>M | No |
ClinGen gnomAD |
|
|
rs1568569458 CA408167307 |
206 | I>N | No |
ClinGen Ensembl |
|
|
CA408167302 rs1038579531 |
207 | F>I | No |
ClinGen TOPMed |
|
|
rs773937171 CA9754307 |
207 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs1038579531 CA311167063 |
207 | F>V | No |
ClinGen TOPMed |
|
|
rs1210187481 CA408167295 |
208 | C>G | No |
ClinGen gnomAD |
|
|
CA311167058 rs74315417 |
210 | Q>P | Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) [Ensembl] | No |
ClinGen TOPMed gnomAD |
|
rs1280128456 CA408167264 |
212 | W>* | No |
ClinGen gnomAD |
|
|
CA408167254 rs1282698960 |
214 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1350448238 CA408167233 |
217 | Q>K | No |
ClinGen gnomAD |
|
|
CA9754305 rs762408043 |
218 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754304 rs774883653 |
218 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754303 rs553934141 |
219 | Y>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1051636587 CA408167199 |
221 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1254922111 CA408167202 |
221 | K>R | No |
ClinGen TOPMed |
|
|
rs1190803620 CA408167193 |
222 | S>F | No |
ClinGen TOPMed |
|
|
CA408167197 rs1361056066 |
222 | S>P | No |
ClinGen gnomAD |
|
|
CA408167190 rs1568569424 |
223 | Y>D | No |
ClinGen Ensembl |
|
|
CA408167189 rs1324972718 |
223 | Y>S | No |
ClinGen Ensembl |
|
|
rs1172893710 CA408167180 |
224 | F>S | No |
ClinGen gnomAD |
|
|
CA9754302 rs746325344 |
225 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1177067067 CA408167171 |
226 | F>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1171039394 CA408167160 |
227 | I>N | No |
ClinGen TOPMed |
|
|
rs1428140954 CA408167152 |
228 | F>S | No |
ClinGen gnomAD |
|
|
CA9754300 rs771405878 |
229 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs538606142 CA9754298 |
231 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs748456023 CA9754296 |
233 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754294 rs755153779 |
234 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs935819272 CA311166942 |
235 | P>S | No |
ClinGen Ensembl |
|
|
CA9754293 rs750316537 |
236 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1219969494 CA408167091 |
238 | T>I | No |
ClinGen gnomAD |
|
|
CA311166924 rs932482448 |
240 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA408167065 COSM174367 rs1303201731 |
242 | C>* | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA408167064 rs1303201731 |
242 | C>W | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 244 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1292174805 CA408167054 |
244 | A>S | No |
ClinGen TOPMed |
|
|
CA408167035 rs1461718981 |
247 | S>P | No |
ClinGen gnomAD |
|
|
rs1478200076 CA408167021 |
249 | E>D | No |
ClinGen gnomAD |
|
|
CA408167025 rs1245205482 |
249 | E>K | No |
ClinGen TOPMed |
|
|
rs1476479515 CA408167004 |
252 | F>I | No |
ClinGen TOPMed |
|
|
rs945720170 CA311166911 |
253 | K>N | No |
ClinGen Ensembl |
|
|
CA408166989 rs1415464915 |
254 | A>T | No |
ClinGen gnomAD |
|
|
CA408166976 rs1417178145 |
256 | P>S | No |
ClinGen gnomAD |
|
|
CA9754290 rs772347118 |
257 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772347118 CA9754289 |
257 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1257370060 CA408166966 |
258 | F>L | No |
ClinGen gnomAD |
|
|
CA9754287 rs759139837 |
259 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA9754286 rs370738961 |
260 | T>M | Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA408166949 rs370738961 |
260 | T>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1200077710 CA408166947 |
261 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA9754283 rs148868355 |
264 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs772609927 CA9754282 |
264 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA9754280 rs143647776 |
266 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
COSM1165632 rs146729363 CA9754281 |
266 | R>W | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs781065670 CA9754277 |
268 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA9754276 rs757207828 |
269 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA9754274 rs777513102 |
270 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777513102 CA9754275 |
270 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777513102 CA408166893 |
270 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754272 rs374194956 |
271 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs188744190 CA9754271 |
272 | K>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs779117079 CA9754270 |
273 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754268 rs369831329 |
274 | V>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1272442694 CA408166854 |
277 | L>F | No |
ClinGen gnomAD |
|
|
CA408166836 rs1180199391 |
279 | C>F | No |
ClinGen gnomAD |
|
|
rs1262266798 CA408166832 |
280 | I>V | No |
ClinGen TOPMed |
|
|
rs761237584 CA9754267 |
282 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA9754266 rs773923265 |
282 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408166806 rs1357799030 |
284 | Y>C | No |
ClinGen gnomAD |
|
|
CA408166810 rs1568569285 |
284 | Y>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs749276855 CA9754261 |
287 | C>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408166790 rs749276855 |
287 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754259 rs769901726 |
288 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs780085295 CA9754260 |
288 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs746940128 CA9754258 |
289 | A>E | No |
ClinGen ExAC gnomAD |
|
|
rs758067611 CA9754256 |
290 | P>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 290 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 293 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201311009 CA9754254 COSM163754 |
293 | G>S | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
| TCGA novel | 294 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA9754253 rs754639802 |
295 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753588291 CA9754252 |
295 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA311166564 rs754639802 |
295 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408166730 rs1360362791 |
296 | I>M | No |
ClinGen TOPMed |
|
|
rs1382617920 CA408166735 |
296 | I>V | No |
ClinGen gnomAD |
|
|
rs139399061 CA408166729 |
297 | V>L | Hypogonadotropic hypogonadism 3 with or without anosmia (hh3) [Ensembl] | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
COSM76063 rs1042038054 CA311166529 |
298 | R>C | ovary large_intestine Variant assessed as Somatic; impact. skin [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs755743973 CA9754250 |
298 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs372968364 CA9754249 |
299 | D>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA408166693 rs1241224140 |
302 | P>L | No |
ClinGen TOPMed |
|
|
CA311166502 rs199958585 |
302 | P>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA9754246 rs774799224 |
304 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA408166669 rs1351702997 |
306 | V>G | No |
ClinGen TOPMed |
|
|
CA9754244 rs199696443 |
306 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA408166647 rs1240563443 |
309 | K>T | No |
ClinGen gnomAD |
|
|
rs1346822828 CA408166639 |
310 | H>L | No |
ClinGen TOPMed gnomAD |
|
|
CA9754242 rs769846786 |
311 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA9754241 rs745956475 |
312 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1381073853 CA408166624 |
313 | T>A | No |
ClinGen gnomAD |
|
|
CA9754239 rs772071476 |
313 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200449168 CA311166456 |
315 | F>I | No |
ClinGen 1000Genomes |
|
|
CA311166450 rs200449168 |
315 | F>L | No |
ClinGen 1000Genomes |
|
|
rs1439763410 CA408166610 |
315 | F>L | No |
ClinGen TOPMed |
|
|
rs1434509032 CA408166597 |
317 | V>A | No |
ClinGen gnomAD |
|
|
CA9754238 rs778739474 |
317 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754237 rs778739474 |
317 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA408166589 rs754796297 |
319 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA408166588 rs1170446948 |
319 | E>A | No |
ClinGen gnomAD |
|
|
CA408166580 rs1469839205 |
320 | C>Y | No |
ClinGen gnomAD |
|
|
rs779869864 CA408166567 |
322 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779869864 CA9754234 COSM179145 |
322 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA9754233 rs755621527 |
323 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs1174707777 CA408166549 |
324 | S>R | No |
ClinGen TOPMed |
|
|
rs1403321022 CA408166541 |
325 | N>K | No |
ClinGen TOPMed |
|
|
rs749986762 CA9754232 |
328 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1568569186 CA408166507 |
330 | T>S | No |
ClinGen Ensembl |
|
|
CA408166482 rs371564610 CA408166481 |
334 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs755562438 CA9754225 |
335 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755562438 VAR_030967 CA9754224 |
335 | T>M | No |
ClinGen UniProt ExAC TOPMed dbSNP gnomAD |
|
|
rs755562438 CA408166474 |
335 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs973089809 CA311166342 |
338 | N>K | No |
ClinGen Ensembl |
|
|
CA9754222 rs759570423 |
339 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs776752188 CA9754221 COSM163755 |
341 | M>I | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs962871336 CA311166341 |
341 | M>T | No |
ClinGen gnomAD |
|
|
CA9754220 rs770957119 |
342 | K>* | No |
ClinGen ExAC gnomAD |
|
|
rs748112834 CA408166429 |
342 | K>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754219 rs748112834 |
342 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408166420 rs1374093067 |
343 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
CA9754218 rs774213973 |
343 | Y>N | No |
ClinGen ExAC gnomAD |
|
|
CA311166272 rs983344068 |
345 | K>M | No |
ClinGen TOPMed gnomAD |
|
|
CA311166257 rs951686828 |
347 | M>R | No |
ClinGen Ensembl |
|
|
rs368145317 CA9754217 |
348 | M>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs368145317 CA311166256 |
348 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs749102757 CA9754216 |
349 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs749102757 CA408166381 |
349 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA9754213 rs745562390 |
352 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs745562390 CA408166359 |
352 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA9754214 rs769594711 |
352 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs1235576605 CA408166355 |
353 | R>C | No |
ClinGen gnomAD |
|
|
COSM117279 RCV001310452 CA9754212 rs576243101 |
353 | R>H | ovary Variant assessed as Somatic; 0.0001848 impact. pancreas central_nervous_system stomach [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ClinVar 1000Genomes ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA9754210 rs752089250 |
354 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1272592822 CA408166350 |
354 | P>S | No |
ClinGen gnomAD |
|
|
rs1466558251 CA408166339 |
356 | Q>* | No |
ClinGen TOPMed |
|
|
CA408166335 rs1258784930 |
356 | Q>H | No |
ClinGen gnomAD |
|
|
CA408166333 rs375036628 |
357 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA9754207 rs753089596 |
357 | R>Q | Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs759725558 CA9754205 |
361 | S>T | No |
ClinGen ExAC gnomAD |
|
|
CA9754204 rs754076450 |
362 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA408166292 rs1388799619 |
363 | A>D | No |
ClinGen TOPMed |
|
|
rs766469410 CA9754203 |
364 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA311166081 rs867274082 |
366 | D>N | No |
ClinGen gnomAD |
|
|
CA408166276 rs867274082 |
366 | D>Y | No |
ClinGen gnomAD |
|
|
rs762790551 CA9754199 |
370 | N>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 371 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA311166041 rs866410846 |
373 | P>A | No |
ClinGen Ensembl |
|
|
rs866410846 CA311166029 |
373 | P>S | No |
ClinGen Ensembl |
|
|
rs1210137443 CA408166226 |
374 | T>S | No |
ClinGen TOPMed |
|
|
rs1400166987 CA408166220 |
375 | T>R | No |
ClinGen gnomAD |
|
|
CA9754192 rs778301898 |
377 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs758925950 CA9754191 |
378 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA9754189 rs753244742 |
380 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs779246131 CA9754188 |
382 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA408166172 rs1444187780 |
382 | R>S | No |
ClinGen gnomAD |
|
|
rs147311278 CA9754187 |
385 | K>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
1 associated diseases with Q8NFJ6
[MIM: 244200]: Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269|PubMed:17054399, ECO:0000269|PubMed:18559922, ECO:0000269|PubMed:18826963, ECO:0000269|PubMed:22927827, ECO:0000269|PubMed:23643382, ECO:0000269|PubMed:25077900}. Note=The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in PROKR2 as well as in other HH-associated genes including KAL1, SEMA3A, PROK2, GNRH1 and FGFR1 (PubMed:17054399, PubMed:22927827, PubMed:23643382). {ECO:0000269|PubMed:17054399, ECO:0000269|PubMed:22927827, ECO:0000269|PubMed:23643382, ECO:0000269|PubMed:28858133}.
Without disease ID
- A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269|PubMed:17054399, ECO:0000269|PubMed:18559922, ECO:0000269|PubMed:18826963, ECO:0000269|PubMed:22927827, ECO:0000269|PubMed:23643382, ECO:0000269|PubMed:25077900}. Note=The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in PROKR2 as well as in other HH-associated genes including KAL1, SEMA3A, PROK2, GNRH1 and FGFR1 (PubMed:17054399, PubMed:22927827, PubMed:23643382). {ECO:0000269|PubMed:17054399, ECO:0000269|PubMed:22927827, ECO:0000269|PubMed:23643382, ECO:0000269|PubMed:28858133}.
1 regional properties for Q8NFJ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 63 - 358 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| neuropeptide Y receptor activity | Combining with neuropeptide Y to initiate a change in cell activity. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
119 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| P35348 | ADRA1A | Alpha-1A adrenergic receptor | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAQNGNTSF | TPNFNPPQDH | ASSLSFNFSY | GDYDLPMDED | EDMTKTRTFF | AAKIVIGIAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGIMLVCGIG | NFVFIAALTR | YKKLRNLTNL | LIANLAISDF | LVAIICCPFE | MDYYVVRQLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WEHGHVLCAS | VNYLRTVSLY | VSTNALLAIA | IDRYLAIVHP | LKPRMNYQTA | SFLIALVWMV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SILIAIPSAY | FATETVLFIV | KSQEKIFCGQ | IWPVDQQLYY | KSYFLFIFGV | EFVGPVVTMT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LCYARISREL | WFKAVPGFQT | EQIRKRLRCR | RKTVLVLMCI | LTAYVLCWAP | FYGFTIVRDF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FPTVFVKEKH | YLTAFYVVEC | IAMSNSMINT | VCFVTVKNNT | MKYFKKMMLL | HWRPSQRGSK |
| 370 | 380 | ||||
| SSADLDLRTN | GVPTTEEVDC | IRLK |