P35348
PR
Gene name |
ADRA1A (ADRA1C) |
Protein name |
Alpha-1A adrenergic receptor |
Names |
Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:148 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
467 variants for P35348
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1239344489 CA370942562 |
2 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA4687314 rs372749147 |
5 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA370942537 rs1252741705 |
6 | G>R | No |
ClinGen gnomAD |
|
|
CA370942527 rs1439268438 |
7 | N>S | No |
ClinGen TOPMed |
|
|
rs1585870948 CA370942520 |
8 | A>G | No |
ClinGen Ensembl |
|
|
CA370942508 rs1272706820 |
10 | D>E | No |
ClinGen gnomAD |
|
|
rs751394079 CA4687312 |
10 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1010863998 CA370942512 |
10 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA174607429 rs1010863998 |
10 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1189407397 CA370942505 |
11 | S>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA174607428 rs1052544656 |
12 | S>F | No |
ClinGen TOPMed |
|
|
rs779800024 CA4687311 |
13 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370942489 rs1229448814 |
13 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs754001123 CA4687309 |
14 | C>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687310 rs754001123 |
14 | C>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370942479 rs1243355346 COSM184208 COSM184207 |
15 | T>A | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA174607427 rs977548564 |
15 | T>I | No |
ClinGen Ensembl |
|
|
rs760692242 CA4687307 |
17 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764320184 CA4687308 |
17 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370942455 rs1359699553 |
19 | A>S | No |
ClinGen gnomAD |
|
|
CA4687302 rs771422009 |
20 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs774916687 CA4687303 |
20 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370942413 rs1354852913 |
25 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA370942411 rs1400692981 |
26 | A>P | No |
ClinGen TOPMed |
|
|
rs1272137415 CA370942407 |
26 | A>V | No |
ClinGen TOPMed |
|
|
CA4687300 rs772748755 |
27 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1431288722 CA370942398 |
28 | L>Q | No |
ClinGen gnomAD |
|
|
CA370942375 rs1184664083 |
32 | I>F | No |
ClinGen gnomAD |
|
|
rs1184664083 CA370942377 |
32 | I>V | No |
ClinGen gnomAD |
|
|
rs1482185797 CA370942365 |
33 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
rs1232726760 CA370942360 |
34 | G>A | No |
ClinGen gnomAD |
|
| rs752308205 | 35 | G>A | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1453844304 CA370942354 |
35 | G>D | No |
ClinGen gnomAD |
|
|
rs1212873153 CA370942351 |
36 | L>I | No |
ClinGen TOPMed |
|
| TCGA novel | 36 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370942340 rs1288288049 |
37 | I>S | No |
ClinGen gnomAD |
|
| TCGA novel | 38 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs768627895 CA4687295 |
40 | G>R | No |
ClinGen ExAC gnomAD |
|
| VAR_035756 | 40 | G>W | a breast cancer sample; somatic mutation [UniProt] | No | UniProt |
|
TCGA novel CA370942314 rs1585870468 |
41 | V>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA Ensembl |
|
CA370942290 rs1329289376 |
45 | I>T | No |
ClinGen gnomAD |
|
|
rs779890003 CA4687292 |
47 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370942282 rs1243477642 |
47 | V>M | No |
ClinGen TOPMed |
|
|
CA4687290 rs186663065 |
48 | I>F | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs756330556 CA174607424 |
48 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA4687289 rs61757011 |
48 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687291 rs186663065 |
48 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4687287 rs752771643 |
49 | L>P | No |
ClinGen ExAC gnomAD |
|
|
COSM1098627 COSM1098624 COSM1098625 CA4687286 rs767695098 COSM1098626 |
51 | V>I | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA4687285 rs376184998 |
52 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4687282 rs373498579 |
55 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs764835112 CA4687280 |
59 | S>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687278 rs754697137 |
63 | Y>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA174607422 rs768150925 |
65 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687276 rs768150925 |
65 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746449370 CA4687275 |
67 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs969571942 CA370942145 |
69 | A>E | No |
ClinGen TOPMed gnomAD |
|
|
rs969571942 CA174607421 |
69 | A>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 70 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs756351673 CA4687270 |
71 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370942127 rs1455659706 |
72 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
rs748400751 CA4687269 |
72 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748400751 CA370942132 |
72 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781501725 CA4687268 |
73 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1177102605 CA370942123 |
73 | L>H | No |
ClinGen gnomAD |
|
|
rs781501725 CA370942124 |
73 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA370942122 rs1177102605 |
73 | L>P | No |
ClinGen gnomAD |
|
|
rs1245323372 CA370942111 |
75 | L>H | No |
ClinGen gnomAD |
|
|
rs758905419 CA4687264 |
76 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs758905419 CA174607419 |
76 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1394977476 COSM486342 COSM486345 COSM486343 COSM486344 CA370942107 |
76 | T>S | kidney [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA370942099 rs1450642808 |
78 | T>A | No |
ClinGen gnomAD |
|
|
COSM1456331 COSM1456329 COSM1456330 CA370942094 rs1250383956 COSM1456332 |
78 | T>M | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs1250383956 CA370942095 |
78 | T>R | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 82 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370942061 rs765619798 |
84 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687262 rs765619798 |
84 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1211865288 CA370942042 |
87 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA370942041 rs1211865288 |
87 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1442823078 CA370942032 |
88 | V>F | No |
ClinGen TOPMed |
|
|
CA370942019 rs1310063298 |
90 | G>V | No |
ClinGen gnomAD |
|
| TCGA novel | 91 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370942005 rs1301029687 |
92 | W>* | No |
ClinGen TOPMed |
|
|
CA370941993 rs1279432417 |
94 | F>L | No |
ClinGen gnomAD |
|
| TCGA novel | 94 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1490073463 CA370941986 |
95 | G>S | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 96 | R>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4687259 rs763678602 |
97 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs776269898 CA174607418 |
97 | V>F | No |
ClinGen ExAC gnomAD |
|
|
rs763678602 CA370941972 |
97 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs776269898 CA4687260 |
97 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs760210202 CA4687258 |
100 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA370941947 rs1585869659 |
101 | I>L | No |
ClinGen Ensembl |
|
|
rs774951943 CA4687257 |
101 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1212095943 CA370941927 |
103 | A>E | No |
ClinGen TOPMed gnomAD |
|
|
COSM3834486 CA4687256 COSM3834489 COSM3834491 COSM3834487 rs772047975 COSM3834488 |
104 | A>S | breast [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs1430747545 CA370941907 |
107 | V>M | No |
ClinGen gnomAD |
|
|
COSM184204 CA370941888 rs1167310025 COSM184203 |
110 | C>R | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA370941870 rs1428420974 |
112 | A>E | No |
ClinGen gnomAD |
|
|
CA174607416 rs888236558 |
112 | A>T | No |
ClinGen Ensembl |
|
|
CA4687253 rs370082307 |
113 | S>C | No |
ClinGen ESP ExAC gnomAD |
|
|
CA370941865 rs370082307 |
113 | S>F | No |
ClinGen ESP ExAC gnomAD |
|
|
CA370941868 rs1183094263 |
113 | S>P | No |
ClinGen gnomAD |
|
|
CA370941862 rs1256300248 |
114 | I>F | No |
ClinGen TOPMed gnomAD |
|
|
CA4687252 rs748982353 |
114 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1256300248 CA370941863 |
114 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA370941857 rs1048084241 |
115 | M>L | No |
ClinGen gnomAD |
|
|
CA174607415 rs1048084241 |
115 | M>V | No |
ClinGen gnomAD |
|
|
CA370941836 rs1272181275 |
118 | C>G | No |
ClinGen gnomAD |
|
| TCGA novel | 118 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1420086628 CA370941829 |
119 | I>V | No |
ClinGen TOPMed |
|
|
rs1226673014 CA370941816 |
121 | S>T | No |
ClinGen gnomAD |
|
|
rs755206633 CA4687250 |
122 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA4687251 rs781583369 |
122 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 123 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs61757010 CA174607412 |
123 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs747122943 CA4687249 |
124 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747122943 CA370941798 |
124 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747122943 CA174607411 |
124 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780256497 CA4687248 |
125 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA370941785 rs1372847806 |
126 | I>L | No |
ClinGen gnomAD |
|
|
CA4687246 rs375074012 |
126 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4687247 rs202189077 |
126 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1166314604 CA370941778 |
127 | G>A | No |
ClinGen gnomAD |
|
|
rs1350911177 CA370941782 |
127 | G>S | No |
ClinGen gnomAD |
|
|
CA370941774 rs1416479497 |
128 | V>E | No |
ClinGen gnomAD |
|
|
COSM93864 CA174607410 rs938487720 |
128 | V>M | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA4687243 rs754163272 |
129 | S>I | No |
ClinGen ExAC gnomAD |
|
|
rs1249430407 CA370941766 |
129 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA370941751 rs1281091213 |
131 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1281091213 CA370941753 |
131 | P>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA370941744 COSM1098602 COSM1098601 rs968763557 COSM1098599 COSM1098600 |
133 | R>C | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs752263648 CA4687240 |
133 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs752263648 CA4687241 |
133 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA370941743 rs752263648 |
133 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs968763557 CA174607409 |
133 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1223908061 CA370941741 |
134 | Y>H | No |
ClinGen gnomAD |
|
|
CA174607408 rs914665795 |
135 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1292727649 CA370941729 |
136 | T>P | No |
ClinGen gnomAD |
|
|
rs1563321365 CA370941717 |
137 | I>M | No |
ClinGen Ensembl |
|
|
rs1229307094 CA370941719 |
137 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA4687239 rs140950299 |
138 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA370941695 rs1295839175 |
141 | R>K | No |
ClinGen gnomAD |
|
|
CA4687234 rs762868796 |
143 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA4687233 rs371827279 |
145 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs560257931 CA4687232 |
146 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4687230 rs780346708 |
148 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs772196043 CA4687229 |
149 | C>* | No |
ClinGen ExAC gnomAD |
|
|
rs745878118 CA4687228 |
152 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs61757009 RCV000958609 CA4687227 |
154 | S>A | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs890568698 CA174607407 |
154 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
rs61757009 CA370941616 |
154 | S>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4687225 rs754251205 |
155 | L>R | No |
ClinGen ExAC gnomAD |
|
|
CA4687224 rs555670585 |
158 | S>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4687223 rs755834390 |
159 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs900391637 CA174607405 |
160 | G>* | No |
ClinGen TOPMed |
|
|
rs1037610094 CA174607404 |
160 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
CA370941582 rs1037610094 |
160 | G>E | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 160 | G>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200323122 CA370941577 |
161 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA4687221 rs200323122 |
161 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs752353466 CA4687222 |
161 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA4687217 rs762958890 CA370941567 |
163 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA4687219 rs766377205 |
163 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687218 rs766377205 |
163 | F>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773197131 CA4687216 |
164 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA174607403 rs997765683 |
165 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA370941552 rs1314932778 |
166 | R>G | No |
ClinGen Ensembl |
|
|
CA4687215 rs56233953 |
166 | R>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4687213 rs759868914 |
168 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs772136338 CA4687212 |
169 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1448774990 CA370941529 |
170 | P>T | No |
ClinGen gnomAD |
|
|
rs778837172 CA4687210 |
171 | E>* | No |
ClinGen ExAC gnomAD |
|
|
rs1204831166 CA370941520 |
171 | E>G | No |
ClinGen gnomAD |
|
|
rs1250025758 CA370941515 |
172 | D>N | No |
ClinGen TOPMed |
|
|
CA4687209 rs771487761 |
173 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756487113 CA4687206 |
175 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs1347816678 CA370941491 |
175 | I>N | No |
ClinGen TOPMed gnomAD |
|
|
rs376531409 CA4687205 |
179 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs780932474 CA370941458 |
180 | E>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754551028 CA4687203 |
180 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA4687204 rs780932474 |
180 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs551511934 CA174607401 |
182 | P>S | No |
ClinGen Ensembl |
|
|
rs1403821912 CA370941436 |
183 | G>D | No |
ClinGen gnomAD |
|
|
rs1371091444 CA370941440 |
183 | G>S | No |
ClinGen TOPMed |
|
|
CA370941428 rs1310861678 |
184 | Y>* | No |
ClinGen gnomAD |
|
|
rs1432527989 CA370941425 |
185 | V>L | No |
ClinGen Ensembl |
|
|
rs1205168061 CA370941413 |
187 | F>L | No |
ClinGen gnomAD |
|
|
CA4687200 rs371939148 |
189 | A>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 189 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4687199 rs750389026 |
190 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs556158813 CA4687197 |
191 | G>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs556158813 CA4687198 |
191 | G>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs776249765 CA4687196 |
192 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1192561072 CA370941384 |
192 | S>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 193 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA4687195 rs767829617 |
194 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759665734 CA4687194 |
194 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
CA370941343 rs1377263749 |
199 | I>N | No |
ClinGen TOPMed |
|
|
CA370941345 rs1275734523 |
199 | I>V | No |
ClinGen gnomAD |
|
|
VAR_049370 CA4687192 rs2229125 |
200 | I>S | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA4687191 rs61757008 |
201 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1244862946 CA370941325 |
202 | V>A | No |
ClinGen gnomAD |
|
|
rs770251050 CA4687189 |
203 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs1291020451 CA370941319 |
203 | M>R | No |
ClinGen gnomAD |
|
|
rs1293034019 CA370941314 |
204 | Y>H | No |
ClinGen TOPMed |
|
|
CA370941298 rs1285479324 |
206 | R>G | No |
ClinGen gnomAD |
|
|
CA4687187 rs781384654 |
207 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA4687185 rs570621342 |
209 | V>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA370941275 rs1167460016 |
210 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
CA370941264 rs1420064493 |
211 | A>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 214 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs749902900 CA4687182 |
215 | S>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 215 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200422473 CA4687180 |
216 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA370941233 rs1252993409 |
216 | R>Q | No |
ClinGen gnomAD |
|
|
rs200422473 CA4687181 |
216 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4687177 rs760453930 |
217 | G>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370941230 rs150544480 |
217 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs150544480 CA4687178 |
217 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766542151 CA4687175 |
218 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs770330974 CA4687172 CA370941217 |
219 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA4687174 rs763055494 |
219 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773249771 CA4687173 |
219 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs748586055 CA4687171 |
220 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201098896 CA4687170 |
221 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1324162537 CA370941204 |
222 | L>F | No |
ClinGen gnomAD |
|
|
CA370941205 rs1324162537 |
222 | L>I | No |
ClinGen gnomAD |
|
|
rs1406968822 CA370941202 |
222 | L>P | No |
ClinGen gnomAD |
|
|
CA370941188 rs1461181789 |
224 | T>I | No |
ClinGen gnomAD |
|
|
rs1041496781 CA174607398 |
224 | T>P | No |
ClinGen Ensembl |
|
|
rs745411477 CA4687165 |
225 | D>H | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 225 | D>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201951243 CA4687164 |
227 | S>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs999941374 CA174607395 |
228 | D>G | No |
ClinGen TOPMed gnomAD |
|
|
CA4687163 rs757286802 |
232 | V>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs753725490 CA4687162 |
233 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs986191041 CA174607394 |
235 | R>C | No |
ClinGen TOPMed |
|
|
rs986191041 CA370941122 |
235 | R>G | No |
ClinGen TOPMed |
|
|
COSM1157803 rs755886691 COSM1157805 COSM3395002 CA370941120 COSM1157802 COSM1157804 |
235 | R>H | pancreas [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA4687160 rs755886691 |
235 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370941108 rs1262421772 |
237 | H>L | No |
ClinGen Ensembl |
|
|
rs1262421772 CA370941107 |
237 | H>R | No |
ClinGen Ensembl |
|
|
rs1221677387 CA370941109 |
237 | H>Y | No |
ClinGen gnomAD |
|
|
CA4687159 rs141722973 |
238 | R>W | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1275161397 CA370941087 |
240 | N>S | No |
ClinGen gnomAD |
|
|
CA370941079 rs1308349036 |
241 | A>D | No |
ClinGen TOPMed |
|
| TCGA novel | 241 | A>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1368688997 CA370941076 |
242 | P>A | No |
ClinGen gnomAD |
|
|
CA4687157 rs763135595 |
242 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370941073 rs763135595 |
242 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370941072 rs1406610294 |
243 | A>T | No |
ClinGen gnomAD |
|
|
rs765293217 CA4687155 |
244 | G>A | No |
ClinGen ExAC gnomAD |
|
|
COSM1098585 rs1389708992 CA370941065 COSM1098586 COSM1098584 COSM1098587 |
244 | G>R | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs140371319 CA4687154 |
246 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs777015396 CA4687153 |
246 | S>R | No |
ClinGen ExAC gnomAD |
|
|
COSM184200 rs3730287 COSM184199 CA4687151 CA4687152 |
247 | G>R | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
| TCGA novel | 248 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775965765 CA4687150 |
248 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1190480468 CA370941044 |
248 | M>V | No |
ClinGen TOPMed |
|
|
rs1251659077 CA370941034 |
249 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
rs778643760 CA4687148 |
251 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA4687147 rs778643760 |
251 | A>G | No |
ClinGen ExAC gnomAD |
|
|
COSM1098582 COSM1098581 COSM1098579 CA4687149 COSM1098580 rs777863824 |
251 | A>T | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs777605702 CA4687144 |
255 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA4687143 rs756051939 |
256 | H>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA174607392 rs886364953 |
256 | H>P | No |
ClinGen TOPMed |
|
|
rs569147612 CA174607391 COSM73602 |
256 | H>Q | ovary [Cosmic] | No |
ClinGen cosmic curated 1000Genomes gnomAD |
| TCGA novel | 259 | V>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370940961 rs1302545795 |
261 | L>I | No |
ClinGen gnomAD |
|
|
CA4687141 rs752541661 |
262 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA370940946 rs1299232273 |
263 | K>R | No |
ClinGen TOPMed |
|
|
CA370940936 rs1376249244 |
264 | F>L | No |
ClinGen TOPMed |
|
|
rs780947238 CA4687139 |
265 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA370940926 rs750645265 |
266 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687137 rs750645265 |
266 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370940928 rs1344821349 |
266 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA370940925 rs1393618610 |
267 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
CA370940923 rs1393618610 |
267 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1173589608 CA370940910 |
268 | K>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs765438943 CA4687136 |
270 | A>E | No |
ClinGen ExAC gnomAD |
|
|
CA370940877 rs1218686921 |
273 | T>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
CA4687134 rs201224020 |
275 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA174607388 rs948494007 |
279 | G>D | No |
ClinGen TOPMed |
|
|
rs948494007 CA370940843 |
279 | G>V | No |
ClinGen TOPMed |
|
|
CA370940829 rs1307815039 |
281 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA174607387 rs916744865 |
281 | F>V | No |
ClinGen TOPMed |
|
|
CA174607386 rs562058379 |
284 | C>Y | No |
ClinGen Ensembl |
|
|
rs532108221 CA370940802 |
285 | W>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4687131 rs532108221 |
285 | W>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4687130 rs772571115 |
289 | F>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 289 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 290 | L>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370940764 rs1585866764 |
291 | V>A | No |
ClinGen Ensembl |
|
|
CA174607385 rs984918313 |
291 | V>L | No |
ClinGen Ensembl |
|
|
rs952210470 CA174607384 |
292 | M>V | No |
ClinGen Ensembl |
|
|
COSM93863 CA4687129 rs148938279 |
293 | P>S | lung [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs148938279 CA370940754 |
293 | P>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4687127 rs770575130 |
294 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA174607383 rs894242368 |
294 | I>T | No |
ClinGen Ensembl |
|
|
rs774167863 CA4687128 |
294 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687126 rs201898898 |
295 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4687064 rs771862634 |
295 | G>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 295 | G>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1352949837 CA370800623 |
298 | F>L | No |
ClinGen gnomAD |
|
|
CA4687063 rs530226078 |
299 | P>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs773993150 CA4687062 |
300 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs924812539 CA174206430 |
305 | E>A | No |
ClinGen TOPMed |
|
|
CA4687059 rs149810611 |
305 | E>D | No |
ClinGen ESP ExAC gnomAD |
|
|
rs924812539 CA174206428 |
305 | E>V | No |
ClinGen TOPMed |
|
|
CA4687057 rs747014204 |
307 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1193215914 CA370800493 |
310 | I>V | No |
ClinGen TOPMed |
|
|
CA4687055 rs758801521 |
311 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA174206424 COSM2787553 rs267601877 COSM2787552 COSM36671 COSM2787551 |
311 | V>I | Variant assessed as Somatic; impact. urinary_tract skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
CA4687054 rs750850144 |
313 | W>* | No |
ClinGen ExAC |
|
|
CA370800451 rs1455916431 |
314 | L>F | No |
ClinGen gnomAD |
|
|
COSM1456312 CA4687052 rs756970856 COSM1456311 COSM1456314 COSM1456313 |
315 | G>R | pancreas large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA4687051 rs753502612 |
316 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA4687050 rs561399406 |
317 | L>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA4687049 rs760261856 |
321 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1315965898 CA370800350 |
322 | N>K | No |
ClinGen TOPMed |
|
|
CA370800352 rs1458563910 |
322 | N>S | No |
ClinGen TOPMed |
|
|
CA174206410 rs747781549 |
323 | P>L | No |
ClinGen Ensembl |
|
|
rs914980492 CA174206412 |
323 | P>S | No |
ClinGen Ensembl |
|
|
CA370800341 rs1212939994 |
324 | I>T | No |
ClinGen gnomAD |
|
|
rs778336110 CA370800324 |
326 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs1326198666 CA370800329 |
326 | Y>H | No |
ClinGen TOPMed gnomAD |
|
|
CA370800315 rs1436732422 |
328 | C>R | No |
ClinGen TOPMed |
|
|
CA4687046 rs544693873 |
329 | S>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA370800296 rs1362965212 |
330 | S>R | No |
ClinGen gnomAD |
|
|
rs774350712 CA4687045 |
331 | Q>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs147708857 CA174206402 |
332 | E>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4687044 rs766276890 |
332 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1313869976 CA370800270 |
334 | K>T | No |
ClinGen gnomAD |
|
|
rs1437190962 CA370800260 |
335 | K>T | No |
ClinGen gnomAD |
|
|
rs147084464 CA4687042 |
336 | A>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs147084464 CA370800253 |
336 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA370800229 rs1174794179 |
339 | N>K | No |
ClinGen gnomAD |
|
| TCGA novel | 342 | R>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA174206396 rs893538993 |
345 | C>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1048101 CA370800179 |
347 | C>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4687038 rs1048101 VAR_019509 |
347 | C>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA370800180 rs1048101 |
347 | C>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA4687036 rs965188288 |
347 | C>Y | No |
ClinGen Ensembl |
|
|
rs999009558 CA174206392 |
348 | R>T | No |
ClinGen TOPMed |
|
|
rs1183017316 CA370800167 |
349 | K>E | No |
ClinGen TOPMed |
|
|
rs746357923 CA4687035 |
351 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA4687034 rs779325768 |
352 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1255305650 CA370800138 |
353 | K>R | No |
ClinGen gnomAD |
|
|
CA4687032 rs368862425 |
355 | A>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA174206386 rs368862425 |
355 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA4687030 rs376514624 |
356 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1416977142 CA370800116 |
357 | G>D | No |
ClinGen gnomAD |
|
|
CA4687028 rs766929695 |
357 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs751552739 CA4687026 |
359 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687025 rs766374819 |
360 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA370800092 rs1585649468 |
361 | H>P | No |
ClinGen Ensembl |
|
|
rs140157368 CA174206375 |
361 | H>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs764428220 CA4687022 |
362 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764428220 CA4687023 |
362 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370800082 rs1438457309 |
363 | P>R | No |
ClinGen gnomAD |
|
|
CA370800073 rs1255156476 |
364 | S>R | No |
ClinGen gnomAD |
|
|
rs760797135 CA4687021 |
366 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1481575037 CA370800059 |
366 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA4687017 rs774870151 |
367 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA370800058 rs528677959 |
367 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs528677959 CA4687018 COSM1244531 COSM1244532 COSM1244529 COSM1244530 |
367 | V>M | Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs150908283 CA4687016 |
369 | G>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs900091309 CA174206358 |
369 | G>R | No |
ClinGen TOPMed |
|
|
CA370800036 rs1461161669 |
370 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA4687015 rs749700097 |
371 | H>D | No |
ClinGen ExAC gnomAD |
|
|
CA4687013 rs755860403 |
374 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA4687014 rs536980137 |
374 | M>V | No |
ClinGen ExAC TOPMed |
|
|
CA4687012 rs61731555 |
375 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
COSM1098558 COSM1098557 COSM1098556 CA4687010 COSM1098559 rs1496121 |
376 | R>C | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA174206348 rs1496121 |
376 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs140512348 CA4687009 |
376 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs140512348 CA174206344 |
376 | R>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA370799999 rs1496121 |
376 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA370799991 rs758390565 |
377 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4687004 rs573286753 |
379 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM3382200 COSM3382199 rs573286753 COSM3382201 CA4687005 COSM3382198 |
379 | V>M | Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs556667784 CA4687002 |
381 | S>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA370799956 rs1159553140 |
383 | E>D | No |
ClinGen gnomAD |
|
|
rs759652152 CA4687001 |
386 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA4686999 rs771483951 |
387 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA4686997 rs151273238 |
391 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
COSM1699873 rs748492860 COSM1699874 CA4686995 COSM1699875 COSM1699872 |
392 | D>N | Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA174206323 rs947542247 |
394 | V>A | No |
ClinGen Ensembl |
|
|
CA370799874 rs558845106 |
394 | V>F | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA4686991 rs558845106 |
394 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs61760514 CA4686989 |
395 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370799843 rs1195322775 |
397 | W>* | No |
ClinGen TOPMed |
|
|
CA370799819 rs1563237725 |
399 | F>L | No |
ClinGen Ensembl |
|
|
CA4686987 rs757033660 |
402 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753637648 CA4686986 |
403 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370799781 rs1389544003 |
404 | P>L | No |
ClinGen gnomAD |
|
|
CA4686985 rs767679858 |
404 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA4686984 rs759739923 |
405 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4686983 rs567016649 |
405 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA370799772 rs1358339890 |
406 | G>E | No |
ClinGen gnomAD |
|
|
rs999313378 CA174206309 |
406 | G>R | No |
ClinGen TOPMed |
|
|
rs766449308 CA4686982 |
407 | S>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 407 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs368275566 CA4686979 |
408 | A>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA4686980 rs368275566 |
408 | A>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs762959100 CA4686981 |
408 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs1416395119 CA370799751 |
410 | I>F | No |
ClinGen gnomAD |
|
|
CA174206302 rs576498291 |
412 | V>A | No |
ClinGen gnomAD |
|
|
CA370799722 rs1402376311 |
412 | V>M | No |
ClinGen TOPMed |
|
|
CA174206300 VAR_049371 rs3730247 |
414 | K>R | No |
ClinGen UniProt TOPMed dbSNP |
|
| TCGA novel | 415 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370799647 rs1585648786 |
417 | S>T | No |
ClinGen Ensembl |
|
|
CA4686977 rs777034772 |
417 | S>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs908462360 CA174206294 |
418 | S>F | No |
ClinGen gnomAD |
|
|
CA4686975 rs372173736 |
419 | C>R | No |
ClinGen ESP ExAC |
|
|
CA370799615 rs1382450299 |
419 | C>W | No |
ClinGen TOPMed |
|
|
rs779788145 CA4686974 |
422 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA4686973 rs771722367 |
423 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs367786537 CA174206289 |
423 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP NCI-TCGA TOPMed |
|
rs745335442 CA4686972 |
424 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA4686971 rs778755383 |
425 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370799534 rs1563237483 |
426 | S>G | No |
ClinGen Ensembl |
|
|
CA4686970 rs757196717 |
426 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA174206282 rs757196717 |
426 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4686969 rs753632480 |
428 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 428 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777539457 CA4686968 |
430 | L>S | No |
ClinGen ExAC gnomAD |
|
|
CA4686966 rs1048102 |
431 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA174206276 rs1048102 |
431 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751790994 CA4686965 |
431 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs1377173003 CA370799454 |
431 | Q>R | No |
ClinGen gnomAD |
|
|
rs137939451 CA4686964 |
433 | C>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 434 | C>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA370799408 rs1460677639 |
434 | C>Y | No |
ClinGen TOPMed |
|
|
CA4686963 rs758500506 |
435 | C>S | No |
ClinGen ExAC gnomAD |
|
|
rs765717995 CA4686960 |
439 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4686959 rs762370840 |
440 | T>A | No |
ClinGen ExAC TOPMed |
|
|
rs776927741 CA4686958 |
440 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA174206264 rs958681910 |
441 | P>A | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 442 | S>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs138751075 CA174206262 |
442 | S>C | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs138751075 CA370799304 |
442 | S>R | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA4686956 rs761063889 |
443 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1563237380 CA370799273 |
444 | D>N | No |
ClinGen Ensembl |
|
|
rs1406020875 CA370799221 |
446 | N>I | No |
ClinGen TOPMed |
|
|
CA370799219 rs1244140376 |
446 | N>K | No |
ClinGen gnomAD |
|
|
CA370799223 rs1406020875 |
446 | N>T | No |
ClinGen TOPMed |
|
|
rs771818468 CA4686954 |
448 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1563237349 CA370799130 COSM1456309 |
451 | T>I | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs1357081338 CA370799120 |
452 | I>N | No |
ClinGen gnomAD |
|
|
CA4686951 rs770838608 |
452 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA4686949 rs777627486 |
453 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1168557189 CA370799089 |
454 | V>A | No |
ClinGen gnomAD |
|
|
CA4686948 rs373717543 |
454 | V>I | No |
ClinGen ESP ExAC gnomAD |
|
|
CA174206250 rs866461368 |
455 | H>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1421717697 CA370799064 |
456 | T>A | No |
ClinGen gnomAD |
|
|
CA370799066 rs1421717697 |
456 | T>P | No |
ClinGen gnomAD |
|
|
CA370799029 rs1204162907 |
458 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
rs747894155 CA4686947 |
460 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA370798990 rs747894155 |
460 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201746874 CA4686946 |
462 | N>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA174206239 rs867611987 |
463 | G>E | No |
ClinGen Ensembl |
|
|
CA174206241 rs766671226 |
463 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA4686942 rs757219537 |
464 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA4686940 rs2229126 VAR_049372 |
465 | E>D | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1199954998 CA370798888 |
465 | E>K | No |
ClinGen gnomAD |
No associated diseases with P35348
No regional properties for P35348
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P35348 | |||
Functions
16 GO annotations of cellular component
| Name | Definition |
|---|---|
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dopaminergic synapse | A synapse that uses dopamine as a neurotransmitter. |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of postsynaptic membrane | The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of presynaptic membrane | The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| T-tubule | Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha1-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
40 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of phospholipase C activity | The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand. |
| adenylate cyclase-activating adrenergic receptor signaling pathway | An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. |
| adult heart development | The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. |
| aging | A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| calcium ion transport into cytosol | The directed movement of calcium ions (Ca2+) into the cytosol. |
| cell growth involved in cardiac muscle cell development | The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. |
| cell-cell signaling | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| micturition | The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body. |
| multicellular organism aging | An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). |
| negative regulation of autophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure | Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure. |
| negative regulation of Rho protein signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. |
| neuron-glial cell signaling | Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. |
| norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure | A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| pilomotor reflex | The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect. |
| positive regulation of action potential | Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. |
| positive regulation of cardiac muscle contraction | Any process that increases the frequency, rate or extent of cardiac muscle contraction. |
| positive regulation of cardiac muscle hypertrophy | Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of ERK1 and ERK2 cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of heart rate by epinephrine-norepinephrine | The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of non-membrane spanning protein tyrosine kinase activity | Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity. |
| positive regulation of protein kinase C signaling | Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. |
| positive regulation of smooth muscle contraction | Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. |
| positive regulation of synaptic transmission, GABAergic | Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). |
| positive regulation of systemic arterial blood pressure | The process that increases the force with which blood travels through the systemic arterial circulatory system. |
| positive regulation of the force of heart contraction by epinephrine-norepinephrine | Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings. |
| positive regulation of vasoconstriction | Any process that activates or increases the frequency, rate or extent of vasoconstriction. |
| regulation of synaptic vesicle exocytosis | Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. |
| response to hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| smooth muscle contraction | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. |
119 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0GBZ5 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Bos taurus (Bovine) | PR |
| Q17QD8 | GPR37L1 | G-protein coupled receptor 37-like 1 | Bos taurus (Bovine) | PR |
| Q8SPN1 | PROKR2 | Prokineticin receptor 2 | Bos taurus (Bovine) | PR |
| P46626 | ADRB3 | Beta-3 adrenergic receptor | Bos taurus (Bovine) | PR |
| O46639 | TRHR | Thyrotropin-releasing hormone receptor | Bos taurus (Bovine) | PR |
| Q8SPN2 | PROKR1 | Prokineticin receptor 1 | Bos taurus (Bovine) | PR |
| B9VR26 | CMLKR1 | Chemerin-like receptor 1 | Bos taurus (Bovine) | PR |
| B4XF06 | GPR39 | G-protein coupled receptor 39 | Bos taurus (Bovine) | PR |
| Q2YDN1 | GPR161 | G protein-coupled receptor 161 | Bos taurus (Bovine) | PR |
| P18130 | ADRA1A | Alpha-1A adrenergic receptor | Bos taurus (Bovine) | PR |
| O18913 | OPN1LW | Long-wave-sensitive opsin 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| P28683 | PRA1 | Green-sensitive opsin | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P08099 | Rh2 | Opsin Rh2 | Drosophila melanogaster (Fruit fly) | PR |
| P06002 | ninaE | Opsin Rh1 | Drosophila melanogaster (Fruit fly) | PR |
| Q4LBB9 | Octbeta2R | Octopamine receptor beta-2R | Drosophila melanogaster (Fruit fly) | PR |
| Q8NFJ6 | PROKR2 | Prokineticin receptor 2 | Homo sapiens (Human) | PR |
| Q13585 | GPR50 | Melatonin-related receptor | Homo sapiens (Human) | PR |
| Q9BZJ6 | GPR63 | Probable G-protein coupled receptor 63 | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P28336 | NMBR | Neuromedin-B receptor | Homo sapiens (Human) | PR |
| Q9Y5Y3 | GPR45 | Probable G-protein coupled receptor 45 | Homo sapiens (Human) | PR |
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| P51681 | CCR5 | C-C chemokine receptor type 5 | Homo sapiens (Human) | PR |
| Q8TCW9 | PROKR1 | Prokineticin receptor 1 | Homo sapiens (Human) | PR |
| Q99788 | CMKLR1 | Chemerin-like receptor 1 | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| P30559 | OXTR | Oxytocin receptor | Homo sapiens (Human) | PR |
| P32239 | CCKBR | Gastrin/cholecystokinin type B receptor | Homo sapiens (Human) | PR |
| O60883 | GPR37L1 | G-protein coupled receptor 37-like 1 | Homo sapiens (Human) | PR |
| Q8TDU9 | RXFP4 | Relaxin-3 receptor 2 | Homo sapiens (Human) | PR |
| P04000 | OPN1LW | Long-wave-sensitive opsin 1 | Homo sapiens (Human) | PR |
| Q6U736 | OPN5 | Opsin-5 | Homo sapiens (Human) | PR |
| P34972 | CNR2 | Cannabinoid receptor 2 | Homo sapiens (Human) | PR |
| P24530 | EDNRB | Endothelin receptor type B | Homo sapiens (Human) | PR |
| Q6W5P4 | NPSR1 | Neuropeptide S receptor | Homo sapiens (Human) | PR |
| O43613 | HCRTR1 | Orexin/Hypocretin receptor type 1 | Homo sapiens (Human) | PR |
| P61073 | CXCR4 | C-X-C chemokine receptor type 4 | Homo sapiens (Human) | PR |
| Q9BXC0 | HCAR1 | Hydroxycarboxylic acid receptor 1 | Homo sapiens (Human) | PR |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | Homo sapiens (Human) | PR |
| Q15761 | NPY5R | Neuropeptide Y receptor type 5 | Homo sapiens (Human) | PR |
| Q6DWJ6 | GPR139 | Probable G-protein coupled receptor 139 | Homo sapiens (Human) | PR |
| P21462 | FPR1 | fMet-Leu-Phe receptor | Homo sapiens (Human) | PR |
| P35414 | APLNR | Apelin receptor | Homo sapiens (Human) | PR |
| P46091 | CMKLR2 | Chemerin-like receptor 2 | Homo sapiens (Human) | PR |
| P32745 | SSTR3 | Somatostatin receptor type 3 | Homo sapiens (Human) | PR |
| P41439 | FOLR3 | Folate receptor gamma | Homo sapiens (Human) | PR |
| Q8N6U8 | GPR161 | G-protein coupled receptor 161 | Homo sapiens (Human) | PR |
| P08913 | ADRA2A | Alpha-2A adrenergic receptor | Homo sapiens (Human) | PR |
| P19973 | Lsp1 | Lymphocyte-specific protein 1 | Mus musculus (Mouse) | PR |
| O54799 | Nmbr | Neuromedin-B receptor | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P51675 | Ccr1 | C-C chemokine receptor type 1 | Mus musculus (Mouse) | PR |
| Q5U431 | Gpr39 | G-protein coupled receptor 39 | Mus musculus (Mouse) | PR |
| Q99JG2 | Gpr37l1 | G-protein coupled receptor 37-like 1 | Mus musculus (Mouse) | PR |
| P97295 | Npy2r | Neuropeptide Y receptor type 2 | Mus musculus (Mouse) | PR |
| O08786 | Cckar | Cholecystokinin receptor type A | Mus musculus (Mouse) | PR |
| P56481 | Cckbr | Gastrin/cholecystokinin type B receptor | Mus musculus (Mouse) | PR |
| P30731 | Gpr83 | G-protein coupled receptor 83 | Mus musculus (Mouse) | PR |
| P97468 | Cmklr1 | Chemerin-like receptor 1 | Mus musculus (Mouse) | PR |
| P21761 | Trhr | Thyrotropin-releasing hormone receptor | Mus musculus (Mouse) | PR |
| Q5QD16 | Taar3 | Trace amine-associated receptor 3 | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q9EQQ3 | Gpr63 | Probable G-protein coupled receptor 63 | Mus musculus (Mouse) | PR |
| Q924H0 | Npffr2 | Neuropeptide FF receptor 2 | Mus musculus (Mouse) | PR |
| P34971 | Adrb1 | Beta-1 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| O88416 | Gpr33 | Probable G-protein coupled receptor 33 | Mus musculus (Mouse) | PR |
| Q8K087 | Cmklr2 | Chemerin-like receptor 2 | Mus musculus (Mouse) | PR |
| P70658 | Cxcr4 | C-X-C chemokine receptor type 4 | Mus musculus (Mouse) | PR |
| Q9WV08 | Aplnr | Apelin receptor | Mus musculus (Mouse) | PR |
| Q8BZP8 | Npsr1 | Neuropeptide S receptor | Mus musculus (Mouse) | PR |
| Q8K458 | Prokr2 | Prokineticin receptor 2 | Mus musculus (Mouse) | PR |
| P58308 | Hcrtr2 | Orexin receptor type 2 | Mus musculus (Mouse) | PR |
| Q7TQP3 | Gpr119 | Glucose-dependent insulinotropic receptor | Mus musculus (Mouse) | PR |
| Q8BGE9 | Rxfp3 | Relaxin-3 receptor 1 | Mus musculus (Mouse) | PR |
| Q6VZZ7 | Opn5 | Opsin-5 | Mus musculus (Mouse) | PR |
| Q8CIM5 | Gpr84 | G-protein coupled receptor 84 | Mus musculus (Mouse) | PR |
| P25962 | Adrb3 | Beta-3 adrenergic receptor | Mus musculus (Mouse) | PR |
| Q80UC8 | Gpr139 | Probable G-protein coupled receptor 139 | Mus musculus (Mouse) | PR |
| P0C5I1 | Gpr25 | Probable G-protein coupled receptor 25 | Mus musculus (Mouse) | PR |
| P47936 | Cnr2 | Cannabinoid receptor 2 | Mus musculus (Mouse) | PR |
| Q5QD13 | Taar6 | Trace amine-associated receptor 6 | Mus musculus (Mouse) | PR |
| P35846 | Folr1 | Folate receptor alpha | Mus musculus (Mouse) | PR |
| P58307 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Mus musculus (Mouse) | PR |
| Q8C131 | Hcar1 | Hydroxycarboxylic acid receptor 1 | Mus musculus (Mouse) | PR |
| Q9EQQ4 | Gpr45 | Probable G-protein coupled receptor 45 | Mus musculus (Mouse) | PR |
| B2RPY5 | Gpr161 | G-protein coupled receptor 161 | Mus musculus (Mouse) | PR |
| P97718 | Adra1a | Alpha-1A adrenergic receptor | Mus musculus (Mouse) | PR |
| Q764M9 | CXCR4 | C-X-C chemokine receptor type 4 | Sus scrofa (Pig) | PR |
| Q9EQD2 | Npffr2 | Neuropeptide FF receptor 2 | Rattus norvegicus (Rat) | PR |
| O08565 | Cxcr4 | C-X-C chemokine receptor type 4 | Rattus norvegicus (Rat) | PR |
| Q01717 | Trhr | Thyrotropin-releasing hormone receptor | Rattus norvegicus (Rat) | PR |
| P30936 | Sstr3 | Somatostatin receptor type 3 | Rattus norvegicus (Rat) | PR |
| Q9JHG3 | Aplnr | Apelin receptor | Rattus norvegicus (Rat) | PR |
| P19327 | Htr1a | 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Rat) | PR |
| P56719 | Hcrtr2 | Orexin receptor type 2 | Rattus norvegicus (Rat) | PR |
| P28564 | Htr1b | 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Rat) | PR |
| P56718 | Hcrtr1 | Orexin/Hypocretin receptor type 1 | Rattus norvegicus (Rat) | PR |
| P28647 | Adora3 | Adenosine receptor A3 | Rattus norvegicus (Rat) | PR |
| P25102 | Hrh2 | Histamine H2 receptor | Rattus norvegicus (Rat) | PR |
| P23944 | Adra1d | Alpha-1D adrenergic receptor | Rattus norvegicus (Rat) | PR |
| Q8R415 | Prokr2 | Prokineticin receptor 2 | Rattus norvegicus (Rat) | PR |
| Q5QD24 | Taar3 | Trace amine-associated receptor 3 | Rattus norvegicus (Rat) | PR |
| P0C0W8 | Gpr139 | Probable G-protein coupled receptor 139 | Rattus norvegicus (Rat) | PR |
| P35370 | Oprl1 | Nociceptin receptor | Rattus norvegicus (Rat) | PR |
| P46090 | Cmklr2 | Chemerin-like receptor 2 | Rattus norvegicus (Rat) | PR |
| P43140 | Adra1a | Alpha-1A adrenergic receptor | Rattus norvegicus (Rat) | PR |
| O97664 | CMKLR2 | Chemerin-like receptor 2 | Macaca mulatta (Rhesus macaque) | PR |
| O97666 | APLNR | Apelin receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q56H79 | NPSR1 | Neuropeptide S receptor | Macaca mulatta (Rhesus macaque) | PR |
| Q18904 | npr-8 | Probable G-protein coupled receptor npr-8 | Caenorhabditis elegans | PR |
| Q09388 | gar-2 | Muscarinic acetylcholine receptor gar-2 | Caenorhabditis elegans | PR |
| B3DM66 | gpr161 | G-protein coupled receptor 161 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q9W6A6 | opn1mw4 | Green-sensitive opsin-4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q9W6A5 | opn1mw1 | Green-sensitive opsin-1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYM7 | opn1mw3 | Green-sensitive opsin-3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8AYN0 | opn1lw2 | Red-sensitive opsin-2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q90X46 | gpr161 | G-protein coupled receptor 161 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFLSGNASD | SSNCTQPPAP | VNISKAILLG | VILGGLILFG | VLGNILVILS | VACHRHLHSV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| THYYIVNLAV | ADLLLTSTVL | PFSAIFEVLG | YWAFGRVFCN | IWAAVDVLCC | TASIMGLCII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SIDRYIGVSY | PLRYPTIVTQ | RRGLMALLCV | WALSLVISIG | PLFGWRQPAP | EDETICQINE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EPGYVLFSAL | GSFYLPLAII | LVMYCRVYVV | AKRESRGLKS | GLKTDKSDSE | QVTLRIHRKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| APAGGSGMAS | AKTKTHFSVR | LLKFSREKKA | AKTLGIVVGC | FVLCWLPFFL | VMPIGSFFPD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKPSETVFKI | VFWLGYLNSC | INPIIYPCSS | QEFKKAFQNV | LRIQCLCRKQ | SSKHALGYTL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HPPSQAVEGQ | HKDMVRIPVG | SRETFYRISK | TDGVCEWKFF | SSMPRGSARI | TVSKDQSSCT |
| 430 | 440 | 450 | 460 | ||
| TARVRSKSFL | QVCCCVGPST | PSLDKNHQVP | TIKVHTISLS | ENGEEV |