Q0GBZ5

PR
Gene name
HCRTR1
Protein name
Orexin/Hypocretin receptor type 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282248
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

221-318 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0GBZ5

Entry ID Method Resolution Chain Position Source
AF-Q0GBZ5-F1 Predicted AlphaFoldDB

152 variants for Q0GBZ5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs453218114 8 G>R No EVA
rs441158585 11 M>L No EVA
rs440924731 25 P>Q No EVA
rs474249678 30 E>G No EVA
rs461671187 59 V>I No EVA
rs481713853 74 N>T No EVA
rs463329360 75 H>L No EVA
rs478064956 81 T>P No EVA
rs478064956 81 T>S No EVA
rs459557818 83 Y>F No EVA
rs474153984 96 T>A No EVA
rs462133054 97 A>V No EVA
rs443690417 113 L>I No EVA
rs444710416 134 V>L No EVA
rs471314093 135 L>R No EVA
rs451281506 136 T>S No EVA
rs432807747 137 L>I No EVA
rs465864253 138 S>C No EVA
rs435350504 140 I>N No EVA
rs482904782 147 A>G No EVA
rs446002693 150 H>P No EVA
rs460617537 153 L>V No EVA
rs442075498 154 F>V No EVA
rs481383048 155 K>Q No EVA
rs462979677 156 S>G No EVA
rs444648977 156 S>I No EVA
rs471284398 157 T>N No EVA
rs439153754 159 R>W No EVA
rs210287891 162 R>W No EVA
rs468310380 165 I>L No EVA
rs456324946 169 W>C No EVA
rs437813238 170 A>G No EVA
rs464445632 171 V>E No EVA
rs445906133 172 S>L No EVA
rs433925391 177 V>G No EVA
rs466815832 179 Q>P No EVA
rs481320654 181 A>G No EVA
rs477672059 188 V>A No EVA
rs477672059 188 V>G No EVA
rs440695340 193 A>S No EVA
rs460124802 194 N>H No EVA
rs441686671 194 N>T No EVA
rs456261548 195 R>H No EVA
rs456261548 195 R>P No EVA
rs474674566 195 R>S No EVA
rs437755827 196 T>P No EVA
rs383226125 197 R>W No EVA
rs452341983 203 D>N No EVA
rs466756262 207 A>P No EVA
rs448372301 208 D>H No EVA
rs438685964 211 Y>S No EVA
rs471729625 213 K>Q No EVA
rs515980103 219 F>L No EVA
rs472678403 223 T>P No EVA
rs441271442 243 W>* No EVA
rs474281712 244 G>A No EVA
rs437365809 246 Q>K No EVA
rs458217533 247 I>M No EVA
rs446100102 252 S>L No EVA
rs478970706 254 L>P No EVA
rs460567481 255 V>G No EVA
rs475093989 256 R>G No EVA
rs463233967 257 N>D No EVA
rs476211534 257 N>K No EVA
rs443187110 257 N>T No EVA
rs451341842 258 W>R No EVA
rs432835818 259 K>N No EVA
rs522722163 259 K>R No EVA
rs210846681 260 R>Q No EVA
rs435411843 261 P>A No EVA
rs449924348 262 S>P No EVA
rs464530266 263 V>G No EVA
rs446064099 264 Q>P No EVA
rs478907728 265 L>Q No EVA
rs460504135 266 E>G No EVA
rs448560811 267 E>V No EVA
rs481446176 268 Q>E No EVA
rs463219118 268 Q>R No EVA
rs471345650 270 Q>E No EVA
rs439255440 270 Q>H No EVA
rs457661373 270 Q>R No EVA
rs453841234 272 L>R No EVA
rs474812684 274 A>G No EVA
rs437874742 275 E>D No EVA
rs445981413 277 Q>K No EVA
rs466876840 280 A>P No EVA
rs448497057 280 A>V No EVA
rs469550830 281 R>H No EVA
rs469550830 281 R>L No EVA
rs481626449 281 R>S No EVA
rs451128165 283 F>V No EVA
rs459284547 286 E>A No EVA
rs459284547 286 E>G No EVA
rs439189996 287 V>A No EVA
rs460184917 288 K>Q No EVA
rs441746251 288 K>R No EVA
rs474765322 291 R>P No EVA
rs456265041 294 R>T No EVA
rs444246965 295 K>E No EVA
rs470856217 296 T>A No EVA
rs452312281 297 A>P No EVA
rs466813704 298 K>R No EVA
rs454817921 300 L>M No EVA
rs469531930 303 V>M No EVA
rs477656313 304 L>Q No EVA
rs447174114 305 L>P No EVA
rs478561421 306 V>G No EVA
rs441686712 311 Y>S No EVA
rs462684237 313 P>H No EVA
rs470812583 315 S>N No EVA
rs452250950 316 V>F No EVA
rs460634518 365 F>L No EVA
rs442299192 367 E>* No EVA
rs461691322 368 Q>H No EVA
rs475390910 368 Q>P No EVA
rs476270335 370 K>N No EVA
rs451445426 371 A>P No EVA
rs439382818 372 A>P No EVA
rs472397428 373 F>S No EVA
rs453941371 374 S>P No EVA
rs435474753 375 C>S No EVA
rs456450200 378 P>L No EVA
rs437971263 379 G>A No EVA
rs464464998 380 L>R No EVA
rs478971040 383 C>R No EVA
rs466993432 383 C>W No EVA
rs448694812 386 L>R No EVA
rs463280455 387 K>N No EVA
rs481758466 387 K>R No EVA
rs443169798 388 V>A No EVA
rs443169798 388 V>D No EVA
rs457793509 389 P>H No EVA
rs439319446 390 S>G No EVA
rs472335844 392 R>P No EVA
rs453817639 393 S>A No EVA
rs474872236 394 S>A No EVA
rs474872236 394 S>P No EVA
rs438210504 395 A>P No EVA
rs464401633 397 H>P No EVA
rs452430678 400 L>M No EVA
rs467123583 402 L>F No EVA
rs434047655 402 L>W No EVA
rs448550166 403 Q>* No EVA
rs715422535 405 R>Q No EVA
rs481690104 406 C>R No EVA
rs469613844 408 V>G No EVA
rs477740854 412 S>L No EVA
rs439251487 413 E>A No EVA
rs460265977 414 H>P No EVA
rs478686254 414 H>Y No EVA
rs441763298 415 V>E No EVA
rs444289267 418 T>P No EVA

No associated diseases with Q0GBZ5

1 regional properties for Q0GBZ5

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 32 - 358 IPR017452

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
orexin receptor activity Combining with orexin to initiate a change in cell activity.

5 GO annotations of biological process

Name Definition
feeding behavior Behavior associated with the intake of food.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
neuropeptide signaling pathway A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
regulation of cytosolic calcium ion concentration Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.

119 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2YDN1 GPR161 G protein-coupled receptor 161 Bos taurus (Bovine) PR
Q17QD8 GPR37L1 G-protein coupled receptor 37-like 1 Bos taurus (Bovine) PR
P46626 ADRB3 Beta-3 adrenergic receptor Bos taurus (Bovine) PR
O46639 TRHR Thyrotropin-releasing hormone receptor Bos taurus (Bovine) PR
B9VR26 CMLKR1 Chemerin-like receptor 1 Bos taurus (Bovine) PR
P18130 ADRA1A Alpha-1A adrenergic receptor Bos taurus (Bovine) PR
B4XF06 GPR39 G-protein coupled receptor 39 Bos taurus (Bovine) PR
Q8SPN1 PROKR2 Prokineticin receptor 2 Bos taurus (Bovine) PR
Q8SPN2 PROKR1 Prokineticin receptor 1 Bos taurus (Bovine) PR
O18913 OPN1LW Long-wave-sensitive opsin 1 Felis catus (Cat) (Felis silvestris catus) PR
P28683 PRA1 Green-sensitive opsin Gallus gallus (Chicken) PR
Q9N298 HTR1A 5-hydroxytryptamine receptor 1A Pan troglodytes (Chimpanzee) PR
P08099 Rh2 Opsin Rh2 Drosophila melanogaster (Fruit fly) PR
P06002 ninaE Opsin Rh1 Drosophila melanogaster (Fruit fly) PR
Q4LBB9 Octbeta2R Octopamine receptor beta-2R Drosophila melanogaster (Fruit fly) PR
Q8NFJ6 PROKR2 Prokineticin receptor 2 Homo sapiens (Human) PR
Q13585 GPR50 Melatonin-related receptor Homo sapiens (Human) PR
Q9BZJ6 GPR63 Probable G-protein coupled receptor 63 Homo sapiens (Human) PR
Q9H3N8 HRH4 Histamine H4 receptor Homo sapiens (Human) PR
P28336 NMBR Neuromedin-B receptor Homo sapiens (Human) PR
Q9Y5Y3 GPR45 Probable G-protein coupled receptor 45 Homo sapiens (Human) PR
P08913 ADRA2A Alpha-2A adrenergic receptor Homo sapiens (Human) PR
P41597 CCR2 C-C chemokine receptor type 2 Homo sapiens (Human) PR
P51681 CCR5 C-C chemokine receptor type 5 Homo sapiens (Human) PR
Q8TCW9 PROKR1 Prokineticin receptor 1 Homo sapiens (Human) PR
Q99788 CMKLR1 Chemerin-like receptor 1 Homo sapiens (Human) PR
P08908 HTR1A 5-hydroxytryptamine receptor 1A Homo sapiens (Human) PR
P30559 OXTR Oxytocin receptor Homo sapiens (Human) PR
P32239 CCKBR Gastrin/cholecystokinin type B receptor Homo sapiens (Human) PR
O60883 GPR37L1 G-protein coupled receptor 37-like 1 Homo sapiens (Human) PR
Q8TDU9 RXFP4 Relaxin-3 receptor 2 Homo sapiens (Human) PR
P04000 OPN1LW Long-wave-sensitive opsin 1 Homo sapiens (Human) PR
Q6U736 OPN5 Opsin-5 Homo sapiens (Human) PR
P34972 CNR2 Cannabinoid receptor 2 Homo sapiens (Human) PR
P24530 EDNRB Endothelin receptor type B Homo sapiens (Human) PR
P35348 ADRA1A Alpha-1A adrenergic receptor Homo sapiens (Human) PR
Q6W5P4 NPSR1 Neuropeptide S receptor Homo sapiens (Human) PR
P61073 CXCR4 C-X-C chemokine receptor type 4 Homo sapiens (Human) PR
Q9BXC0 HCAR1 Hydroxycarboxylic acid receptor 1 Homo sapiens (Human) PR
P30556 AGTR1 Type-1 angiotensin II receptor Homo sapiens (Human) PR
Q15761 NPY5R Neuropeptide Y receptor type 5 Homo sapiens (Human) PR
Q8N6U8 GPR161 G-protein coupled receptor 161 Homo sapiens (Human) PR
Q6DWJ6 GPR139 Probable G-protein coupled receptor 139 Homo sapiens (Human) PR
P21462 FPR1 fMet-Leu-Phe receptor Homo sapiens (Human) PR
P35414 APLNR Apelin receptor Homo sapiens (Human) PR
P46091 CMKLR2 Chemerin-like receptor 2 Homo sapiens (Human) PR
P32745 SSTR3 Somatostatin receptor type 3 Homo sapiens (Human) PR
P41439 FOLR3 Folate receptor gamma Homo sapiens (Human) PR
O43613 HCRTR1 Orexin/Hypocretin receptor type 1 Homo sapiens (Human) PR
P19973 Lsp1 Lymphocyte-specific protein 1 Mus musculus (Mouse) PR
O54799 Nmbr Neuromedin-B receptor Mus musculus (Mouse) PR
Q64264 Htr1a 5-hydroxytryptamine receptor 1A Mus musculus (Mouse) PR
P51675 Ccr1 C-C chemokine receptor type 1 Mus musculus (Mouse) PR
Q5U431 Gpr39 G-protein coupled receptor 39 Mus musculus (Mouse) PR
Q99JG2 Gpr37l1 G-protein coupled receptor 37-like 1 Mus musculus (Mouse) PR
P97295 Npy2r Neuropeptide Y receptor type 2 Mus musculus (Mouse) PR
O08786 Cckar Cholecystokinin receptor type A Mus musculus (Mouse) PR
P56481 Cckbr Gastrin/cholecystokinin type B receptor Mus musculus (Mouse) PR
P30731 Gpr83 G-protein coupled receptor 83 Mus musculus (Mouse) PR
P97468 Cmklr1 Chemerin-like receptor 1 Mus musculus (Mouse) PR
P21761 Trhr Thyrotropin-releasing hormone receptor Mus musculus (Mouse) PR
Q5QD16 Taar3 Trace amine-associated receptor 3 Mus musculus (Mouse) PR
P97292 Hrh2 Histamine H2 receptor Mus musculus (Mouse) PR
Q9EQQ3 Gpr63 Probable G-protein coupled receptor 63 Mus musculus (Mouse) PR
Q924H0 Npffr2 Neuropeptide FF receptor 2 Mus musculus (Mouse) PR
P34971 Adrb1 Beta-1 adrenergic receptor Mus musculus (Mouse) PR
Q91ZY2 Hrh4 Histamine H4 receptor Mus musculus (Mouse) PR
O88416 Gpr33 Probable G-protein coupled receptor 33 Mus musculus (Mouse) PR
Q8K087 Cmklr2 Chemerin-like receptor 2 Mus musculus (Mouse) PR
P70658 Cxcr4 C-X-C chemokine receptor type 4 Mus musculus (Mouse) PR
Q9WV08 Aplnr Apelin receptor Mus musculus (Mouse) PR
P97718 Adra1a Alpha-1A adrenergic receptor Mus musculus (Mouse) PR
Q8BZP8 Npsr1 Neuropeptide S receptor Mus musculus (Mouse) PR
Q8K458 Prokr2 Prokineticin receptor 2 Mus musculus (Mouse) PR
P58308 Hcrtr2 Orexin receptor type 2 Mus musculus (Mouse) PR
Q7TQP3 Gpr119 Glucose-dependent insulinotropic receptor Mus musculus (Mouse) PR
Q8BGE9 Rxfp3 Relaxin-3 receptor 1 Mus musculus (Mouse) PR
Q6VZZ7 Opn5 Opsin-5 Mus musculus (Mouse) PR
Q8CIM5 Gpr84 G-protein coupled receptor 84 Mus musculus (Mouse) PR
P25962 Adrb3 Beta-3 adrenergic receptor Mus musculus (Mouse) PR
Q80UC8 Gpr139 Probable G-protein coupled receptor 139 Mus musculus (Mouse) PR
P0C5I1 Gpr25 Probable G-protein coupled receptor 25 Mus musculus (Mouse) PR
P47936 Cnr2 Cannabinoid receptor 2 Mus musculus (Mouse) PR
Q5QD13 Taar6 Trace amine-associated receptor 6 Mus musculus (Mouse) PR
P35846 Folr1 Folate receptor alpha Mus musculus (Mouse) PR
Q8C131 Hcar1 Hydroxycarboxylic acid receptor 1 Mus musculus (Mouse) PR
Q9EQQ4 Gpr45 Probable G-protein coupled receptor 45 Mus musculus (Mouse) PR
B2RPY5 Gpr161 G-protein coupled receptor 161 Mus musculus (Mouse) PR
P58307 Hcrtr1 Orexin/Hypocretin receptor type 1 Mus musculus (Mouse) PR
Q764M9 CXCR4 C-X-C chemokine receptor type 4 Sus scrofa (Pig) PR
Q9EQD2 Npffr2 Neuropeptide FF receptor 2 Rattus norvegicus (Rat) PR
O08565 Cxcr4 C-X-C chemokine receptor type 4 Rattus norvegicus (Rat) PR
Q01717 Trhr Thyrotropin-releasing hormone receptor Rattus norvegicus (Rat) PR
P30936 Sstr3 Somatostatin receptor type 3 Rattus norvegicus (Rat) PR
Q9JHG3 Aplnr Apelin receptor Rattus norvegicus (Rat) PR
P43140 Adra1a Alpha-1A adrenergic receptor Rattus norvegicus (Rat) PR
P19327 Htr1a 5-hydroxytryptamine receptor 1A Rattus norvegicus (Rat) PR
P56719 Hcrtr2 Orexin receptor type 2 Rattus norvegicus (Rat) PR
P28564 Htr1b 5-hydroxytryptamine receptor 1B Rattus norvegicus (Rat) PR
P28647 Adora3 Adenosine receptor A3 Rattus norvegicus (Rat) PR
P25102 Hrh2 Histamine H2 receptor Rattus norvegicus (Rat) PR
P23944 Adra1d Alpha-1D adrenergic receptor Rattus norvegicus (Rat) PR
Q8R415 Prokr2 Prokineticin receptor 2 Rattus norvegicus (Rat) PR
Q5QD24 Taar3 Trace amine-associated receptor 3 Rattus norvegicus (Rat) PR
P0C0W8 Gpr139 Probable G-protein coupled receptor 139 Rattus norvegicus (Rat) PR
P35370 Oprl1 Nociceptin receptor Rattus norvegicus (Rat) PR
P46090 Cmklr2 Chemerin-like receptor 2 Rattus norvegicus (Rat) PR
P56718 Hcrtr1 Orexin/Hypocretin receptor type 1 Rattus norvegicus (Rat) PR
O97664 CMKLR2 Chemerin-like receptor 2 Macaca mulatta (Rhesus macaque) PR
O97666 APLNR Apelin receptor Macaca mulatta (Rhesus macaque) PR
Q56H79 NPSR1 Neuropeptide S receptor Macaca mulatta (Rhesus macaque) PR
Q18904 npr-8 Probable G-protein coupled receptor npr-8 Caenorhabditis elegans PR
Q09388 gar-2 Muscarinic acetylcholine receptor gar-2 Caenorhabditis elegans PR
B3DM66 gpr161 G-protein coupled receptor 161 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q9W6A6 opn1mw4 Green-sensitive opsin-4 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q9W6A5 opn1mw1 Green-sensitive opsin-1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q8AYM7 opn1mw3 Green-sensitive opsin-3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q8AYN0 opn1lw2 Red-sensitive opsin-2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q90X46 gpr161 G-protein coupled receptor 161 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEPSATPGPQ MGVPTEGRER SPEPPDYEDE FLRYLWRDYL YPKQYEWVLI AAYVAVFFVA
70 80 90 100 110 120
LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL PASLLVDITE SWLFGHALCK
130 140 150 160 170 180
VIPYLQAVSV SVAVLTLSFI ALDRWYAICH PLLFKSTARR ARGSILGIWA VSLAVMVPQA
190 200 210 220 230 240
AVMECSSVLP ELANRTRLFS VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR
250 260 270 280 290 300
KLWGRQIPGT TSALVRNWKR PSVQLEEQGQ GLGAEPQPRA RAFLAEVKQM RARRKTAKML
310 320 330 340 350 360
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN SAANPIIYNF
370 380 390 400 410 420
LSGKFREQFK AAFSCCLPGL GPCVSLKVPS PRSSASHKSL SLQSRCSVSK ASEHVLLTSV
TTVLP