Q9Z2J6

PR
Gene name
Ptgdr2 (Crth2, Gpr44)
Protein name
Prostaglandin D2 receptor 2
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14764
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

306-377 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Z2J6

Entry ID Method Resolution Chain Position Source
AF-Q9Z2J6-F1 Predicted AlphaFoldDB

24 variants for Q9Z2J6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389434200 30 I>M No EVA
rs3389527027 33 V>E No EVA
rs3389493536 51 L>I No EVA
rs3389531660 80 A>P No EVA
rs3389527178 100 T>I No EVA
rs3389528051 100 T>S No EVA
rs3389519880 120 L>M No EVA
rs3408261739 127 D>H No EVA
rs3389538667 128 R>H No EVA
rs3389538667 128 R>P No EVA
rs36896636 190 P>A No EVA
rs3389519844 201 R>G No EVA
rs3389434249 205 L>M No EVA
rs3408858618 210 F>L* No EVA
rs39072783 215 M>V No EVA
rs3408944200 280 L>P No EVA
rs3409337352 281 A>T No EVA
rs3408778043 282 S>* No EVA
rs3409046960 284 G>E No EVA
rs3389493568 324 S>I No EVA
rs3389522359 332 Q>H No EVA
rs226740627 340 R>H No EVA
rs37600949 359 I>L No EVA
rs3389506077 376 A>V No EVA

No associated diseases with Q9Z2J6

1 regional properties for Q9Z2J6

Type Name Position InterPro Accession
domain Olfactomedin-like domain 385 - 642 IPR003112

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Internalized receptors colocalized with RAB11A
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

6 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
neuropeptide binding Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).
peptide binding Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
prostaglandin D receptor activity Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity.
prostaglandin F receptor activity Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity.
prostaglandin J receptor activity Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.

7 GO annotations of biological process

Name Definition
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
negative regulation of male germ cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation.
neuropeptide signaling pathway A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
positive regulation of G protein-coupled receptor signaling pathway Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y5Y4 PTGDR2 Prostaglandin D2 receptor 2 Homo sapiens (Human) PR
Q8K087 Cmklr2 Chemerin-like receptor 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MANVTLKPLC PLLEEMVQLP NHSNSSLRYI DHVSVLLHGL ASLLGLVENG LILFVVGCRM
70 80 90 100 110 120
RQTVVTTWVL HLALSDLLAA ASLPFFTYFL AVGHSWELGT TFCKLHSSVF FLNMFASGFL
130 140 150 160 170 180
LSAISLDRCL QVVRPVWAQN HRTVAVAHRV CLMLWALAVL NTIPYFVFRD TIPRLDGRIM
190 200 210 220 230 240
CYYNLLLWNP GPDRDTTCDY RQKALAVSKF LLAFMVPLAI IASSHVAVSL RLHHRGRQRT
250 260 270 280 290 300
GRFVRLVAAI VVAFVLCWGP YHIFSLLEAR AHSVTTLRQL ASRGLPFVTS LAFFNSVVNP
310 320 330 340 350 360
LLYVFTCPDM LYKLRRSLRA VLESVLVEDS DQSGGLRNRR RRASSTATPA STLLLADRIP
370 380
QLRPTRLIGW MRRGSAEVPQ RV