O18793
PR
Gene name |
CCR2 (CMKBR2) |
Protein name |
C-C chemokine receptor type 2 |
Names |
|
Species |
Macaca mulatta (Rhesus macaque) |
KEGG Pathway |
mcc:574098 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O18793
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O18793-F1 | Predicted | AlphaFoldDB |
No variants for O18793
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O18793 | |||||
No associated diseases with O18793
1 regional properties for O18793
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 84 - 543 | IPR017452 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| C-C chemokine binding | Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
| C-C chemokine receptor activity | Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| blood vessel remodeling | The reorganization or renovation of existing blood vessels. |
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
| cell chemotaxis | The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| immune response | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| inflammatory response to wounding | The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. |
| macrophage migration | The orderly movement of a macrophage from one site to another. |
| monocyte extravasation | The migration of a monocyte from the blood vessels into the surrounding tissue. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of monocyte chemotaxis | Any process that increases the frequency, rate, or extent of monocyte chemotaxis. |
| positive regulation of synaptic transmission, glutamatergic | Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. |
| positive regulation of thymocyte migration | Any process that activates or increases the frequency, rate or extent of thymocyte migration. |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
| regulation of T cell cytokine production | Any process that modulates the frequency, rate, or extent of T cell cytokine production. |
| regulation of T cell differentiation | Any process that modulates the frequency, rate or extent of T cell differentiation. |
| sensory perception of pain | The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41597 | CCR2 | C-C chemokine receptor type 2 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSTSRSRFI | RNTNGSGEEV | TTFFDYDYGA | PCHKFDVKQI | GAQLLPPLYS | LVFIFGFVGN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MLVVLILINC | KKLKSLTDIY | LLNLAISDLL | FLITLPLWAH | SAANEWVFGN | AMCKLFTGLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HIGYLGGIFF | IILLTIDRYL | AIVHAVFALK | ARTVTFGVVT | SVITWLVAVF | ASVPGIIFTK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CQEEDSVYIC | GPYFPRGWNN | FHTIMRNILG | LVLPLLIMVI | CYSGILKTLL | RCRNEKKRHR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AVRLIFTIMI | VYFLFWTPYN | IVILLNTFQE | FFGLSNCEST | RQLDQATQVT | ETLGMTHCCI |
| 310 | 320 | 330 | 340 | 350 | |
| NPIIYAFVGE | KFRRYLSMFF | RKYITKRFCK | QCPVFYRETV | DGVTSTNTPS | TAEQEVSVGL |