Q5DRC8
PR
Gene name |
PCDHB6 |
Protein name |
Protocadherin beta-6 |
Names |
PCDH-beta-6 |
Species |
Pan troglodytes (Chimpanzee) |
KEGG Pathway |
ptr:462130 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5DRC8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5DRC8-F1 | Predicted | AlphaFoldDB |
1 variants for Q5DRC8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs25178109 | 480 | I>T | No | Ensembl |
No associated diseases with Q5DRC8
11 regional properties for Q5DRC8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin-like | 53 - 130 | IPR002126-1 |
| domain | Cadherin-like | 133 - 241 | IPR002126-2 |
| domain | Cadherin-like | 241 - 345 | IPR002126-3 |
| domain | Cadherin-like | 346 - 559 | IPR002126-4 |
| domain | Cadherin-like | 574 - 669 | IPR002126-5 |
| domain | Cadherin, N-terminal | 30 - 111 | IPR013164 |
| conserved_site | Cadherin conserved site | 229 - 239 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 333 - 343 | IPR020894-2 |
| conserved_site | Cadherin conserved site | 437 - 447 | IPR020894-3 |
| conserved_site | Cadherin conserved site | 547 - 557 | IPR020894-4 |
| domain | Cadherin, cytoplasmic C-terminal domain | 684 - 766 | IPR032455 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| identical protein binding | Binding to an identical protein or proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cell-cell recognition | Cell recognition between cells. May involve the formation of specialized cell junctions. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
46 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRC1 | PCDHGA10 | Protocadherin gamma-A10 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF2 | PCDHA12 | Protocadherin alpha-12 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF4 | PCDHA10 | Protocadherin alpha-10 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF3 | PCDHA11 | Protocadherin alpha-11 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF5 | PCDHA1 | Protocadherin alpha-1 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMQTKVQNKK | RQVAFFILLM | LWGEVGSESI | QYSVLEETES | GTFVANLTKD | LGLRVGELAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGARVVFKGN | RQHLQFDPQT | HDLLLNEKLD | REELCGSTEL | CVLPFQVLLE | NPLQFFQASL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVRDINDHAP | EFPAREMLLK | ISEITMPGKI | FPLKMAHDLD | TGSNGLQRYT | ISSNPHFHVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TRNRSEGRKF | PELVLDKPLD | REEQPQLRLT | LIALDGGSPP | RSGTSEIQIQ | VLDINDNVPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FAEELYEAQV | PENNPLGSLV | ITVSARDLDA | GSFGKVSYAL | FQVDDVNQPF | EINAITGEIR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRKALDFEEI | QSYDLDVEAT | DGGGLSGKCS | LLVRVLDVND | NAPELTMSFF | ISPIPENLPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IIVAVFSVSD | ADSGHNQQVI | CSIENNLPFL | LRPTVENFYT | LVTEGALDRE | SRAEYNITIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VTDLGTPRLK | TQQSITVQVS | DVNDNAPAFT | QTSYTLFVRE | NNSPALHIGS | VSATDRDSGI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NAQVTYSLLP | PQDPHLPLAS | LVSINADNGH | LFALRSLDYE | ALQAFEFRVG | ATDRGSPALS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SEALVRVLVL | DANDNSPFVL | YPLQNGSAPC | TELVPRAAEP | GYLVTKVVAV | DGDSGQNAWL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SYQLLKATEL | GLFGVWAHNG | EVRTARLLSE | RDAAKHRLVV | LVKDNGEPPR | SATATLHVLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VDGFSQPYLP | LPEAAPAPAQ | ADLLTVYLVV | ALASVSSLFL | FSVLLFVAVR | LCRRSRAASV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GRCSVPEGPF | PEHLVDVNGT | GTLSQSYQYK | VCLTGGSETN | EFKFLKPIMP | NFPPQGTERE |
| 790 | |||||
| MEETPTSRNS | FPFS |