Q5DRE4
PR
Gene name |
PCDHA8 |
Protein name |
Protocadherin alpha-8 |
Names |
PCDH-alpha-8 |
Species |
Pan troglodytes (Chimpanzee) |
KEGG Pathway |
ptr:100034715 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5DRE4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5DRE4-F1 | Predicted | AlphaFoldDB |
1 variants for Q5DRE4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs25192729 | 576 | S>A | No | Ensembl |
No associated diseases with Q5DRE4
10 regional properties for Q5DRE4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin-like | 34 - 133 | IPR002126-1 |
| domain | Cadherin-like | 142 - 242 | IPR002126-2 |
| domain | Cadherin-like | 242 - 350 | IPR002126-3 |
| domain | Cadherin-like | 351 - 565 | IPR002126-4 |
| domain | Cadherin-like | 581 - 678 | IPR002126-5 |
| domain | Cadherin, N-terminal | 30 - 111 | IPR013164 |
| conserved_site | Cadherin conserved site | 230 - 240 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 443 - 453 | IPR020894-2 |
| conserved_site | Cadherin conserved site | 553 - 563 | IPR020894-3 |
| domain | Cadherin, C-terminal catenin-binding domain | 800 - 933 | IPR031904 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVYHWRGDLG | SWRLLLLLLL | LAAWKVGSGQ | LHYSVPEEAK | HGTFVGRIAQ | DLGLELAELV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRLFRVASKR | HRDLLEVNLQ | NGILFVNSRI | DREELCGRSA | ECSIHLEVIV | DRPLQVFHVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VEVKDVNDNP | PVFRVKEQKL | FVSESRMPDS | RFPLEGASDA | DVGANSVLTY | RLSFHDYFML |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DVNSKNDENK | LVELVLRKSL | DREDAPAHDL | FLTATDGGKP | ELTGTVQLLV | TVLDVNDNAP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NFEQSEYEVR | IFENADNGTT | VIKLNASDRD | EGANGAISYS | FNSLVETMVI | DHFSIDRNTG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EIVIRGNLDF | EQENFYKIRI | DATDKGHPPM | AGHCTVLVRI | LDKNDNVPEI | ALTSLSLPVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EDAQFGTVIA | LISVNDLDSG | ANGQVTCSLM | PHVPFKLVST | FKNYYSLVLD | SALDRESVSA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YELVVTARDG | GSPSLWATAS | LSVEVADVND | NAPAFAQPEY | TVFVKENNPP | GCHIFTVSAR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DADAQENALV | SYSLVERRVG | ERSLSSYVSV | HTESGKVYAL | QPLDHEELEL | LQFQVSARDA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GVPPLGSNVT | LQVFVLDEND | NAPALLEPRV | GGTGGSASEL | VPRSVGAGHV | VAKVRAVDAD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SGYNAWLSYE | LQPAASSPRI | PFRVGLYTGE | ISTTRVLDEA | DSPRHRLLVL | VKDHGEPALT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ATATVLVSLV | ESGQAPKASS | RQSAGVVGPE | AALVDVNVYL | IIAICAVSSL | LVLTLLLYTA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LRCSALPTEG | GCRAGKPTLV | CSSAVGSWSY | SQQQSQRVCS | GEGPPKTDLM | AFSPCLPPDL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GSVDVGEERD | LNVDHGLKPR | QPNPDWRYSA | SLRAGMHSSV | HLEEAGILRA | GPGGPDQQWP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TVSSATPEPE | AGEVSPPVGA | GVNSNSWTFK | YGPGNPKQSG | PGELPDKFII | PGSPAIISIR |
| 910 | 920 | 930 | 940 | ||
| QEPANSQIDK | SDFITFGKKE | ETKKKKKKKK | GNKTQEKKEK | GNSTTDNSDQ |