Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5DRE6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5DRE6-F1 | Predicted | AlphaFoldDB |
No variants for Q5DRE6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5DRE6 | |||||
No associated diseases with Q5DRE6
9 regional properties for Q5DRE6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 423 - 646 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1211 - 1444 | IPR003439-2 |
| domain | AAA+ ATPase domain | 450 - 639 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1237 - 1419 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 82 - 350 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 860 - 1158 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 548 - 562 | IPR017871 |
| domain | CFTR regulator domain | 639 - 849 | IPR025837 |
| domain | Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 | 389 - 670 | IPR047082 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFTPEDRLG | KQCLLLPLLL | LAAWKVGSGQ | LHYSVPEEAK | HGTFVGRIAQ | DLGLELAELV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRLFRMASKD | REDLLEVNLQ | NGILFVNSRI | DREELCGRSA | ECSIHLEVIV | DRPLQVFHVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VEVRDINDNP | PLFPVEEQRV | LIYESRLPDS | VFPLEGASDA | DVGSNSILTY | KLSSSEYFGL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DVKINSDDNK | QIGLLLKKSL | DREEAPAHNL | FLTATDGGKP | ELTGTVQLLV | TVLDVNDNAP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NFEQSEYEVR | IFENADNGTT | VIKLNASDRD | EGANGAISYS | FNSLVAAMVI | DHFSIDRNTG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EIVIRGNLDF | EQENFYKIRI | DATDKGHPPM | AGHCTVLVRI | LDKNDNVPEI | ALTSLSLPVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EDAQFGTVIA | LISVNDLDSG | ANGQVNCSLT | PHVPFKLVST | FKNYYSLVLD | SALDRESVSA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YELVVTARDG | GSPSLWATAS | LSVEVADVND | NAPAFAQPEY | TVFVKENNPP | GCHIFTVSAR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DADAQENALV | SYSLVERRVG | ERALSSYISV | HAESGKVYAL | QPLDHEELEL | LQFQVSARDA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GVPPLGSNVT | LQVFVLDEND | NAPALLAPRV | GGTGGAVSEL | VPRSVGAGQV | VAKVRAVDAD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SGYNAWLSYE | LQPPASSARF | PFRVGLYTGE | ISTTRVLDEA | DSPRHRLLVL | VKDHGEPALT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ATATVLVSLV | ESGQAPKASS | RASVGAAGPE | AALVDVNVYL | IIAICAVSSL | LVLTLLLYTA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LRCSAPSTEG | ACTADKPTLV | CSSAVGSWSY | SQQRRQRVCS | GEGPPKMDLM | AFSPSLSPCP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IMMGKAENQD | LNEDHDAKPR | QPNPDWRYSA | SLRAGMHSSV | HLEEAGILRA | GPGGPDQQWP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TVSSATPEPE | AGEVSPPVGA | GVNSNSWTFK | YGPGNPKQSG | PGELPDKFII | PGSPAIISIR |
| 910 | 920 | 930 | 940 | ||
| QEPANSQIDK | SDFITFGKKE | ETKKKKKKKK | GNKTQEKKEK | GNSTTDNSDQ |