P70408
PR
Gene name |
Cdh10 |
Protein name |
Cadherin-10 |
Names |
T2-cadherin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320873 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P70408
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6CG6 | X-ray | 271 A | A | 55-261 | PDB |
| AF-P70408-F1 | Predicted | AlphaFoldDB |
30 variants for P70408
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389356642 | 24 | L>V | No | EVA | |
| rs250521368 | 25 | T>M | No | EVA | |
| rs3389364774 | 35 | M>V | No | EVA | |
| rs3404367333 | 43 | R>E | No | EVA | |
| rs250658670 | 135 | R>K | No | EVA | |
| rs3389317216 | 258 | T>S | No | EVA | |
| rs3389360293 | 282 | S>Y | No | EVA | |
| rs3389336821 | 301 | N>I | No | EVA | |
| rs3389345095 | 378 | V>A | No | EVA | |
| rs230787678 | 378 | V>L | No | EVA | |
| rs230787678 | 378 | V>M | No | EVA | |
| rs3389325851 | 423 | D>N | No | EVA | |
| rs3389345127 | 515 | K>* | No | EVA | |
| rs3405825340 | 542 | D>R | No | EVA | |
| rs3389317218 | 585 | R>S | No | EVA | |
| rs3389364748 | 586 | V>M | No | EVA | |
| rs47021013 | 598 | C>W | No | EVA | |
| rs3389364753 | 641 | E>D | No | EVA | |
| rs3389336784 | 652 | D>E | No | EVA | |
| rs3389307389 | 685 | K>E | No | EVA | |
| rs3389356625 | 686 | L>F | No | EVA | |
| rs3389360290 | 707 | N>T | No | EVA | |
| rs3389352752 | 716 | E>* | No | EVA | |
| rs3389336805 | 731 | D>H | No | EVA | |
| rs3389349832 | 733 | L>P | No | EVA | |
| rs3405821656 | 745 | A>S | No | EVA | |
| rs3389364726 | 759 | D>A | No | EVA | |
| rs3389275247 | 769 | G>E | No | EVA | |
| rs3389364813 | 778 | M>L | No | EVA | |
| rs3389348683 | 782 | G>V | No | EVA |
No associated diseases with P70408
8 regional properties for P70408
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin, Y-type LIR-motif | 722 - 780 | IPR000233 |
| domain | Cadherin-like | 70 - 160 | IPR002126-1 |
| domain | Cadherin-like | 160 - 280 | IPR002126-2 |
| domain | Cadherin-like | 270 - 384 | IPR002126-3 |
| domain | Cadherin-like | 385 - 489 | IPR002126-4 |
| domain | Cadherin-like | 489 - 603 | IPR002126-5 |
| conserved_site | Cadherin conserved site | 257 - 267 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 477 - 487 | IPR020894-2 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| catenin complex | Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of postsynaptic specialization membrane | The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of presynaptic active zone membrane | The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| adherens junction organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. |
| calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. |
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| cell-cell adhesion via plasma-membrane adhesion molecules | The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. |
| cell-cell junction assembly | The aggregation, arrangement and bonding together of a set of components to form a junction between cells. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTIYQFLRLF | VLWACLPHFC | CPELTFRRTP | GIQQMTAESR | APRSDGKILH | RQKRGWMWNQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FFLLEEYTGS | DYQYVGKLHS | DQDKGDGSLK | YILSGDGAGT | LFIIDEKTGD | IHATRRIDRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKAFYTLRAQ | AINRRTLRPV | EPESEFVIKI | HDINDNEPTF | PEEIYTASVP | EMSVVGTSVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QVTATDADDP | SYGNSARVIY | SILQGQPYFS | VEPETGIIRT | ALPNMNRENK | EQYQVVIQAK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DMGGQMGGLS | GTTTVNITLT | DVNDNPPRFP | QNTIHLRVLE | SSPVGTAVGS | VKATDADTGK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NAEVDYRIID | GDGTDMFDII | TEKDTQEGII | TVKKPLDYEN | RRLYTLKVEA | ENTHVDPRFY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YLGPFKDTTI | VKISIEDVDE | PPVFSRSSYL | FEVHEDIEVG | TIIGTVMARD | PDSTSSPIRF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TLDRHTDLDR | IFNIHSGNGS | LYTSKPLDRE | LSQWHNLTVI | AAEINNPKET | TRVSVFVRIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DVNDNAPQFA | VFYDTFVCEN | ARPGQLIQTI | SAVDKDDPLG | GQKFFFSLAA | VNPNFTVQDN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EDNTARILTR | KNGFNRHEIS | TYLLPVVISD | NDYPIQSSTG | TLTIRVCACD | SQGNMQSCSA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EALLLPAGLS | TGALIAILLC | IIILLVIVVL | FAALKRQRKK | EPLILSKEDI | RDNIVSYNDE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GGGEEDTQAF | DIGTLRNPAA | IEEKKLRRDI | IPETLFIPRR | TPTAPDNTDV | RDFINERLKE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HDLDPTAPPY | DSLATYAYEG | NDSVAESLSS | LESGTTEGDQ | NYDYLREWGP | RFNKLAEMYG |
| GGESDKDA |