Q767I8

PR
Gene name
Pcdha4
Protein name
Protocadherin alpha-4
Names
PCDH-alpha-4, Cadherin-related neuronal receptor 4
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:116741
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

878-947 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q767I8

Entry ID Method Resolution Chain Position Source
AF-Q767I8-F1 Predicted AlphaFoldDB

2 variants for Q767I8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs8148367 188 R>Q No EVA
rs3323218780 208 L>I No EVA

No associated diseases with Q767I8

10 regional properties for Q767I8

Type Name Position InterPro Accession
domain Cadherin-like 33 - 132 IPR002126-1
domain Cadherin-like 133 - 241 IPR002126-2
domain Cadherin-like 241 - 349 IPR002126-3
domain Cadherin-like 350 - 564 IPR002126-4
domain Cadherin-like 580 - 677 IPR002126-5
domain Cadherin, N-terminal 29 - 110 IPR013164
conserved_site Cadherin conserved site 229 - 239 IPR020894-1
conserved_site Cadherin conserved site 337 - 347 IPR020894-2
conserved_site Cadherin conserved site 552 - 562 IPR020894-3
domain Cadherin, C-terminal catenin-binding domain 786 - 919 IPR031904

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Detected in dendrites and synapses
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
identical protein binding Binding to an identical protein or proteins.

3 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SWX5 CDH6 Cadherin-6 Bos taurus (Bovine) PR
P79995 CDH10 Cadherin-10 Gallus gallus (Chicken) PR
Q8UVJ7 CDHR1 Cadherin-related family member 1 Gallus gallus (Chicken) PR
Q5DRC8 PCDHB6 Protocadherin beta-6 Pan troglodytes (Chimpanzee) PR
Q5DRE4 PCDHA8 Protocadherin alpha-8 Pan troglodytes (Chimpanzee) PR
Q5DRE6 PCDHA6 Protocadherin alpha-6 Pan troglodytes (Chimpanzee) PR
Q5DRF0 PCDHA2 Protocadherin alpha-2 Pan troglodytes (Chimpanzee) PR
Q5DRE7 PCDHA5 Protocadherin alpha-5 Pan troglodytes (Chimpanzee) PR
Q9VJB6 CadN2 Putative neural-cadherin 2 Drosophila melanogaster (Fruit fly) PR
Q9ULB4 CDH9 Cadherin-9 Homo sapiens (Human) PR
Q9Y5E3 PCDHB6 Protocadherin beta-6 Homo sapiens (Human) PR
Q9Y5F1 PCDHB12 Protocadherin beta-12 Homo sapiens (Human) PR
O60330 PCDHGA12 Protocadherin gamma-A12 Homo sapiens (Human) PR
P12830 CDH1 Cadherin-1 Homo sapiens (Human) PR
Q9H159 CDH19 Cadherin-19 Homo sapiens (Human) PR
Q9P2E7 PCDH10 Protocadherin-10 Homo sapiens (Human) PR
Q9Y6N8 CDH10 Cadherin-10 Homo sapiens (Human) PR
P55285 CDH6 Cadherin-6 Homo sapiens (Human) PR
P19022 CDH2 Cadherin-2 Homo sapiens (Human) PR
Q9Y5I2 PCDHA10 Protocadherin alpha-10 Homo sapiens (Human) PR
Q6ZTQ4 CDHR3 Cadherin-related family member 3 Homo sapiens (Human) PR
Q9Y5H3 PCDHGA10 Protocadherin gamma-A10 Homo sapiens (Human) PR
Q9UN75 PCDHA12 Protocadherin alpha-12 Homo sapiens (Human) PR
Q9Y5I1 PCDHA11 Protocadherin alpha-11 Homo sapiens (Human) PR
Q9Y5H8 PCDHA3 Protocadherin alpha-3 Homo sapiens (Human) PR
Q9Y5H9 PCDHA2 Protocadherin alpha-2 Homo sapiens (Human) PR
Q9UN73 PCDHA6 Protocadherin alpha-6 Homo sapiens (Human) PR
Q9Y5H6 PCDHA8 Protocadherin alpha-8 Homo sapiens (Human) PR
Q9UN72 PCDHA7 Protocadherin alpha-7 Homo sapiens (Human) PR
Q9Y5H7 PCDHA5 Protocadherin alpha-5 Homo sapiens (Human) PR
Q9Y5G4 PCDHGA9 Protocadherin gamma-A9 Homo sapiens (Human) PR
Q9Y5G0 PCDHGB5 Protocadherin gamma-B5 Homo sapiens (Human) PR
Q9UN74 PCDHA4 Protocadherin alpha-4 Homo sapiens (Human) PR
P09803 Cdh1 Cadherin-1 Mus musculus (Mouse) PR
P15116 Cdh2 Cadherin-2 Mus musculus (Mouse) PR
P70407 Cdh9 Cadherin-9 Mus musculus (Mouse) PR
P97326 Cdh6 Cadherin-6 Mus musculus (Mouse) PR
P70408 Cdh10 Cadherin-10 Mus musculus (Mouse) PR
Q8VHF2 Cdhr5 Cadherin-related family member 5 Mus musculus (Mouse) PR
O88689 Pcdha4 Protocadherin alpha-4 Mus musculus (Mouse) PR
P55280 Cdh6 Cadherin-6 Rattus norvegicus (Rat) PR
Q9Z1Y3 Cdh2 Cadherin-2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MEFSWGSGQE SQRLLLSFLF LAIWEPGNSQ LHYSIPEEAK HGTFVGRIAQ DLGLELAELV
70 80 90 100 110 120
PRLFRVASKD RGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVE
130 140 150 160 170 180
VEVRDINDNP PTFPTTQKNL FIAESRPLDT WFPLEGASDS DIGINAVLTY RLSPNDYFSL
190 200 210 220 230 240
EKPTNSERVK GLGLILRKSL DREETPELFL VLTVTDGGKP ELTGSVQLLI TVLDANDNSP
250 260 270 280 290 300
VFDRSLYTVK LPENVPNGTL VVKVNASDLD EGANGEVMYS FSTDISPNVK NKFHIDPVTG
310 320 330 340 350 360
EIAVKGYIDF EECTSYEILI EGIDKGQLPL SGHCKVIVQV EDINDNAPEL EFKSLSLPIR
370 380 390 400 410 420
ENAPVGTVIA LISVFDPDTG VNGQVTCSLT PQVPFKLVST FKNYYSLVLD SALDRETTAD
430 440 450 460 470 480
YKVVVIARDG GLPSLWATAS VSVEVADVND NAPAFAQPEY TVFVKENNPP GAHIFTVSAV
490 500 510 520 530 540
DADSQENALV SYSLVERRVG ERLLSSYVSV HAESGKVFAL QPLDHEELEL LQFQVSARDA
550 560 570 580 590 600
GVPALGSNVT LQVFVLDEND NAPTLLEPEA GISGGIVSRL VSRSVGAGHV VAKVRAVDAD
610 620 630 640 650 660
SGYNAWLSYE LQSSEGNSRS LFRVGLYTGE ISTTRSLDEA DSPRQRLLVL VKDHGDPAMM
670 680 690 700 710 720
VTATVLVSLV ENGPLPKAPS RVSTRVTNAE ASLVDVNVYL IIAICAVSSL LVLTLLLYSA
730 740 750 760 770 780
LRCSTVPSES VCGPPKPVMV CSSAVGSWSY SQQRRQRVCS GEYPPKTDLM AFSPSLSDSR
790 800 810 820 830 840
DREDQLQSTE DSSGKPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS
850 860 870 880 890 900
SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQPGPGE LPDKFIIPGS PAIISIRQES
910 920 930 940
ANNQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ