Q8VHF2
PR
Gene name |
Cdhr5 |
Protein name |
Cadherin-related family member 5 |
Names |
Mu-protocadherin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72040 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VHF2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VHF2-F1 | Predicted | AlphaFoldDB |
No variants for Q8VHF2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8VHF2 | |||||
No associated diseases with Q8VHF2
10 regional properties for Q8VHF2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin-like | 28 - 133 | IPR002126-1 |
| domain | Cadherin-like | 134 - 242 | IPR002126-2 |
| domain | Cadherin-like | 242 - 350 | IPR002126-3 |
| domain | Cadherin-like | 351 - 565 | IPR002126-4 |
| domain | Cadherin-like | 587 - 678 | IPR002126-5 |
| domain | Cadherin, N-terminal | 30 - 111 | IPR013164 |
| conserved_site | Cadherin conserved site | 230 - 240 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 443 - 453 | IPR020894-2 |
| conserved_site | Cadherin conserved site | 553 - 563 | IPR020894-3 |
| domain | Cadherin, C-terminal catenin-binding domain | 797 - 930 | IPR031904 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| brush border membrane | The portion of the plasma membrane surrounding the brush border. |
| clathrin-coated pit | A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| microvillus membrane | The portion of the plasma membrane surrounding a microvillus. |
| spanning component of plasma membrane | The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-catenin binding | Binding to a catenin beta subunit. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| cell adhesion molecule binding | Binding to a cell adhesion molecule. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| intermicrovillar adhesion | The cell-cell adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin. |
| regulation of microvillus length | A process that modulates the length of a microvillus. |
43 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| Q91Y11 | Pcdha9 | Protocadherin alpha-9 | Mus musculus (Mouse) | PR |
| O88689 | Pcdha4 | Protocadherin alpha-4 | Mus musculus (Mouse) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGAPALLWPS | LLLPWLTVLF | GQPPGTLAQT | QVCSVNQTIF | RVEENTTVSE | PLVNIFVPDG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHVTLGPLST | PYAFRIEGKD | LFLNVTPDYE | ENSLLQADVE | CKRGDAVVVR | LEVFVAVLDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NDNAPKFSFE | IKTFNVSEDT | KVNTTVIPET | QLKATDADIN | DILVYTLQEV | TPNASKFFSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EGVNYPALKL | DQTLDYFKNQ | NMTFMLLARD | TWEENVEPSH | TATATLVLNT | LPADLRTPWF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPCSFTDGYV | CIHAQYSAVV | PTGHKLPSPL | IMSPGPIYAV | DGDQAINQSI | IYSIIAGNTD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GTFIINAHDG | NLTMTKSIPS | PMKFTLLIRA | DQEDMAQYSV | TQAIVEARSV | TGNPLQFSQS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LYYGTVVLGS | EAGTAVKDKT | FPSEILRIQA | QYPGFPDLNS | AVTYRVTNSS | EFMMNKDIML |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TAVPMEEART | IRVEVEASNT | VTKDTATAVV | EIQVSERERT | PTPPEAGGTT | GPSSNTTMEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PLTSGTSQRP | ATTSSGGSVG | PFPPGGTTLR | PPTPASSIPG | GSPTLGTSTS | PQTTTPGGDS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AQTPKPGTSH | PTAPTSRTST | SLMTTSSRSD | STQTPKPGTS | QPMVPIPGAS | TSSQPATPSG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SSPQTPKPGT | SQSTATGPIS | LPSTGAGEQG | DGQRFSTVDM | AVLGGVLGAL | LLLALICLVI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LVHKHYRHRL | ACCSGKASEP | QPSGYDNLTF | LPDHKAKWSP | TPNRKPEPSP | KLAQPPLRPP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SPMSSSPTPP | SSTPPSPQPK | ASGSPKTVQA | GDSPSAVRSI | LTKERRPEGE | GGYKAVWFGK |
| 790 | 800 | 810 | 820 | 830 | |
| DIGAEADVVV | LNEPTADVDS | ASASGSEGSD | DDDPDQKKTL | RFGVDADNTY | I |