P97326
PR
Gene name |
Cdh6 |
Protein name |
Cadherin-6 |
Names |
Kidney cadherin, K-cadherin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12563 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P97326
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3LND | X-ray | 282 A | A/B/C/D | 58-260 | PDB |
| 6CGB | X-ray | 299 A | A | 156-260 | PDB |
| 6CGU | X-ray | 190 A | A/B/C/D | 54-260 | PDB |
| AF-P97326-F1 | Predicted | AlphaFoldDB |
35 variants for P97326
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389336831 | 19 | T>I | No | EVA | |
| rs217994715 | 33 | A>T | No | EVA | |
| rs3389343697 | 116 | L>Q | No | EVA | |
| rs3389348686 | 120 | E>G | No | EVA | |
| rs3389343712 | 130 | A>D | No | EVA | |
| rs3389360316 | 136 | G>R | No | EVA | |
| rs3389325121 | 139 | V>L | No | EVA | |
| rs3389356699 | 153 | N>H | No | EVA | |
| rs3389325099 | 230 | E>D | No | EVA | |
| rs3389336815 | 242 | G>S | No | EVA | |
| rs3389356512 | 256 | I>F | No | EVA | |
| rs3389356617 | 325 | Q>* | No | EVA | |
| rs3389349855 | 332 | K>I | No | EVA | |
| rs3389275189 | 334 | L>H | No | EVA | |
| rs3389369289 | 341 | K>Q | No | EVA | |
| rs3389317167 | 355 | E>K | No | EVA | |
| rs241319374 | 356 | P>S | No | EVA | |
| rs3389336814 | 384 | S>G | No | EVA | |
| rs3389356499 | 495 | F>V | No | EVA | |
| rs3389275221 | 527 | L>* | No | EVA | |
| rs31868071 | 534 | S>G | No | EVA | |
| rs3389343750 | 537 | F>I | No | EVA | |
| rs3404333056 | 566 | L>V | No | EVA | |
| rs3405539746 | 567 | P>S | No | EVA | |
| rs3404997095 | 578 | Q>* | No | EVA | |
| rs3404997058 | 582 | G>R | No | EVA | |
| rs3389336769 | 654 | D>E | No | EVA | |
| rs3389275262 | 655 | N>S | No | EVA | |
| rs3389352693 | 659 | Y>F | No | EVA | |
| rs48108000 | 686 | S>G | No | EVA | |
| rs3389307419 | 691 | D>N | No | EVA | |
| rs3389352730 | 693 | V>L | No | EVA | |
| rs3404333066 | 735 | L>S | No | EVA | |
| rs3389349787 | 781 | Y>* | No | EVA | |
| rs3389348669 | 781 | Y>* | No | EVA |
No associated diseases with P97326
8 regional properties for P97326
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin, Y-type LIR-motif | 723 - 782 | IPR000233 |
| domain | Cadherin-like | 74 - 159 | IPR002126-1 |
| domain | Cadherin-like | 159 - 279 | IPR002126-2 |
| domain | Cadherin-like | 269 - 383 | IPR002126-3 |
| domain | Cadherin-like | 384 - 488 | IPR002126-4 |
| domain | Cadherin-like | 488 - 610 | IPR002126-5 |
| conserved_site | Cadherin conserved site | 256 - 266 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 476 - 486 | IPR020894-2 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| catenin complex | Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. |
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| adherens junction organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. |
| calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. |
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| cell-cell adhesion via plasma-membrane adhesion molecules | The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. |
| cell-cell junction assembly | The aggregation, arrangement and bonding together of a set of components to form a junction between cells. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| Notch signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRTYRYFLLL | FWVGQPYPTF | SNPLSKRTSG | FPAKRKALEL | SANSRNELSR | SKRSWMWNQF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLLEEYTGSD | YQYVGKLHSD | QDRGDGSLKY | ILSGDGAGDL | FIINENTGDI | QATKRLDREE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPVYILRAQA | VNRRTGRPVE | PESEFIIKIH | DINDNEPIFT | KDVYTATVPE | MADVGTFVVQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTATDADDPT | YGNSAKVVYS | ILQGQPYFSV | ESETGIIKTA | LLNMDRENRE | QYQVVIQAKD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MGGQMGGLSG | TTTVNITLTD | VNDNPPRFPQ | STYQFKTPES | SPPGTPIGRI | KASDADVGEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AEIEYSITDG | EGHEMFDVIT | DQETQEGIIT | VKKLLDFEKK | KVYTLKVEAS | NPHVEPRFLY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGPFKDSATV | RIVVDDVDEP | PVFSKLAYIL | QIREDARINT | TIGSVAAQDP | DAARNPVKYS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VDRHTDMDRI | FNIDSGNGSI | FTSKLLDRET | LLWHNITVIA | TEINNPKQSS | RVPLYIKVLD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VNDNAPEFAE | FYETFVCEKA | KADQLIQTLR | AVDKDDPYSG | HQFSFSLAPE | AASSSNFTIQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DNKDNTAGIL | TRKNGYNRHE | MSTYLLPVVI | SDNDYPVQSS | TGTVTVRVCA | CDHHGNMQSC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HAEALIHPTG | LSTGALVAIL | LCIVILLVTV | VLFAALRRQR | KKEPLIISKE | DIRDNIVSYN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DEGGGEEDTQ | AFDIGTLRNP | EAMEDSKSRR | DIVPEALFLP | RRTPTARDNT | DVRDFINQRL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KENDTDPTAP | PYDSLATYAY | EGTGSVADSL | SSLESVTTDG | DQDYDYLSDW | GPRFKKLADM |
| YGGMDSDKDS |