Q9VJB6
PR
Gene name |
CadN2 (CG42829, CG7527) |
Protein name |
Putative neural-cadherin 2 |
Names |
Cadherin-N2, dN2-cadherin |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG42829 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9VJB6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9VJB6-F1 | Predicted | AlphaFoldDB |
No variants for Q9VJB6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9VJB6 | |||||
No associated diseases with Q9VJB6
9 regional properties for Q9VJB6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 423 - 646 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1211 - 1444 | IPR003439-2 |
| domain | AAA+ ATPase domain | 450 - 639 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1237 - 1419 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 82 - 350 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 860 - 1158 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 548 - 562 | IPR017871 |
| domain | CFTR regulator domain | 639 - 849 | IPR025837 |
| domain | Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1 | 389 - 670 | IPR047082 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| catenin complex | Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| axon extension involved in axon guidance | The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. |
| calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. |
| cell-cell adhesion mediated by cadherin | The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains. |
| cell-cell adhesion via plasma-membrane adhesion molecules | The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| ommatidial rotation | The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification. |
| R7 cell development | The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium. |
| R8 cell development | The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium. |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVDPLKIFWV | LTNSTYLVTK | FVRIGIADKN | DSPPYFDRFL | YETEIDENAD | LQSTVLTVNA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDHNESTNIR | YQITGGNIGN | AFAVQNTTGV | IYVASPLDYE | TRPRYELRLE | ATRNRKNNYT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TVVINVRDVN | DNPPVFDRQT | YRTQITEEDD | RNLPKRILQV | TATDGDVDRP | INIVYFLTGQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GIDPDNPANS | KFDINRTTGD | IFVLKPLDRD | QPNGRPQWRF | TVFAQDEGGE | GLVGYADIQV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NLKDINDNAP | QFPQGIYFGN | VTENGTAGSS | VMTMSAVDYD | DPNESTNAKL | IYSIEKNVIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EETGAPIFEI | EPETGLIKTA | VCCLDRERTP | DYSIQVVAMD | GGGLKGTGTA | SIRVKDLNDM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PPQFTKDEWV | TEVDETNGTY | IPETPILTVT | VQDEDETNTF | QYKVVPNSGF | GADKFAMVRN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GDGTGSLKII | QPLDYEDPLQ | SSGFRFRIQV | NDKGDDGPGG | SDKYHVAYSW | VVVKLRDIND |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NVPKFDREHI | EVSIYEDTKV | GTILEQFKAT | DADQGGHSKV | AYKIVRSTNR | KRQFAISDRG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AVSIQRPLDR | ETQDRHHIQI | LAIDDGSPAR | TATATLTVIV | KDVNDNAPTF | AQDYKPTLPE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NVSGKKILEV | AAKDPDDRLR | GNGGPFTFRL | DPLASDEIKA | GFKVEYDRRG | DNENGVAIIS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SLRPFDREAQ | KSYAIPIEIK | DNGAPAMTGT | STLTVTIGDV | NDNKMQPGSK | SVLVYNYQGQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SQDTPIGRVY | VNDPDDWDVP | DKKYYWEVQE | HQRFKLDTDT | GILTMRAGTR | RGRYQLRFKV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YDREHGQEDI | PANLSVTVRD | ITAEAVQQAG | SMRLSHITDE | DFVRTWNPVK | NQVEPSKLER |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FRNKLAELLY | TDRDNVDVFS | VQLKEGSPYP | LTDVHFAARS | ATQQPYFKAV | RLNGVVQMHR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EEIEKDVGLN | ITMVNINECL | HEGKGKCGSN | SCTSKVELGK | KPYTVSVNRT | ALVGVRLDIS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AQCVCRARNF | THQDHNCRTH | LCYNGGRCVE | TRNGPKCVAC | PVGYNGPRCQ | QSTRSFRGNG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| WAWYPPLQLC | QESHLSLEFI | TRVADGLILY | NGPIVPPKPE | ETVISDFIAL | ELEQGYPRLL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| IDFGSGTLEL | RVKTKKTLDD | GVWHRLDIFW | DTENVRMVVD | FCRTALVSEM | EDGTPPEFDD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| NACQARGQIP | PFAESLNLNQ | PLQLGGLYRQ | HFDQTLYNWQ | YAFSSKGFDG | CIRNVIHNSE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| HYDLAFPALA | RNSFPACPQT | DEVCLKTEHT | ARCWEHGNCV | ASLVQAKCHC | QPGWMGPGCN |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VPTIPTTFKA | QSYVKFALSF | EPDRFSTQLQ | LRFRTREQGG | ELFRVSDQHH | REYAILELRR |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| GHLQFRYNLN | SMRNEEQLLT | LTAIAVNDGQ | WHVIRISRYG | SAALMELDGG | ESRRYNESFH |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| FTGHQWLTID | KQEGVYAGGK | AEYTGIKTFE | VQSDFQRSCL | DDIRLDGKHL | PLPPAMNGTQ |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| WGQATMARNL | ERNCPSNRPC | SNVICPDPFD | CVDLWNEYEC | TCSEGRIMSS | DTKGCVDRNE |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| CLDLPCLNGA | TCINLEPRLR | YRCICPEGYW | GENCELVQEG | QRLKLSMGAL | GAIFVCLIII |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| LILALIFVLY | SRKRKTTKKK | KRSGPEKDVR | ETVISYEDEG | GGEDDMTAFD | ITPLQIPISA |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| QGGPPDIAAC | KMPIIYPVMT | LLPPGQELNV | AYLMEERKQR | IDKDNNAPPF | DDLRNFTFEG |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| SGSIAESLSS | LASGTDDENQ | DFNYLQNWGP | RFNALAAMYV | HDKAKASSQL | PSDGGGGSGD |
| 1750 | 1760 | 1770 | 1780 | 1790 | |
| GPGPGASSSS | PLGGGGTGGG | SGIPGNVLAV | VATGSGAGPG | GGGGSSGLMP | LPEVDKVVL |