P09803
PR
Gene name |
Cdh1 |
Protein name |
Cadherin-1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12550 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
21 structures for P09803
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1EDH | X-ray | 200 A | A/B | 156-380 | PDB |
| 1FF5 | X-ray | 293 A | A/B | 157-374 | PDB |
| 1I7W | X-ray | 200 A | B/D | 734-884 | PDB |
| 1I7X | X-ray | 300 A | B/D | 734-884 | PDB |
| 1Q1P | X-ray | 320 A | A | 158-369 | PDB |
| 1SUH | NMR | - | A | 156-300 | PDB |
| 2OMW | X-ray | 185 A | B | 158-256 | PDB |
| 2QVF | X-ray | 240 A | B | 157-369 | PDB |
| 3IFQ | X-ray | 280 A | C/D | 778-884 | PDB |
| 3LNE | X-ray | 200 A | A | 157-369 | PDB |
| 3LNF | X-ray | 250 A | A/B | 157-369 | PDB |
| 3LNG | X-ray | 270 A | A/B | 157-369 | PDB |
| 3LNH | X-ray | 260 A | A/B | 157-369 | PDB |
| 3LNI | X-ray | 230 A | A/B | 157-369 | PDB |
| 3Q2L | X-ray | 270 A | A/B | 157-369 | PDB |
| 3Q2N | X-ray | 273 A | A/B | 157-369 | PDB |
| 3Q2V | X-ray | 340 A | A/B | 157-700 | PDB |
| 3QRB | X-ray | 180 A | A/B | 157-369 | PDB |
| 4QD2 | X-ray | 240 A | E/J | 157-369 | PDB |
| 7AR4 | X-ray | 260 A | PaP | 783-798 | PDB |
| AF-P09803-F1 | Predicted | AlphaFoldDB |
No variants for P09803
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P09803 | |||||
No associated diseases with P09803
9 regional properties for P09803
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin, Y-type LIR-motif | 820 - 879 | IPR000233 |
| domain | Cadherin-like | 163 - 264 | IPR002126-1 |
| domain | Cadherin-like | 264 - 388 | IPR002126-2 |
| domain | Cadherin-like | 378 - 488 | IPR002126-3 |
| domain | Cadherin-like | 489 - 597 | IPR002126-4 |
| domain | Cadherin-like | 605 - 688 | IPR002126-5 |
| domain | Cadherin prodomain | 29 - 118 | IPR014868 |
| conserved_site | Cadherin conserved site | 365 - 375 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 585 - 595 | IPR020894-2 |
Functions
28 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| apical junction complex | A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. |
| apical part of cell | The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| axon terminus | Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| catenin complex | Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. |
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| cortical actin cytoskeleton | The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic side of plasma membrane | The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| flotillin complex | A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| lateral loop | Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| node of Ranvier | An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| Schmidt-Lanterman incisure | Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
14 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-catenin binding | Binding to catenin complex alpha subunit. |
| ankyrin binding | Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. |
| beta-catenin binding | Binding to a catenin beta subunit. |
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| cell adhesion molecule binding | Binding to a cell adhesion molecule. |
| cytoskeletal protein binding | Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). |
| gamma-catenin binding | Binding to catenin complex gamma subunit. |
| GTPase activating protein binding | Binding to a GTPase activating protein. |
| identical protein binding | Binding to an identical protein or proteins. |
| molecular adaptor activity | The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein phosphatase binding | Binding to a protein phosphatase. |
| protein tyrosine kinase binding | Binding to protein tyrosine kinase. |
43 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| adherens junction organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. |
| bicellular tight junction assembly | The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. |
| calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. |
| canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| cell-cell adhesion mediated by cadherin | The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains. |
| cell-cell adhesion via plasma-membrane adhesion molecules | The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. |
| cellular response to amino acid stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. |
| cellular response to indole-3-methanol | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus. |
| cellular response to lithium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. |
| cochlea development | The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. |
| decidualization | The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. |
| embryo implantation | Attachment of the blastocyst to the uterine lining. |
| epithelial cell morphogenesis | The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| intestinal epithelial cell development | The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. |
| negative regulation of axon extension | Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of cell-cell adhesion | Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. |
| negative regulation of epithelial cell proliferation | Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. |
| negative regulation of protein localization to plasma membrane | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. |
| negative regulation of protein processing | Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. |
| positive regulation of cell-cell adhesion | Any process that activates or increases the rate or extent of cell adhesion to another cell. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of protein import into nucleus | Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein metabolic process | The chemical reactions and pathways involving a protein. Includes protein modification. |
| regulation of branching involved in salivary gland morphogenesis | Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium. |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process | Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of neuron migration | Any process that modulates the frequency, rate or extent of neuron migration. |
| regulation of protein catabolic process at postsynapse, modulating synaptic transmission | Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
| regulation of protein localization to cell surface | Any process that modulates the frequency, rate or extent of protein localization to the cell surface. |
| regulation of water loss via skin | A process that modulates the rate or extent of water loss from an organism via the skin. |
| salivary gland cavitation | The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland. |
| sensory perception of sound | The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. |
| synapse assembly | The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). |
| trophectodermal cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. |
| uterine epithelium development | The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGARCRSFSA | LLLLLQVSSW | LCQELEPESC | SPGFSSEVYT | FPVPERHLER | GHVLGRVRFE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GCTGRPRTAF | FSEDSRFKVA | TDGTITVKRH | LKLHKLETSF | LVRARDSSHR | ELSTKVTLKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MGHHHHRHHH | RDPASESNPE | LLMFPSVYPG | LRRQKRDWVI | PPISCPENEK | GEFPKNLVQI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KSNRDKETKV | FYSITGQGAD | KPPVGVFIIE | RETGWLKVTQ | PLDREAIAKY | ILYSHAVSSN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GEAVEDPMEI | VITVTDQNDN | RPEFTQEVFE | GSVAEGAVPG | TSVMKVSATD | ADDDVNTYNA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AIAYTIVSQD | PELPHKNMFT | VNRDTGVISV | LTSGLDRESY | PTYTLVVQAA | DLQGEGLSTT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AKAVITVKDI | NDNAPVFNPS | TYQGQVPENE | VNARIATLKV | TDDDAPNTPA | WKAVYTVVND |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PDQQFVVVTD | PTTNDGILKT | AKGLDFEAKQ | QYILHVRVEN | EEPFEGSLVP | STATVTVDVV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DVNEAPIFMP | AERRVEVPED | FGVGQEITSY | TAREPDTFMD | QKITYRIWRD | TANWLEINPE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TGAIFTRAEM | DREDAEHVKN | STYVALIIAT | DDGSPIATGT | GTLLLVLLDV | NDNAPIPEPR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NMQFCQRNPQ | PHIITILDPD | LPPNTSPFTA | ELTHGASVNW | TIEYNDAAQE | SLILQPRKDL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EIGEYKIHLK | LADNQNKDQV | TTLDVHVCDC | EGTVNNCMKA | GIVAAGLQVP | AILGILGGIL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ALLILILLLL | LFLRRRTVVK | EPLLPPDDDT | RDNVYYYDEE | GGGEEDQDFD | LSQLHRGLDA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RPEVTRNDVA | PTLMSVPQYR | PRPANPDEIG | NFIDENLKAA | DSDPTAPPYD | SLLVFDYEGS |
| 850 | 860 | 870 | 880 | ||
| GSEAASLSSL | NSSESDQDQD | YDYLNEWGNR | FKKLADMYGG | GEDD |