P55280
PR
Gene name |
Cdh6 (Kcad) |
Protein name |
Cadherin-6 |
Names |
Kidney cadherin, K-cadherin |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:25409 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P55280
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P55280-F1 | Predicted | AlphaFoldDB |
No variants for P55280
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P55280 | |||||
No associated diseases with P55280
8 regional properties for P55280
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin, Y-type LIR-motif | 723 - 781 | IPR000233 |
| domain | Cadherin-like | 74 - 159 | IPR002126-1 |
| domain | Cadherin-like | 159 - 279 | IPR002126-2 |
| domain | Cadherin-like | 269 - 383 | IPR002126-3 |
| domain | Cadherin-like | 384 - 488 | IPR002126-4 |
| domain | Cadherin-like | 488 - 610 | IPR002126-5 |
| conserved_site | Cadherin conserved site | 256 - 266 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 476 - 486 | IPR020894-2 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| catenin complex | Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cadherin binding | Binding to cadherin, a type I membrane protein involved in cell adhesion. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| adherens junction organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. |
| calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. |
| cell morphogenesis | The developmental process in which the size or shape of a cell is generated and organized. |
| cell-cell adhesion via plasma-membrane adhesion molecules | The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. |
| cell-cell junction assembly | The aggregation, arrangement and bonding together of a set of components to form a junction between cells. |
| female gonad development | The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| Notch signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
41 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| Q9Y5E3 | PCDHB6 | Protocadherin beta-6 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRTYRYFLLL | FWVGQPYPTF | SNPLSKRTSG | FPAKRRALEL | SANSRNELSR | SKRSWMWNQF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLLEEYTGSD | YQYVGKLHSD | QDRGDGSLKY | ILSGDGAGDL | FIINENTGDI | QATKRLDREE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPVYILRAQA | INRRTGRPVE | PESEFIIKIH | DINDNEPIFT | KDVYTATVPE | MADVGTFVVQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTATDADDPT | YGNSAKVVYS | ILQGQPYFSV | ESETGIIKTA | LLNMDRENRE | QYQVVIQAKD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MGGQMGGLSG | TTTVNITLTD | VNDNPPRFPQ | STYQFKTPES | SPPGTPIGRI | KASDADVGEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AEIEYSITDG | EGHDMFDVIT | DQETQEGIIT | VKKLLDFEKK | RVYTLKVEAS | NPHIEPRFLY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGPFKDSATV | RIVVDDVDEP | PVFSKPAYIL | QIREDAQINT | TIGSVAAQDP | DAARNPVKYS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VDRHTDMDRI | FNIDSGNGSI | FTSKLLDRET | LLWHNITVIA | TEINNPKQSS | RVPLYIKVLD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VNDNAPEFAE | FYETFVCEKA | KADQLIQTLH | AVDKDDPYSG | HQFSFSLAPE | AASGSNFTIQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DNKDNTAGIL | TRKNGYNRHE | MSTYLLPVVI | SDNDYPVQSS | TGTVTVRVCA | CDHHGNMQSC |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HAEALIHPTG | LSTGALVAIL | LCIVILLVTV | VLFAALRRQR | KKEPLIISKE | DIRDNIVSYN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DEGGGEEDTQ | AFDIGTLRNP | KPWRQQSRRD | MVPEALFLPR | RTPTARDNTD | VRDFISQRLR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KMNTDPTAPP | YDSLATYAYE | GTGSVADSLS | SLESVTTDGD | QDYGYLSDWG | PRFKKLADMY |
| GGMDSDKDS |