Q9Y5E3
PR
Gene name |
PCDHB6 |
Protein name |
Protocadherin beta-6 |
Names |
PCDH-beta-6 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:56130 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Y5E3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Y5E3-F1 | Predicted | AlphaFoldDB |
6 variants for Q9Y5E3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs3776096 CA3457580 VAR_021879 |
231 | V>I | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
VAR_033705 CA3457582 rs10076554 |
232 | L>F | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA128389901 VAR_070665 rs246707 |
446 | V>V | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
VAR_033706 CA3457922 rs246703 |
636 | H>Q | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
COSM3941115 CA128390337 rs17685621 VAR_033707 |
747 | Y>H | oesophagus [Cosmic] | No |
ClinGen cosmic curated UniProt Ensembl dbSNP |
|
rs17844444 VAR_070666 CA3458034 |
776 | G>D | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
No associated diseases with Q9Y5E3
10 regional properties for Q9Y5E3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin-like | 28 - 133 | IPR002126-1 |
| domain | Cadherin-like | 143 - 242 | IPR002126-2 |
| domain | Cadherin-like | 242 - 350 | IPR002126-3 |
| domain | Cadherin-like | 351 - 565 | IPR002126-4 |
| domain | Cadherin-like | 581 - 678 | IPR002126-5 |
| domain | Cadherin, N-terminal | 30 - 111 | IPR013164 |
| conserved_site | Cadherin conserved site | 230 - 240 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 443 - 453 | IPR020894-2 |
| conserved_site | Cadherin conserved site | 553 - 563 | IPR020894-3 |
| domain | Cadherin, C-terminal catenin-binding domain | 800 - 933 | IPR031904 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| identical protein binding | Binding to an identical protein or proteins. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| cell-cell recognition | Cell recognition between cells. May involve the formation of specialized cell junctions. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| synapse assembly | The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). |
45 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SWX5 | CDH6 | Cadherin-6 | Bos taurus (Bovine) | PR |
| P79995 | CDH10 | Cadherin-10 | Gallus gallus (Chicken) | PR |
| Q8UVJ7 | CDHR1 | Cadherin-related family member 1 | Gallus gallus (Chicken) | PR |
| Q5DRE4 | PCDHA8 | Protocadherin alpha-8 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE6 | PCDHA6 | Protocadherin alpha-6 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q9VJB6 | CadN2 | Putative neural-cadherin 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULB4 | CDH9 | Cadherin-9 | Homo sapiens (Human) | PR |
| P12830 | CDH1 | Cadherin-1 | Homo sapiens (Human) | PR |
| Q9H159 | CDH19 | Cadherin-19 | Homo sapiens (Human) | PR |
| Q9Y6N8 | CDH10 | Cadherin-10 | Homo sapiens (Human) | PR |
| P55285 | CDH6 | Cadherin-6 | Homo sapiens (Human) | PR |
| P19022 | CDH2 | Cadherin-2 | Homo sapiens (Human) | PR |
| Q6ZTQ4 | CDHR3 | Cadherin-related family member 3 | Homo sapiens (Human) | PR |
| Q9BZA8 | PCDH11Y | Protocadherin-11 Y-linked | Homo sapiens (Human) | PR |
| Q08174 | PCDH1 | Protocadherin-1 | Homo sapiens (Human) | PR |
| Q9HC56 | PCDH9 | Protocadherin-9 | Homo sapiens (Human) | PR |
| Q9P2E7 | PCDH10 | Protocadherin-10 | Homo sapiens (Human) | PR |
| Q9Y5H8 | PCDHA3 | Protocadherin alpha-3 | Homo sapiens (Human) | PR |
| Q9UN75 | PCDHA12 | Protocadherin alpha-12 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q9UN72 | PCDHA7 | Protocadherin alpha-7 | Homo sapiens (Human) | PR |
| Q9UN74 | PCDHA4 | Protocadherin alpha-4 | Homo sapiens (Human) | PR |
| Q9Y5I1 | PCDHA11 | Protocadherin alpha-11 | Homo sapiens (Human) | PR |
| Q9Y5H7 | PCDHA5 | Protocadherin alpha-5 | Homo sapiens (Human) | PR |
| Q9UN73 | PCDHA6 | Protocadherin alpha-6 | Homo sapiens (Human) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9Y5I3 | PCDHA1 | Protocadherin alpha-1 | Homo sapiens (Human) | PR |
| Q9Y5H9 | PCDHA2 | Protocadherin alpha-2 | Homo sapiens (Human) | PR |
| Q9Y5H3 | PCDHGA10 | Protocadherin gamma-A10 | Homo sapiens (Human) | PR |
| O60330 | PCDHGA12 | Protocadherin gamma-A12 | Homo sapiens (Human) | PR |
| Q9Y5G4 | PCDHGA9 | Protocadherin gamma-A9 | Homo sapiens (Human) | PR |
| Q9Y5G0 | PCDHGB5 | Protocadherin gamma-B5 | Homo sapiens (Human) | PR |
| Q9Y5F1 | PCDHB12 | Protocadherin beta-12 | Homo sapiens (Human) | PR |
| P09803 | Cdh1 | Cadherin-1 | Mus musculus (Mouse) | PR |
| P15116 | Cdh2 | Cadherin-2 | Mus musculus (Mouse) | PR |
| P70407 | Cdh9 | Cadherin-9 | Mus musculus (Mouse) | PR |
| P97326 | Cdh6 | Cadherin-6 | Mus musculus (Mouse) | PR |
| P70408 | Cdh10 | Cadherin-10 | Mus musculus (Mouse) | PR |
| Q8VHF2 | Cdhr5 | Cadherin-related family member 5 | Mus musculus (Mouse) | PR |
| P55280 | Cdh6 | Cadherin-6 | Rattus norvegicus (Rat) | PR |
| Q9Z1Y3 | Cdh2 | Cadherin-2 | Rattus norvegicus (Rat) | PR |
| Q767I8 | Pcdha4 | Protocadherin alpha-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMQTKVQNKK | RQVAFFILLM | LWGEVGSESI | QYSVLEETES | GTFVANLTKD | LGLRVGELAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGARVVFKGN | RQHLQFDPQT | HDLLLNEKLD | REELCGSTEP | CVLPFQVLLE | NPLQFFQASL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVRDINDHAP | EFPAREMLLK | ISEITMPGKI | FPLKMAHDLD | TGSNGLQRYT | ISSNPHFHVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TRNRSEGRKF | PELVLDKPLD | REEQPQLRLT | LIALDGGSPP | RSGTSEIQIQ | VLDINDNVPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FAQELYEAQV | PENNPLGSLV | ITVSARDLDA | GSFGKVSYAL | FQVDDVNQPF | EINAITGEIR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRKALDFEEI | QSYDVDVEAT | DGGGLSGKCS | LVVRVLDVND | NAPELTMSFF | ISLIPENLPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITVAVFSVSD | ADSGHNQQVI | CSIENNLPFL | LRPSVENFYT | LVTEGALDRE | SRAEYNITIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VTDLGTPRLK | TQQSITVQVS | DVNDNVPAFT | QTSYTLFVRE | NNSPALHIGS | VSATDRDSGI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NAQVTYSLLP | PQDPHLPLSS | LVSINADNGH | LFALRSLDYE | ALQSFEFRVG | ATDRGSPALS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SEALVRLLVL | DANDNSPFVL | YPLQNGSAPC | TELVPRAAEP | GYLVTKVVAV | DGDSGQNAWL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SYQLLKATEL | GLFGVWAHNG | EVRTARLLSE | RDAAKHRLVV | LVKDNGEPPR | SATATLHVLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VDGFSQPYLP | LPEAAPAQAQ | ADSLTVYLVV | ALASVSSLFL | FSVLLFVAVR | LCRRSRAASV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GRYSVPEGPF | PGHLVDVSGT | GTLSQSYQYK | VCLTGGSETN | EFKFLKPIMP | NFPPQGTERE |
| 790 | |||||
| MEETPTSRNS | FPFS |