AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

798-947 (Predicted disordered autoinhibitory region) PR

798-947 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1WUZ	NMR	-	A	27-129	PDB
5DZW	X-ray	243 A	A	30-450	PDB
AF-O88689-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs24885023	11	S>P	No	EVA
rs236455201	89	R>W	No	EVA
rs3389497423	122	E>G	No	EVA
rs3389497378	137	Q>*	No	EVA
rs3389497454	203	E>D	No	EVA
rs3389508447	227	Q>H	No	EVA
rs3389503511	233	L>Q	No	EVA
rs24885031	239	A>S	No	EVA
rs24885032	262	V>I	No	EVA
rs24885034	276	D>N	No	EVA
rs24885035	358	P>L	No	EVA
rs3389488555	384	Q>H	No	EVA
rs24885036	391	S>N	No	EVA
rs24885037	420	D>G	No	EVA
rs3389503521	427	A>V	No	EVA
rs3389492763	459	E>K	No	EVA
rs3389499961	468	N>I	No	EVA
rs585317379	480	M>V	No	EVA
rs3389476001	495	V>M	No	EVA
rs3389475942	530	L>M	No	EVA
rs24885043	532	R>Q	No	EVA
rs3389510787	559	N>K	No	EVA
rs3389495853	586	G>S	No	EVA
rs3389497406	611	L>M	No	EVA
rs24885047	612	Q>K	No	EVA
rs24885048	616	G>S	No	EVA
rs24885049	624	V>I	No	EVA
rs24885050	625	G>S	No	EVA
rs3408253013	629	G>A	No	EVA
rs3408431419	629	G>R	No	EVA
rs24885053	636	I>A	No	EVA
rs257527861	636	I>T	No	EVA
rs13489528	636	I>V	No	EVA
rs3389405583	639	E>G	No	EVA
rs3389497398	657	P>S	No	EVA
rs13489529	661	V>F	No	EVA
rs3389496231	685	S>C	No	EVA
rs250448853	686	V>A	No	EVA
rs3389488593	687	T>I	No	EVA
rs1131814018	688	H>D	No	EVA
rs1132656963	688	H>P	No	EVA
rs24885055	696	V>I	No	EVA
rs13489530	752	Q>H	No	EVA
rs3388438143	759	C>Y	No	EVA
rs3389503526	767	T>N	No	EVA
rs3389508446	784	D>N	No	EVA
rs3389497431	786	L>*	No	EVA
rs3389492780	828	G>D	No	EVA
rs3389491513	836	W>C	No	EVA
rs3389488566	869	G>*	No	EVA

Type	Name	Position	InterPro Accession
domain	Cadherin-like	20 - 133	IPR002126-1
domain	Cadherin-like	134 - 242	IPR002126-2
domain	Cadherin-like	242 - 350	IPR002126-3
domain	Cadherin-like	351 - 565	IPR002126-4
domain	Cadherin-like	581 - 681	IPR002126-5
domain	Cadherin, N-terminal	30 - 111	IPR013164
conserved_site	Cadherin conserved site	230 - 240	IPR020894-1
conserved_site	Cadherin conserved site	443 - 453	IPR020894-2
conserved_site	Cadherin conserved site	553 - 563	IPR020894-3
domain	Cadherin, C-terminal catenin-binding domain	797 - 930	IPR031904

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein	Detected in dendrites and synapses
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
identical protein binding	Binding to an identical protein or proteins.

Name	Definition
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
homophilic cell adhesion via plasma membrane adhesion molecules	The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UN74	PCDHA4	Protocadherin alpha-4	Homo sapiens (Human)	PR
Q8VHF2	Cdhr5	Cadherin-related family member 5	Mus musculus (Mouse)	PR
Q91Y11	Pcdha9	Protocadherin alpha-9	Mus musculus (Mouse)	PR
Q767I8	Pcdha4	Protocadherin alpha-4	Rattus norvegicus (Rat)	PR