Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5DRF4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5DRF4-F1 | Predicted | AlphaFoldDB |
No variants for Q5DRF4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5DRF4 | |||||
No associated diseases with Q5DRF4
10 regional properties for Q5DRF4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cadherin-like | 27 - 132 | IPR002126-1 |
| domain | Cadherin-like | 133 - 241 | IPR002126-2 |
| domain | Cadherin-like | 241 - 349 | IPR002126-3 |
| domain | Cadherin-like | 350 - 564 | IPR002126-4 |
| domain | Cadherin-like | 587 - 689 | IPR002126-5 |
| domain | Cadherin, N-terminal | 29 - 110 | IPR013164 |
| conserved_site | Cadherin conserved site | 229 - 239 | IPR020894-1 |
| conserved_site | Cadherin conserved site | 442 - 452 | IPR020894-2 |
| conserved_site | Cadherin conserved site | 552 - 562 | IPR020894-3 |
| domain | Cadherin, C-terminal catenin-binding domain | 798 - 931 | IPR031904 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5DRF2 | PCDHA12 | Protocadherin alpha-12 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF3 | PCDHA11 | Protocadherin alpha-11 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRE7 | PCDHA5 | Protocadherin alpha-5 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF5 | PCDHA1 | Protocadherin alpha-1 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRF0 | PCDHA2 | Protocadherin alpha-2 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRC1 | PCDHGA10 | Protocadherin gamma-A10 | Pan troglodytes (Chimpanzee) | PR |
| Q5DRC8 | PCDHB6 | Protocadherin beta-6 | Pan troglodytes (Chimpanzee) | PR |
| Q9Y5H6 | PCDHA8 | Protocadherin alpha-8 | Homo sapiens (Human) | PR |
| Q9Y5I2 | PCDHA10 | Protocadherin alpha-10 | Homo sapiens (Human) | PR |
| Q91Y11 | Pcdha9 | Protocadherin alpha-9 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSRCSCLGV | QCLLLSLLLL | AAWEVGSGQL | HYSVYEEARH | GTFVGRIAQD | LGLELAELVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLFRVASKRH | GDLLEVNLQN | GILFVNSRID | REELCGRSVE | CSIHLEVIVD | RPLQVFHVDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVKDINDNPP | RFSVTEQKLS | IPESRLLDSR | FPLEGASDAD | VGENALLTYK | LSPNEYFVLD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IINKKDKDKF | PVLVLRKLLD | REENPQLKLL | LTATDGGKPE | FTGSVSLLIL | VLDANDNAPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FDRPVYEVKM | YENQVNQTLV | IRLNASDSDE | GINKEMMYSF | SSLVPPTIRR | KFWINERTGE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IKVNDAIDFE | DSNTYQIHVD | VTDKGNPPMV | GHCTVLVELL | DENDNSPEVI | VTSLSLPVKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DAQVGTVIAL | ISVSDHDSGA | NGQVTCSLTP | HVPFKLVSTY | KNYYSLVLDS | ALDRERVSAY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELVVTARDGG | SPPLWATASV | SVEVADVNDN | APAFAQPEYT | VFVKENNPPG | YHIFTVSAWD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ADAQENALVS | YSLVERRLGE | RSLSSYVSVH | AQSGKVYALQ | PLDHEELELL | QFQVSARDGG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VPPLGSNLTL | QVFVLDENDN | APALLASPAG | SAGGAVSELV | LRSVGAGHVV | AKVRAVDADS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GYNAWLSYEL | QSAAVGARIP | FRVGLYTGEI | STTRALDEAD | SPRQRLLVLV | KDHGEPSLTA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TATVLVSLVE | GSQAPKASSR | ASVGVAPEVA | LVDVNVYLII | AICAVSSLLV | LTLLLYTALR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CSAAPTEGAC | GPVKPTLVCS | STVGSWSYSQ | QRRQRVCSGE | GLPKADLMAF | SPSLPPCPMV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DVDGEDQSIG | GDHSRKPRQP | NPDWRYSASL | RAGMHSSVHL | EEAGILRAGP | GGPDQQWPTV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SSATPEPEAG | EVSPPVGAGV | NSNSWTFKYG | PGNPKQSGPG | ELPDKFIIPG | SPAIISIRQE |
| 910 | 920 | 930 | 940 | ||
| PANSQIDKSD | FITFGKKEET | KKKKKKKKGN | KTQEKKEKGN | STTDNSDQ |