Q5DRF3

PR
Gene name
PCDHA11
Protein name
Protocadherin alpha-11
Names
PCDH-alpha-11
Species
Pan troglodytes (Chimpanzee)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

726-949 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5DRF3

Entry ID Method Resolution Chain Position Source
AF-Q5DRF3-F1 Predicted AlphaFoldDB

No variants for Q5DRF3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5DRF3

No associated diseases with Q5DRF3

10 regional properties for Q5DRF3

Type Name Position InterPro Accession
domain Cadherin-like 28 - 133 IPR002126-1
domain Cadherin-like 142 - 242 IPR002126-2
domain Cadherin-like 242 - 349 IPR002126-3
domain Cadherin-like 350 - 564 IPR002126-4
domain Cadherin-like 580 - 677 IPR002126-5
domain Cadherin, N-terminal 30 - 111 IPR013164
conserved_site Cadherin conserved site 230 - 240 IPR020894-1
conserved_site Cadherin conserved site 442 - 452 IPR020894-2
conserved_site Cadherin conserved site 552 - 562 IPR020894-3
domain Cadherin, C-terminal catenin-binding domain 799 - 932 IPR031904

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).

3 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5DRF2 PCDHA12 Protocadherin alpha-12 Pan troglodytes (Chimpanzee) PR
Q5DRF4 PCDHA10 Protocadherin alpha-10 Pan troglodytes (Chimpanzee) PR
Q5DRE7 PCDHA5 Protocadherin alpha-5 Pan troglodytes (Chimpanzee) PR
Q5DRF5 PCDHA1 Protocadherin alpha-1 Pan troglodytes (Chimpanzee) PR
Q5DRF0 PCDHA2 Protocadherin alpha-2 Pan troglodytes (Chimpanzee) PR
Q5DRC1 PCDHGA10 Protocadherin gamma-A10 Pan troglodytes (Chimpanzee) PR
Q5DRC8 PCDHB6 Protocadherin beta-6 Pan troglodytes (Chimpanzee) PR
Q9Y5H6 PCDHA8 Protocadherin alpha-8 Homo sapiens (Human) PR
Q9Y5I1 PCDHA11 Protocadherin alpha-11 Homo sapiens (Human) PR
10 20 30 40 50 60
MFGFQRRGLG TPRLQLWLLL LEFWEVGSGQ LHYSVSEEAK HGTFVGRIAQ DLGLELAELV
70 80 90 100 110 120
PRLFRVASKT HGDLLEVNLQ NGILFVNSRI DREELCGQSA ECSIHLEVIV DRPLQVFHVN
130 140 150 160 170 180
VEVKDINDNP PVFSLREQKL LIAESKQSDS RFPLEGASDA DIEENALLTY RLSKNEYFSL
190 200 210 220 230 240
DSPTNGKQIK RLSLILKKSL DREKTPELNL MVTATDGGKP ELTGTVRLLV QVLDVNDNDP
250 260 270 280 290 300
DFDKSEYKVS LMENAAKETL VLKLNATDRD EGVNGEVTYS LMSIKPNGRH LFTLDQNNGE
310 320 330 340 350 360
VRVNGTLDYE ENKFYKIEVQ ATDKGTPPMA GHCTVWVEIL DTNDNSPEVA VTSLSLPVRE
370 380 390 400 410 420
DAQPSTVIAL ISVSDRDSGV NGQVTCSLTP HVPFKLVSTF KNYYSLVLDS ALDRESVWAY
430 440 450 460 470 480
ELVVTARDGG SPSLWATARV SVEVADVNDN APAFAQPEYT VFVKENNPPG CHIFTVSARD
490 500 510 520 530 540
ADAQENALVS YSLVERRLGD RALSSYVSVH AESGKVYALQ PLDHEELELL QFQVSARDAG
550 560 570 580 590 600
VPPLGSNVTL QVFVLDENDN APALLATQAG SAGGAVNKLV PRSVGAGHVV AKVRAVDADS
610 620 630 640 650 660
GYNAWLSYEL QPAAGGSRIP FRVGLYTGEI STTRALDEAD SPRHRLLVLV KDHGEPALTA
670 680 690 700 710 720
TATVLVSLVE SGQAPKASSR TLVGAASPEA ALVDVNVYLI IAICVVSSLL VLTLLLYTAL
730 740 750 760 770 780
WCSATPTEGA CAPGKPTLVC SRAVGSWSYS QQRRQRVCSE EGPPKTDLMA FSPSLPLGLN
790 800 810 820 830 840
KEEEGERQEP GSNHPGQPRQ PNPDWRYSAS LRAGMHSSVH LEEAGILRAG PGGPDQQWPT
850 860 870 880 890 900
VSSATPEPEA GEVSPPVGAG VNSNSWTFKY GPGNPKQSGP GELPDKFIIP GSPAIISIRQ
910 920 930 940
EPANSQIDKS DFITFGKKEE TKKKKKKKKG NKTQEKKEKG NSTTDNSDQ