Q5DRF2

PR
Gene name
PCDHA12
Protein name
Protocadherin alpha-12
Names
PCDH-alpha-12
Species
Pan troglodytes (Chimpanzee)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

886-941 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5DRF2

Entry ID Method Resolution Chain Position Source
AF-Q5DRF2-F1 Predicted AlphaFoldDB

No variants for Q5DRF2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5DRF2

No associated diseases with Q5DRF2

10 regional properties for Q5DRF2

Type Name Position InterPro Accession
domain Cadherin-like 28 - 133 IPR002126-1
domain Cadherin-like 134 - 242 IPR002126-2
domain Cadherin-like 242 - 350 IPR002126-3
domain Cadherin-like 351 - 565 IPR002126-4
domain Cadherin-like 581 - 678 IPR002126-5
domain Cadherin, N-terminal 30 - 111 IPR013164
conserved_site Cadherin conserved site 230 - 240 IPR020894-1
conserved_site Cadherin conserved site 443 - 453 IPR020894-2
conserved_site Cadherin conserved site 553 - 563 IPR020894-3
domain Cadherin, C-terminal catenin-binding domain 791 - 924 IPR031904

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).

3 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5DRF0 PCDHA2 Protocadherin alpha-2 Pan troglodytes (Chimpanzee) PR
Q5DRC1 PCDHGA10 Protocadherin gamma-A10 Pan troglodytes (Chimpanzee) PR
Q5DRC8 PCDHB6 Protocadherin beta-6 Pan troglodytes (Chimpanzee) PR
Q5DRF4 PCDHA10 Protocadherin alpha-10 Pan troglodytes (Chimpanzee) PR
Q5DRF3 PCDHA11 Protocadherin alpha-11 Pan troglodytes (Chimpanzee) PR
Q5DRE7 PCDHA5 Protocadherin alpha-5 Pan troglodytes (Chimpanzee) PR
Q5DRF5 PCDHA1 Protocadherin alpha-1 Pan troglodytes (Chimpanzee) PR
Q9Y5H6 PCDHA8 Protocadherin alpha-8 Homo sapiens (Human) PR
Q9UN75 PCDHA12 Protocadherin alpha-12 Homo sapiens (Human) PR
Q91Y11 Pcdha9 Protocadherin alpha-9 Mus musculus (Mouse) PR
10 20 30 40 50 60
MVIIGPRGPG SQRLLLSLLL LAAWEVGSGQ LHYSVYEEAK HGTFVGRIAQ DLGLELAELV
70 80 90 100 110 120
PRLFRVASKR HGDLLEVNLQ NGILFVNSRI DREKLCGRSA ECSIHLEVIV DRPLQVFHVD
130 140 150 160 170 180
VEVKDINDNP PVFREREQKV PVSESAPLDS HFPLEGASDA DIGVNSLLTY ALSLNEHFEL
190 200 210 220 230 240
KIKTKKDKSI LPELVLRKLL DREQTPKLNL LLMVIDGGKP ELTGSVQIQI TVLDVNDNGP
250 260 270 280 290 300
AFDKPSYKVV LSENVQNDTR VIQLNASDPD EGLNGEISYG IKMILPVSEK CMFSINPDTG
310 320 330 340 350 360
EIRIYGELDF EENNAYEIQV NAIDKGIPSM AGHSMVLVEV LDVNDNVPEV MVTSLSLPVQ
370 380 390 400 410 420
EDAQVGTVIA LISVSDRDSG ANGQVICSLT PHVPFKLVST YKNYYSLVLD SALDRESVSA
430 440 450 460 470 480
YELVVTARDG GSPSLWATAR VSVEVADVND NAPAFAQPEY TVFVKENNPP GCHIFTVSAW
490 500 510 520 530 540
DADAQKNALV SYSLVERRVG EHALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA
550 560 570 580 590 600
GVPPLGSNVT LQVFVLDEND NAPALLATPA GSAGGAVSEL VPRSVGAGHV VAKVRAVDAD
610 620 630 640 650 660
SGYNAWLSYE LQPAAVGAHI PFHVGLYTGE ISTTRILDEA DAPRHRLLVL VKDHGEPALT
670 680 690 700 710 720
STATVLVSLV ENGQAPKTSS RASVGAVDPE AALVDINVYL IIAICAVSSL LVLTLLLYTA
730 740 750 760 770 780
LRCSAPPTVS RCAPGKPTLV CSSAVGSWSY SQQRRQRVCS GESPPKTDLM AFSPSLQLSR
790 800 810 820 830 840
EDCLNPPSEP RQPNPDWRYS ASLRAGMHSS VHLEEAGILR AGPGGPDQQW PTVSSATPEP
850 860 870 880 890 900
EAGEVSPPVG AGVNSNSWTF KYGPGNPKQS GPGELPDKFI IPGSPAIISI RQEPANSQID
910 920 930 940
KSDFITFGKK EETKKKKKKK KGNKTQEKKE KGNSTTDNSD Q