A3A871

PR
Gene name
CYP71Z6 (Os02g0570500, LOC_Os02g36150, OsJ_07206, OSJNBa0008E01.28)
Protein name
Ent-isokaurene C2/C3-hydroxylase
Names
Cytochrome P450 71Z6
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4329725
EC number
1.14.14.76: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3A871

Entry ID Method Resolution Chain Position Source
AF-A3A871-F1 Predicted AlphaFoldDB

No variants for A3A871

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3A871

No associated diseases with A3A871

1 regional properties for A3A871

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 445 - 454 IPR017972

Functions

Description
EC Number 1.14.14.76 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
ent-isokaurene C2-hydroxylase activity Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

1 GO annotations of biological process

Name Definition
diterpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units.

57 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18963 CYP2E1 Cytochrome P450 2E1 Bos taurus (Bovine) PR
Q0IIF9 CYP2U1 Cytochrome P450 2U1 Bos taurus (Bovine) PR
P12394 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Gallus gallus (Chicken) PR
Q8HYN1 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Pan troglodytes (Chimpanzee) PR
Q95078 Cyp18a1 Cytochrome P450 18a1 Drosophila melanogaster (Fruit fly) PR
P10632 CYP2C8 Cytochrome P450 2C8 Homo sapiens (Human) PR
P33260 CYP2C18 Cytochrome P450 2C18 Homo sapiens (Human) PR
Q7Z449 CYP2U1 Cytochrome P450 2U1 Homo sapiens (Human) PR
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens (Human) PR
P05177 CYP1A2 Cytochrome P450 1A2 Homo sapiens (Human) PR
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens (Human) PR
P51589 CYP2J2 Cytochrome P450 2J2 Homo sapiens (Human) PR
Q9CX98 Cyp2u1 Cytochrome P450 2U1 Mus musculus (Mouse) PR
O54749 Cyp2j5 Cytochrome P450 2J5 Mus musculus (Mouse) PR
O54750 Cyp2j6 Cytochrome P450 2J6 Mus musculus (Mouse) PR
P24456 Cyp2d10 Cytochrome P450 2D10 Mus musculus (Mouse) PR
P24457 Cyp2d11 Cytochrome P450 2D11 Mus musculus (Mouse) PR
P27786 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Mus musculus (Mouse) PR
Q9D816 Cyp2c55 Cytochrome P450 2C55 Mus musculus (Mouse) PR
P79383 CYP2E1 Cytochrome P450 2E1 Sus scrofa (Pig) PR
P10633 Cyp2d1 Cytochrome P450 2D1 Rattus norvegicus (Rat) PR
P11715 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Rat) PR
P12939 Cyp2d10 Cytochrome P450 2D10 Rattus norvegicus (Rat) PR
P20814 Cyp2c13 Cytochrome P450 2C13, male-specific Rattus norvegicus (Rat) PR
O35293 Cyp2f2 Cytochrome P450 2F2 Rattus norvegicus (Rat) PR
P05179 Cyp2c7 Cytochrome P450 2C7 Rattus norvegicus (Rat) PR
P05182 Cyp2e1 Cytochrome P450 2E1 Rattus norvegicus (Rat) PR
P12938 Cyp2d3 Cytochrome P450 2D3 Rattus norvegicus (Rat) PR
P24470 Cyp2c23 Cytochrome P450 2C23 Rattus norvegicus (Rat) PR
P33273 Cyp2c55 Cytochrome P450 2C55 Rattus norvegicus (Rat) PR
Q8HYM9 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Macaca mulatta (Rhesus macaque) PR
Q6YV88 CYP71Z7 Ent-cassadiene hydroxylase Oryza sativa subsp japonica (Rice) PR
Q7X7X4 CYP99A2 Cytochrome P450 99A2 Oryza sativa subsp japonica (Rice) PR
Q27513 cyp-13A4 Putative cytochrome P450 CYP13A4 Caenorhabditis elegans PR
Q27519 cyp-13A7 Putative cytochrome P450 CYP13A7 Caenorhabditis elegans PR
Q09653 cyp-13A10 Putative cytochrome P450 CYP13A10 Caenorhabditis elegans PR
Q27518 cyp-13A2 Putative cytochrome P450 CYP13A2 Caenorhabditis elegans PR
O48957 CYP99A1 Cytochrome P450 CYP99A1 Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q42797 CYP73A11 Trans-cinnamate 4-monooxygenase Glycine max (Soybean) (Glycine hispida) PR
Q9XHC6 CYP93E1 Beta-amyrin 24-hydroxylase Glycine max (Soybean) (Glycine hispida) PR
O81971 CYP71D9 Cytochrome P450 71D9 Glycine max (Soybean) (Glycine hispida) PR
O48922 CYP98A2 Cytochrome P450 98A2 Glycine max (Soybean) (Glycine hispida) PR
Q9SAE4 CYP71B29 Cytochrome P450 71B29 Arabidopsis thaliana (Mouse-ear cress) PR
Q96514 CYP71B7 Cytochrome P450 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q949U1 CYP79F1 Dihomomethionine N-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
Q9CA61 CYP98A8 Cytochrome P450 98A8 Arabidopsis thaliana (Mouse-ear cress) PR
O49340 CYP71A12 Cytochrome P450 71A12 Arabidopsis thaliana (Mouse-ear cress) PR
O64636 CYP76C1 Cytochrome P450 76C1 Arabidopsis thaliana (Mouse-ear cress) PR
O64638 CYP76C3 Cytochrome P450 76C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SRQ1 CYP89A9 Cytochrome P450 89A9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM7 CYP71B16 Cytochrome P450 71B16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM6 CYP71B17 Cytochrome P450 71B17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM0 CYP71B23 Cytochrome P450 71B23 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVD2 CYP71B10 Cytochrome P450 71B10 Arabidopsis thaliana (Mouse-ear cress) PR
P58049 CYP71B11 Cytochrome P450 71B11 Arabidopsis thaliana (Mouse-ear cress) PR
P58050 CYP71B13 Cytochrome P450 71B13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZU07 CYP71B12 Cytochrome P450 71B12 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEDKLILDLC LSALFVVVLS KLVSSAMKPR LNLPPGPWTL PLIGSLHHLV MTKSPQTHRS
70 80 90 100 110 120
LRALSEKHGP IMQLWMGEVP AVVVSSPAVA EEVLKHQDLR FADRHLTATT EEVFFGGRDV
130 140 150 160 170 180
IFGPYSERWR HLRKICMQEL LTAARVRSFQ GVREREVARL VRELAADAGA GGDAGVNLNE
190 200 210 220 230 240
RISKLANDIV MVSSVGGRCS HRDEFLDALE VAKKQITWLS VADLFPSSKL ARMVAVAPRK
250 260 270 280 290 300
GLASRKRMEL VIRRIIQERK DQLMDDSAAG AGEAAAGKDC FLDVLLRLQK EGGTPVPVTD
310 320 330 340 350 360
EIIVVLLFDM ISGASETSPT VLIWTLAELM RNPRIMAKAQ AEVRQAVAGK TTITEDDIVG
370 380 390 400 410 420
LSYLKMVIKE TLRLHPPAPL LNPRKCRETS QVMGYDIPKG TSVFVNMWAI CRDSRYWEDP
430 440 450 460 470 480
EEYKPERFEN NSVDYKGNNF EFLPFGSGRR ICPGINLGVA NLELPLASLL YHFDWKLPNG
490 500 510
MAPKDLDMHE TSGMVAAKLI TLNICPITHI APSSA