Q9SRQ1

PR
Gene name
CYP89A9
Protein name
Cytochrome P450 89A9
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G03470
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

252-328 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SRQ1

Entry ID Method Resolution Chain Position Source
AF-Q9SRQ1-F1 Predicted AlphaFoldDB

67 variants for Q9SRQ1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13862676 17 S>F No 1000Genomes
ENSVATH05762941 19 F>L No 1000Genomes
ENSVATH05762940 25 F>S No 1000Genomes
ENSVATH02107909 26 F>S No 1000Genomes
tmp_3_826267_A_G 27 S>P No 1000Genomes
ENSVATH05762939 38 F>L No 1000Genomes
ENSVATH00303940 41 I>V No 1000Genomes
tmp_3_826222_C_T 42 G>R No 1000Genomes
ENSVATH10470825 54 D>E No 1000Genomes
ENSVATH10470764 58 V>I No 1000Genomes
ENSVATH10470763 68 P>T No 1000Genomes
ENSVATH05762937 90 Q>L No 1000Genomes
tmp_3_826062_T_G 95 N>T No 1000Genomes
tmp_3_826056_G_A 97 A>V No 1000Genomes
ENSVATH02107908 98 V>I No 1000Genomes
tmp_3_826036_G_T 104 L>I No 1000Genomes
tmp_3_825979_C_T 123 V>I No 1000Genomes
ENSVATH10470762 141 Q>R No 1000Genomes
ENSVATH05762934 143 S>P No 1000Genomes
tmp_3_825900_G_T 149 A>E No 1000Genomes
tmp_3_825897_G_T 150 P>Q No 1000Genomes
ENSVATH13862634 160 V>L No 1000Genomes
ENSVATH02107901 180 L>F No 1000Genomes
tmp_3_825629_C_A 239 E>D No 1000Genomes
ENSVATH13862633 242 E>K No 1000Genomes
tmp_3_825595_T_G 251 I>L No 1000Genomes
ENSVATH05762929 268 C>S No 1000Genomes
tmp_3_825529_G_C 273 L>V No 1000Genomes
tmp_3_825505_C_T 281 E>K No 1000Genomes
ENSVATH02107895 284 E>D No 1000Genomes
ENSVATH07951414 284 E>G No 1000Genomes
ENSVATH07951413 285 G>E No 1000Genomes
ENSVATH10470761 286 G>E No 1000Genomes
ENSVATH05762924 288 K>M No 1000Genomes
tmp_3_825467_G_T 293 D>E No 1000Genomes
ENSVATH02107894 314 S>A No 1000Genomes
ENSVATH13862632 327 E>G No 1000Genomes
ENSVATH05762922 330 R>K No 1000Genomes
tmp_3_825346_C_G 334 E>Q No 1000Genomes
tmp_3_825338_C_T 336 M>I No 1000Genomes
ENSVATH00303933 338 T>S No 1000Genomes
ENSVATH02107893 339 V>A No 1000Genomes
ENSVATH05762921 339 V>M No 1000Genomes
tmp_3_825325_C_A 341 A>S No 1000Genomes
ENSVATH02107892 345 E>G No 1000Genomes
ENSVATH02107891 351 R>K No 1000Genomes
ENSVATH05762920 353 E>D No 1000Genomes
ENSVATH05762917 394 I>V No 1000Genomes
ENSVATH02107886 396 R>H No 1000Genomes
ENSVATH10470759 398 G>S No 1000Genomes
tmp_3_825032_G_T 399 T>N No 1000Genomes
ENSVATH05762915 411 P>L No 1000Genomes
tmp_3_824984_T_C 415 E>G No 1000Genomes
ENSVATH02107874 415 E>K No 1000Genomes
ENSVATH02107873 428 N>D No 1000Genomes
ENSVATH02107872 428 N>S No 1000Genomes
tmp_3_824934_A_G 432 C>R No 1000Genomes
ENSVATH02107870 432 C>Y No 1000Genomes
ENSVATH02107866 458 A>T No 1000Genomes
ENSVATH00303926 466 Y>F No 1000Genomes
tmp_3_824810_C_G 473 W>S No 1000Genomes
ENSVATH02107864 474 K>E No 1000Genomes
ENSVATH02107863 482 G>V No 1000Genomes
ENSVATH05762914 490 K>R No 1000Genomes
ENSVATH13862630 494 I>T No 1000Genomes
ENSVATH05762912 511 K>N No 1000Genomes
ENSVATH05762913 511 K>Q No 1000Genomes

No associated diseases with Q9SRQ1

2 regional properties for Q9SRQ1

Type Name Position InterPro Accession
domain Sec7 domain 54 - 243 IPR000904
domain Pleckstrin homology domain 259 - 377 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

5 GO annotations of molecular function

Name Definition
fluorescent chlorophyll catabolite monooxygenase (deformylase) activity Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
NADPH-hemoprotein reductase activity Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

2 GO annotations of biological process

Name Definition
chlorophyll a catabolic process The chemical reactions and pathways leading to the breakdown of chlorophyll a.
chlorophyll catabolic process The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products.

53 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18963 CYP2E1 Cytochrome P450 2E1 Bos taurus (Bovine) PR
Q0IIF9 CYP2U1 Cytochrome P450 2U1 Bos taurus (Bovine) PR
P12394 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Gallus gallus (Chicken) PR
Q8HYN1 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Pan troglodytes (Chimpanzee) PR
Q95078 Cyp18a1 Cytochrome P450 18a1 Drosophila melanogaster (Fruit fly) PR
P10632 CYP2C8 Cytochrome P450 2C8 Homo sapiens (Human) PR
P33260 CYP2C18 Cytochrome P450 2C18 Homo sapiens (Human) PR
Q7Z449 CYP2U1 Cytochrome P450 2U1 Homo sapiens (Human) PR
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens (Human) PR
P05177 CYP1A2 Cytochrome P450 1A2 Homo sapiens (Human) PR
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens (Human) PR
P51589 CYP2J2 Cytochrome P450 2J2 Homo sapiens (Human) PR
Q9CX98 Cyp2u1 Cytochrome P450 2U1 Mus musculus (Mouse) PR
O54749 Cyp2j5 Cytochrome P450 2J5 Mus musculus (Mouse) PR
O54750 Cyp2j6 Cytochrome P450 2J6 Mus musculus (Mouse) PR
P24456 Cyp2d10 Cytochrome P450 2D10 Mus musculus (Mouse) PR
P24457 Cyp2d11 Cytochrome P450 2D11 Mus musculus (Mouse) PR
P27786 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Mus musculus (Mouse) PR
Q9D816 Cyp2c55 Cytochrome P450 2C55 Mus musculus (Mouse) PR
P79383 CYP2E1 Cytochrome P450 2E1 Sus scrofa (Pig) PR
P10633 Cyp2d1 Cytochrome P450 2D1 Rattus norvegicus (Rat) PR
P11715 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Rat) PR
P12939 Cyp2d10 Cytochrome P450 2D10 Rattus norvegicus (Rat) PR
P20814 Cyp2c13 Cytochrome P450 2C13, male-specific Rattus norvegicus (Rat) PR
O35293 Cyp2f2 Cytochrome P450 2F2 Rattus norvegicus (Rat) PR
P05182 Cyp2e1 Cytochrome P450 2E1 Rattus norvegicus (Rat) PR
P12938 Cyp2d3 Cytochrome P450 2D3 Rattus norvegicus (Rat) PR
P24470 Cyp2c23 Cytochrome P450 2C23 Rattus norvegicus (Rat) PR
P33273 Cyp2c55 Cytochrome P450 2C55 Rattus norvegicus (Rat) PR
P05179 Cyp2c7 Cytochrome P450 2C7 Rattus norvegicus (Rat) PR
Q8HYM9 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Macaca mulatta (Rhesus macaque) PR
A3A871 CYP71Z6 Ent-isokaurene C2/C3-hydroxylase Oryza sativa subsp japonica (Rice) PR
Q6YV88 CYP71Z7 Ent-cassadiene hydroxylase Oryza sativa subsp japonica (Rice) PR
Q7X7X4 CYP99A2 Cytochrome P450 99A2 Oryza sativa subsp japonica (Rice) PR
O48957 CYP99A1 Cytochrome P450 CYP99A1 Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q42797 CYP73A11 Trans-cinnamate 4-monooxygenase Glycine max (Soybean) (Glycine hispida) PR
Q9XHC6 CYP93E1 Beta-amyrin 24-hydroxylase Glycine max (Soybean) (Glycine hispida) PR
O81971 CYP71D9 Cytochrome P450 71D9 Glycine max (Soybean) (Glycine hispida) PR
O48922 CYP98A2 Cytochrome P450 98A2 Glycine max (Soybean) (Glycine hispida) PR
Q9SAE4 CYP71B29 Cytochrome P450 71B29 Arabidopsis thaliana (Mouse-ear cress) PR
Q96514 CYP71B7 Cytochrome P450 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CA61 CYP98A8 Cytochrome P450 98A8 Arabidopsis thaliana (Mouse-ear cress) PR
O49340 CYP71A12 Cytochrome P450 71A12 Arabidopsis thaliana (Mouse-ear cress) PR
O64636 CYP76C1 Cytochrome P450 76C1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM7 CYP71B16 Cytochrome P450 71B16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM6 CYP71B17 Cytochrome P450 71B17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM0 CYP71B23 Cytochrome P450 71B23 Arabidopsis thaliana (Mouse-ear cress) PR
P58049 CYP71B11 Cytochrome P450 71B11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZU07 CYP71B12 Cytochrome P450 71B12 Arabidopsis thaliana (Mouse-ear cress) PR
P58050 CYP71B13 Cytochrome P450 71B13 Arabidopsis thaliana (Mouse-ear cress) PR
O64638 CYP76C3 Cytochrome P450 76C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVD2 CYP71B10 Cytochrome P450 71B10 Arabidopsis thaliana (Mouse-ear cress) PR
Q949U1 CYP79F1 Dihomomethionine N-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEITTIIFLI ISSLTFSIFL KLIFFFSTHK LPPGPPRFPV IGNIIWLKKN NFSDFQGVLR
70 80 90 100 110 120
DLASRHGPII TLHVGSKPSI WVTDRSLAHQ ALVQNGAVFS DRSLALPTTK VITSNQHDIH
130 140 150 160 170 180
SSVYGSLWRT LRRNLTSEIL QPSRVKAHAP SRKWSLEILV DLFETEQREK GHISDALDHL
190 200 210 220 230 240
RHAMFYLLAL MCFGEKLRKE EIREIEEAQY QMLISYTKFS VLNIFPSVTK FLLRRKWKEF
250 260 270 280 290 300
LELRKSQESV ILRYVNARSK ETTGDVLCYV DTLLNLEIPT EEKEGGKKRK LSDSEIVSLC
310 320 330 340 350 360
SEFLNAATDP TATSMQWIMA IMVKYPEIQR KVYEEMKTVF AGEEEEREEI REEDLGKLSY
370 380 390 400 410 420
LKAVILECLR RHPPGHYLSY HKVTHDTVLG GFLIPRQGTI NFMVGEMGRD PKIWEDPLTF
430 440 450 460 470 480
KPERFLENGE ACDFDMTGTR EIKMMPFGAG RRMCPGYALS LLHLEYYVAN LVWKFEWKCV
490 500 510
EGEEVDLSEK QQFITMVMKN PFKANIYPRR K