O64638

PR
Gene name
CYP76C3 (At2g45580, F17K2.11)
Protein name
Cytochrome P450 76C3
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G45580
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

242-318 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O64638

Entry ID Method Resolution Chain Position Source
AF-O64638-F1 Predicted AlphaFoldDB

61 variants for O64638

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13648079 17 L>V No 1000Genomes
ENSVATH05722885 18 T>I No 1000Genomes
ENSVATH13648077 19 L>F No 1000Genomes
ENSVATH01991426 19 L>I No 1000Genomes
ENSVATH05722884 63 A>T No 1000Genomes
tmp_2_18784075_G_A 71 P>L No 1000Genomes
tmp_2_18784004_G_T 95 L>I No 1000Genomes
ENSVATH13648076 101 V>F No 1000Genomes
ENSVATH05722883 102 M>I No 1000Genomes
ENSVATH05722882 103 S>T No 1000Genomes
tmp_2_18783935_T_A 118 K>* No 1000Genomes
ENSVATH05722881 122 V>L No 1000Genomes
ENSVATH01991425 124 I>N No 1000Genomes
ENSVATH05722878 138 T>I No 1000Genomes
ENSVATH13648074 145 Q>* No 1000Genomes
ENSVATH13648072 156 R>G No 1000Genomes
ENSVATH00276110 160 E>V No 1000Genomes
tmp_2_18783642_C_A 162 V>L No 1000Genomes
ENSVATH14618424 167 E>* No 1000Genomes
ENSVATH13648071 170 E>* No 1000Genomes
tmp_2_18783581_A_T 182 F>Y No 1000Genomes
ENSVATH01991423 184 T>S No 1000Genomes
ENSVATH05722876 188 I>T No 1000Genomes
ENSVATH13648070 192 A>V No 1000Genomes
tmp_2_18783485_A_C 214 V>G No 1000Genomes
ENSVATH00276108 219 D>E No 1000Genomes
ENSVATH05722875 223 I>V No 1000Genomes
tmp_2_18783455_G_T 224 P>H No 1000Genomes
tmp_2_18783431_T_C 232 Y>C No 1000Genomes
tmp_2_18783408_C_T 240 G>S No 1000Genomes
tmp_2_18783401_C_G 242 R>P No 1000Genomes
ENSVATH14618422 245 A>V No 1000Genomes
ENSVATH05722873 251 K>N No 1000Genomes
ENSVATH13648068 255 V>G No 1000Genomes
ENSVATH13648069 255 V>I No 1000Genomes
tmp_2_18783348_T_G 260 I>L No 1000Genomes
tmp_2_18783347_A_G 260 I>T No 1000Genomes
ENSVATH00276107 263 R>Q No 1000Genomes
ENSVATH13648067 269 S>C No 1000Genomes
tmp_2_18783250_C_A 292 Q>H No 1000Genomes
ENSVATH05722870 313 A>T No 1000Genomes
ENSVATH05722869 345 Q>* No 1000Genomes
tmp_2_18782997_T_A 350 N>Y No 1000Genomes
ENSVATH05722867 370 E>Q No 1000Genomes
tmp_2_18782903_A_T 381 I>N No 1000Genomes
ENSVATH05722866 381 I>V No 1000Genomes
ENSVATH00276104 398 K>I No 1000Genomes
ENSVATH00276104 398 K>R No 1000Genomes
tmp_2_18782846_G_A 400 T>I No 1000Genomes
tmp_2_18782632_T_G 435 K>T No 1000Genomes
ENSVATH01991419 437 R>T No 1000Genomes
tmp_2_18782613_C_A 441 L>F No 1000Genomes
ENSVATH05722863 445 G>R No 1000Genomes
ENSVATH00276103 454 I>M No 1000Genomes
ENSVATH13648052 479 G>D No 1000Genomes
ENSVATH05722861 481 V>I No 1000Genomes
tmp_2_18782488_C_T 483 G>E No 1000Genomes
tmp_2_18782440_T_A 499 K>I No 1000Genomes
tmp_2_18782426_C_G 504 V>L No 1000Genomes
ENSVATH05722859 512 S>T No 1000Genomes
ENSVATH05722858 515 Y>* No 1000Genomes

No associated diseases with O64638

1 regional properties for O64638

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 444 - 453 IPR017972

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

53 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18963 CYP2E1 Cytochrome P450 2E1 Bos taurus (Bovine) PR
Q0IIF9 CYP2U1 Cytochrome P450 2U1 Bos taurus (Bovine) PR
P12394 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Gallus gallus (Chicken) PR
Q8HYN1 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Pan troglodytes (Chimpanzee) PR
Q95078 Cyp18a1 Cytochrome P450 18a1 Drosophila melanogaster (Fruit fly) PR
P10632 CYP2C8 Cytochrome P450 2C8 Homo sapiens (Human) PR
P33260 CYP2C18 Cytochrome P450 2C18 Homo sapiens (Human) PR
Q7Z449 CYP2U1 Cytochrome P450 2U1 Homo sapiens (Human) PR
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens (Human) PR
P05177 CYP1A2 Cytochrome P450 1A2 Homo sapiens (Human) PR
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens (Human) PR
P51589 CYP2J2 Cytochrome P450 2J2 Homo sapiens (Human) PR
Q9CX98 Cyp2u1 Cytochrome P450 2U1 Mus musculus (Mouse) PR
O54749 Cyp2j5 Cytochrome P450 2J5 Mus musculus (Mouse) PR
O54750 Cyp2j6 Cytochrome P450 2J6 Mus musculus (Mouse) PR
P24456 Cyp2d10 Cytochrome P450 2D10 Mus musculus (Mouse) PR
P24457 Cyp2d11 Cytochrome P450 2D11 Mus musculus (Mouse) PR
P27786 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Mus musculus (Mouse) PR
Q9D816 Cyp2c55 Cytochrome P450 2C55 Mus musculus (Mouse) PR
P79383 CYP2E1 Cytochrome P450 2E1 Sus scrofa (Pig) PR
P10633 Cyp2d1 Cytochrome P450 2D1 Rattus norvegicus (Rat) PR
P11715 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Rat) PR
P12939 Cyp2d10 Cytochrome P450 2D10 Rattus norvegicus (Rat) PR
P20814 Cyp2c13 Cytochrome P450 2C13, male-specific Rattus norvegicus (Rat) PR
O35293 Cyp2f2 Cytochrome P450 2F2 Rattus norvegicus (Rat) PR
P05182 Cyp2e1 Cytochrome P450 2E1 Rattus norvegicus (Rat) PR
P12938 Cyp2d3 Cytochrome P450 2D3 Rattus norvegicus (Rat) PR
P24470 Cyp2c23 Cytochrome P450 2C23 Rattus norvegicus (Rat) PR
P33273 Cyp2c55 Cytochrome P450 2C55 Rattus norvegicus (Rat) PR
P05179 Cyp2c7 Cytochrome P450 2C7 Rattus norvegicus (Rat) PR
Q8HYM9 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Macaca mulatta (Rhesus macaque) PR
A3A871 CYP71Z6 Ent-isokaurene C2/C3-hydroxylase Oryza sativa subsp japonica (Rice) PR
Q6YV88 CYP71Z7 Ent-cassadiene hydroxylase Oryza sativa subsp japonica (Rice) PR
Q7X7X4 CYP99A2 Cytochrome P450 99A2 Oryza sativa subsp japonica (Rice) PR
O48957 CYP99A1 Cytochrome P450 CYP99A1 Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q42797 CYP73A11 Trans-cinnamate 4-monooxygenase Glycine max (Soybean) (Glycine hispida) PR
Q9XHC6 CYP93E1 Beta-amyrin 24-hydroxylase Glycine max (Soybean) (Glycine hispida) PR
O81971 CYP71D9 Cytochrome P450 71D9 Glycine max (Soybean) (Glycine hispida) PR
O48922 CYP98A2 Cytochrome P450 98A2 Glycine max (Soybean) (Glycine hispida) PR
Q9SAE4 CYP71B29 Cytochrome P450 71B29 Arabidopsis thaliana (Mouse-ear cress) PR
Q96514 CYP71B7 Cytochrome P450 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CA61 CYP98A8 Cytochrome P450 98A8 Arabidopsis thaliana (Mouse-ear cress) PR
O49340 CYP71A12 Cytochrome P450 71A12 Arabidopsis thaliana (Mouse-ear cress) PR
O64636 CYP76C1 Cytochrome P450 76C1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM7 CYP71B16 Cytochrome P450 71B16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM6 CYP71B17 Cytochrome P450 71B17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM0 CYP71B23 Cytochrome P450 71B23 Arabidopsis thaliana (Mouse-ear cress) PR
P58049 CYP71B11 Cytochrome P450 71B11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZU07 CYP71B12 Cytochrome P450 71B12 Arabidopsis thaliana (Mouse-ear cress) PR
P58050 CYP71B13 Cytochrome P450 71B13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVD2 CYP71B10 Cytochrome P450 71B10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SRQ1 CYP89A9 Cytochrome P450 89A9 Arabidopsis thaliana (Mouse-ear cress) PR
Q949U1 CYP79F1 Dihomomethionine N-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDLSLIQGMS LPLYFLLTLF FFFFATAKTR RSSSTGTLPP GPPILPLVGN IFQLGFNPHR
70 80 90 100 110 120
SLAAFSKTYG PIMSLKLGRL TAVVISSPEA AKEALRTHDH VMSARTFNDA LRAFDHHKHS
130 140 150 160 170 180
IVWIPPSARW RFLKKTITKY LLSPQNLDAI QSLRMRKVEE LVSLVNEFRE RGEAIDLARA
190 200 210 220 230 240
SFVTSFNIIS NALFSVDLAT YDSNSSSYEF HNTVVHLTDI AGIPNVGDYF QYMRFLDLQG
250 260 270 280 290 300
TRKKAVLCIE KLFRVFQEFI DARLAKRFSR TEKEPKEASS IDMLDSLLDL TQQNEAELTM
310 320 330 340 350 360
NDLKHLLLDV FVAGTDTNSS TMEWAMTELF RSTEKMVKAQ SEIRQVIGQN GFVQESDIPS
370 380 390 400 410 420
LPYLQAIVKE TLRLHPAAPL IPRKSESDVQ IMGFLVPKNT QVVVNVWAIG RDASVWENPM
430 440 450 460 470 480
KFEPERFLLR ETDVKGRDFE LIPFGSGRRM CPGISMALKT MHMVLASLLY SFDWKLQNGV
490 500 510
VPGNIDMSET FGLTLHKAKS LCAVPVKKPT ISSSY