P05177
PR
Gene name |
CYP1A2 |
Protein name |
Cytochrome P450 1A2 |
Names |
CYPIA2, Cholesterol 25-hydroxylase, Cytochrome P(3)450, Cytochrome P450 4, Cytochrome P450-P3, Hydroperoxy icosatetraenoate dehydratase |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:1544 |
EC number |
1.14.14.1: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P05177
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2HI4 | X-ray | 195 A | A | 27-516 | PDB |
| AF-P05177-F1 | Predicted | AlphaFoldDB |
496 variants for P05177
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA7659661 rs758501844 |
3 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs201871401 CA7659660 |
3 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393176629 rs1253621868 |
6 | S>P | No |
ClinGen gnomAD |
|
|
CA393176626 rs1253621868 |
6 | S>T | No |
ClinGen gnomAD |
|
|
rs764359866 CA7659662 |
6 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1193278468 CA393176655 |
7 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
CA393176671 rs1477139859 |
8 | P>H | No |
ClinGen gnomAD |
|
|
CA7659663 rs751760377 |
8 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA7659664 rs372412769 |
10 | S>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393176717 rs1471159041 |
11 | A>S | No |
ClinGen gnomAD |
|
|
CA7659667 rs756588544 |
13 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs1401787029 CA393176764 |
14 | L>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7659668 rs60086777 |
15 | L>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs17861152 CA7659671 VAR_023196 |
18 | S>C | No |
ClinGen UniProt 1000Genomes ESP TOPMed dbSNP gnomAD |
|
|
rs17861152 CA393176805 |
18 | S>F | No |
ClinGen 1000Genomes ESP TOPMed gnomAD |
|
|
rs17861152 CA272820333 |
18 | S>Y | No |
ClinGen 1000Genomes ESP TOPMed gnomAD |
|
|
rs1047643383 CA272820343 |
19 | A>P | No |
ClinGen TOPMed |
|
| TCGA novel | 19 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs771691950 CA7659673 |
19 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs773045980 CA7659674 |
20 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs56160784 VAR_008349 CA7659675 |
21 | F>L | allele CYP1A2*2 [UniProt] | No |
ClinGen UniProt ExAC TOPMed dbSNP gnomAD |
| TCGA novel | 21 | F>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1330830770 CA393176899 |
22 | C>Y | No |
ClinGen gnomAD |
|
|
rs142454118 CA7659676 |
25 | F>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA272820350 rs142454118 |
25 | F>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs776313064 CA7659677 |
26 | W>* | No |
ClinGen ExAC gnomAD |
|
|
CA7659678 rs759309532 |
27 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393176986 rs1263283830 |
28 | L>I | No |
ClinGen gnomAD |
|
|
CA7659679 rs765154807 |
30 | G>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1244631935 CA393177058 |
32 | R>K | No |
ClinGen TOPMed |
|
| TCGA novel | 32 | R>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 33 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775486408 CA7659680 |
33 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA272820365 rs941101723 |
34 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs201934979 COSM122455 CA7659681 |
34 | R>W | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP TOPMed gnomAD |
|
rs1192297220 CA393177095 |
35 | V>G | No |
ClinGen gnomAD |
|
|
rs1174406258 CA393177107 |
36 | P>L | No |
ClinGen gnomAD |
|
|
CA7659683 rs146974121 |
36 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7659684 rs146974121 |
36 | P>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393177111 rs1313870798 |
37 | K>* | No |
ClinGen TOPMed |
|
|
rs751602658 CA393177117 |
37 | K>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751602658 CA7659685 |
37 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200789139 CA7659688 |
40 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs72547511 VAR_025182 CA272820394 |
42 | P>R | allele CYP1A2*15 [UniProt] | No |
ClinGen UniProt Ensembl dbSNP |
|
CA7659689 rs756500317 |
42 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA7659690 rs3743482 |
44 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs539368728 CA7659692 |
46 | W>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7659691 rs568839929 |
46 | W>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA7659693 rs777457540 |
47 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs939000746 CA272820407 |
47 | G>S | No |
ClinGen gnomAD |
|
|
rs1215275194 CA393177294 |
48 | W>* | No |
ClinGen gnomAD |
|
|
rs201763966 CA7659695 |
48 | W>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA272820429 rs946281188 |
49 | P>T | No |
ClinGen Ensembl |
|
|
rs1393868624 CA393177326 |
50 | L>F | No |
ClinGen TOPMed gnomAD |
|
|
CA7659697 rs745706596 |
51 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA7659699 rs376605220 CA393177346 |
52 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs762906326 CA7659700 |
53 | H>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1420021422 CA393177358 |
53 | H>N | No |
ClinGen gnomAD |
|
|
CA393177392 rs1378709714 |
56 | T>A | No |
ClinGen gnomAD |
|
|
rs1177351603 CA393177445 |
59 | K>R | No |
ClinGen TOPMed |
|
|
CA7659703 rs761818825 |
61 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA272820459 rs760561182 |
61 | P>S | No |
ClinGen Ensembl |
|
|
CA7659704 rs753312654 |
64 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs71651689 CA7659705 |
65 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7659706 rs760996321 |
67 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA272820481 rs1031668682 |
69 | S>G | No |
ClinGen TOPMed |
|
|
rs754113457 CA7659708 |
70 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA7659709 rs755565165 |
71 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659710 rs779505412 |
71 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393177660 rs1310252720 |
72 | Y>H | No |
ClinGen TOPMed |
|
|
rs780755833 CA7659713 |
73 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA7659712 VAR_025183 rs45565238 |
73 | G>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs45565238 CA272820514 |
73 | G>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs35407132 CA393177697 |
74 | D>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1236685625 CA393177677 |
74 | D>N | No |
ClinGen gnomAD |
|
|
CA393177708 rs150164960 |
75 | V>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7659715 rs150164960 |
75 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA272820521 rs899874249 |
77 | Q>E | No |
ClinGen TOPMed |
|
|
rs761941661 COSM1737262 CA7659720 |
79 | R>C | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs752037611 CA7659721 |
79 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA7659722 rs752037611 |
79 | R>L | No |
ClinGen ExAC gnomAD |
|
|
rs1465950058 CA393177808 |
80 | I>T | No |
ClinGen TOPMed |
|
|
CA393177823 rs1445648921 |
81 | G>D | No |
ClinGen gnomAD |
|
|
rs1315277043 CA393177841 |
82 | S>F | No |
ClinGen gnomAD |
|
|
CA7659723 VAR_020848 rs138652540 |
83 | T>M | allele CYP1A2*9 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA272820538 rs766652315 |
84 | P>T | No |
ClinGen gnomAD |
|
|
CA7659727 rs759912942 |
85 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs759912942 CA7659726 |
85 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA7659728 rs753232890 |
86 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA393177937 rs1425061768 |
89 | S>G | No |
ClinGen TOPMed |
|
|
rs556218799 CA7659730 COSM1938753 |
90 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs556218799 CA393177949 |
90 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201551575 CA7659731 COSM1374560 |
90 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed |
|
rs201551575 CA272820553 |
90 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
CA393177948 rs556218799 |
90 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7659733 rs755802066 |
92 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA7659734 rs779502284 |
93 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1335262830 CA393178007 |
94 | I>S | No |
ClinGen Ensembl |
|
|
CA7659737 rs754758658 |
95 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754758658 CA7659736 |
95 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659735 rs749152552 |
95 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs781680722 CA7659739 |
97 | A>D | No |
ClinGen ExAC |
|
|
rs545726003 COSM471060 CA7659738 |
97 | A>T | kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs781680722 CA272820576 |
97 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
CA7659740 rs773366123 |
98 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA393178067 rs1195559808 |
99 | V>M | No |
ClinGen gnomAD |
|
|
CA7659743 rs201650099 COSM1374561 |
100 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs145266863 CA7659742 |
100 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs763535401 CA7659747 |
103 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA7659749 rs34067076 COSM701191 VAR_025184 |
104 | D>N | lung [Cosmic] | No |
ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs1031616307 CA272820594 |
106 | K>Q | No |
ClinGen TOPMed |
|
|
CA393178216 COSM1374562 rs1300519560 |
107 | G>D | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA7659752 COSM1323847 rs376179316 |
108 | R>Q | ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs766082944 CA7659751 |
108 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754811709 CA7659754 |
110 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs45442197 CA7659756 VAR_025185 |
111 | L>F | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs747891878 CA7659757 |
112 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs936160269 CA272820616 |
114 | S>F | No |
ClinGen gnomAD |
|
|
rs201820772 CA7659759 |
114 | S>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7659761 rs377141209 |
116 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393178357 rs377141209 |
116 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393178369 rs1406048542 |
117 | I>N | No |
ClinGen gnomAD |
|
|
rs746122928 CA7659763 |
120 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs770091203 CA7659764 |
121 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs763157275 CA7659766 |
124 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs55802037 CA272820643 |
125 | F>I | No |
ClinGen Ensembl |
|
|
CA7659767 rs141543251 |
125 | F>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs774711732 CA7659768 |
128 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs998243684 CA272820656 |
129 | S>C | No |
ClinGen TOPMed |
|
|
CA7659769 rs760284408 |
131 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393178577 rs1262511137 |
131 | P>T | No |
ClinGen gnomAD |
|
|
rs1476915394 CA393178602 |
133 | W>* | No |
ClinGen gnomAD |
|
|
CA7659772 rs368187861 |
136 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM243936 rs150893756 CA7659773 |
136 | R>H | Variant assessed as Somatic; 4.644e-05 impact. prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA393178646 rs150893756 |
136 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs139412032 CA7659776 |
137 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM964891 rs758124536 CA7659775 |
137 | R>W | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA7659778 rs757176570 |
138 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA7659779 rs59410695 |
138 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7659780 rs745883159 |
139 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770142375 CA7659781 |
141 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA7659782 rs780416016 |
142 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1038912692 CA272820678 |
143 | A>D | No |
ClinGen TOPMed |
|
|
rs1285458880 CA393178735 |
143 | A>T | No |
ClinGen gnomAD |
|
| TCGA novel | 146 | T>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7659785 rs774966785 |
148 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA393178834 rs1449738143 |
149 | I>V | No |
ClinGen gnomAD |
|
|
rs1477440128 CA393178852 |
150 | A>D | No |
ClinGen TOPMed |
|
|
rs192799115 COSM166508 CA7659786 |
150 | A>T | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs770950827 CA7659788 |
151 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs758981719 CA7659789 |
152 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA7659791 rs752279053 |
153 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs1389226935 CA393178902 |
153 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA7659793 rs763825636 |
154 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659795 rs751318508 |
159 | C>S | No |
ClinGen ExAC gnomAD |
|
|
CA7659796 rs757272055 |
162 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA393179027 rs1282443707 |
164 | H>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs781205661 CA7659797 |
165 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs72547512 CA272820722 |
168 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs72547512 VAR_020849 CA7659798 |
168 | E>Q | allele CYP1A2*10 [UniProt] | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
CA393179097 rs1258512880 |
170 | K>E | No |
ClinGen gnomAD |
|
|
CA7659799 rs756244484 |
171 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA393179116 rs756244484 |
171 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA393179120 rs1196434185 |
172 | L>M | No |
ClinGen gnomAD |
|
|
CA7659800 rs780368294 |
175 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA7659801 rs774282507 |
176 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs998884543 CA272820742 |
177 | Q>K | No |
ClinGen TOPMed |
|
|
CA7659802 rs768885942 |
178 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA7659804 rs56075956 |
180 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA272820745 rs367873883 |
182 | G>E | No |
ClinGen ESP |
|
|
CA393179213 rs1427789337 |
182 | G>R | No |
ClinGen gnomAD |
|
|
rs1596357591 CA393179222 |
183 | P>A | No |
ClinGen Ensembl |
|
|
rs1331022381 CA393179227 |
183 | P>L | No |
ClinGen gnomAD |
|
|
CA7659806 CA7659805 rs147248980 |
185 | H>Q | No |
ClinGen ESP ExAC gnomAD |
|
|
VAR_020850 CA272820762 rs72547513 |
186 | F>L | allele CYP1A2*11; drastic reduction in O-deethylation of phenacetin and 7-ethoxyresorufin; has a Vmax of approximately 5% of that of the wild-type and 5-fold lower Km value [UniProt] | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
CA272820783 rs960745484 |
187 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
rs369511887 CA7659808 |
187 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA393179270 rs1278748858 |
188 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs775025915 CA7659809 |
189 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA7659810 rs140747247 |
191 | Q>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs763743676 CA7659811 |
193 | V>E | No |
ClinGen ExAC gnomAD |
|
|
CA393179323 rs1465104157 |
194 | V>A | No |
ClinGen TOPMed |
|
|
rs1281521673 CA393179344 |
197 | A>T | No |
ClinGen Ensembl |
|
|
CA7659812 rs774018071 |
197 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA393179359 rs1567205259 |
198 | N>S | No |
ClinGen Ensembl |
|
|
rs144697774 CA7659814 |
199 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA272820808 rs145783435 |
200 | I>T | No |
ClinGen ESP TOPMed |
|
|
CA7659816 rs750360601 |
201 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs750360601 CA7659815 |
201 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs950873240 CA272820823 |
201 | G>V | No |
ClinGen TOPMed |
|
|
CA7659817 rs766404946 |
203 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs371514690 CA272820825 |
203 | M>V | No |
ClinGen ESP |
|
|
VAR_025186 rs45540640 CA7659818 |
205 | F>V | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA7659820 rs200836818 |
206 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393179439 rs1567205296 |
206 | G>V | No |
ClinGen Ensembl |
|
|
rs1467810049 CA393179467 |
209 | F>L | No |
ClinGen gnomAD |
|
|
rs202191520 CA7659821 |
210 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1401658009 CA393179491 |
211 | E>A | No |
ClinGen TOPMed gnomAD |
|
|
CA393179490 rs1401658009 |
211 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
CA7659822 VAR_020851 rs758748797 |
212 | S>C | allele CYP1A2*12 [UniProt] | No |
ClinGen UniProt ExAC dbSNP gnomAD |
|
CA7659824 rs747544962 |
214 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1271532274 CA393179526 |
215 | E>K | No |
ClinGen TOPMed |
|
|
CA272820853 rs963042990 |
216 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs771419575 CA7659825 |
218 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1235038748 CA393179568 |
218 | S>R | No |
ClinGen gnomAD |
|
|
rs768256912 CA7659828 |
220 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA7659830 rs761744781 |
223 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761744781 CA393179614 |
223 | T>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773105304 CA7659832 |
224 | H>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA272820884 rs773105304 |
224 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760714274 CA7659833 |
225 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA272820895 rs936216430 |
227 | V>A | No |
ClinGen Ensembl |
|
|
CA7659834 rs373580935 |
227 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393179677 rs1174302244 |
229 | T>A | No |
ClinGen gnomAD |
|
|
rs755082460 CA7659836 |
229 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs765435682 CA7659837 |
230 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 230 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1171510781 CA393179702 |
231 | S>F | No |
ClinGen TOPMed |
|
| TCGA novel | 232 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201537008 CA7659838 |
233 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1358653797 CA393179727 |
234 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
rs200328907 CA7659839 |
235 | P>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 235 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7659840 rs200328907 |
235 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 236 | L>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 237 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7659841 rs200571120 |
238 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659842 rs757707764 |
239 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs375045680 CA7659844 |
243 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs768186715 CA7659845 |
243 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1280147841 CA393179827 |
245 | L>Q | No |
ClinGen TOPMed |
|
| TCGA novel | 246 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs542879792 CA7659848 |
247 | N>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1555462472 CA393179869 |
248 | P>L | No |
ClinGen Ensembl |
|
|
rs1216594446 CA393179859 |
248 | P>T | No |
ClinGen gnomAD |
|
|
CA7659849 rs575035489 |
249 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1489714576 CA393179898 |
250 | L>R | No |
ClinGen gnomAD |
|
|
CA393179937 rs1452550218 |
252 | R>K | No |
ClinGen gnomAD |
|
|
CA393179991 rs1180705757 |
254 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1439165020 CA393180051 |
257 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA7659851 rs561167723 |
257 | N>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs775258473 CA393180060 |
258 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
CA272820945 rs775258473 |
258 | Q>K | No |
ClinGen TOPMed gnomAD |
|
|
CA393180066 rs1350414549 |
258 | Q>L | No |
ClinGen gnomAD |
|
|
rs776619123 CA7659853 |
265 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
CA393180152 rs1172740473 |
266 | K>Q | No |
ClinGen gnomAD |
|
|
rs1447126231 CA393180156 |
266 | K>R | No |
ClinGen gnomAD |
|
|
rs1285429482 CA393180168 |
267 | T>A | No |
ClinGen TOPMed |
|
|
rs759584175 CA7659854 |
267 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA393180197 rs1374100939 |
269 | Q>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs752723652 CA7659856 |
271 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659859 rs140421378 |
272 | Y>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs764233104 CA7659858 |
272 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs370942811 CA7659860 |
276 | D>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7659861 COSM1582923 rs370942811 |
276 | D>N | meninges [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs1038333951 CA393180323 |
277 | K>N | No |
ClinGen gnomAD |
|
|
rs750907355 CA7659862 |
277 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs1286765352 CA393163796 |
280 | V>I | No |
ClinGen gnomAD |
|
|
rs267604321 CA7659885 |
281 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
RCV000894430 CA7659884 VAR_025187 rs45468096 |
281 | R>W | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA7659886 rs746644895 |
282 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
COSM1374564 CA7659887 rs368776150 |
284 | T>M | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA272814995 rs746031187 |
285 | G>V | No |
ClinGen Ensembl |
|
|
CA393163881 rs1412353936 |
286 | A>G | No |
ClinGen gnomAD |
|
|
CA7659890 rs745581564 |
286 | A>S | No |
ClinGen ExAC gnomAD |
|
|
rs745581564 CA7659889 |
286 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA7659891 rs775392030 |
287 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs762114920 CA393163927 |
289 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 289 | K>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs774252909 CA7659894 |
289 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs771876603 CA7659896 |
290 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA7659897 rs773632297 |
291 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs760946724 CA7659898 |
292 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs767051591 CA7659899 |
294 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs866210877 CA272815006 |
295 | P>S | No |
ClinGen Ensembl |
|
|
rs1355915373 CA393164027 |
297 | A>D | No |
ClinGen gnomAD |
|
|
VAR_024709 rs17861157 CA7659900 |
298 | S>R | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs35796837 CA7659902 VAR_020852 |
299 | G>S | allele CYP1A2*13 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA7659903 rs750975192 |
299 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs1222061640 CA393164068 |
300 | N>S | No |
ClinGen gnomAD |
|
|
CA393164080 rs1248203623 |
301 | L>F | No |
ClinGen gnomAD |
|
|
rs1248203623 CA393164078 |
301 | L>V | No |
ClinGen gnomAD |
|
|
CA7659904 rs756936781 |
302 | I>N | No |
ClinGen ExAC gnomAD |
|
|
rs756936781 CA393164092 |
302 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1567205738 CA393164101 |
303 | P>S | No |
ClinGen Ensembl |
|
|
CA393164153 rs1380440987 |
306 | K>R | No |
ClinGen gnomAD |
|
|
rs1440996448 CA393164165 |
307 | I>L | No |
ClinGen gnomAD |
|
|
CA7659905 rs780704581 |
307 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs755877881 COSM378204 CA393164197 |
309 | N>K | lung [Cosmic] | No |
ClinGen cosmic curated ExAC |
|
CA7659906 rs745733376 |
309 | N>Y | No |
ClinGen ExAC gnomAD |
|
|
rs780002436 CA7659908 |
310 | L>H | No |
ClinGen ExAC gnomAD |
|
|
rs780002436 CA393164206 |
310 | L>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 311 | V>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA393164264 rs1567205764 |
314 | I>M | No |
ClinGen Ensembl |
|
|
rs28399418 VAR_024710 CA7659910 |
314 | I>V | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1022231223 CA272815017 |
316 | G>A | No |
ClinGen TOPMed |
|
|
CA272815019 rs867784817 |
317 | A>T | No |
ClinGen Ensembl |
|
|
rs1302160533 CA393164306 |
317 | A>V | No |
ClinGen TOPMed |
|
|
rs748321462 CA7659929 |
318 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1438101486 CA393164311 |
318 | G>R | No |
ClinGen TOPMed |
|
| TCGA novel | 319 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 321 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778097570 CA7659931 |
324 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659932 rs778097570 |
324 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659933 rs771230051 |
327 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA7659934 rs777138577 |
328 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393164538 rs1596358218 |
329 | S>I | No |
ClinGen Ensembl |
|
|
rs1167543869 CA393164540 |
329 | S>R | No |
ClinGen gnomAD |
|
|
CA272815183 rs995673317 |
331 | M>I | No |
ClinGen TOPMed |
|
|
CA7659936 rs200303014 |
331 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659935 rs200303014 |
331 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393164575 rs1397866966 |
332 | Y>N | No |
ClinGen gnomAD |
|
|
rs369659890 CA7659937 |
333 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393164606 rs1414047313 |
334 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1278651713 CA393164619 |
335 | T>A | No |
ClinGen gnomAD |
|
|
CA7659939 rs766962627 |
337 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1206500755 CA393164649 |
337 | P>S | No |
ClinGen TOPMed |
|
|
CA7659941 rs749883467 |
338 | E>Q | No |
ClinGen ExAC |
|
|
rs760330726 CA7659942 |
339 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs765952249 CA7659943 |
340 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393164689 rs1201701676 |
341 | R>M | No |
ClinGen TOPMed gnomAD |
|
|
CA393164718 rs1567205948 |
342 | K>N | No |
ClinGen Ensembl |
|
|
rs1277524462 CA393164740 |
344 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
CA7659944 rs765006100 |
345 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA7659945 rs574824024 |
346 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA393164789 rs1427106271 |
347 | L>V | No |
ClinGen gnomAD |
|
|
CA7659946 VAR_020793 rs56276455 |
348 | D>N | allele CYP1A2*3; increases N-hydroxylation activity of heterocyclic amines; reduces phenacetin O-deethylation activity [UniProt] | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
CA7659970 rs752489908 |
349 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs764121366 CA7659972 |
350 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA393165068 rs1453893545 |
352 | G>C | No |
ClinGen TOPMed |
|
|
rs1453893545 CA393165065 |
352 | G>S | No |
ClinGen TOPMed |
|
|
CA272815269 rs896388635 |
354 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA7659974 rs144076129 |
355 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7659973 rs148157092 |
355 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7659976 rs55918015 |
356 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs147333000 CA7659975 COSM1374565 |
356 | R>W | large_intestine prostate [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs756307932 CA7659977 |
357 | P>A | No |
ClinGen ExAC |
|
|
CA7659980 rs769113145 |
358 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749598098 CA7659979 |
358 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs774829338 CA7659981 |
359 | L>I | No |
ClinGen ExAC gnomAD |
|
|
rs574726215 CA7659982 |
361 | D>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA393165278 rs1596358382 |
362 | R>S | No |
ClinGen Ensembl |
|
|
rs1368910480 CA393165314 |
363 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA393165295 rs1337589199 |
363 | P>S | No |
ClinGen TOPMed |
|
|
rs770400672 CA7659983 |
365 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs776078971 CA7659984 |
366 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1447014399 CA393165384 |
368 | L>V | No |
ClinGen gnomAD |
|
|
rs994894269 CA272815298 |
370 | A>T | No |
ClinGen TOPMed |
|
|
rs764887010 CA7659986 |
374 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA393165580 rs1382418569 |
376 | F>L | No |
ClinGen TOPMed |
|
|
CA393165592 rs1383695226 |
376 | F>S | No |
ClinGen TOPMed |
|
|
CA7659988 rs762793689 |
377 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7659989 rs72547515 |
377 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
VAR_025188 rs72547515 CA272815302 |
377 | R>Q | allele CYP1A2*16 [UniProt] | No |
ClinGen UniProt ExAC TOPMed dbSNP gnomAD |
| TCGA novel | 378 | H>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs751510035 CA7659991 |
379 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
CA7659993 rs767723757 |
382 | L>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs953378109 CA272815313 |
385 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs750455376 CA7659994 |
385 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs72547516 VAR_020794 CA7659996 |
386 | I>F | allele CYP1A2*4; increases catalytic efficiency of N-hydroxylation towards some heterocyclic amines and reduces towards others; reduces catalytic efficiency of phenacetin O-deethylation due to a high decrease in the affinity for phenacetin [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA7659997 rs749674595 |
386 | I>T | No |
ClinGen ExAC |
|
|
rs72547516 CA7659995 |
386 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA393165807 rs1429333138 |
387 | P>T | No |
ClinGen TOPMed |
|
|
rs557412265 CA393165822 |
388 | H>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7659998 rs557412265 |
388 | H>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1465860100 CA393165857 |
389 | S>G | No |
ClinGen gnomAD |
|
|
rs774289191 CA7660026 |
390 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA7660027 rs761693521 |
392 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA393167018 rs1208724378 |
392 | R>M | No |
ClinGen gnomAD |
|
|
CA272815630 rs762326858 |
392 | R>S | No |
ClinGen Ensembl |
|
|
rs1279527923 CA393167056 |
394 | T>I | No |
ClinGen gnomAD |
|
|
CA272815632 rs911014711 |
395 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs149928755 CA7660028 |
395 | T>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA393167077 rs1389711492 |
396 | L>P | No |
ClinGen TOPMed |
|
|
CA393167093 rs1567206457 |
397 | N>S | No |
ClinGen Ensembl |
|
|
CA393167104 rs1474899560 |
398 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs866111643 CA272815648 |
402 | P>S | No |
ClinGen Ensembl |
|
|
rs55889066 CA272815657 VAR_020795 |
406 | C>Y | allele CYP1A2*5; increases N-hydroxylation activity of heterocyclic amines; reduces catalytic efficiency of phenacetin O-deethylation [UniProt] | No |
ClinGen UniProt TOPMed dbSNP gnomAD |
|
CA7660034 rs759768496 |
407 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA7660035 rs759768496 |
407 | V>D | No |
ClinGen ExAC gnomAD |
|
|
rs1402912656 CA393167318 |
407 | V>I | No |
ClinGen gnomAD |
|
|
rs752138293 CA7660039 |
409 | V>E | No |
ClinGen ExAC gnomAD |
|
|
CA7660038 rs377527644 |
409 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1233676520 CA393167421 |
410 | N>K | No |
ClinGen gnomAD |
|
|
rs1220847965 CA393167469 |
412 | W>* | No |
ClinGen TOPMed |
|
|
rs748737498 CA7660042 |
414 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs376674911 CA7660040 |
414 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7660041 rs376674911 |
414 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1052561630 CA272815679 |
415 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA393167568 rs1351879965 |
416 | H>Y | No |
ClinGen TOPMed |
|
|
rs1288583289 CA393167630 |
418 | P>A | No |
ClinGen TOPMed |
|
|
CA7660043 rs768486827 |
418 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA272816047 rs530650066 |
419 | E>G | No |
ClinGen gnomAD |
|
|
CA272816051 rs969721209 |
425 | S>T | No |
ClinGen gnomAD |
|
|
CA7660059 rs374433914 |
426 | E>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 427 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs145557631 CA7660062 |
428 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs145557631 CA7660063 |
428 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7660061 rs149710194 |
428 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA393169209 rs1468916294 |
430 | E>A | No |
ClinGen TOPMed |
|
|
rs1426774448 CA393169217 |
430 | E>D | No |
ClinGen TOPMed |
|
|
rs747837686 CA7660064 |
430 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393169231 rs1328210184 |
431 | R>L | No |
ClinGen gnomAD |
|
|
rs1328210184 CA393169229 |
431 | R>P | No |
ClinGen gnomAD |
|
|
rs1328210184 CA393169228 |
431 | R>Q | No |
ClinGen gnomAD |
|
|
CA7660065 VAR_020796 rs28399424 COSM471061 |
431 | R>W | kidney allele CYP1A2*6; not detected when expressed in heterologous system as it may be critical for maintenance of protein tertiary structure [Cosmic, UniProt] | No |
ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA7660068 rs201485133 |
432 | F>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs770969636 CA7660069 |
434 | T>P | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 435 | A>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775498266 CA7660073 |
436 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs144148965 CA393169307 |
436 | D>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7660072 rs144148965 |
436 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs763246035 CA7660074 |
438 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs45486893 CA7660075 VAR_020853 |
438 | T>I | allele CYP1A2*14 [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs45486893 CA7660076 |
438 | T>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs763246035 CA393169336 |
438 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA272816095 rs889339647 |
443 | P>L | No |
ClinGen Ensembl |
|
|
CA7660078 rs140757511 |
444 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7660079 rs750931037 |
445 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393169495 rs1306066932 |
446 | E>G | No |
ClinGen TOPMed |
|
|
rs566851431 CA7660081 |
447 | K>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7660082 rs752196823 COSM458961 |
448 | M>I | cervix [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA393169533 rs1167453607 |
448 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1596359295 CA393169535 |
448 | M>T | No |
ClinGen Ensembl |
|
|
CA393169562 rs1314644872 |
449 | M>I | No |
ClinGen gnomAD |
|
|
CA7660083 rs758078387 |
449 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA393169572 rs1373475971 |
450 | L>P | No |
ClinGen gnomAD |
|
|
rs1336741799 CA393169612 |
453 | M>T | No |
ClinGen TOPMed |
|
|
rs746882435 CA7660085 |
454 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs367858322 CA7660086 |
456 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
VAR_025189 CA7660087 rs72547517 |
456 | R>H | allele CYP1A2*8 [UniProt] | No |
ClinGen UniProt ExAC TOPMed dbSNP gnomAD |
|
CA7660092 rs745824533 |
457 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7660091 rs745824533 |
457 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA7660088 VAR_055563 rs34151816 |
457 | R>W | No |
ClinGen UniProt 1000Genomes TOPMed dbSNP |
|
|
CA272816128 rs982089694 |
458 | C>R | No |
ClinGen TOPMed |
|
|
CA7660094 rs780107971 |
459 | I>V | No |
ClinGen ExAC |
|
|
COSM964897 rs768979898 CA7660096 |
460 | G>R | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA7660099 rs772597894 |
461 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs199528490 CA7660100 |
462 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1455643099 CA393169798 |
464 | A>D | No |
ClinGen gnomAD |
|
|
rs752325643 CA7660103 |
465 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs762359586 CA7660104 |
466 | W>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763859277 CA7660105 |
467 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1289271309 CA393169848 |
467 | E>G | No |
ClinGen gnomAD |
|
|
CA7660106 rs751143438 |
468 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393169861 rs751143438 |
468 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs756883321 CA7660107 |
470 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs780975619 CA7660108 |
473 | A>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393170027 rs1300577537 |
474 | I>N | No |
ClinGen gnomAD |
|
|
rs779953096 CA7660111 |
478 | Q>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA272816155 rs4646428 |
478 | Q>H | No |
ClinGen Ensembl |
|
|
rs768585881 CA7660113 |
479 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs779013270 CA7660114 |
480 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393170231 rs1253879147 |
482 | S>G | No |
ClinGen gnomAD |
|
|
CA393170245 rs1469949040 |
482 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs143028942 CA7660115 COSM434300 |
483 | V>M | Variant assessed as Somatic; 0.0 impact. endometrium breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA272816156 rs370476434 |
484 | P>L | No |
ClinGen Ensembl |
|
|
CA393170268 rs1252415879 |
484 | P>S | No |
ClinGen gnomAD |
|
|
CA7660117 rs773716931 |
485 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393170292 rs773716931 |
485 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs140211191 CA7660119 |
486 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1451363283 CA393170305 |
486 | G>S | No |
ClinGen gnomAD |
|
|
rs571663822 CA7660121 RCV000918468 |
487 | V>M | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA393170360 rs1323371696 |
488 | K>E | No |
ClinGen gnomAD |
|
|
CA272816157 rs960678173 |
489 | V>I | No |
ClinGen Ensembl |
|
|
rs763531887 CA7660122 |
490 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA393170429 rs1315589602 |
492 | T>P | No |
ClinGen gnomAD |
|
|
CA7660126 rs143193369 |
495 | Y>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs761456419 CA7660124 |
495 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA7660127 CA272816158 rs755880133 |
496 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs946810948 CA272816159 |
497 | L>P | No |
ClinGen Ensembl |
|
|
CA7660128 rs780006160 |
498 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1252607238 CA393170577 |
499 | M>T | No |
ClinGen gnomAD |
|
|
rs772253005 CA272816160 |
499 | M>V | No |
ClinGen Ensembl |
|
|
rs1181238166 COSM1374568 CA393170639 |
502 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA272816161 rs550827905 |
503 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA7660130 rs754897375 |
503 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA393170702 rs1162348403 |
505 | E>K | No |
ClinGen gnomAD |
|
|
CA393170737 rs1348874507 |
506 | H>L | No |
ClinGen gnomAD |
|
|
CA7660132 rs748192662 |
507 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA7660133 rs200075745 |
508 | Q>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs778132807 CA7660135 |
509 | A>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1303192114 CA393170793 |
509 | A>P | No |
ClinGen gnomAD |
|
|
rs778132807 CA7660134 |
509 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7660138 rs374094758 |
510 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA272816163 rs374094758 |
510 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM964900 rs138459442 CA7660137 |
510 | R>W | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA7660139 rs770266566 |
512 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA7660140 rs773795301 |
512 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1292978023 CA393170868 |
513 | F>C | No |
ClinGen TOPMed |
|
|
rs767206057 CA7660142 |
514 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs1204339109 CA393170877 |
514 | S>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs35647699 CA7660143 |
515 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs766110906 CA7660145 |
516 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1352233952 CA393170930 |
517 | N>L | No |
ClinGen gnomAD |
|
|
CA393170924 rs1171948620 |
517 | N>R | No |
ClinGen gnomAD |
No associated diseases with P05177
1 regional properties for P05177
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 451 - 460 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.1 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
13 GO annotations of molecular function
| Name | Definition |
|---|---|
| aromatase activity | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. |
| caffeine oxidase activity | Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O. |
| demethylase activity | Catalysis of the removal of a methyl group from a substrate. |
| electron transfer activity | Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| estrogen 16-alpha-hydroxylase activity | Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O. |
| estrogen 2-hydroxylase activity | Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| hydroperoxy icosatetraenoate dehydratase activity | A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O. |
| iron ion binding | Binding to an iron (Fe) ion. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. |
25 GO annotations of biological process
| Name | Definition |
|---|---|
| aflatoxin metabolic process | The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. |
| alkaloid metabolic process | The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). |
| cellular respiration | The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). |
| cellular response to cadmium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. |
| cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
| dibenzo-p-dioxin metabolic process | The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern. |
| epoxygenase P450 pathway | The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. |
| estrogen metabolic process | The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. |
| heterocycle metabolic process | The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). |
| hydrogen peroxide biosynthetic process | The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. |
| long-chain fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22. |
| lung development | The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| monocarboxylic acid metabolic process | The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). |
| monoterpenoid metabolic process | The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton. |
| omega-hydroxylase P450 pathway | The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. |
| oxidative demethylation | The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. |
| porphyrin-containing compound metabolic process | The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| retinol metabolic process | The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. |
| steroid catabolic process | The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
| toxin biosynthetic process | The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. |
| xenobiotic catabolic process | The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| xenobiotic metabolic process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0IIF9 | CYP2U1 | Cytochrome P450 2U1 | Bos taurus (Bovine) | PR |
| O18963 | CYP2E1 | Cytochrome P450 2E1 | Bos taurus (Bovine) | PR |
| P12394 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Gallus gallus (Chicken) | PR |
| Q95078 | Cyp18a1 | Cytochrome P450 18a1 | Drosophila melanogaster (Fruit fly) | PR |
| P33260 | CYP2C18 | Cytochrome P450 2C18 | Homo sapiens (Human) | PR |
| Q7Z449 | CYP2U1 | Cytochrome P450 2U1 | Homo sapiens (Human) | PR |
| P05093 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (Human) | PR |
| P51589 | CYP2J2 | Cytochrome P450 2J2 | Homo sapiens (Human) | PR |
| P10632 | CYP2C8 | Cytochrome P450 2C8 | Homo sapiens (Human) | PR |
| P05181 | CYP2E1 | Cytochrome P450 2E1 | Homo sapiens (Human) | PR |
| Q9D816 | Cyp2c55 | Cytochrome P450 2C55 | Mus musculus (Mouse) | PR |
| P27786 | Cyp17a1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Mus musculus (Mouse) | PR |
| O54749 | Cyp2j5 | Cytochrome P450 2J5 | Mus musculus (Mouse) | PR |
| O54750 | Cyp2j6 | Cytochrome P450 2J6 | Mus musculus (Mouse) | PR |
| P24456 | Cyp2d10 | Cytochrome P450 2D10 | Mus musculus (Mouse) | PR |
| Q9CX98 | Cyp2u1 | Cytochrome P450 2U1 | Mus musculus (Mouse) | PR |
| P24457 | Cyp2d11 | Cytochrome P450 2D11 | Mus musculus (Mouse) | PR |
| P79383 | CYP2E1 | Cytochrome P450 2E1 | Sus scrofa (Pig) | PR |
| P33273 | Cyp2c55 | Cytochrome P450 2C55 | Rattus norvegicus (Rat) | PR |
| P05182 | Cyp2e1 | Cytochrome P450 2E1 | Rattus norvegicus (Rat) | PR |
| P24470 | Cyp2c23 | Cytochrome P450 2C23 | Rattus norvegicus (Rat) | PR |
| P11715 | Cyp17a1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Rat) | PR |
| P12939 | Cyp2d10 | Cytochrome P450 2D10 | Rattus norvegicus (Rat) | PR |
| P10633 | Cyp2d1 | Cytochrome P450 2D1 | Rattus norvegicus (Rat) | PR |
| P05179 | Cyp2c7 | Cytochrome P450 2C7 | Rattus norvegicus (Rat) | PR |
| P12938 | Cyp2d3 | Cytochrome P450 2D3 | Rattus norvegicus (Rat) | PR |
| O35293 | Cyp2f2 | Cytochrome P450 2F2 | Rattus norvegicus (Rat) | PR |
| P20814 | Cyp2c13 | Cytochrome P450 2C13, male-specific | Rattus norvegicus (Rat) | PR |
| Q8HYM9 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Macaca mulatta (Rhesus macaque) | PR |
| Q6YV88 | CYP71Z7 | Ent-cassadiene hydroxylase | Oryza sativa subsp japonica (Rice) | PR |
| A3A871 | CYP71Z6 | Ent-isokaurene C2/C3-hydroxylase | Oryza sativa subsp japonica (Rice) | PR |
| Q7X7X4 | CYP99A2 | Cytochrome P450 99A2 | Oryza sativa subsp japonica (Rice) | PR |
| O48957 | CYP99A1 | Cytochrome P450 CYP99A1 | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
| Q42797 | CYP73A11 | Trans-cinnamate 4-monooxygenase | Glycine max (Soybean) (Glycine hispida) | PR |
| Q9XHC6 | CYP93E1 | Beta-amyrin 24-hydroxylase | Glycine max (Soybean) (Glycine hispida) | PR |
| O81971 | CYP71D9 | Cytochrome P450 71D9 | Glycine max (Soybean) (Glycine hispida) | PR |
| O48922 | CYP98A2 | Cytochrome P450 98A2 | Glycine max (Soybean) (Glycine hispida) | PR |
| O49340 | CYP71A12 | Cytochrome P450 71A12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64638 | CYP76C3 | Cytochrome P450 76C3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P58049 | CYP71B11 | Cytochrome P450 71B11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P58050 | CYP71B13 | Cytochrome P450 71B13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96514 | CYP71B7 | Cytochrome P450 71B7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CA61 | CYP98A8 | Cytochrome P450 98A8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM0 | CYP71B23 | Cytochrome P450 71B23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM6 | CYP71B17 | Cytochrome P450 71B17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM7 | CYP71B16 | Cytochrome P450 71B16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVD2 | CYP71B10 | Cytochrome P450 71B10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAE4 | CYP71B29 | Cytochrome P450 71B29 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SRQ1 | CYP89A9 | Cytochrome P450 89A9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZU07 | CYP71B12 | Cytochrome P450 71B12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64636 | CYP76C1 | Cytochrome P450 76C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q949U1 | CYP79F1 | Dihomomethionine N-hydroxylase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALSQSVPFS | ATELLLASAI | FCLVFWVLKG | LRPRVPKGLK | SPPEPWGWPL | LGHVLTLGKN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PHLALSRMSQ | RYGDVLQIRI | GSTPVLVLSR | LDTIRQALVR | QGDDFKGRPD | LYTSTLITDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QSLTFSTDSG | PVWAARRRLA | QNALNTFSIA | SDPASSSSCY | LEEHVSKEAK | ALISRLQELM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AGPGHFDPYN | QVVVSVANVI | GAMCFGQHFP | ESSDEMLSLV | KNTHEFVETA | SSGNPLDFFP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILRYLPNPAL | QRFKAFNQRF | LWFLQKTVQE | HYQDFDKNSV | RDITGALFKH | SKKGPRASGN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LIPQEKIVNL | VNDIFGAGFD | TVTTAISWSL | MYLVTKPEIQ | RKIQKELDTV | IGRERRPRLS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DRPQLPYLEA | FILETFRHSS | FLPFTIPHST | TRDTTLNGFY | IPKKCCVFVN | QWQVNHDPEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WEDPSEFRPE | RFLTADGTAI | NKPLSEKMML | FGMGKRRCIG | EVLAKWEIFL | FLAILLQQLE |
| 490 | 500 | 510 | |||
| FSVPPGVKVD | LTPIYGLTMK | HARCEHVQAR | LRFSIN |