P27786
PR
Gene name |
Cyp17a1 (Cyp17) |
Protein name |
Steroid 17-alpha-hydroxylase/17,20 lyase |
Names |
17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13074 |
EC number |
1.14.14.19: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P27786
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P27786-F1 | Predicted | AlphaFoldDB |
37 variants for P27786
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389548842 | 3 | E>V | No | EVA | |
| rs3389540927 | 18 | P>H | No | EVA | |
| rs217635120 | 72 | T>A | No | EVA | |
| rs259546354 | 73 | A>T | No | EVA | |
| rs3389540931 | 112 | V>L | No | EVA | |
| rs3389501433 | 116 | D>V | No | EVA | |
| rs3389553610 | 117 | S>R | No | EVA | |
| rs252207398 | 118 | S>G | No | EVA | |
| rs3389523813 | 130 | S>N | No | EVA | |
| rs3389546225 | 146 | C>* | No | EVA | |
| rs3389452704 | 151 | S>T | No | EVA | |
| rs3389545129 | 153 | C>Y | No | EVA | |
| rs8239543 | 179 | C>S | No | EVA | |
| rs3389553666 | 188 | E>D | No | EVA | |
| rs3389537842 | 191 | D>V | No | EVA | |
| rs3389493195 | 203 | G>S | No | EVA | |
| rs3389548752 | 215 | D>Y | No | EVA | |
| rs3389493236 | 219 | W>* | No | EVA | |
| rs3389501428 | 222 | I>N | No | EVA | |
| rs3389560509 | 237 | I>F | No | EVA | |
| rs3389553651 | 250 | K>M | No | EVA | |
| rs3389540954 | 260 | S>I | No | EVA | |
| rs3409752247 | 265 | L>H | No | EVA | |
| rs3389545124 | 269 | K>M | No | EVA | |
| rs261687534 | 284 | S>N | No | EVA | |
| rs245333556 | 293 | V>I | No | EVA | |
| rs8239572 | 295 | V>L | No | EVA | |
| rs8239572 | 295 | V>M | No | EVA | |
| rs3389538387 | 306 | T>S | No | EVA | |
| rs255621048 | 319 | H>Y | No | EVA | |
| rs3389540963 | 338 | S>R | No | EVA | |
| rs3389560508 | 358 | E>D | No | EVA | |
| rs3389546125 | 393 | I>T | No | EVA | |
| rs3389548813 | 402 | K>E | No | EVA | |
| rs3389540946 | 414 | E>G | No | EVA | |
| rs3389523786 | 453 | I>V | No | EVA | |
| rs3389523836 | 468 | D>E | No | EVA |
No associated diseases with P27786
1 regional properties for P27786
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 430 - 439 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.19 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 17-alpha-hydroxyprogesterone aldolase activity | Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| steroid 17-alpha-monooxygenase activity | Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| glucocorticoid biosynthetic process | The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
| hormone biosynthetic process | The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. |
| positive regulation of steroid hormone biosynthetic process | Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. |
| progesterone metabolic process | The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. |
| steroid biosynthetic process | The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. |
| steroid metabolic process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
53 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0IIF9 | CYP2U1 | Cytochrome P450 2U1 | Bos taurus (Bovine) | PR |
| O18963 | CYP2E1 | Cytochrome P450 2E1 | Bos taurus (Bovine) | PR |
| P12394 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Gallus gallus (Chicken) | PR |
| Q8HYN1 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Pan troglodytes (Chimpanzee) | PR |
| Q95078 | Cyp18a1 | Cytochrome P450 18a1 | Drosophila melanogaster (Fruit fly) | PR |
| P33260 | CYP2C18 | Cytochrome P450 2C18 | Homo sapiens (Human) | PR |
| Q7Z449 | CYP2U1 | Cytochrome P450 2U1 | Homo sapiens (Human) | PR |
| P05177 | CYP1A2 | Cytochrome P450 1A2 | Homo sapiens (Human) | PR |
| P51589 | CYP2J2 | Cytochrome P450 2J2 | Homo sapiens (Human) | PR |
| P10632 | CYP2C8 | Cytochrome P450 2C8 | Homo sapiens (Human) | PR |
| P05181 | CYP2E1 | Cytochrome P450 2E1 | Homo sapiens (Human) | PR |
| P05093 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (Human) | PR |
| Q9D816 | Cyp2c55 | Cytochrome P450 2C55 | Mus musculus (Mouse) | PR |
| O54749 | Cyp2j5 | Cytochrome P450 2J5 | Mus musculus (Mouse) | PR |
| O54750 | Cyp2j6 | Cytochrome P450 2J6 | Mus musculus (Mouse) | PR |
| P24456 | Cyp2d10 | Cytochrome P450 2D10 | Mus musculus (Mouse) | PR |
| Q9CX98 | Cyp2u1 | Cytochrome P450 2U1 | Mus musculus (Mouse) | PR |
| P24457 | Cyp2d11 | Cytochrome P450 2D11 | Mus musculus (Mouse) | PR |
| P79383 | CYP2E1 | Cytochrome P450 2E1 | Sus scrofa (Pig) | PR |
| P33273 | Cyp2c55 | Cytochrome P450 2C55 | Rattus norvegicus (Rat) | PR |
| P05182 | Cyp2e1 | Cytochrome P450 2E1 | Rattus norvegicus (Rat) | PR |
| P24470 | Cyp2c23 | Cytochrome P450 2C23 | Rattus norvegicus (Rat) | PR |
| P12939 | Cyp2d10 | Cytochrome P450 2D10 | Rattus norvegicus (Rat) | PR |
| P10633 | Cyp2d1 | Cytochrome P450 2D1 | Rattus norvegicus (Rat) | PR |
| P05179 | Cyp2c7 | Cytochrome P450 2C7 | Rattus norvegicus (Rat) | PR |
| P12938 | Cyp2d3 | Cytochrome P450 2D3 | Rattus norvegicus (Rat) | PR |
| O35293 | Cyp2f2 | Cytochrome P450 2F2 | Rattus norvegicus (Rat) | PR |
| P20814 | Cyp2c13 | Cytochrome P450 2C13, male-specific | Rattus norvegicus (Rat) | PR |
| P11715 | Cyp17a1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Rat) | PR |
| Q8HYM9 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Macaca mulatta (Rhesus macaque) | PR |
| Q6YV88 | CYP71Z7 | Ent-cassadiene hydroxylase | Oryza sativa subsp japonica (Rice) | PR |
| A3A871 | CYP71Z6 | Ent-isokaurene C2/C3-hydroxylase | Oryza sativa subsp japonica (Rice) | PR |
| Q7X7X4 | CYP99A2 | Cytochrome P450 99A2 | Oryza sativa subsp japonica (Rice) | PR |
| O48957 | CYP99A1 | Cytochrome P450 CYP99A1 | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
| Q42797 | CYP73A11 | Trans-cinnamate 4-monooxygenase | Glycine max (Soybean) (Glycine hispida) | PR |
| O48922 | CYP98A2 | Cytochrome P450 98A2 | Glycine max (Soybean) (Glycine hispida) | PR |
| Q9XHC6 | CYP93E1 | Beta-amyrin 24-hydroxylase | Glycine max (Soybean) (Glycine hispida) | PR |
| O81971 | CYP71D9 | Cytochrome P450 71D9 | Glycine max (Soybean) (Glycine hispida) | PR |
| O49340 | CYP71A12 | Cytochrome P450 71A12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64638 | CYP76C3 | Cytochrome P450 76C3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P58049 | CYP71B11 | Cytochrome P450 71B11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P58050 | CYP71B13 | Cytochrome P450 71B13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96514 | CYP71B7 | Cytochrome P450 71B7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CA61 | CYP98A8 | Cytochrome P450 98A8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM0 | CYP71B23 | Cytochrome P450 71B23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM6 | CYP71B17 | Cytochrome P450 71B17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM7 | CYP71B16 | Cytochrome P450 71B16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVD2 | CYP71B10 | Cytochrome P450 71B10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAE4 | CYP71B29 | Cytochrome P450 71B29 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SRQ1 | CYP89A9 | Cytochrome P450 89A9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZU07 | CYP71B12 | Cytochrome P450 71B12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64636 | CYP76C1 | Cytochrome P450 76C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q949U1 | CYP79F1 | Dihomomethionine N-hydroxylase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWELVGLLLL | ILAYFFWPKS | KTPNAKFPRS | LPFLPLVGSL | PFLPRRGHMH | ANFFKLQEKY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPIYSLRLGT | TTAVIVGHYQ | LAREVLVKKG | KEFSGRPQMV | TLGLLSDQGK | GVAFADSSSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WQLHRKLVFS | TFSLFRDDQK | LEKMICQEAN | SLCDLILTYD | GESRDLSTLI | FKSVINIICT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ICFNISFENK | DPILTTIQTF | TEGIVDVLGH | SDLVDIFPWL | KIFPNKNLEM | IKEHTKIREK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TLVEMFEKCK | EKFNSESLSS | LTDILIQAKM | NAENNNTGEG | QDPSVFSDKH | ILVTVGDIFG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AGIETTSSVL | NWILAFLVHN | PEVKRKIQKE | IDQYVGFSRT | PSFNDRTHLL | MLEATIREVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RIRPVAPLLI | PHKANIDSSI | GEFAIPKDTH | VIINLWALHH | DKNEWDQPDR | FMPERFLDPT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GSHLITPTPS | YLPFGAGPRS | CIGEALARQE | LFIFMALLLQ | RFDFDVSDDK | QLPCLVGDPK |
| 490 | 500 | ||||
| VVFLIDPFKV | KITVRQAWKD | AQVEVST |