Q949U1
PR
Gene name |
CYP79F1 (BUS1, SPS1, At1g16410, F3O9.21) |
Protein name |
Dihomomethionine N-hydroxylase |
Names |
Cytochrome P450 79F1, Protein BUSHY 1, Protein SUPERSHOOT 1, Trihomomethionine N-hydroxylase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G16410 |
EC number |
1.14.14.42: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q949U1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q949U1-F1 | Predicted | AlphaFoldDB |
46 variants for Q949U1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_5608895_T_A | 12 | F>I | No | 1000Genomes | |
| ENSVATH00026674 | 43 | C>R | strain: cv. Ag-0, cv. Br-0, cv. C24, cv. Ct-1, cv. Edi-0, cv. Kas-1, cv. Kin-0, cv. Landsberg erecta, cv. Ll-0, cv. Lz-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo, cv. Van-0, cv. Wa-1 and cv. Wassilewskija [UniProt] | No | 1000Genomes |
| ENSVATH11328331 | 83 | A>G | strain: cv. Se-0 [UniProt] | No | 1000Genomes |
| tmp_1_5609149_C_A | 96 | N>K | No | 1000Genomes | |
| tmp_1_5609176_T_A | 105 | F>L | No | 1000Genomes | |
| ENSVATH11328332 | 106 | R>T | No | 1000Genomes | |
| ENSVATH00026675 | 120 | I>T | strain: cv. Br-0 and cv. Mt-0 [UniProt] | No | 1000Genomes |
| tmp_1_5609223_T_C | 121 | M>T | No | 1000Genomes | |
| tmp_1_5609239_C_A | 126 | D>E | No | 1000Genomes | |
| ENSVATH04585705 | 138 | E>K | No | 1000Genomes | |
| ENSVATH01058600 | 154 | V>F | strain: cv. Ag-0, cv. Cvi-1, cv. Edi-0, cv. Ll-0 and cv. Nok-3 [UniProt] | No | 1000Genomes |
| tmp_1_5609328_C_G | 156 | T>R | No | 1000Genomes | |
| ENSVATH00026676 | 158 | K>N | strain: cv. Ag-0, cv. Br-0, cv. Cvi-1, cv. Edi-0, cv. Ll-0, cv. Lz-0, cv. Mt-0, cv. Nok-3 and cv. Van-0 [UniProt] | No | 1000Genomes |
| ENSVATH11328333 | 159 | M>I | strain: cv. Nd-1 [UniProt] | No | 1000Genomes |
| ENSVATH00026677 | 159 | M>L | No | 1000Genomes | |
| ENSVATH01058601 | 161 | E>K | strain: cv. Lz-0 and cv. Van-0 [UniProt] | No | 1000Genomes |
| ENSVATH11328334 | 165 | T>N | No | 1000Genomes | |
| tmp_1_5609394_T_C | 178 | M>T | No | 1000Genomes | |
| tmp_1_5609405_T_A | 182 | S>T | No | 1000Genomes | |
| ENSVATH11328465 | 192 | R>W | strain: cv. Kin-0 [UniProt] | No | 1000Genomes |
| tmp_1_5609438_G_A | 193 | V>I | No | 1000Genomes | |
| tmp_1_5609498_A_T | 213 | N>Y | No | 1000Genomes | |
| ENSVATH00026679 | 222 | G>V | strain: cv. Ll-0 [UniProt] | No | 1000Genomes |
| ENSVATH11328467 | 223 | N>K | No | 1000Genomes | |
| tmp_1_5609531_G_A | 224 | A>T | No | 1000Genomes | |
| ENSVATH11328468 | 230 | E>Q | No | 1000Genomes | |
| tmp_1_5609552_G_T | 231 | V>L | No | 1000Genomes | |
| ENSVATH11328469 | 234 | N>D | No | 1000Genomes | |
| ENSVATH13906272 | 258 | D>G | No | 1000Genomes | |
| tmp_1_5609672_G_T | 271 | V>F | No | 1000Genomes | |
| ENSVATH00026680 | 289 | E>K | No | 1000Genomes | |
| ENSVATH11328538 | 334 | P>S | No | 1000Genomes | |
| ENSVATH11328539 | 401 | L>F | No | 1000Genomes | |
| ENSVATH04585710 | 405 | D>N | No | 1000Genomes | |
| tmp_1_5610753_C_A | 418 | H>N | No | 1000Genomes | |
| ENSVATH11328650 | 449 | G>R | No | 1000Genomes | |
| ENSVATH04585715 | 453 | E>A | No | 1000Genomes | |
| ENSVATH11328651 | 453 | E>D | No | 1000Genomes | |
| tmp_1_5610864_A_C | 455 | T>P | No | 1000Genomes | |
| ENSVATH11328652 | 462 | R>G | No | 1000Genomes | |
| ENSVATH01058612 | 476 | V>A | No | 1000Genomes | |
| tmp_1_5610943_T_C | 481 | I>T | No | 1000Genomes | |
| tmp_1_5611071_G_A | 524 | V>I | No | 1000Genomes | |
| tmp_1_5611102_C_A | 534 | P>Q | No | 1000Genomes | |
| ENSVATH01058613 | 535 | K>N | No | 1000Genomes | |
| ENSVATH04585717 | 536 | F>S | No | 1000Genomes |
No associated diseases with Q949U1
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.42 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| CYP79F1 dihomomethionine monooxygenase activity | Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP. |
| CYP79F1 trihomomethionine monooxygenase activity | Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glucosinolate biosynthetic process | The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. |
| response to insect | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect. |
53 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18963 | CYP2E1 | Cytochrome P450 2E1 | Bos taurus (Bovine) | PR |
| Q0IIF9 | CYP2U1 | Cytochrome P450 2U1 | Bos taurus (Bovine) | PR |
| P12394 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Gallus gallus (Chicken) | PR |
| Q8HYN1 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Pan troglodytes (Chimpanzee) | PR |
| Q95078 | Cyp18a1 | Cytochrome P450 18a1 | Drosophila melanogaster (Fruit fly) | PR |
| P10632 | CYP2C8 | Cytochrome P450 2C8 | Homo sapiens (Human) | PR |
| P33260 | CYP2C18 | Cytochrome P450 2C18 | Homo sapiens (Human) | PR |
| Q7Z449 | CYP2U1 | Cytochrome P450 2U1 | Homo sapiens (Human) | PR |
| P05093 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (Human) | PR |
| P05177 | CYP1A2 | Cytochrome P450 1A2 | Homo sapiens (Human) | PR |
| P05181 | CYP2E1 | Cytochrome P450 2E1 | Homo sapiens (Human) | PR |
| P51589 | CYP2J2 | Cytochrome P450 2J2 | Homo sapiens (Human) | PR |
| Q9CX98 | Cyp2u1 | Cytochrome P450 2U1 | Mus musculus (Mouse) | PR |
| O54749 | Cyp2j5 | Cytochrome P450 2J5 | Mus musculus (Mouse) | PR |
| O54750 | Cyp2j6 | Cytochrome P450 2J6 | Mus musculus (Mouse) | PR |
| P24456 | Cyp2d10 | Cytochrome P450 2D10 | Mus musculus (Mouse) | PR |
| P24457 | Cyp2d11 | Cytochrome P450 2D11 | Mus musculus (Mouse) | PR |
| P27786 | Cyp17a1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Mus musculus (Mouse) | PR |
| Q9D816 | Cyp2c55 | Cytochrome P450 2C55 | Mus musculus (Mouse) | PR |
| P79383 | CYP2E1 | Cytochrome P450 2E1 | Sus scrofa (Pig) | PR |
| P10633 | Cyp2d1 | Cytochrome P450 2D1 | Rattus norvegicus (Rat) | PR |
| P11715 | Cyp17a1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Rat) | PR |
| P12939 | Cyp2d10 | Cytochrome P450 2D10 | Rattus norvegicus (Rat) | PR |
| P20814 | Cyp2c13 | Cytochrome P450 2C13, male-specific | Rattus norvegicus (Rat) | PR |
| O35293 | Cyp2f2 | Cytochrome P450 2F2 | Rattus norvegicus (Rat) | PR |
| P05182 | Cyp2e1 | Cytochrome P450 2E1 | Rattus norvegicus (Rat) | PR |
| P12938 | Cyp2d3 | Cytochrome P450 2D3 | Rattus norvegicus (Rat) | PR |
| P24470 | Cyp2c23 | Cytochrome P450 2C23 | Rattus norvegicus (Rat) | PR |
| P33273 | Cyp2c55 | Cytochrome P450 2C55 | Rattus norvegicus (Rat) | PR |
| P05179 | Cyp2c7 | Cytochrome P450 2C7 | Rattus norvegicus (Rat) | PR |
| Q8HYM9 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Macaca mulatta (Rhesus macaque) | PR |
| A3A871 | CYP71Z6 | Ent-isokaurene C2/C3-hydroxylase | Oryza sativa subsp japonica (Rice) | PR |
| Q6YV88 | CYP71Z7 | Ent-cassadiene hydroxylase | Oryza sativa subsp japonica (Rice) | PR |
| Q7X7X4 | CYP99A2 | Cytochrome P450 99A2 | Oryza sativa subsp japonica (Rice) | PR |
| O48957 | CYP99A1 | Cytochrome P450 CYP99A1 | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
| Q42797 | CYP73A11 | Trans-cinnamate 4-monooxygenase | Glycine max (Soybean) (Glycine hispida) | PR |
| Q9XHC6 | CYP93E1 | Beta-amyrin 24-hydroxylase | Glycine max (Soybean) (Glycine hispida) | PR |
| O81971 | CYP71D9 | Cytochrome P450 71D9 | Glycine max (Soybean) (Glycine hispida) | PR |
| O48922 | CYP98A2 | Cytochrome P450 98A2 | Glycine max (Soybean) (Glycine hispida) | PR |
| Q9SAE4 | CYP71B29 | Cytochrome P450 71B29 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96514 | CYP71B7 | Cytochrome P450 71B7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CA61 | CYP98A8 | Cytochrome P450 98A8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O49340 | CYP71A12 | Cytochrome P450 71A12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64636 | CYP76C1 | Cytochrome P450 76C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM7 | CYP71B16 | Cytochrome P450 71B16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM6 | CYP71B17 | Cytochrome P450 71B17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM0 | CYP71B23 | Cytochrome P450 71B23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P58049 | CYP71B11 | Cytochrome P450 71B11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZU07 | CYP71B12 | Cytochrome P450 71B12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P58050 | CYP71B13 | Cytochrome P450 71B13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64638 | CYP76C3 | Cytochrome P450 76C3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVD2 | CYP71B10 | Cytochrome P450 71B10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SRQ1 | CYP89A9 | Cytochrome P450 89A9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMSFTTSLPY | PFHILLVFIL | SMASITLLGR | ILSRPTKTKD | RSCQLPPGPP | GWPILGNLPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LFMTRPRSKY | FRLAMKELKT | DIACFNFAGI | RAITINSDEI | AREAFRERDA | DLADRPQLFI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| METIGDNYKS | MGISPYGEQF | MKMKRVITTE | IMSVKTLKML | EAARTIEADN | LIAYVHSMYQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RSETVDVREL | SRVYGYAVTM | RMLFGRRHVT | KENVFSDDGR | LGNAEKHHLE | VIFNTLNCLP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFSPADYVER | WLRGWNVDGQ | EKRVTENCNI | VRSYNNPIID | ERVQLWREEG | GKAAVEDWLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TFITLKDQNG | KYLVTPDEIK | AQCVEFCIAA | IDNPANNMEW | TLGEMLKNPE | ILRKALKELD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EVVGRDRLVQ | ESDIPNLNYL | KACCRETFRI | HPSAHYVPSH | LARQDTTLGG | YFIPKGSHIH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VCRPGLGRNP | KIWKDPLVYK | PERHLQGDGI | TKEVTLVETE | MRFVSFSTGR | RGCIGVKVGT |
| 490 | 500 | 510 | 520 | 530 | |
| IMMVMLLARF | LQGFNWKLHQ | DFGPLSLEED | DASLLMAKPL | HLSVEPRLAP | NLYPKFRP |