AiPD: Autoinhibited Protein Database

P05181

Gene name	CYP2E1
Protein name	Cytochrome P450 2E1
Names	4-nitrophenol 2-hydroxylase, CYPIIE1, Cytochrome P450-J
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1571
EC number	1.14.13.n7: With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

217-291 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

217-291 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for P05181

Entry ID	Method	Resolution	Chain	Position	Source
3E4E	X-ray	260 A	A/B	32-493	PDB
3E6I	X-ray	220 A	A/B	32-493	PDB
3GPH	X-ray	270 A	A/B	32-493	PDB
3KOH	X-ray	290 A	A/B	32-493	PDB
3LC4	X-ray	310 A	A/B	32-493	PDB
3T3Z	X-ray	235 A	A/B/C/D	32-493	PDB
AF-P05181-F1	Predicted				AlphaFoldDB

421 variants for P05181

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs753713804 CA5767430	4	L>F		No	ClinGen ExAC gnomAD
rs1589952770 CA378830946	4	L>R		No	ClinGen Ensembl
rs1401576094 CA378830947	5	G>R		No	ClinGen TOPMed
CA378830998 rs1338671524	8	V>M		No	ClinGen gnomAD
CA5767433 rs543066971	11	L>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1457901117 CA378831051	12	V>L		No	ClinGen gnomAD
rs1457901117 CA378831054	12	V>M		No	ClinGen gnomAD
rs757352167 CA5767434	13	W>L		No	ClinGen ExAC gnomAD
TCGA novel	13	W>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM268976 CA5767435 rs563043306	14	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs1467974326 CA378831117	15	A>V		No	ClinGen TOPMed
rs367957731 CA5767437	17	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780358119 CA5767438	19	L>P		No	ClinGen ExAC gnomAD
CA378831203 rs1402586895	20	V>M		No	ClinGen gnomAD
rs772430702 CA216856460 CA378831258	22	M>I		No	ClinGen TOPMed
CA378831254 rs1336298850	22	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA216856457 rs900694954	22	M>V		No	ClinGen TOPMed
CA378831278 rs1377320782	23	W>*		No	ClinGen gnomAD
rs769059259 CA5767440	26	V>G		No	ClinGen ExAC gnomAD
CA216856464 rs59868347	26	V>M		No	ClinGen TOPMed
CA216856466 rs775675704	28	S>G		No	ClinGen gnomAD
rs773963522 CA5767441	28	S>N		No	ClinGen ExAC gnomAD
rs1259959217 CA378831411	29	S>R		No	ClinGen gnomAD
CA378831422 rs1317965193	29	S>T		No	ClinGen gnomAD
rs1443704595 CA378831478	31	N>I		No	ClinGen TOPMed
rs1260858117 CA378831506	33	P>S		No	ClinGen gnomAD
CA378831521 rs1484033642	34	P>T		No	ClinGen gnomAD
rs747825060 CA5767442	36	P>A		No	ClinGen ExAC gnomAD
rs771599544 CA5767443	37	F>L		No	ClinGen ExAC gnomAD
CA378831619 rs1428404245	37	F>L		No	ClinGen gnomAD
CA378831639 rs76271067	38	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5767444 rs76271067	38	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs979091921 CA216856482	40	P>R		No	ClinGen Ensembl
rs759372423 CA5767448	43	G>R		No	ClinGen ExAC TOPMed gnomAD
CA378831801 rs527949682 CA5767449	44	N>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1241054527 CA378831836	47	Q>E		No	ClinGen TOPMed
TCGA novel	49	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5767452 rs143746211	52	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378831922 rs143746211	52	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	53	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750499891 CA5767453	54	P>L		No	ClinGen ExAC gnomAD
CA378831957 rs1265920662	54	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	56	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA216856502 rs958141259	56	S>F		No	ClinGen TOPMed
CA5767454 rs756596289	57	F>L		No	ClinGen ExAC TOPMed gnomAD
rs780517566 CA5767455	58	T>S		No	ClinGen ExAC gnomAD
TCGA novel	59	R>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA216856516 rs779311330	59	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5767458 rs779311330	59	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1259826192 CA378832042	59	R>W		No	ClinGen TOPMed gnomAD
rs768536485 CA5767488	62	Q>E		No	ClinGen ExAC gnomAD
rs773302720 CA5767489	62	Q>R		No	ClinGen ExAC gnomAD
rs374426412 CA216856959	63	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs374426412 CA5767490	63	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA378832115 rs1354838426	63	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1294436417 CA378832122	64	F>L		No	ClinGen TOPMed gnomAD
CA216856962 rs80297454 CA378832124	65	G>R		No	ClinGen gnomAD
CA378832154 rs1324031177	69	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5767498 CA5767496 rs35844228	72	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs35844228 CA5767497	72	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	73	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	73	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5767499 rs764575539	74	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1589953328 CA378832185	75	Q>P		No	ClinGen Ensembl
CA378832192 rs1329756728	76	R>C		No	ClinGen TOPMed
rs72559710 VAR_008360 CA5767500	76	R>H	allele CYP2E1*2; reduced activity [UniProt]	No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA378832193 rs72559710	76	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs72559710 CA216856975	76	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA216856977 rs78902616	77	M>V		No	ClinGen Ensembl
CA5767501 rs756973880	78	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	79	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378832221 rs1179970516	80	M>I		No	ClinGen gnomAD
rs745393299 CA5767503	81	H>D		No	ClinGen ExAC gnomAD
CA378832225 rs1468421016	81	H>L		No	ClinGen TOPMed gnomAD
CA378832228 rs967340990	81	H>Q		No	ClinGen TOPMed gnomAD
CA378832233 rs1397166316	82	G>D		No	ClinGen TOPMed
CA5767504 rs755735655	82	G>S		No	ClinGen ExAC TOPMed gnomAD
CA378832241 rs779825840	83	Y>*		No	ClinGen ExAC gnomAD
CA378832235 rs1171967427	83	Y>H		No	ClinGen TOPMed
rs749315338 CA5767506	84	K>R		No	ClinGen ExAC gnomAD
CA216856986 rs977417894	85	A>V		No	ClinGen Ensembl
rs1381670040 CA378832256	86	V>L		No	ClinGen gnomAD
CA5767509 rs747170540	89	A>V		No	ClinGen ExAC TOPMed gnomAD
rs771177357 CA5767510	96	E>D		No	ClinGen ExAC TOPMed gnomAD
rs776646693 CA5767511	98	S>L		No	ClinGen ExAC TOPMed gnomAD
CA378832432 rs1185071578	99	G>A		No	ClinGen TOPMed gnomAD
rs1185071578 CA378832427	99	G>D		No	ClinGen TOPMed gnomAD
CA216856995 rs1047104054	103	L>F		No	ClinGen TOPMed gnomAD
rs543855005 CA5767517	104	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs543855005 CA378832512	104	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764296273 CA5767516	104	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1412420588 CA378832518	105	A>T		No	ClinGen gnomAD
CA5767520 rs750140082	108	A>E		No	ClinGen ExAC TOPMed gnomAD
CA378832585 rs750140082	108	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA216857008 rs911058446	109	H>L		No	ClinGen TOPMed
rs911058446 CA378832598	109	H>R		No	ClinGen TOPMed
rs1589953400 CA378832609	110	R>G		No	ClinGen Ensembl
rs899693063 CA216857009	110	R>K		No	ClinGen TOPMed gnomAD
TCGA novel	111	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378832679 rs1339182501	113	G>R		No	ClinGen gnomAD
CA5767549 rs777555849	116	F>C		No	ClinGen ExAC TOPMed gnomAD
CA378833708 rs1345641544	120	P>L		No	ClinGen gnomAD
rs770084630 CA5767551	120	P>S		No	ClinGen ExAC gnomAD
CA5767552 rs779948307	121	T>I		No	ClinGen ExAC gnomAD
rs1371933261 CA378833755	122	W>*		No	ClinGen gnomAD
CA5767553 rs377658981	123	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA216857700 rs56864127	126	R>L		No	ClinGen ExAC TOPMed gnomAD
rs56864127 CA5767555	126	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs60719153 CA5767554 COSM204515	126	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA5767558 rs773718909	127	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5767557 rs772509721	127	R>W		No	ClinGen ExAC TOPMed gnomAD
rs905415600 CA378833879	130	L>V		No	ClinGen gnomAD
rs1290001392 CA378833917	132	T>I		No	ClinGen gnomAD
CA5767560 rs148644999	133	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	133	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5767561 rs765056111	134	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1239678934 CA378833944	134	R>W		No	ClinGen gnomAD
CA5767562 rs759059865	136	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA378834024 rs1456859372	138	M>L		No	ClinGen gnomAD
CA5767564 rs752570058	139	G>E		No	ClinGen ExAC gnomAD
CA5767563 rs764780713	139	G>R		No	ClinGen ExAC gnomAD
CA378834071 rs1323264151	140	K>R		No	ClinGen TOPMed
CA378834084 rs1465213740	141	Q>*		No	ClinGen gnomAD
CA5767566 rs777502721	141	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs758334170 CA5767565	141	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA378834127 rs1311765376	142	G>A		No	ClinGen gnomAD
rs751390447 CA5767567	142	G>S		No	ClinGen ExAC gnomAD
rs757050207 CA5767568	144	E>D		No	ClinGen ExAC
CA5767570 rs749539588	146	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs370419762 CA5767569	146	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs200955165 CA5767571	150	E>A		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	151	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5767572 rs779148806	152	H>Q		No	ClinGen ExAC gnomAD
CA216857719 rs1033628393	152	H>R		No	ClinGen TOPMed
CA378834343 rs1208223809	153	F>V		No	ClinGen gnomAD
CA5767574 rs373427672	154	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs142907528 CA5767577	156	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA5767578 rs776328834	158	L>I		No	ClinGen ExAC TOPMed gnomAD
CA216857728 rs958935789	159	R>G		No	ClinGen TOPMed
rs991726526 CA378834463	159	R>S		No	ClinGen TOPMed
TCGA novel	161	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	162	Q>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759119506 CA5767580	162	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1353571191 CA378835008	164	Q>*		No	ClinGen gnomAD
CA5767607 rs201167793	165	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA378835026 rs1314163001	165	P>R		No	ClinGen gnomAD
rs201167793 CA378835020	165	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1244383308 CA378835030	166	F>I		No	ClinGen gnomAD
CA378835049 rs1589954708	167	D>A		No	ClinGen Ensembl
rs1320694495 CA378835054	167	D>E		No	ClinGen TOPMed
TCGA novel	167	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1190685941 CA378835044	167	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs755208649 CA5767611	169	T>N		No	ClinGen ExAC TOPMed gnomAD
rs750206115 CA378835075	169	T>P		No	ClinGen ExAC TOPMed gnomAD
rs755208649 CA5767610	169	T>S		No	ClinGen ExAC TOPMed gnomAD
rs750206115 CA5767609	169	T>S		No	ClinGen ExAC TOPMed gnomAD
rs758535504 CA5767613	171	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs139133362 CA378835132	172	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5767614 rs566294180	172	I>V		No	ClinGen ExAC TOPMed gnomAD
COSM4165439 CA5767617 rs60452492	173	G>C	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA5767616 rs60452492	173	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs923179921 CA216857831	174	C>S		No	ClinGen TOPMed
rs56040284 CA5767618	175	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs548262477 CA5767619	175	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs557994567 CA216857836	176	P>S		No	ClinGen TOPMed gnomAD
CA5767621 rs1272538462	178	N>S		No	ClinGen gnomAD
rs6413419 CA378835214	179	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_008361 CA5767624 rs6413419	179	V>I	allele CYP2E1*4 [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs201427783 CA5767625	180	I>M		No	ClinGen ExAC gnomAD
TCGA novel	182	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5767628 rs76138620	182	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1318060013 CA378835294	183	I>T		No	ClinGen gnomAD
CA378835312 rs1220862293	185	F>L		No	ClinGen gnomAD
rs1263786649 CA378835323	185	F>L		No	ClinGen gnomAD
rs140500826 CA5767629	186	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA5767630 rs200871390	186	R>H		No	ClinGen ExAC TOPMed gnomAD
CA5767631 rs752959099	190	D>N		No	ClinGen ExAC
CA5767632 rs763286285	192	N>S		No	ClinGen ExAC gnomAD
rs764189163 CA5767633	194	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1296224047 CA378835486	195	K>M		No	ClinGen TOPMed
rs1365307411 CA378835545	198	R>K		No	ClinGen TOPMed
TCGA novel	200	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757401077 CA5767635	200	M>L		No	ClinGen ExAC gnomAD
CA378835585 rs1564848264	200	M>R		No	ClinGen Ensembl
CA378835740 rs1351088713	208	H>P		No	ClinGen gnomAD
CA216857856 rs772559232	208	H>Q		No	ClinGen ExAC gnomAD
CA378835744 rs1351088713	208	H>R		No	ClinGen gnomAD
rs750987941 CA5767637	208	H>Y		No	ClinGen ExAC gnomAD
rs1397676621 CA378835762	209	L>Q		No	ClinGen TOPMed gnomAD
rs1281657912 CA378835792	211	S>G		No	ClinGen gnomAD
CA5767642 rs778445040	212	T>A		No	ClinGen ExAC TOPMed gnomAD
CA216857865 rs907445349	213	P>R		No	ClinGen TOPMed
rs577159401 CA5767644	213	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378835904 rs1194608147	216	Q>K		No	ClinGen TOPMed
rs41299426 CA5767668 VAR_055382 RCV000960923	219	N>D		No	ClinGen ClinVar UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs78313785 CA216857993	219	N>S		No	ClinGen Ensembl
rs769691101 CA5767669	220	N>T		No	ClinGen ExAC TOPMed gnomAD
CA5767672 rs767527110	224	F>S		No	ClinGen ExAC TOPMed gnomAD
rs773301045 CA5767673	226	H>Y		No	ClinGen ExAC gnomAD
CA378836227 rs1433319688	227	Y>*		No	ClinGen TOPMed
CA216858001 rs761129818	228	L>S		No	ClinGen ExAC gnomAD
rs761129818 CA5767674	228	L>W		No	ClinGen ExAC gnomAD
rs1193278838 CA378836273	230	G>E		No	ClinGen gnomAD
rs766838345 CA5767675	230	G>R		No	ClinGen ExAC gnomAD
CA378836285 rs1327451829	231	S>N		No	ClinGen TOPMed
rs1476850745 CA378836327	233	R>S		No	ClinGen gnomAD
rs1245708136 CA378836322	233	R>T		No	ClinGen gnomAD
rs1172122956 CA378836344	234	K>R		No	ClinGen gnomAD
rs754388548 CA5767676	235	V>I		No	ClinGen ExAC gnomAD
rs375484572 CA5767677	236	I>L		No	ClinGen ESP ExAC gnomAD
CA216858007 rs569948279	236	I>T		No	ClinGen 1000Genomes
TCGA novel	237	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	238	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752221593 CA5767679	238	N>Y		No	ClinGen ExAC gnomAD
CA5767680 rs758094862	242	V>I		No	ClinGen ExAC gnomAD
CA378836463 rs369888957	244	E>D		No	ClinGen ESP ExAC gnomAD
rs555344732 CA5767683	245	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
rs756879881 CA378836483	246	V>L		No	ClinGen ExAC TOPMed gnomAD
COSM249734 CA5767684 rs756879881	246	V>M	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA216858018 rs762739956	249	R>S		No	ClinGen Ensembl
rs1352765108 CA378836540	251	K>N		No	ClinGen gnomAD
CA216858020 rs978002991	252	E>D		No	ClinGen TOPMed gnomAD
rs745886844 CA5767686	254	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	255	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769409483 CA5767687	257	L>Q		No	ClinGen ExAC gnomAD
CA378836581 rs769409483	257	L>R		No	ClinGen ExAC gnomAD
rs748268978 CA5767689	260	N>S		No	ClinGen ExAC TOPMed gnomAD
rs772311713 CA5767690	261	C>*		No	ClinGen ExAC TOPMed gnomAD
CA5767691 rs540609626	262	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	262	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5767693 rs766501004	263	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs372834832 CA5767692	263	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
COSM4165440 rs1390074994 CA378836618	264	D>H	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA5767694 rs776997036	265	L>F		No	ClinGen ExAC gnomAD
rs201869253 CA5767695	267	D>N		No	ClinGen ESP ExAC gnomAD
rs201869253 CA378836641	267	D>Y		No	ClinGen ESP ExAC gnomAD
rs1271339688 CA378836651	268	C>S		No	ClinGen TOPMed
CA378836662 rs1445693067	268	C>W		No	ClinGen gnomAD
rs912558367 CA216858032	271	V>M		No	ClinGen TOPMed
CA5767697 rs753140012	273	M>V		No	ClinGen ExAC gnomAD
rs372404508 CA216858035	274	E>Q		No	ClinGen ESP TOPMed
CA378836863 rs1326260648	277	K>N		No	ClinGen TOPMed
CA378836857 rs1449208969	277	K>R		No	ClinGen TOPMed
CA378836876 rs1190104776	278	H>Q		No	ClinGen TOPMed gnomAD
CA378836873 rs1316414071	278	H>R		No	ClinGen gnomAD
rs1383519539 CA378836890	279	S>R		No	ClinGen TOPMed
CA5767718 rs751192911	280	A>V		No	ClinGen ExAC TOPMed gnomAD
COSM204516 CA5767720 rs375149895	282	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs749979006 CA5767721	282	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs375149895 CA378836916	282	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5767722 rs138201091	285	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA378836956 rs1195094707	285	T>I		No	ClinGen TOPMed
CA378836962 rs1373503578	286	M>V		No	ClinGen gnomAD
rs61710826 CA5767725	288	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5767726 rs778681344	290	T>I		No	ClinGen ExAC gnomAD
rs1589955387 CA378837048	290	T>S		No	ClinGen Ensembl
CA5767728 rs771160948	291	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1589955394 CA378837099	293	V>L		No	ClinGen Ensembl
CA5767730 rs745942247	294	A>V		No	ClinGen ExAC gnomAD
CA216858248 rs1007026512	295	D>N		No	ClinGen TOPMed gnomAD
rs1264055833 CA378837245	299	A>S		No	ClinGen gnomAD
rs533468318 CA5767734	299	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs761515989 CA5767736	300	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs750089893 CA5767738	301	T>S		No	ClinGen ExAC gnomAD
CA216858256 rs201120875	303	T>N		No	ClinGen 1000Genomes
CA5767740 rs765869376	304	T>S		No	ClinGen ExAC gnomAD
TCGA novel	305	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5767741 rs753706527	305	S>N		No	ClinGen ExAC gnomAD
CA378837392 rs1385845866	307	T>I		No	ClinGen gnomAD
rs866605553 CA216858263	308	L>V		No	ClinGen Ensembl
CA5767743 rs764958966	309	R>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs867501702 CA216858265	311	G>R		No	ClinGen Ensembl
COSM1703290 rs374740281 CA5767745	312	L>F	skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs973002990 CA216858270	313	L>Q		No	ClinGen gnomAD
CA216858272 rs142845267	314	I>S		No	ClinGen ESP
CA5767747 rs746145983	316	M>L		No	ClinGen ExAC gnomAD
CA5767748 rs756153015	318	Y>H		No	ClinGen ExAC gnomAD
rs1564848820 CA378837613	319	P>A		No	ClinGen Ensembl
CA216858277 rs984244601	319	P>H		No	ClinGen TOPMed gnomAD
rs915909 RCV000455117	321	I>=		No	ClinVar dbSNP
rs915909 CA378837645	321	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378837636 rs1251438410	321	I>V		No	ClinGen gnomAD
COSM1703291 rs138223492 CA5767750	322	E>K	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA5767772 rs773459833	324	K>E		No	ClinGen ExAC gnomAD
CA5767773 rs746620834	325	L>V		No	ClinGen ExAC gnomAD
TCGA novel	327	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA216858847 COSM260352 rs969893824	328	E>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA216858849 CA378839109 rs980349044	328	E>D		No	ClinGen TOPMed
CA5767774 rs770517759	329	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1337093867 CA378839136	330	D>Y		No	ClinGen gnomAD
rs1212628802 CA378839182	332	V>L		No	ClinGen TOPMed
CA5767778 rs775343042	333	I>M		No	ClinGen ExAC gnomAD
CA5767777 rs764799317	333	I>T		No	ClinGen ExAC gnomAD
CA378839203 rs1466872326	333	I>V		No	ClinGen TOPMed
rs1233332302 CA378839218	334	G>R		No	ClinGen gnomAD
rs762813109 CA5767779	335	P>A		No	ClinGen ExAC TOPMed gnomAD
CA378839234 rs762813109	335	P>T		No	ClinGen ExAC TOPMed gnomAD
CA216858850 rs200228968	337	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD
CA5767781 rs759707874	337	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5767780 rs759707874 COSM1346961	337	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1589956950 CA378839329	340	A>V		No	ClinGen Ensembl
rs61644766 CA5767783	341	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5767784 rs754169072	342	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1408513149 CA378839359 COSM139866	343	D>N	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1173015245 CA378839385	344	R>K		No	ClinGen gnomAD
CA216858854 rs912887278	345	Q>R		No	ClinGen TOPMed
rs947057503 CA216858855	346	E>D		No	ClinGen Ensembl
rs1355581068 CA378839448	347	M>L		No	ClinGen gnomAD
rs1042802318 CA216858857	347	M>T		No	ClinGen TOPMed
rs753186824 CA5767788	349	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA5767789 rs150514905	350	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA378839512 rs1396367463	350	M>V		No	ClinGen TOPMed
CA5767791 rs747302212	354	V>L		No	ClinGen ExAC TOPMed gnomAD
CA378839600 rs747302212	354	V>M		No	ClinGen ExAC TOPMed gnomAD
rs745528149 CA378839674	359	R>P		No	ClinGen ExAC TOPMed gnomAD
rs745528149 COSM204517 CA5767794	359	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs780820318 CA5767793	359	R>W		No	ClinGen ExAC TOPMed gnomAD
rs769239142 CA5767795	361	I>F		No	ClinGen ExAC gnomAD
rs372279263 CA5767796	362	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1589956979 CA378839728	362	T>P		No	ClinGen Ensembl
CA378839766 rs1436679183	364	V>A		No	ClinGen TOPMed
rs762908601 CA5767797	364	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	365	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_055383 rs41299434 CA216858860	366	S>C		No	ClinGen UniProt 1000Genomes dbSNP
rs1239952047 CA378839849	367	N>D		No	ClinGen gnomAD
TCGA novel	368	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768448978 CA5767798	369	P>L		No	ClinGen ExAC gnomAD
CA216858861 rs1005539701	371	E>G		No	ClinGen TOPMed gnomAD
CA5767799 rs59981143	373	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA216858863 rs370530375	374	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs370530375 CA5767800	374	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5767801 rs767486762	374	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5767803 rs759847516	375	D>E		No	ClinGen ExAC TOPMed gnomAD
rs754046416 CA5767802	375	D>G		No	ClinGen ExAC gnomAD
rs765355752 CA5767804	378	F>L		No	ClinGen ExAC gnomAD
CA378840212 rs752748963	380	G>E		No	ClinGen ExAC gnomAD
rs752748963 CA5767805	380	G>V		No	ClinGen ExAC gnomAD
CA378840239 rs1433121603	381	Y>H		No	ClinGen gnomAD
CA378840311 rs1437497706	382	L>F		No	ClinGen TOPMed
rs752179109 CA5767809	383	I>M		No	ClinGen ExAC TOPMed gnomAD
CA5767811 rs199856651	385	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA378840637 rs1327701553	388	V>A		No	ClinGen gnomAD
rs1425889399 CA378840635	388	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs55897648 VAR_008362 CA5767824	389	V>I	allele CYP2E1*3 [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs55897648 CA5767825	389	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	390	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757788272 CA5767826	393	L>V		No	ClinGen ExAC gnomAD
CA378840722 rs1223857405	394	D>E		No	ClinGen gnomAD
rs60207639 CA5767827	394	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
RCV000911448 CA5767828 rs59656378	396	V>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA216858938 rs1027409770	398	Y>F		No	ClinGen TOPMed
CA5767829 rs756521777	400	N>S		No	ClinGen ExAC gnomAD
rs779561569 CA5767830	401	Q>P		No	ClinGen ExAC gnomAD
rs749034745 CA5767831	405	D>E		No	ClinGen ExAC gnomAD
CA216858943 rs200177135	406	P>A		No	ClinGen TOPMed gnomAD
CA378840876 rs1352233539	407	E>G		No	ClinGen TOPMed
CA378840881 rs1304810209	408	K>E		No	ClinGen gnomAD
CA378840890 rs1414127010	409	F>L		No	ClinGen TOPMed
CA216858947 rs892558134	409	F>L		No	ClinGen Ensembl
rs1362640892 CA378840911	412	E>*		No	ClinGen gnomAD
CA216858949 rs369048851	413	H>R		No	ClinGen Ensembl
CA378840951 rs1304386663	416	N>S		No	ClinGen TOPMed
CA5767833 rs57702102	418	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1328203136 CA378840988	420	K>E		No	ClinGen gnomAD
rs748046628 CA5767834	420	K>M		No	ClinGen ExAC TOPMed gnomAD
rs2515641 RCV001707691 RCV000455849	421	F>=		No	ClinVar dbSNP
CA216858956 CA378841006 rs2515641	421	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	423	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1564850279 CA378841021	423	Y>H		No	ClinGen Ensembl
CA5767837 rs142767992	424	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs151041343 CA5767838	429	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1182003917 CA378841971	435	R>*		No	ClinGen TOPMed
CA5767863 rs761257042	436	V>A		No	ClinGen ExAC gnomAD
rs1471904078 CA378842021	437	C>F		No	ClinGen TOPMed
rs1254397224 CA378842056	439	G>R		No	ClinGen TOPMed
rs1196807939 CA378842082	440	E>G		No	ClinGen TOPMed
rs754256199 CA5767865	443	A>D		No	ClinGen ExAC gnomAD
CA5767866 rs140969399	444	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs764917641 CA5767868	444	R>H		No	ClinGen ExAC gnomAD
rs764917641 CA5767867	444	R>L		No	ClinGen ExAC gnomAD
rs764917641 CA5767869	444	R>P		No	ClinGen ExAC gnomAD
rs199855848 CA5767870	445	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1564850583 CA378842214	447	L>F		No	ClinGen Ensembl
CA378842269 rs1383662089	450	L>S		No	ClinGen gnomAD
rs746030618 CA216859152	452	C>S		No	ClinGen Ensembl
CA378842331 rs1297297780	453	A>T		No	ClinGen TOPMed gnomAD
rs369066427 CA216859153	453	A>V		No	ClinGen ESP TOPMed
rs1564850601 CA378842368	456	Q>K		No	ClinGen Ensembl
rs28969387 RCV000965828 VAR_024727 CA5767872	457	H>L		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1266958540 CA378842410	457	H>Y		No	ClinGen TOPMed
rs1589957781 CA378842497	462	P>S		No	ClinGen Ensembl
CA378842523 rs1395292003	464	V>A		No	ClinGen TOPMed
COSM1560867 rs187941410 CA5767874	464	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA5767875 rs769536455	465	D>V		No	ClinGen ExAC TOPMed
rs748372752 CA5767877	466	P>L		No	ClinGen ExAC gnomAD
CA5767876 rs779104532	466	P>S		No	ClinGen ExAC gnomAD
rs1256621896 CA378842569	467	K>N		No	ClinGen gnomAD
rs1203554290 CA378842581	468	D>G		No	ClinGen gnomAD
rs1485596221 CA378842574	468	D>N		No	ClinGen gnomAD
TCGA novel	468	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5767879 rs199954662 COSM1346963	470	D>N	Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs199954662 COSM1202861 CA5767880	470	D>Y	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs771433748 CA5767881	471	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	471	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA378842662 rs1393164404	474	I>L		No	ClinGen gnomAD
CA216859165 rs945150523	475	H>P		No	ClinGen TOPMed gnomAD
rs1589957815 CA378842686	475	H>Y		No	ClinGen Ensembl
rs1176734765 CA378842698	476	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA378842719 rs1453966988	477	G>R		No	ClinGen gnomAD
CA216859167 rs1041844199	477	G>V		No	ClinGen TOPMed
CA378842778 rs1182952256	483	P>S		No	ClinGen TOPMed
CA378842786 rs1451003704	484	R>C		No	ClinGen TOPMed gnomAD
CA5767882 rs55982231	484	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1451003704 CA378842784	484	R>S		No	ClinGen TOPMed gnomAD
CA216859171 rs750408412	486	K>E		No	ClinGen Ensembl
CA378842832 rs1436249380	488	C>W		No	ClinGen gnomAD
rs1184993512 CA378842828	488	C>Y		No	ClinGen TOPMed
CA378842860 rs1325698643	491	P>L		No	ClinGen gnomAD
CA5767884 rs759928543	492	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs147916524 CA5767885 COSM1242169	492	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs752341899 CA5767886	493	S>L		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P05181

1 regional properties for P05181

Type	Name	Position	InterPro Accession
conserved_site	Cytochrome P450, conserved site	430 - 439	IPR017972

Functions

		Description
EC Number	1.14.13.n7	With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Subcellular Localization	Endoplasmic reticulum membrane ; Peripheral membrane protein Microsome membrane ; Peripheral membrane protein Mitochondrion inner membrane ; Peripheral membrane protein	Post-translationally targeted to mitochondria TOMM70 is required for the translocation across the mitochondrial outer membrane After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intrinsic component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

15 GO annotations of molecular function

Name	Definition
4-nitrophenol 2-monooxygenase activity	Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+).
arachidonic acid epoxygenase activity	Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.
aromatase activity	Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
Hsp70 protein binding	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
Hsp90 protein binding	Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
iron ion binding	Binding to an iron (Fe) ion.
long-chain fatty acid omega-1 hydroxylase activity	Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized
monooxygenase activity	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor.
oxygen binding	Binding to oxygen (O2).
steroid hydroxylase activity	Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.

18 GO annotations of biological process

Name	Definition
4-nitrophenol metabolic process	The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion.
benzene metabolic process	The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation.
carbon tetrachloride metabolic process	The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants.
epoxygenase P450 pathway	The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids.
halogenated hydrocarbon metabolic process	The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine.
heterocycle metabolic process	The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
lipid hydroxylation	The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.
long-chain fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.
long-chain fatty acid metabolic process	The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
monoterpenoid metabolic process	The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton.
organic acid metabolic process	The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
response to bacterium	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
response to ethanol	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
response to organonitrogen compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
response to ozone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.
steroid metabolic process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
triglyceride metabolic process	The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
xenobiotic metabolic process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

52 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0IIF9	CYP2U1	Cytochrome P450 2U1	Bos taurus (Bovine)	PR
O18963	CYP2E1	Cytochrome P450 2E1	Bos taurus (Bovine)	PR
P12394	CYP17A1	Steroid 17-alpha-hydroxylase/17,20 lyase	Gallus gallus (Chicken)	PR
Q95078	Cyp18a1	Cytochrome P450 18a1	Drosophila melanogaster (Fruit fly)	PR
P05177	CYP1A2	Cytochrome P450 1A2	Homo sapiens (Human)	PR
P05093	CYP17A1	Steroid 17-alpha-hydroxylase/17,20 lyase	Homo sapiens (Human)	PR
P51589	CYP2J2	Cytochrome P450 2J2	Homo sapiens (Human)	PR
P10632	CYP2C8	Cytochrome P450 2C8	Homo sapiens (Human)	PR
P33260	CYP2C18	Cytochrome P450 2C18	Homo sapiens (Human)	PR
Q7Z449	CYP2U1	Cytochrome P450 2U1	Homo sapiens (Human)	PR
Q9D816	Cyp2c55	Cytochrome P450 2C55	Mus musculus (Mouse)	PR
P27786	Cyp17a1	Steroid 17-alpha-hydroxylase/17,20 lyase	Mus musculus (Mouse)	PR
O54749	Cyp2j5	Cytochrome P450 2J5	Mus musculus (Mouse)	PR
O54750	Cyp2j6	Cytochrome P450 2J6	Mus musculus (Mouse)	PR
P24456	Cyp2d10	Cytochrome P450 2D10	Mus musculus (Mouse)	PR
Q9CX98	Cyp2u1	Cytochrome P450 2U1	Mus musculus (Mouse)	PR
P24457	Cyp2d11	Cytochrome P450 2D11	Mus musculus (Mouse)	PR
P79383	CYP2E1	Cytochrome P450 2E1	Sus scrofa (Pig)	PR
P33273	Cyp2c55	Cytochrome P450 2C55	Rattus norvegicus (Rat)	PR
P24470	Cyp2c23	Cytochrome P450 2C23	Rattus norvegicus (Rat)	PR
P11715	Cyp17a1	Steroid 17-alpha-hydroxylase/17,20 lyase	Rattus norvegicus (Rat)	PR
P12939	Cyp2d10	Cytochrome P450 2D10	Rattus norvegicus (Rat)	PR
P10633	Cyp2d1	Cytochrome P450 2D1	Rattus norvegicus (Rat)	PR
P05179	Cyp2c7	Cytochrome P450 2C7	Rattus norvegicus (Rat)	PR
P12938	Cyp2d3	Cytochrome P450 2D3	Rattus norvegicus (Rat)	PR
O35293	Cyp2f2	Cytochrome P450 2F2	Rattus norvegicus (Rat)	PR
P20814	Cyp2c13	Cytochrome P450 2C13, male-specific	Rattus norvegicus (Rat)	PR
P05182	Cyp2e1	Cytochrome P450 2E1	Rattus norvegicus (Rat)	PR
Q8HYM9	CYP17A1	Steroid 17-alpha-hydroxylase/17,20 lyase	Macaca mulatta (Rhesus macaque)	PR
Q6YV88	CYP71Z7	Ent-cassadiene hydroxylase	Oryza sativa subsp japonica (Rice)	PR
A3A871	CYP71Z6	Ent-isokaurene C2/C3-hydroxylase	Oryza sativa subsp japonica (Rice)	PR
Q7X7X4	CYP99A2	Cytochrome P450 99A2	Oryza sativa subsp japonica (Rice)	PR
O48957	CYP99A1	Cytochrome P450 CYP99A1	Sorghum bicolor (Sorghum) (Sorghum vulgare)	PR
Q42797	CYP73A11	Trans-cinnamate 4-monooxygenase	Glycine max (Soybean) (Glycine hispida)	PR
Q9XHC6	CYP93E1	Beta-amyrin 24-hydroxylase	Glycine max (Soybean) (Glycine hispida)	PR
O81971	CYP71D9	Cytochrome P450 71D9	Glycine max (Soybean) (Glycine hispida)	PR
O48922	CYP98A2	Cytochrome P450 98A2	Glycine max (Soybean) (Glycine hispida)	PR
O49340	CYP71A12	Cytochrome P450 71A12	Arabidopsis thaliana (Mouse-ear cress)	PR
O64638	CYP76C3	Cytochrome P450 76C3	Arabidopsis thaliana (Mouse-ear cress)	PR
P58049	CYP71B11	Cytochrome P450 71B11	Arabidopsis thaliana (Mouse-ear cress)	PR
P58050	CYP71B13	Cytochrome P450 71B13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q96514	CYP71B7	Cytochrome P450 71B7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9CA61	CYP98A8	Cytochrome P450 98A8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LTM0	CYP71B23	Cytochrome P450 71B23	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LTM6	CYP71B17	Cytochrome P450 71B17	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LTM7	CYP71B16	Cytochrome P450 71B16	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LVD2	CYP71B10	Cytochrome P450 71B10	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SAE4	CYP71B29	Cytochrome P450 71B29	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SRQ1	CYP89A9	Cytochrome P450 89A9	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9ZU07	CYP71B12	Cytochrome P450 71B12	Arabidopsis thaliana (Mouse-ear cress)	PR
O64636	CYP76C1	Cytochrome P450 76C1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q949U1	CYP79F1	Dihomomethionine N-hydroxylase	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSALGVTVAL	LVWAAFLLLV	SMWRQVHSSW	NLPPGPFPLP	IIGNLFQLEL	KNIPKSFTRL
70	80	90	100	110	120
AQRFGPVFTL	YVGSQRMVVM	HGYKAVKEAL	LDYKDEFSGR	GDLPAFHAHR	DRGIIFNNGP
130	140	150	160	170	180
TWKDIRRFSL	TTLRNYGMGK	QGNESRIQRE	AHFLLEALRK	TQGQPFDPTF	LIGCAPCNVI
190	200	210	220	230	240
ADILFRKHFD	YNDEKFLRLM	YLFNENFHLL	STPWLQLYNN	FPSFLHYLPG	SHRKVIKNVA
250	260	270	280	290	300
EVKEYVSERV	KEHHQSLDPN	CPRDLTDCLL	VEMEKEKHSA	ERLYTMDGIT	VTVADLFFAG
310	320	330	340	350	360
TETTSTTLRY	GLLILMKYPE	IEEKLHEEID	RVIGPSRIPA	IKDRQEMPYM	DAVVHEIQRF
370	380	390	400	410	420
ITLVPSNLPH	EATRDTIFRG	YLIPKGTVVV	PTLDSVLYDN	QEFPDPEKFK	PEHFLNENGK
430	440	450	460	470	480
FKYSDYFKPF	STGKRVCAGE	GLARMELFLL	LCAILQHFNL	KPLVDPKDID	LSPIHIGFGC
490
IPPRYKLCVI	PRS