Q9ZU07

PR
Gene name
CYP71B12 (At5g25130, F21J6.2)
Protein name
Cytochrome P450 71B12
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G25130
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9ZU07

Entry ID Method Resolution Chain Position Source
AF-Q9ZU07-F1 Predicted AlphaFoldDB

65 variants for Q9ZU07

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH03118114 8 V>I No 1000Genomes
ENSVATH03118115 15 S>T No 1000Genomes
ENSVATH03118116 16 M>I No 1000Genomes
ENSVATH07037935 16 M>L No 1000Genomes
ENSVATH03118117 21 I>N No 1000Genomes
ENSVATH03118118 22 I>T No 1000Genomes
ENSVATH07037937 35 R>K No 1000Genomes
tmp_5_8668635_A_G 39 I>V No 1000Genomes
tmp_5_8668657_G_A 46 G>E No 1000Genomes
ENSVATH14182871 51 R>H No 1000Genomes
ENSVATH00646522 73 T>S No 1000Genomes
ENSVATH00646523 85 V>I No 1000Genomes
tmp_5_8668791_G_A 91 V>I No 1000Genomes
tmp_5_8668796_A_C 92 E>D No 1000Genomes
ENSVATH00646524 98 N>Y No 1000Genomes
ENSVATH03118130 115 S>T No 1000Genomes
ENSVATH03118131 115 S>Y No 1000Genomes
tmp_5_8668874_C_A 118 S>R No 1000Genomes
tmp_5_8668873_G_C 118 S>T No 1000Genomes
ENSVATH14182872 119 K>R No 1000Genomes
ENSVATH11023656 146 K>N No 1000Genomes
ENSVATH00646525 151 A>S No 1000Genomes
ENSVATH07037942 154 D>E No 1000Genomes
ENSVATH03118137 154 D>N No 1000Genomes
ENSVATH07037943 158 Q>E No 1000Genomes
tmp_5_8669071_C_T 184 A>V No 1000Genomes
ENSVATH03118142 199 E>D No 1000Genomes
tmp_5_8669178_G_A 220 V>I No 1000Genomes
tmp_5_8669181_G_A 221 V>I No 1000Genomes
tmp_5_8669232_C_A 238 L>I No 1000Genomes
tmp_5_8669242_C_A 241 A>E No 1000Genomes
tmp_5_8669271_A_G 251 K>E No 1000Genomes
tmp_5_8669288_T_A 256 D>E No 1000Genomes
tmp_5_8669293_T_C 258 I>T No 1000Genomes
tmp_5_8669338_G_A 273 G>E No 1000Genomes
ENSVATH03118147 275 T>I No 1000Genomes
tmp_5_8669347_C_G 276 T>R No 1000Genomes
ENSVATH07037948 305 V>G No 1000Genomes
tmp_5_8669538_G_A 309 V>M No 1000Genomes
ENSVATH11023658 320 L>M No 1000Genomes
tmp_5_8669593_T_G 327 V>G No 1000Genomes
ENSVATH03118156 332 K>E No 1000Genomes
ENSVATH03118157 333 H>N No 1000Genomes
ENSVATH11023659 335 D>V No 1000Genomes
tmp_5_8669619_G_A 336 D>N No 1000Genomes
tmp_5_8669626_T_C 338 I>T No 1000Genomes
ENSVATH03118158 344 R>G No 1000Genomes
tmp_5_8669649_C_G 346 Q>E No 1000Genomes
ENSVATH11023660 349 K>N No 1000Genomes
tmp_5_8669663_G_T 350 M>I No 1000Genomes
ENSVATH14182873 357 R>T No 1000Genomes
ENSVATH03118161 373 D>N No 1000Genomes
ENSVATH03118162 374 V>L No 1000Genomes
tmp_5_8669748_T_C 379 Y>H No 1000Genomes
ENSVATH03118164 380 N>D No 1000Genomes
ENSVATH03118169 422 L>F No 1000Genomes
tmp_5_8669949_G_A 446 V>I No 1000Genomes
ENSVATH11023664 453 L>F No 1000Genomes
ENSVATH11023664 453 L>I No 1000Genomes
ENSVATH11023795 459 W>* No 1000Genomes
tmp_5_8670016_C_A,T 468 A>E No 1000Genomes
tmp_5_8670016_C_A,T 468 A>V No 1000Genomes
tmp_5_8670091_C_G 493 T>S No 1000Genomes
ENSVATH07037956 496 T>I No 1000Genomes
ENSVATH07037956 496 T>S No 1000Genomes

No associated diseases with Q9ZU07

1 regional properties for Q9ZU07

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 429 - 438 IPR017972

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

4 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

53 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18963 CYP2E1 Cytochrome P450 2E1 Bos taurus (Bovine) PR
Q0IIF9 CYP2U1 Cytochrome P450 2U1 Bos taurus (Bovine) PR
P12394 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Gallus gallus (Chicken) PR
Q8HYN1 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Pan troglodytes (Chimpanzee) PR
Q95078 Cyp18a1 Cytochrome P450 18a1 Drosophila melanogaster (Fruit fly) PR
P10632 CYP2C8 Cytochrome P450 2C8 Homo sapiens (Human) PR
P33260 CYP2C18 Cytochrome P450 2C18 Homo sapiens (Human) PR
Q7Z449 CYP2U1 Cytochrome P450 2U1 Homo sapiens (Human) PR
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens (Human) PR
P05177 CYP1A2 Cytochrome P450 1A2 Homo sapiens (Human) PR
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens (Human) PR
P51589 CYP2J2 Cytochrome P450 2J2 Homo sapiens (Human) PR
Q9CX98 Cyp2u1 Cytochrome P450 2U1 Mus musculus (Mouse) PR
O54749 Cyp2j5 Cytochrome P450 2J5 Mus musculus (Mouse) PR
O54750 Cyp2j6 Cytochrome P450 2J6 Mus musculus (Mouse) PR
P24456 Cyp2d10 Cytochrome P450 2D10 Mus musculus (Mouse) PR
P24457 Cyp2d11 Cytochrome P450 2D11 Mus musculus (Mouse) PR
P27786 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Mus musculus (Mouse) PR
Q9D816 Cyp2c55 Cytochrome P450 2C55 Mus musculus (Mouse) PR
P79383 CYP2E1 Cytochrome P450 2E1 Sus scrofa (Pig) PR
P10633 Cyp2d1 Cytochrome P450 2D1 Rattus norvegicus (Rat) PR
P11715 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Rat) PR
P12939 Cyp2d10 Cytochrome P450 2D10 Rattus norvegicus (Rat) PR
P20814 Cyp2c13 Cytochrome P450 2C13, male-specific Rattus norvegicus (Rat) PR
O35293 Cyp2f2 Cytochrome P450 2F2 Rattus norvegicus (Rat) PR
P05182 Cyp2e1 Cytochrome P450 2E1 Rattus norvegicus (Rat) PR
P12938 Cyp2d3 Cytochrome P450 2D3 Rattus norvegicus (Rat) PR
P24470 Cyp2c23 Cytochrome P450 2C23 Rattus norvegicus (Rat) PR
P33273 Cyp2c55 Cytochrome P450 2C55 Rattus norvegicus (Rat) PR
P05179 Cyp2c7 Cytochrome P450 2C7 Rattus norvegicus (Rat) PR
Q8HYM9 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Macaca mulatta (Rhesus macaque) PR
Q6YV88 CYP71Z7 Ent-cassadiene hydroxylase Oryza sativa subsp japonica (Rice) PR
A3A871 CYP71Z6 Ent-isokaurene C2/C3-hydroxylase Oryza sativa subsp japonica (Rice) PR
Q7X7X4 CYP99A2 Cytochrome P450 99A2 Oryza sativa subsp japonica (Rice) PR
O48957 CYP99A1 Cytochrome P450 CYP99A1 Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q42797 CYP73A11 Trans-cinnamate 4-monooxygenase Glycine max (Soybean) (Glycine hispida) PR
Q9XHC6 CYP93E1 Beta-amyrin 24-hydroxylase Glycine max (Soybean) (Glycine hispida) PR
O81971 CYP71D9 Cytochrome P450 71D9 Glycine max (Soybean) (Glycine hispida) PR
O48922 CYP98A2 Cytochrome P450 98A2 Glycine max (Soybean) (Glycine hispida) PR
Q949U1 CYP79F1 Dihomomethionine N-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
Q9CA61 CYP98A8 Cytochrome P450 98A8 Arabidopsis thaliana (Mouse-ear cress) PR
O64636 CYP76C1 Cytochrome P450 76C1 Arabidopsis thaliana (Mouse-ear cress) PR
O64638 CYP76C3 Cytochrome P450 76C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SRQ1 CYP89A9 Cytochrome P450 89A9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVD2 CYP71B10 Cytochrome P450 71B10 Arabidopsis thaliana (Mouse-ear cress) PR
O49340 CYP71A12 Cytochrome P450 71A12 Arabidopsis thaliana (Mouse-ear cress) PR
P58049 CYP71B11 Cytochrome P450 71B11 Arabidopsis thaliana (Mouse-ear cress) PR
P58050 CYP71B13 Cytochrome P450 71B13 Arabidopsis thaliana (Mouse-ear cress) PR
Q96514 CYP71B7 Cytochrome P450 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM0 CYP71B23 Cytochrome P450 71B23 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM6 CYP71B17 Cytochrome P450 71B17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM7 CYP71B16 Cytochrome P450 71B16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAE4 CYP71B29 Cytochrome P450 71B29 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSLWYIIVAF VFFSSMIIVR IIRKTKKNLP PGPPRLPIIG NLHQLGSKPH RSMFKLSETY
70 80 90 100 110 120
GPLMSLKFGS VSTVVASTPE TVKEVLKTFD VECCSRPNMT YPARVTYNLK DLCFSPYSKY
130 140 150 160 170 180
WREVRKMTVV ELYTAKRVQS FQHTRKEEVA ALVDFIKQAA SLEKPVNLNK KLMKLSGSVI
190 200 210 220 230 240
CRVAFGINLQ GSKLENTYEE VIQGTVELVG SFAAADYFPV VGRIIDRITG LHSKCEKLFK
250 260 270 280 290 300
AMDAFFDQSI KHHLEDEIIK DDIIDLLLKM ERGETTLGEF QLTRDHTKGI LANILNAGID
310 320 330 340 350 360
TSAQVMTWVM TYLISNPRVL KKAQAEVREV IKHKDDIIEE DIERLQYLKM VIKETFRINP
370 380 390 400 410 420
LVPLLIPREA SKDVKIGGYN IPKKTWIHVN IWAIHRNPNV WKDPEAFIPE RFMDSQIDYK
430 440 450 460 470 480
GLNFELLPFG SGRRICPGIG MGMALVHLTL INLLYRFDWK LPEGMKVADV DLEESYGLVC
490
PKKIPLQLIP VLTQWT