Q9CA61

PR
Gene name
CYP98A8 (At1g74540, F1M20.22)
Protein name
Cytochrome P450 98A8
Names
p-coumarate 3-hydroxylase
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G74540
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

229-298 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CA61

Entry ID Method Resolution Chain Position Source
AF-Q9CA61-F1 Predicted AlphaFoldDB

29 variants for Q9CA61

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_28013407_C_T 16 L>F No 1000Genomes
tmp_1_28013683_G_A 108 V>I No 1000Genomes
ENSVATH01535939 130 L>P No 1000Genomes
tmp_1_28013778_G_C 139 L>F No 1000Genomes
tmp_1_28013813_T_C 151 I>T No 1000Genomes
ENSVATH05144894 159 S>L No 1000Genomes
tmp_1_28013836_T_C 159 S>P No 1000Genomes
tmp_1_28013840_G_T 160 G>V No 1000Genomes
ENSVATH05144895 170 V>A No 1000Genomes
ENSVATH05144896 172 K>N No 1000Genomes
tmp_1_28013881_C_G 174 L>V No 1000Genomes
ENSVATH05144898 194 E>K No 1000Genomes
tmp_1_28014008_T_A 216 L>H No 1000Genomes
tmp_1_28014013_C_A 218 H>N No 1000Genomes
tmp_1_28014019_T_C 220 W>R No 1000Genomes
ENSVATH05144899 229 F>L No 1000Genomes
ENSVATH05144900 231 S>C No 1000Genomes
tmp_1_28014120_A_C 253 E>D No 1000Genomes
ENSVATH13808333 258 I>M No 1000Genomes
ENSVATH01535940 313 T>I No 1000Genomes
ENSVATH13808335 318 A>V No 1000Genomes
ENSVATH13808336 322 L>F No 1000Genomes
tmp_1_28014418_C_T 353 L>F No 1000Genomes
tmp_1_28014457_A_C 366 S>R No 1000Genomes
tmp_1_28014497_G_A 379 G>E No 1000Genomes
tmp_1_28014607_G_A 416 G>S No 1000Genomes
ENSVATH05144902 476 R>K No 1000Genomes
ENSVATH13808338 489 A>G No 1000Genomes
ENSVATH05144903 494 L>F No 1000Genomes

No associated diseases with Q9CA61

1 regional properties for Q9CA61

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 424 - 433 IPR017972

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

9 GO annotations of molecular function

Name Definition
dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O.
diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O.
monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O.
tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives.
tricoumaroylspermidine meta-hydroxylase activity Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O.
triferuloylspermidine meta-hydroxylase activity Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O.

2 GO annotations of biological process

Name Definition
spermidine hydroxycinnamate conjugate biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates.
spermidine metabolic process The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

53 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18963 CYP2E1 Cytochrome P450 2E1 Bos taurus (Bovine) PR
Q0IIF9 CYP2U1 Cytochrome P450 2U1 Bos taurus (Bovine) PR
P12394 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Gallus gallus (Chicken) PR
Q8HYN1 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Pan troglodytes (Chimpanzee) PR
Q95078 Cyp18a1 Cytochrome P450 18a1 Drosophila melanogaster (Fruit fly) PR
P10632 CYP2C8 Cytochrome P450 2C8 Homo sapiens (Human) PR
P33260 CYP2C18 Cytochrome P450 2C18 Homo sapiens (Human) PR
Q7Z449 CYP2U1 Cytochrome P450 2U1 Homo sapiens (Human) PR
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens (Human) PR
P05177 CYP1A2 Cytochrome P450 1A2 Homo sapiens (Human) PR
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens (Human) PR
P51589 CYP2J2 Cytochrome P450 2J2 Homo sapiens (Human) PR
Q9CX98 Cyp2u1 Cytochrome P450 2U1 Mus musculus (Mouse) PR
O54749 Cyp2j5 Cytochrome P450 2J5 Mus musculus (Mouse) PR
O54750 Cyp2j6 Cytochrome P450 2J6 Mus musculus (Mouse) PR
P24456 Cyp2d10 Cytochrome P450 2D10 Mus musculus (Mouse) PR
P24457 Cyp2d11 Cytochrome P450 2D11 Mus musculus (Mouse) PR
P27786 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Mus musculus (Mouse) PR
Q9D816 Cyp2c55 Cytochrome P450 2C55 Mus musculus (Mouse) PR
P79383 CYP2E1 Cytochrome P450 2E1 Sus scrofa (Pig) PR
P10633 Cyp2d1 Cytochrome P450 2D1 Rattus norvegicus (Rat) PR
P11715 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Rat) PR
P12939 Cyp2d10 Cytochrome P450 2D10 Rattus norvegicus (Rat) PR
P20814 Cyp2c13 Cytochrome P450 2C13, male-specific Rattus norvegicus (Rat) PR
O35293 Cyp2f2 Cytochrome P450 2F2 Rattus norvegicus (Rat) PR
P05182 Cyp2e1 Cytochrome P450 2E1 Rattus norvegicus (Rat) PR
P12938 Cyp2d3 Cytochrome P450 2D3 Rattus norvegicus (Rat) PR
P24470 Cyp2c23 Cytochrome P450 2C23 Rattus norvegicus (Rat) PR
P33273 Cyp2c55 Cytochrome P450 2C55 Rattus norvegicus (Rat) PR
P05179 Cyp2c7 Cytochrome P450 2C7 Rattus norvegicus (Rat) PR
Q8HYM9 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Macaca mulatta (Rhesus macaque) PR
A3A871 CYP71Z6 Ent-isokaurene C2/C3-hydroxylase Oryza sativa subsp japonica (Rice) PR
Q6YV88 CYP71Z7 Ent-cassadiene hydroxylase Oryza sativa subsp japonica (Rice) PR
Q7X7X4 CYP99A2 Cytochrome P450 99A2 Oryza sativa subsp japonica (Rice) PR
O48957 CYP99A1 Cytochrome P450 CYP99A1 Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q42797 CYP73A11 Trans-cinnamate 4-monooxygenase Glycine max (Soybean) (Glycine hispida) PR
Q9XHC6 CYP93E1 Beta-amyrin 24-hydroxylase Glycine max (Soybean) (Glycine hispida) PR
O81971 CYP71D9 Cytochrome P450 71D9 Glycine max (Soybean) (Glycine hispida) PR
O48922 CYP98A2 Cytochrome P450 98A2 Glycine max (Soybean) (Glycine hispida) PR
Q9SAE4 CYP71B29 Cytochrome P450 71B29 Arabidopsis thaliana (Mouse-ear cress) PR
Q96514 CYP71B7 Cytochrome P450 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q949U1 CYP79F1 Dihomomethionine N-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
O49340 CYP71A12 Cytochrome P450 71A12 Arabidopsis thaliana (Mouse-ear cress) PR
O64638 CYP76C3 Cytochrome P450 76C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SRQ1 CYP89A9 Cytochrome P450 89A9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM7 CYP71B16 Cytochrome P450 71B16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM6 CYP71B17 Cytochrome P450 71B17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM0 CYP71B23 Cytochrome P450 71B23 Arabidopsis thaliana (Mouse-ear cress) PR
P58049 CYP71B11 Cytochrome P450 71B11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZU07 CYP71B12 Cytochrome P450 71B12 Arabidopsis thaliana (Mouse-ear cress) PR
P58050 CYP71B13 Cytochrome P450 71B13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVD2 CYP71B10 Cytochrome P450 71B10 Arabidopsis thaliana (Mouse-ear cress) PR
O64636 CYP76C1 Cytochrome P450 76C1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MIIYLISLLP IIVATLMLYQ RWWRSNIPPG PKPKFLLGNL HQMKPLWTHS FSEWSETYGP
70 80 90 100 110 120
IISVWIGSQL TVVVSSSDLA RQVLRDKDHQ LSNRHRIARM TQTGTDLVWS DYSPHYVKLR
130 140 150 160 170 180
KLCTLELFSL KSIENFRSLR EMEARSMVVS ILKDLMSNSG DDQERKPVIV RKYLAAVVLN
190 200 210 220 230 240
TISRLMIGKE FGSEEGKEFK AIVEKEHLLS GSGTILDHVW WLKWVSSWFF SDKEFLAHKD
250 260 270 280 290 300
RRTKWFRGAI MVEEDIEIED HRGFVRKLLV LKEQKELSEE TVGGLVWNML TAGADTTAVV
310 320 330 340 350 360
IEWAMAEMIK CPTVQEKAQQ ELDSVVGSER LMTESDIPIL PYLQCVVKEA LRLHPSTPLM
370 380 390 400 410 420
LPHKASETVW VGGYKVPKGA TVYVNVQAIG RDPANWINPY EFRPERFLQE ETDVKGRDFR
430 440 450 460 470 480
VLPFGSGRRM CPAAQLSMNL MTLVMGNLLH CFSWSSPVPG ERIDMSENPG LLCNMRTPLQ
490
ALALPRAAAR AIPLPLD