P24457
PR
Gene name |
Cyp2d11 (Cyp2d-11) |
Protein name |
Cytochrome P450 2D11 |
Names |
CYPIID11, Cytochrome P450-16-alpha, Cytochrome P450CC, Testosterone 16-alpha hydroxylase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:545123 |
EC number |
1.14.14.1: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P24457
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P24457-F1 | Predicted | AlphaFoldDB |
70 variants for P24457
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389373535 | 22 | L>R | No | EVA | |
| rs49125063 | 27 | H>L | No | EVA | |
| rs579855692 | 31 | H>R | No | EVA | |
| rs579660523 | 36 | C>Y | No | EVA | |
| rs32438093 | 55 | G>D | No | EVA | |
| rs240740403 | 55 | G>S | No | EVA | |
| rs8236429 | 66 | N>K | No | EVA | |
| rs8248234 | 77 | G>A | No | EVA | |
| rs8248233 | 93 | V>M | No | EVA | |
| rs8248232 | 106 | Q>P | No | EVA | |
| rs8248232 | 106 | Q>R | No | EVA | |
| rs8248231 | 112 | Y>H | No | EVA | |
| rs3389294791 | 131 | W>R | No | EVA | |
| rs48787765 | 132 | Q>R | No | EVA | |
| rs50591090 | 154 | D>E | No | EVA | |
| rs579649743 | 161 | R>K | No | EVA | |
| rs260017881 | 161 | R>S | No | EVA | |
| rs3389371252 | 163 | L>H | No | EVA | |
| rs49925026 | 174 | S>P | No | EVA | |
| rs48841404 | 179 | T>P | No | EVA | |
| rs579699258 | 183 | N>K | No | EVA | |
| rs8279240 | 184 | A>S | No | EVA | |
| rs8279243 | 185 | V>A | No | EVA | |
| rs8279242 | 185 | V>M | No | EVA | |
| rs8279245 | 198 | F>L | No | EVA | |
| rs3389371286 | 200 | Y>N | No | EVA | |
| rs8279246 | 204 | Y>F | No | EVA | |
| rs8279247 | 211 | M>V | No | EVA | |
| rs8279284 | 229 | E>A | No | EVA | |
| rs31686715 | 235 | R>C | No | EVA | |
| rs3389358298 | 243 | V>A | No | EVA | |
| rs8240901 | 243 | V>F | No | EVA | |
| rs3389373555 | 254 | L>P | No | EVA | |
| rs3406367687 | 267 | P>H | No | EVA | |
| rs3406312537 | 271 | P>A | No | EVA | |
| rs3389358332 | 280 | A>T | No | EVA | |
| rs3389340561 | 284 | K>R | No | EVA | |
| rs8279227 | 289 | P>A | No | EVA | |
| rs3389371254 | 292 | S>N | No | EVA | |
| rs8279226 | 295 | D>H | No | EVA | |
| rs8279224 | 303 | G>R | No | EVA | |
| rs8279223 | 303 | G>V | No | EVA | |
| rs222114530 | 309 | G>R | No | EVA | |
| rs3389384223 | 319 | W>C | No | EVA | |
| rs3389329326 | 332 | R>G | No | EVA | |
| rs1135226192 | 342 | I>K | No | EVA | |
| rs582044438 | 346 | Q>R | No | EVA | |
| rs579241601 | 355 | R>H | No | EVA | |
| rs3389340544 | 363 | I>N | No | EVA | |
| rs236703674 | 376 | P>H | No | EVA | |
| rs586421219 | 376 | P>T | No | EVA | |
| rs582340914 | 378 | P>Q | No | EVA | |
| rs3389376294 | 378 | P>S | No | EVA | |
| rs3389294819 | 379 | R>H | No | EVA | |
| rs579127514 | 379 | R>S | No | EVA | |
| rs212391649 | 386 | E>Q | No | EVA | |
| rs584624344 | 390 | F>L | No | EVA | |
| rs236244138 | 392 | V>I | No | EVA | |
| rs215238607 | 393 | T>P | No | EVA | |
| rs3389392247 | 401 | N>I | No | EVA | |
| rs32047531 | 402 | M>L | No | EVA | |
| rs255062407 | 405 | V>M | No | EVA | |
| rs47258643 | 408 | D>G | No | EVA | |
| rs3389373526 | 416 | L>F | No | EVA | |
| rs8248302 | 450 | A>P | No | EVA | |
| rs238595679 | 466 | R>H | No | EVA | |
| rs3389392209 | 471 | V>M | No | EVA | |
| rs8279238 | 483 | V>A | No | EVA | |
| rs8279237 | 500 | R>H | No | EVA | |
| rs8279235 | 503 | G>E | No | EVA |
No associated diseases with P24457
1 regional properties for P24457
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 439 - 448 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.1 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| anandamide 11,12 epoxidase activity | Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized |
| anandamide 14,15 epoxidase activity | Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized |
| anandamide 8,9 epoxidase activity | Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized |
| aromatase activity | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. |
| steroid hydroxylase activity | Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| arachidonic acid metabolic process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
| organic acid metabolic process | The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. |
| xenobiotic metabolic process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0IIF9 | CYP2U1 | Cytochrome P450 2U1 | Bos taurus (Bovine) | PR |
| O18963 | CYP2E1 | Cytochrome P450 2E1 | Bos taurus (Bovine) | PR |
| P12394 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Gallus gallus (Chicken) | PR |
| Q95078 | Cyp18a1 | Cytochrome P450 18a1 | Drosophila melanogaster (Fruit fly) | PR |
| P33260 | CYP2C18 | Cytochrome P450 2C18 | Homo sapiens (Human) | PR |
| Q7Z449 | CYP2U1 | Cytochrome P450 2U1 | Homo sapiens (Human) | PR |
| P05177 | CYP1A2 | Cytochrome P450 1A2 | Homo sapiens (Human) | PR |
| P05093 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (Human) | PR |
| P51589 | CYP2J2 | Cytochrome P450 2J2 | Homo sapiens (Human) | PR |
| P10632 | CYP2C8 | Cytochrome P450 2C8 | Homo sapiens (Human) | PR |
| P05181 | CYP2E1 | Cytochrome P450 2E1 | Homo sapiens (Human) | PR |
| P27786 | Cyp17a1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Mus musculus (Mouse) | PR |
| O54749 | Cyp2j5 | Cytochrome P450 2J5 | Mus musculus (Mouse) | PR |
| O54750 | Cyp2j6 | Cytochrome P450 2J6 | Mus musculus (Mouse) | PR |
| P24456 | Cyp2d10 | Cytochrome P450 2D10 | Mus musculus (Mouse) | PR |
| Q9D816 | Cyp2c55 | Cytochrome P450 2C55 | Mus musculus (Mouse) | PR |
| Q9CX98 | Cyp2u1 | Cytochrome P450 2U1 | Mus musculus (Mouse) | PR |
| P79383 | CYP2E1 | Cytochrome P450 2E1 | Sus scrofa (Pig) | PR |
| P33273 | Cyp2c55 | Cytochrome P450 2C55 | Rattus norvegicus (Rat) | PR |
| P05182 | Cyp2e1 | Cytochrome P450 2E1 | Rattus norvegicus (Rat) | PR |
| P24470 | Cyp2c23 | Cytochrome P450 2C23 | Rattus norvegicus (Rat) | PR |
| P11715 | Cyp17a1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Rat) | PR |
| P05179 | Cyp2c7 | Cytochrome P450 2C7 | Rattus norvegicus (Rat) | PR |
| P12938 | Cyp2d3 | Cytochrome P450 2D3 | Rattus norvegicus (Rat) | PR |
| O35293 | Cyp2f2 | Cytochrome P450 2F2 | Rattus norvegicus (Rat) | PR |
| P20814 | Cyp2c13 | Cytochrome P450 2C13, male-specific | Rattus norvegicus (Rat) | PR |
| P10633 | Cyp2d1 | Cytochrome P450 2D1 | Rattus norvegicus (Rat) | PR |
| P12939 | Cyp2d10 | Cytochrome P450 2D10 | Rattus norvegicus (Rat) | PR |
| Q8HYM9 | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase | Macaca mulatta (Rhesus macaque) | PR |
| Q6YV88 | CYP71Z7 | Ent-cassadiene hydroxylase | Oryza sativa subsp japonica (Rice) | PR |
| A3A871 | CYP71Z6 | Ent-isokaurene C2/C3-hydroxylase | Oryza sativa subsp japonica (Rice) | PR |
| Q7X7X4 | CYP99A2 | Cytochrome P450 99A2 | Oryza sativa subsp japonica (Rice) | PR |
| O48957 | CYP99A1 | Cytochrome P450 CYP99A1 | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
| Q42797 | CYP73A11 | Trans-cinnamate 4-monooxygenase | Glycine max (Soybean) (Glycine hispida) | PR |
| O48922 | CYP98A2 | Cytochrome P450 98A2 | Glycine max (Soybean) (Glycine hispida) | PR |
| Q9XHC6 | CYP93E1 | Beta-amyrin 24-hydroxylase | Glycine max (Soybean) (Glycine hispida) | PR |
| O81971 | CYP71D9 | Cytochrome P450 71D9 | Glycine max (Soybean) (Glycine hispida) | PR |
| O49340 | CYP71A12 | Cytochrome P450 71A12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64638 | CYP76C3 | Cytochrome P450 76C3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P58049 | CYP71B11 | Cytochrome P450 71B11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P58050 | CYP71B13 | Cytochrome P450 71B13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96514 | CYP71B7 | Cytochrome P450 71B7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CA61 | CYP98A8 | Cytochrome P450 98A8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM0 | CYP71B23 | Cytochrome P450 71B23 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM6 | CYP71B17 | Cytochrome P450 71B17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTM7 | CYP71B16 | Cytochrome P450 71B16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVD2 | CYP71B10 | Cytochrome P450 71B10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAE4 | CYP71B29 | Cytochrome P450 71B29 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SRQ1 | CYP89A9 | Cytochrome P450 89A9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZU07 | CYP71B12 | Cytochrome P450 71B12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64636 | CYP76C1 | Cytochrome P450 76C1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q949U1 | CYP79F1 | Dihomomethionine N-hydroxylase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELLTGAGLW | SVAIFTVIFI | LLVDLMHRHQ | HWTSRCPPGP | VPWPVLGNLL | QVDLGNMPYS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LYKLQNRYGD | VFSLQMGWKP | MVVINGLKAM | KEVLLTCGED | TADRPQVPIF | EYLGVKPGSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVVLAPYGPE | WQEQRRFSVS | TLRNFGLGKK | SLEDWVTKEA | RHLCDAFTAQ | AGQSINPNTM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNNAVCNVIA | SLIFARRFEY | EDPYLIRMLK | MLKECFTEIS | GFIPGVLNEF | PIFLRIPGLA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DMVFQGQKSF | MAILDNLLTE | NRTTWDPDQP | PRNLTDAFLA | EIEKAKGNPE | SSFNDENLRM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VVGDLFTAGM | VTTSTTLSWA | LLLMILHPDV | QRRVQQEIDA | VIGQVQHPEM | ADQARMPYTN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AVIHEVQRFG | DIAPLPLPRI | TSRDIEVQDF | LVTKGSTLIP | NMSSVLKDET | VWEKPLRFHP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EHFLDAQGHF | VKPEAFMPFS | AGHRSCLGEA | LARMELFLFF | TCLLQRFSIS | VPDGQPQPSN |
| 490 | 500 | ||||
| YRVHAIPVAP | FPYQLCAVMR | EQGH |