Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q96514

Entry ID Method Resolution Chain Position Source
AF-Q96514-F1 Predicted AlphaFoldDB

30 variants for Q96514

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04568508 3 I>T No 1000Genomes
tmp_1_4467293_C_G 8 L>V No 1000Genomes
tmp_1_4467325_A_C 18 L>F No 1000Genomes
ENSVATH04568509 27 P>S No 1000Genomes
ENSVATH11118068 33 P>S No 1000Genomes
tmp_1_4467457_G_T 62 K>N No 1000Genomes
tmp_1_4467606_T_G 112 F>C No 1000Genomes
ENSVATH04568511 147 I>V No 1000Genomes
tmp_1_4467733_G_T 154 L>F No 1000Genomes
ENSVATH13889060 161 E>K No 1000Genomes
tmp_1_4467756_C_T 162 S>F No 1000Genomes
tmp_1_4467767_A_C 166 K>Q No 1000Genomes
tmp_1_4467768_A_G 166 K>R No 1000Genomes
ENSVATH04568512 171 L>M No 1000Genomes
ENSVATH04568513 175 L>V No 1000Genomes
tmp_1_4467809_G_A 180 A>T No 1000Genomes
tmp_1_4467813_G_A 181 S>N No 1000Genomes
tmp_1_4467947_G_A 226 V>M No 1000Genomes
tmp_1_4467995_A_G 242 N>D No 1000Genomes
ENSVATH00021121 268 N>H No 1000Genomes
tmp_1_4468097_C_A 276 L>I No 1000Genomes
ENSVATH04568519 283 E>K No 1000Genomes
ENSVATH04568519 283 E>Q No 1000Genomes
tmp_1_4468318_C_T 326 P>S No 1000Genomes
tmp_1_4468352_G_A 337 R>K No 1000Genomes
tmp_1_4468405_G_C 355 V>L No 1000Genomes
ENSVATH04568520 445 I>V No 1000Genomes
tmp_1_4468759_G_A 473 V>I No 1000Genomes
tmp_1_4468766_A_C 475 K>T No 1000Genomes
ENSVATH04568523 499 V>D No 1000Genomes

No associated diseases with Q96514

1 regional properties for Q96514

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 439 - 448 IPR017972

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

53 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18963 CYP2E1 Cytochrome P450 2E1 Bos taurus (Bovine) PR
Q0IIF9 CYP2U1 Cytochrome P450 2U1 Bos taurus (Bovine) PR
P12394 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Gallus gallus (Chicken) PR
Q8HYN1 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Pan troglodytes (Chimpanzee) PR
Q95078 Cyp18a1 Cytochrome P450 18a1 Drosophila melanogaster (Fruit fly) PR
P10632 CYP2C8 Cytochrome P450 2C8 Homo sapiens (Human) PR
P33260 CYP2C18 Cytochrome P450 2C18 Homo sapiens (Human) PR
Q7Z449 CYP2U1 Cytochrome P450 2U1 Homo sapiens (Human) PR
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens (Human) PR
P05177 CYP1A2 Cytochrome P450 1A2 Homo sapiens (Human) PR
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens (Human) PR
P51589 CYP2J2 Cytochrome P450 2J2 Homo sapiens (Human) PR
Q9CX98 Cyp2u1 Cytochrome P450 2U1 Mus musculus (Mouse) PR
O54749 Cyp2j5 Cytochrome P450 2J5 Mus musculus (Mouse) PR
O54750 Cyp2j6 Cytochrome P450 2J6 Mus musculus (Mouse) PR
P24456 Cyp2d10 Cytochrome P450 2D10 Mus musculus (Mouse) PR
P24457 Cyp2d11 Cytochrome P450 2D11 Mus musculus (Mouse) PR
P27786 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Mus musculus (Mouse) PR
Q9D816 Cyp2c55 Cytochrome P450 2C55 Mus musculus (Mouse) PR
P79383 CYP2E1 Cytochrome P450 2E1 Sus scrofa (Pig) PR
P10633 Cyp2d1 Cytochrome P450 2D1 Rattus norvegicus (Rat) PR
P11715 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Rat) PR
P12939 Cyp2d10 Cytochrome P450 2D10 Rattus norvegicus (Rat) PR
P20814 Cyp2c13 Cytochrome P450 2C13, male-specific Rattus norvegicus (Rat) PR
O35293 Cyp2f2 Cytochrome P450 2F2 Rattus norvegicus (Rat) PR
P05182 Cyp2e1 Cytochrome P450 2E1 Rattus norvegicus (Rat) PR
P12938 Cyp2d3 Cytochrome P450 2D3 Rattus norvegicus (Rat) PR
P24470 Cyp2c23 Cytochrome P450 2C23 Rattus norvegicus (Rat) PR
P33273 Cyp2c55 Cytochrome P450 2C55 Rattus norvegicus (Rat) PR
P05179 Cyp2c7 Cytochrome P450 2C7 Rattus norvegicus (Rat) PR
Q8HYM9 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Macaca mulatta (Rhesus macaque) PR
A3A871 CYP71Z6 Ent-isokaurene C2/C3-hydroxylase Oryza sativa subsp japonica (Rice) PR
Q6YV88 CYP71Z7 Ent-cassadiene hydroxylase Oryza sativa subsp japonica (Rice) PR
Q7X7X4 CYP99A2 Cytochrome P450 99A2 Oryza sativa subsp japonica (Rice) PR
O48957 CYP99A1 Cytochrome P450 CYP99A1 Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q42797 CYP73A11 Trans-cinnamate 4-monooxygenase Glycine max (Soybean) (Glycine hispida) PR
Q9XHC6 CYP93E1 Beta-amyrin 24-hydroxylase Glycine max (Soybean) (Glycine hispida) PR
O81971 CYP71D9 Cytochrome P450 71D9 Glycine max (Soybean) (Glycine hispida) PR
O48922 CYP98A2 Cytochrome P450 98A2 Glycine max (Soybean) (Glycine hispida) PR
Q949U1 CYP79F1 Dihomomethionine N-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
Q9CA61 CYP98A8 Cytochrome P450 98A8 Arabidopsis thaliana (Mouse-ear cress) PR
O64636 CYP76C1 Cytochrome P450 76C1 Arabidopsis thaliana (Mouse-ear cress) PR
O64638 CYP76C3 Cytochrome P450 76C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SRQ1 CYP89A9 Cytochrome P450 89A9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVD2 CYP71B10 Cytochrome P450 71B10 Arabidopsis thaliana (Mouse-ear cress) PR
O49340 CYP71A12 Cytochrome P450 71A12 Arabidopsis thaliana (Mouse-ear cress) PR
P58049 CYP71B11 Cytochrome P450 71B11 Arabidopsis thaliana (Mouse-ear cress) PR
P58050 CYP71B13 Cytochrome P450 71B13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM0 CYP71B23 Cytochrome P450 71B23 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM6 CYP71B17 Cytochrome P450 71B17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM7 CYP71B16 Cytochrome P450 71B16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAE4 CYP71B29 Cytochrome P450 71B29 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZU07 CYP71B12 Cytochrome P450 71B12 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSILLCFLCL LPVFLVSLSI LSKRLKPSKW KLPPGPKTLP IIGNLHNLTG LPHTCFRNLS
70 80 90 100 110 120
QKFGPVMLLH FGFVPVVVIS SKEGAEEALK TQDLECCSRP ETVATRMISY NFKDIGFAPY
130 140 150 160 170 180
GEEWKALRKL VVMELLNTKK FQSFRYIREE ENDLLIKKLT ESALKKSPVN LKKTLFTLVA
190 200 210 220 230 240
SIVCRLAFGV NIHKCEFVDE DNVADLVNKF EMLVAGVAFT DFFPGVGWLV DRISGQNKTL
250 260 270 280 290 300
NNVFSELDTF FQNVLDDHIK PGRQVSENPD VVDVMLDLMK KQEKDGESFK LTTDHLKGII
310 320 330 340 350 360
SDIFLAGVNT SAVTLNWAMA ELIRNPRVMK KVQDEIRTTL GDKKQRITEQ DLSQVHYFKL
370 380 390 400 410 420
VVKEIFRLHP AAPLLLPRET MSHVKIQGYD IPVKTQMMIN IYSIARDPKL WTNPDEFNPD
430 440 450 460 470 480
RFLDSSIDYR GLNFELLPFG SGRRICPGMT LGITTVELGL LNLLYFFDWV VPVGKNVKDI
490 500
NLEETGSIII SKKTTLELVP LVHH