P58050

PR
Gene name
CYP71B13 (At5g25140, T11H3.150)
Protein name
Cytochrome P450 71B13
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G25140
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58050

Entry ID Method Resolution Chain Position Source
AF-P58050-F1 Predicted AlphaFoldDB

74 variants for P58050

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH07038034 4 W>G No 1000Genomes
ENSVATH11024030 5 Y>D No 1000Genomes
ENSVATH11024031 6 I>T No 1000Genomes
ENSVATH07038035 16 I>K No 1000Genomes
ENSVATH03118293 17 F>L No 1000Genomes
tmp_5_8673049_A_G 21 N>D No 1000Genomes
tmp_5_8673052_A_C 22 T>P No 1000Genomes
ENSVATH03118295 54 F>C No 1000Genomes
tmp_5_8673161_A_C 58 E>A No 1000Genomes
tmp_5_8673167_A_T 60 Y>F No 1000Genomes
tmp_5_8673166_T_C 60 Y>H No 1000Genomes
ENSVATH07038036 62 P>L No 1000Genomes
ENSVATH03118296 74 V>I No 1000Genomes
ENSVATH11024032 94 C>Y No 1000Genomes
ENSVATH07038039 98 F>Y No 1000Genomes
ENSVATH07038040 100 T>K No 1000Genomes
ENSVATH03118300 123 A>E No 1000Genomes
ENSVATH03118299 123 A>P No 1000Genomes
tmp_5_8673374_T_G 129 V>G No 1000Genomes
tmp_5_8673391_G_A 135 A>T No 1000Genomes
ENSVATH11024034 143 N>K No 1000Genomes
ENSVATH11024065 146 E>Q No 1000Genomes
tmp_5_8673445_G_A 153 V>I No 1000Genomes
ENSVATH07038043 158 H>Y No 1000Genomes
ENSVATH03118302 164 E>K No 1000Genomes
ENSVATH03118303 165 I>T No 1000Genomes
tmp_5_8673496_C_G 170 Q>E No 1000Genomes
ENSVATH11024066 195 E>A No 1000Genomes
tmp_5_8673576_T_A 196 N>K No 1000Genomes
ENSVATH11024067 197 T>I No 1000Genomes
tmp_5_8673586_G_C 200 E>Q No 1000Genomes
tmp_5_8673616_G_A 210 G>R No 1000Genomes
ENSVATH00646537 211 S>N No 1000Genomes
tmp_5_8673644_C_T 219 P>L No 1000Genomes
ENSVATH03118311 233 N>S No 1000Genomes
ENSVATH03118312 235 C>Y No 1000Genomes
ENSVATH07038044 248 H>Q No 1000Genomes
ENSVATH07038045
ENSVATH07038046
 249 C>S No 1000Genomes
ENSVATH11024068 258 G>S No 1000Genomes
tmp_5_8673784_T_G 266 L>V No 1000Genomes
ENSVATH07038048 269 K>N No 1000Genomes
ENSVATH07038047 269 K>T No 1000Genomes
tmp_5_8673810_G_T 274 E>D No 1000Genomes
ENSVATH11024069 275 I>T No 1000Genomes
tmp_5_8673818_T_G 277 L>R No 1000Genomes
tmp_5_8673823_G_C 279 E>Q No 1000Genomes
ENSVATH07038049 285 N>D No 1000Genomes
ENSVATH07038055 302 S>C No 1000Genomes
ENSVATH11024073 306 I>L No 1000Genomes
tmp_5_8674000_C_T 312 H>Y No 1000Genomes
ENSVATH07038057 323 A>T No 1000Genomes
tmp_5_8674042_G_C 326 E>Q No 1000Genomes
ENSVATH07038060 329 E>G No 1000Genomes
ENSVATH07038059 329 E>K No 1000Genomes
ENSVATH07038062 332 K>E No 1000Genomes
ENSVATH07038063 333 N>K No 1000Genomes
ENSVATH08428166 335 D>Y No 1000Genomes
ENSVATH08428168 336 N>D No 1000Genomes
ENSVATH03118323 341 D>Y No 1000Genomes
ENSVATH07038064 343 E>* No 1000Genomes
ENSVATH07038064 343 E>K No 1000Genomes
ENSVATH03118324 344 G>R No 1000Genomes
ENSVATH07038067 373 D>N No 1000Genomes
ENSVATH07038068 380 N>D No 1000Genomes
ENSVATH07038069 380 N>I No 1000Genomes
ENSVATH03118326 399 N>K No 1000Genomes
tmp_5_8674310_A_G 415 N>S No 1000Genomes
ENSVATH08428170 422 L>F No 1000Genomes
ENSVATH03118330 426 L>F No 1000Genomes
ENSVATH11024128 435 I>T No 1000Genomes
tmp_5_8674395_G_A 443 M>I No 1000Genomes
ENSVATH03118335 446 I>V No 1000Genomes
ENSVATH07038076 460 K>M No 1000Genomes
tmp_5_8674480_C_G 472 L>V No 1000Genomes

No associated diseases with P58050

1 regional properties for P58050

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 429 - 438 IPR017972

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.

4 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

53 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18963 CYP2E1 Cytochrome P450 2E1 Bos taurus (Bovine) PR
Q0IIF9 CYP2U1 Cytochrome P450 2U1 Bos taurus (Bovine) PR
P12394 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Gallus gallus (Chicken) PR
Q8HYN1 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Pan troglodytes (Chimpanzee) PR
Q95078 Cyp18a1 Cytochrome P450 18a1 Drosophila melanogaster (Fruit fly) PR
P10632 CYP2C8 Cytochrome P450 2C8 Homo sapiens (Human) PR
P33260 CYP2C18 Cytochrome P450 2C18 Homo sapiens (Human) PR
Q7Z449 CYP2U1 Cytochrome P450 2U1 Homo sapiens (Human) PR
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens (Human) PR
P05177 CYP1A2 Cytochrome P450 1A2 Homo sapiens (Human) PR
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens (Human) PR
P51589 CYP2J2 Cytochrome P450 2J2 Homo sapiens (Human) PR
Q9CX98 Cyp2u1 Cytochrome P450 2U1 Mus musculus (Mouse) PR
O54749 Cyp2j5 Cytochrome P450 2J5 Mus musculus (Mouse) PR
O54750 Cyp2j6 Cytochrome P450 2J6 Mus musculus (Mouse) PR
P24456 Cyp2d10 Cytochrome P450 2D10 Mus musculus (Mouse) PR
P24457 Cyp2d11 Cytochrome P450 2D11 Mus musculus (Mouse) PR
P27786 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Mus musculus (Mouse) PR
Q9D816 Cyp2c55 Cytochrome P450 2C55 Mus musculus (Mouse) PR
P79383 CYP2E1 Cytochrome P450 2E1 Sus scrofa (Pig) PR
P10633 Cyp2d1 Cytochrome P450 2D1 Rattus norvegicus (Rat) PR
P11715 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Rat) PR
P12939 Cyp2d10 Cytochrome P450 2D10 Rattus norvegicus (Rat) PR
P20814 Cyp2c13 Cytochrome P450 2C13, male-specific Rattus norvegicus (Rat) PR
O35293 Cyp2f2 Cytochrome P450 2F2 Rattus norvegicus (Rat) PR
P05182 Cyp2e1 Cytochrome P450 2E1 Rattus norvegicus (Rat) PR
P12938 Cyp2d3 Cytochrome P450 2D3 Rattus norvegicus (Rat) PR
P24470 Cyp2c23 Cytochrome P450 2C23 Rattus norvegicus (Rat) PR
P33273 Cyp2c55 Cytochrome P450 2C55 Rattus norvegicus (Rat) PR
P05179 Cyp2c7 Cytochrome P450 2C7 Rattus norvegicus (Rat) PR
Q8HYM9 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Macaca mulatta (Rhesus macaque) PR
Q6YV88 CYP71Z7 Ent-cassadiene hydroxylase Oryza sativa subsp japonica (Rice) PR
A3A871 CYP71Z6 Ent-isokaurene C2/C3-hydroxylase Oryza sativa subsp japonica (Rice) PR
Q7X7X4 CYP99A2 Cytochrome P450 99A2 Oryza sativa subsp japonica (Rice) PR
O48957 CYP99A1 Cytochrome P450 CYP99A1 Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q42797 CYP73A11 Trans-cinnamate 4-monooxygenase Glycine max (Soybean) (Glycine hispida) PR
Q9XHC6 CYP93E1 Beta-amyrin 24-hydroxylase Glycine max (Soybean) (Glycine hispida) PR
O81971 CYP71D9 Cytochrome P450 71D9 Glycine max (Soybean) (Glycine hispida) PR
O48922 CYP98A2 Cytochrome P450 98A2 Glycine max (Soybean) (Glycine hispida) PR
Q949U1 CYP79F1 Dihomomethionine N-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
Q9CA61 CYP98A8 Cytochrome P450 98A8 Arabidopsis thaliana (Mouse-ear cress) PR
O64636 CYP76C1 Cytochrome P450 76C1 Arabidopsis thaliana (Mouse-ear cress) PR
O64638 CYP76C3 Cytochrome P450 76C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SRQ1 CYP89A9 Cytochrome P450 89A9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVD2 CYP71B10 Cytochrome P450 71B10 Arabidopsis thaliana (Mouse-ear cress) PR
O49340 CYP71A12 Cytochrome P450 71A12 Arabidopsis thaliana (Mouse-ear cress) PR
P58049 CYP71B11 Cytochrome P450 71B11 Arabidopsis thaliana (Mouse-ear cress) PR
Q96514 CYP71B7 Cytochrome P450 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM0 CYP71B23 Cytochrome P450 71B23 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM6 CYP71B17 Cytochrome P450 71B17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM7 CYP71B16 Cytochrome P450 71B16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAE4 CYP71B29 Cytochrome P450 71B29 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZU07 CYP71B12 Cytochrome P450 71B12 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSLWYIIVVF VFFASIFIAK NTRKTKKNLP PGPPRLPIIG NLHQLGSKPH RSMFKLSEKY
70 80 90 100 110 120
GPLVYLKLGK VPSVVASTPE TVKDVLKTFD KDCCSRAFLT YPARISYNLK DLAFAPYSKY
130 140 150 160 170 180
WKAVRKMTVV ELYTAKRVKS FRNIREEEVA SFVEFIKHSA SLEEIVNLNQ TLVKLSGSVI
190 200 210 220 230 240
CRVGFGINLE GSKLENTYEE VIHGTMEVLG SFAASDYFPV IGGIIDRITG LHNKCEKVFK
250 260 270 280 290 300
GTDSFFDHCI KHHLEDGGSK DDIVDLLLKV ERGEIGLGEF QFTRNHTKGI LLDILLAGVD
310 320 330 340 350 360
TSGHTITWVM THLIKNPRVM KKAQAEVREV IKNKDNITEE DIEGLEYLKM VVKETLRINP
370 380 390 400 410 420
LVPLLTPREA SKDVKIGGYN IPKKTWIHVN IWAIHRNPNV WKDPEAFIPE RFMDNQIDYK
430 440 450 460 470 480
GLNFELLPFG SGRRICPGIG MGMALIHLTL INLLYRFDWK LPEGMEVEDV DLEESYGLVC
490
PKKVPLELIP VLTQWT