Q9D816

PR
Gene name
Cyp2c55
Protein name
Cytochrome P450 2C55
Names
CYPIIC55
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72082
EC number
1.14.14.1: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9D816

Entry ID Method Resolution Chain Position Source
AF-Q9D816-F1 Predicted AlphaFoldDB

28 variants for Q9D816

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389530306 24 S>F No EVA
rs265135466 36 F>L No EVA
rs3389503594 102 I>N No EVA
rs252678544 109 D>N No EVA
rs3409651268 113 I>V No EVA
rs3389530309 148 E>D No EVA
rs224403532 159 A>T No EVA
rs3389550429 174 P>S No EVA
rs3389532444 182 I>F No EVA
rs3389446280 195 L>F No EVA
rs3389493862 197 L>* No EVA
rs213269330 238 T>S No EVA
rs235917261 242 S>C No EVA
rs216627689 304 I>S No EVA
rs3389533062 331 I>F No EVA
rs3409326629 344 R>C No EVA
rs51015455 344 R>H No EVA
rs3389553060 360 D>V No EVA
rs3389493831 376 F>L No EVA
rs3389553045 378 S>R No EVA
rs51596326 386 E>D No EVA
rs3389537957 389 T>K No EVA
rs3409651252 392 T>Q No EVA
rs3389503598 427 P>L No EVA
rs3389550399 463 D>V No EVA
rs266157583 467 I>V No EVA
rs3411830764 468 D>H No EVA
rs3409219715 472 V>A No EVA

No associated diseases with Q9D816

No regional properties for Q9D816

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9D816

Functions

Description
EC Number 1.14.14.1 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum membrane; Peripheral membrane protein
  • Microsome membrane; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

8 GO annotations of molecular function

Name Definition
arachidonic acid epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.
aromatase activity Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
linoleic acid epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor.
retinoic acid 4-hydroxylase activity Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.
steroid hydroxylase activity Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.

6 GO annotations of biological process

Name Definition
arachidonic acid metabolic process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
epoxygenase P450 pathway The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids.
linoleic acid metabolic process The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
retinoic acid metabolic process The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

52 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0IIF9 CYP2U1 Cytochrome P450 2U1 Bos taurus (Bovine) PR
O18963 CYP2E1 Cytochrome P450 2E1 Bos taurus (Bovine) PR
P12394 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Gallus gallus (Chicken) PR
Q95078 Cyp18a1 Cytochrome P450 18a1 Drosophila melanogaster (Fruit fly) PR
Q7Z449 CYP2U1 Cytochrome P450 2U1 Homo sapiens (Human) PR
P05177 CYP1A2 Cytochrome P450 1A2 Homo sapiens (Human) PR
P05093 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens (Human) PR
P51589 CYP2J2 Cytochrome P450 2J2 Homo sapiens (Human) PR
P10632 CYP2C8 Cytochrome P450 2C8 Homo sapiens (Human) PR
P05181 CYP2E1 Cytochrome P450 2E1 Homo sapiens (Human) PR
P33260 CYP2C18 Cytochrome P450 2C18 Homo sapiens (Human) PR
P27786 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Mus musculus (Mouse) PR
O54749 Cyp2j5 Cytochrome P450 2J5 Mus musculus (Mouse) PR
O54750 Cyp2j6 Cytochrome P450 2J6 Mus musculus (Mouse) PR
P24456 Cyp2d10 Cytochrome P450 2D10 Mus musculus (Mouse) PR
P24457 Cyp2d11 Cytochrome P450 2D11 Mus musculus (Mouse) PR
Q9CX98 Cyp2u1 Cytochrome P450 2U1 Mus musculus (Mouse) PR
P79383 CYP2E1 Cytochrome P450 2E1 Sus scrofa (Pig) PR
P05182 Cyp2e1 Cytochrome P450 2E1 Rattus norvegicus (Rat) PR
P24470 Cyp2c23 Cytochrome P450 2C23 Rattus norvegicus (Rat) PR
P11715 Cyp17a1 Steroid 17-alpha-hydroxylase/17,20 lyase Rattus norvegicus (Rat) PR
P12939 Cyp2d10 Cytochrome P450 2D10 Rattus norvegicus (Rat) PR
P10633 Cyp2d1 Cytochrome P450 2D1 Rattus norvegicus (Rat) PR
P05179 Cyp2c7 Cytochrome P450 2C7 Rattus norvegicus (Rat) PR
P12938 Cyp2d3 Cytochrome P450 2D3 Rattus norvegicus (Rat) PR
O35293 Cyp2f2 Cytochrome P450 2F2 Rattus norvegicus (Rat) PR
P20814 Cyp2c13 Cytochrome P450 2C13, male-specific Rattus norvegicus (Rat) PR
P33273 Cyp2c55 Cytochrome P450 2C55 Rattus norvegicus (Rat) PR
Q8HYM9 CYP17A1 Steroid 17-alpha-hydroxylase/17,20 lyase Macaca mulatta (Rhesus macaque) PR
Q6YV88 CYP71Z7 Ent-cassadiene hydroxylase Oryza sativa subsp japonica (Rice) PR
A3A871 CYP71Z6 Ent-isokaurene C2/C3-hydroxylase Oryza sativa subsp japonica (Rice) PR
Q7X7X4 CYP99A2 Cytochrome P450 99A2 Oryza sativa subsp japonica (Rice) PR
O48957 CYP99A1 Cytochrome P450 CYP99A1 Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
Q42797 CYP73A11 Trans-cinnamate 4-monooxygenase Glycine max (Soybean) (Glycine hispida) PR
O48922 CYP98A2 Cytochrome P450 98A2 Glycine max (Soybean) (Glycine hispida) PR
Q9XHC6 CYP93E1 Beta-amyrin 24-hydroxylase Glycine max (Soybean) (Glycine hispida) PR
O81971 CYP71D9 Cytochrome P450 71D9 Glycine max (Soybean) (Glycine hispida) PR
O49340 CYP71A12 Cytochrome P450 71A12 Arabidopsis thaliana (Mouse-ear cress) PR
O64638 CYP76C3 Cytochrome P450 76C3 Arabidopsis thaliana (Mouse-ear cress) PR
P58049 CYP71B11 Cytochrome P450 71B11 Arabidopsis thaliana (Mouse-ear cress) PR
P58050 CYP71B13 Cytochrome P450 71B13 Arabidopsis thaliana (Mouse-ear cress) PR
Q96514 CYP71B7 Cytochrome P450 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CA61 CYP98A8 Cytochrome P450 98A8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM0 CYP71B23 Cytochrome P450 71B23 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM6 CYP71B17 Cytochrome P450 71B17 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LTM7 CYP71B16 Cytochrome P450 71B16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVD2 CYP71B10 Cytochrome P450 71B10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAE4 CYP71B29 Cytochrome P450 71B29 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SRQ1 CYP89A9 Cytochrome P450 89A9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZU07 CYP71B12 Cytochrome P450 71B12 Arabidopsis thaliana (Mouse-ear cress) PR
O64636 CYP76C1 Cytochrome P450 76C1 Arabidopsis thaliana (Mouse-ear cress) PR
Q949U1 CYP79F1 Dihomomethionine N-hydroxylase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDPVLVLVLT LSCLLLLSLW RQNSGRGKLP PGPTPFPIIG NILQIDIKNI SKSFNYFSKV
70 80 90 100 110 120
YGPVFTLYFG SKPTVVVHGY EAVKEALDDL GEEFSGRGSF QIFERINNDL GVIFSNGTKW
130 140 150 160 170 180
KELRRFSIMT LRSFGMGKRS IEDRIQEEAS CLVEELRKAN GSLCDPTFIL SCAPSNVICS
190 200 210 220 230 240
VIFHNRFDYK DEKFLNLMER LNENFKILNS PWMQVYNALP TLINYLPGSH NKVIKNFTEI
250 260 270 280 290 300
KSYILGRVKE HQETLDMDNP RDFIDCFLIK MEQEKHNPHS EFTIESLMAT VTDIFVAGTE
310 320 330 340 350 360
TTNITLRYGL LLLLKHTEVT AKVQAEIDHV IGRHRSPCMQ DRTRMPYTDA MVHEIQRYID
370 380 390 400 410 420
LIPNNVPHAA TCNVRFRSYF IPKGTELVTS LTSVLHDDKE FPNPEVFDPG HFLDENGNFK
430 440 450 460 470 480
KSDYFMPFSI GKRMCVGEAL ARTELFLILT TILQNFNLKS LVDTKDIDTT PVANTFGRVP
PSYQLYFIPR