Q9FG61

PR
Gene name
At5g36250 (T30G6.11)
Protein name
Probable protein phosphatase 2C 74
Names
AtPP2C74
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G36250
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FG61

Entry ID Method Resolution Chain Position Source
AF-Q9FG61-F1 Predicted AlphaFoldDB

49 variants for Q9FG61

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12026391 9 G>R No 1000Genomes
ENSVATH00677298 22 H>R No 1000Genomes
ENSVATH07227983 28 R>W No 1000Genomes
ENSVATH07227984 32 P>L No 1000Genomes
ENSVATH12026393 37 P>L No 1000Genomes
ENSVATH00677300 122 L>P No 1000Genomes
tmp_5_14283084_C_G 127 H>D No 1000Genomes
tmp_5_14283117_C_T 138 L>F No 1000Genomes
ENSVATH07227999 149 K>M No 1000Genomes
ENSVATH07228001 150 I>V No 1000Genomes
ENSVATH07228002 154 L>I No 1000Genomes
ENSVATH07228005 162 E>D No 1000Genomes
ENSVATH07228006 164 R>Q No 1000Genomes
ENSVATH07228007 171 V>M No 1000Genomes
ENSVATH07228010 177 I>V No 1000Genomes
tmp_5_14283250_G_C 182 G>A No 1000Genomes
ENSVATH07228011 185 V>I No 1000Genomes
ENSVATH07228013 215 K>N No 1000Genomes
ENSVATH12026448 216 Q>L No 1000Genomes
ENSVATH07228020 234 V>M No 1000Genomes
ENSVATH07228021 243 P>H No 1000Genomes
tmp_5_14283539_T_A 246 L>I No 1000Genomes
ENSVATH12026512 259 E>K No 1000Genomes
tmp_5_14283722_C_A 280 L>M No 1000Genomes
ENSVATH07228028 316 R>G No 1000Genomes
ENSVATH07228034 339 E>D No 1000Genomes
ENSVATH07228035 341 V>I No 1000Genomes
ENSVATH07228036 342 K>E No 1000Genomes
tmp_5_14284057_T_C 343 I>T No 1000Genomes
ENSVATH07228039 349 T>M No 1000Genomes
ENSVATH12026514 350 R>H No 1000Genomes
tmp_5_14284093_G_A 355 R>Q No 1000Genomes
tmp_5_14284135_T_A 369 F>Y No 1000Genomes
ENSVATH07228043 371 T>I No 1000Genomes
tmp_5_14284159_G_T 377 C>F No 1000Genomes
ENSVATH07228047 388 P>L No 1000Genomes
ENSVATH12026547 389 N>S No 1000Genomes
ENSVATH12026548 390 R>K No 1000Genomes
tmp_5_14284201_T_C 391 L>S No 1000Genomes
ENSVATH03254320 396 F>Y No 1000Genomes
ENSVATH07228050 399 E>G No 1000Genomes
ENSVATH12026549 418 T>A No 1000Genomes
ENSVATH12026550 418 T>N No 1000Genomes
tmp_5_14284300_G_C 424 G>A No 1000Genomes
tmp_5_14284299_G_A 424 G>R No 1000Genomes
ENSVATH12026551 430 G>E No 1000Genomes
tmp_5_14284338_C_G,T 437 L>F No 1000Genomes
tmp_5_14284338_C_G,T 437 L>V No 1000Genomes
ENSVATH07228055 443 Y>N No 1000Genomes

No associated diseases with Q9FG61

1 regional properties for Q9FG61

Type Name Position InterPro Accession
domain PPM-type phosphatase-like domain 57 - 384 IPR001932

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

2 GO annotations of biological process

Name Definition
peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.

35 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A5PJZ2 PPM1L Protein phosphatase 1L Bos taurus (Bovine) PR
P49593 PPM1F Protein phosphatase 1F Homo sapiens (Human) PR
Q5SGD2 PPM1L Protein phosphatase 1L Homo sapiens (Human) PR
O15297 PPM1D Protein phosphatase 1D Homo sapiens (Human) PR
Q8N819 PPM1N Probable protein phosphatase 1N Homo sapiens (Human) PR
Q8CGA0 Ppm1f Protein phosphatase 1F Mus musculus (Mouse) PR
Q80TL0 Ppm1e Protein phosphatase 1E Mus musculus (Mouse) PR
Q8BHN0 Ppm1l Protein phosphatase 1L Mus musculus (Mouse) PR
Q5JKN1 Os01g0552300 Probable protein phosphatase 2C 5 Oryza sativa subsp japonica (Rice) PR
Q0JLP9 PP2C06 Probable protein phosphatase 2C 6 Oryza sativa subsp japonica (Rice) PR
Q5SN75 Os01g0656200 Probable protein phosphatase 2C 8 Oryza sativa subsp japonica (Rice) PR
Q6K5I0 Os02g0600000 Probable protein phosphatase 2C 20 Oryza sativa subsp japonica (Rice) PR
Q6L482 Os05g0358500 Probable protein phosphatase 2C 48 Oryza sativa subsp japonica (Rice) PR
Q6L4R7 PP2C53 Protein phosphatase 2C 53 Oryza sativa subsp japonica (Rice) PR
Q6ZKL8 Os08g0500300 Probable protein phosphatase 2C 66 Oryza sativa subsp japonica (Rice) PR
Q7XW27 Os04g0321800 Probable protein phosphatase 2C 38 Oryza sativa subsp japonica (Rice) PR
Q9LMT1 At1g18030 Probable protein phosphatase 2C 8 Arabidopsis thaliana (Mouse-ear cress) PR
O81716 PPC4-2 Probable protein phosphatase 2C 21 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SD02 At3g51470 Probable protein phosphatase 2C 47 Arabidopsis thaliana (Mouse-ear cress) PR
P49599 PPH1 Protein phosphatase 2C 57 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AT1 At5g53140 Probable protein phosphatase 2C 76 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDA7 At3g15260 Probable protein phosphatase 2C 39 Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAZ3 At3g27140 Putative protein phosphatase 2C-like protein 45 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GY60 At4g03415 Probable protein phosphatase 2C 52 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZN9 At1g43900 Probable protein phosphatase 2C 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FIF5 SAG113 Probable protein phosphatase 2C 78 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNP9 HAB2 Protein phosphatase 2C 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ9 PP2C38 Probable protein phosphatase 2C 38 Arabidopsis thaliana (Mouse-ear cress) PR
Q94CL8 PP2C6 Probable protein phosphatase 2C 48 Arabidopsis thaliana (Mouse-ear cress) PR
O81760 PP2C63 Probable protein phosphatase 2C 63 Arabidopsis thaliana (Mouse-ear cress) PR
Q501F9 PP2C67 Probable protein phosphatase 2C 67 Arabidopsis thaliana (Mouse-ear cress) PR
O04719 ABI2 Protein phosphatase 2C 77 Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAJ0 HAB1 Protein phosphatase 2C 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRZ4 At3g16800 Probable protein phosphatase 2C 41 Arabidopsis thaliana (Mouse-ear cress) PR
Q84JD5 PP2C68 Probable protein phosphatase 2C 68 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGSCLSSSGG GGSRRSLHGS PHVPGPGRRK RPPKRRPGSC SSSFDNTEEP LLHRIPGRMF
70 80 90 100 110 120
LNGSTDTVSL FSQQGKKGPN QDAMIVWENF GSMEDTVFCG VFDGHGPYGH IVAKRVRDLL
130 140 150 160 170 180
PLKLGSHLES YVSPEEVLKE ISLNTDDRKI SEDLVHISAN GESRVYNKDY VKDQDMIQML
190 200 210 220 230 240
IGSIVKAYRF MDKELKMQVD VDCFCSGTTA VTMVKQGQHL VIGNIGDSRA VLGVRNKDNK
250 260 270 280 290 300
LVPFQLTEDL KPDVPAEAER IKRCRGRIFA LRDEPGVARL WLPNHNSPGL AMARAFGDFC
310 320 330 340 350 360
LKDFGLISVP DVSYRRLTEK DEFVVLATDG IWDALTNEEV VKIVAKAPTR SSAGRALVEA
370 380 390 400 410 420
AVRNWRWKFP TSKVDDCAVV CLFLDSEPNR LSTASFSKEK HINNGVTEPE PDTASSSTPD
430 440
SGTGSPELNG VNRIDTLVNL PVYVPTKE