Q80TL0
PR
Gene name |
Ppm1e (Camkn, Kiaa1072) |
Protein name |
Protein phosphatase 1E |
Names |
Ca(2+)/calmodulin-dependent protein kinase phosphatase N, CaMKP-N, CaMKP-nucleus, CaMKN, Partner of PIX 1, Partner of PIX-alpha, Partner of PIXA |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320472 |
EC number |
3.1.3.16: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80TL0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80TL0-F1 | Predicted | AlphaFoldDB |
26 variants for Q80TL0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3402559839 | 221 | R>S | No | EVA | |
| rs3389127766 | 225 | I>F | No | EVA | |
| rs3389191412 | 241 | M>I | No | EVA | |
| rs3389190144 | 246 | V>I | No | EVA | |
| rs3389190144 | 246 | V>L | No | EVA | |
| rs3389160578 | 264 | A>T | No | EVA | |
| rs3389204543 | 274 | G>E | No | EVA | |
| rs3389192643 | 279 | I>F | No | EVA | |
| rs3389200988 | 299 | P>R | No | EVA | |
| rs3389160540 | 307 | F>S | No | EVA | |
| rs3402442013 | 316 | Q>Q* | No | EVA | |
| rs3389198187 | 317 | K>M | No | EVA | |
| rs3402442013 | 317 | K>Q | No | EVA | |
| rs3389198249 | 390 | V>M | No | EVA | |
| rs3389192572 | 414 | D>V | No | EVA | |
| rs3389190024 | 417 | S>F | No | EVA | |
| rs3412932512 | 441 | D>N | No | EVA | |
| rs3389194603 | 442 | E>G | No | EVA | |
| rs3389190195 | 471 | D>E | No | EVA | |
| rs3389127764 | 494 | V>A | No | EVA | |
| rs3389201000 | 495 | S>R | No | EVA | |
| rs3389204602 | 499 | E>D | No | EVA | |
| rs3389178321 | 526 | W>R | No | EVA | |
| rs3389187426 | 542 | R>* | No | EVA | |
| rs3389198205 | 594 | P>S | No | EVA | |
| rs3389198226 | 638 | E>* | No | EVA |
No associated diseases with Q80TL0
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.16 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| myosin phosphatase activity | Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. |
| protein serine/threonine phosphatase activity | Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| negative regulation of protein kinase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. |
| peptidyl-threonine dephosphorylation | The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. |
| positive regulation of stress fiber assembly | Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
30 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PJZ2 | PPM1L | Protein phosphatase 1L | Bos taurus (Bovine) | PR |
| O15297 | PPM1D | Protein phosphatase 1D | Homo sapiens (Human) | PR |
| Q5SGD2 | PPM1L | Protein phosphatase 1L | Homo sapiens (Human) | PR |
| P49593 | PPM1F | Protein phosphatase 1F | Homo sapiens (Human) | PR |
| Q8CGA0 | Ppm1f | Protein phosphatase 1F | Mus musculus (Mouse) | PR |
| Q3UYC0 | Ppm1h | Protein phosphatase 1H | Mus musculus (Mouse) | PR |
| Q8BHN0 | Ppm1l | Protein phosphatase 1L | Mus musculus (Mouse) | PR |
| Q5JKN1 | Os01g0552300 | Probable protein phosphatase 2C 5 | Oryza sativa subsp japonica (Rice) | PR |
| Q0JLP9 | PP2C06 | Probable protein phosphatase 2C 6 | Oryza sativa subsp japonica (Rice) | PR |
| Q5SN75 | Os01g0656200 | Probable protein phosphatase 2C 8 | Oryza sativa subsp japonica (Rice) | PR |
| Q6K5I0 | Os02g0600000 | Probable protein phosphatase 2C 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XW27 | Os04g0321800 | Probable protein phosphatase 2C 38 | Oryza sativa subsp japonica (Rice) | PR |
| Q6L482 | Os05g0358500 | Probable protein phosphatase 2C 48 | Oryza sativa subsp japonica (Rice) | PR |
| Q6L4R7 | PP2C53 | Protein phosphatase 2C 53 | Oryza sativa subsp japonica (Rice) | PR |
| Q6ZKL8 | Os08g0500300 | Probable protein phosphatase 2C 66 | Oryza sativa subsp japonica (Rice) | PR |
| Q9LNP9 | HAB2 | Protein phosphatase 2C 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMT1 | At1g18030 | Probable protein phosphatase 2C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAJ0 | HAB1 | Protein phosphatase 2C 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81716 | PPC4-2 | Probable protein phosphatase 2C 21 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRZ4 | At3g16800 | Probable protein phosphatase 2C 41 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3EAZ3 | At3g27140 | Putative protein phosphatase 2C-like protein 45 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SD02 | At3g51470 | Probable protein phosphatase 2C 47 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY60 | At4g03415 | Probable protein phosphatase 2C 52 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P49599 | PPH1 | Protein phosphatase 2C 57 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG61 | At5g36250 | Probable protein phosphatase 2C 74 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O04719 | ABI2 | Protein phosphatase 2C 77 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FIF5 | SAG113 | Probable protein phosphatase 2C 78 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZN9 | At1g43900 | Probable protein phosphatase 2C 11 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AT1 | At5g53140 | Probable protein phosphatase 2C 76 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDA7 | At3g15260 | Probable protein phosphatase 2C 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGCIPEEKT | YRRFLELFLG | EFRGPCGGGE | PEPEPESEPE | PEPEAELVAA | EAAEASGEEP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEDAATVEAT | EEGEQDQDPE | PEDEAVEEET | ATEGEEEEEE | EAAAPGHSAV | PPPPQPQLPP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPPLPRPLSE | RITREEVEGE | SLDLCLQQLY | KYNCPSFLAA | ALARATSDEV | LQSDLSAHCI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PKETDGTEGT | VEIETVKLAR | SVFSKLHEIC | CSWVKDFPLR | RRPQIYYETS | IHAIKNMRRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MEDKHVCIPD | FNMLFNLEDQ | EEQAYFAVFD | GHGGVDAAIY | ASVHLHVNLV | RQEMFPHDPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EALCRAFRVT | DERFVQKAAR | ESLRCGTTGV | VTFIRGNMLH | VAWVGDSQVM | LVRKGQAVEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MKPHKPDRED | EKQRIEALGG | CVVWFGAWRV | NGSLSVSRAI | GDAEHKPYIC | GDADSASTVL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DGTEDYLILA | CDGFYDTVNP | DEAVKVVSDH | LKENNGDSSM | VAHKLVASAR | DAGSSDNITV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IVVFLRDMNK | AVNVSEESEW | TENSFQGGQE | DGGDDKETHG | ECKRPWPQHQ | CSAPADLGYE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GRVDSFTDRT | SLSPGPQINV | LEDPDYLDLT | QIEASKPHST | QFLPPVEMIG | PGAPKKDLNE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LIMEERSVKS | SLPERSGAGE | PRVSFNLGST | GQQICRMENL | SPVSSGLENE | QFKSRGKTAS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RLYHLRHHYS | KRQRGFRFNP | KFYSFLSARE | PSHKIGISLS | SLTRSGKRNK | MLRSSLPWRE |
| 730 | 740 | ||||
| NSWEGYSGNV | KIRKRNDIPC | PDFPWSYKI |